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P21803

- FGFR2_MOUSE

UniProt

P21803 - FGFR2_MOUSE

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Protein
Fibroblast growth factor receptor 2
Gene
Fgfr2, Bek, Ect1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.4 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei517 – 5171ATP By similarity
Binding sitei571 – 5711ATP By similarity
Active sitei626 – 6261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi487 – 4959ATP By similarity
Nucleotide bindingi565 – 5673ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor binding Source: MGI
  3. fibroblast growth factor-activated receptor activity Source: InterPro
  4. heparin binding Source: UniProtKB-KW
  5. protein binding Source: IntAct

GO - Biological processi

  1. angiogenesis Source: MGI
  2. apoptotic process Source: UniProtKB-KW
  3. axonogenesis Source: MGI
  4. bone development Source: MGI
  5. bone mineralization Source: MGI
  6. bone morphogenesis Source: MGI
  7. branch elongation involved in salivary gland morphogenesis Source: MGI
  8. branching involved in labyrinthine layer morphogenesis Source: MGI
  9. branching involved in prostate gland morphogenesis Source: MGI
  10. branching involved in salivary gland morphogenesis Source: MGI
  11. branching morphogenesis of a nerve Source: MGI
  12. bud elongation involved in lung branching Source: MGI
  13. cell fate commitment Source: MGI
  14. cell-cell signaling Source: MGI
  15. coronal suture morphogenesis Source: MGI
  16. digestive tract development Source: MGI
  17. embryonic cranial skeleton morphogenesis Source: InterPro
  18. embryonic digestive tract morphogenesis Source: MGI
  19. embryonic organ development Source: MGI
  20. embryonic organ morphogenesis Source: MGI
  21. embryonic pattern specification Source: MGI
  22. endodermal digestive tract morphogenesis Source: MGI
  23. epidermis morphogenesis Source: MGI
  24. epithelial cell differentiation Source: MGI
  25. epithelial cell proliferation Source: MGI
  26. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  27. epithelial tube branching involved in lung morphogenesis Source: MGI
  28. fibroblast growth factor receptor signaling pathway Source: MGI
  29. fibroblast growth factor receptor signaling pathway involved in hemopoiesis Source: UniProtKB
  30. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  31. fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow Source: UniProtKB
  32. fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development Source: UniProtKB
  33. fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow Source: UniProtKB
  34. gland morphogenesis Source: MGI
  35. hair follicle morphogenesis Source: MGI
  36. in utero embryonic development Source: MGI
  37. inner ear morphogenesis Source: MGI
  38. lacrimal gland development Source: MGI
  39. lateral sprouting from an epithelium Source: MGI
  40. lens fiber cell development Source: MGI
  41. limb bud formation Source: MGI
  42. lung alveolus development Source: MGI
  43. lung development Source: MGI
  44. lung lobe morphogenesis Source: MGI
  45. lung-associated mesenchyme development Source: MGI
  46. mammary gland bud formation Source: MGI
  47. membranous septum morphogenesis Source: MGI
  48. mesenchymal cell differentiation Source: MGI
  49. mesenchymal cell differentiation involved in lung development Source: MGI
  50. mesenchymal cell proliferation involved in lung development Source: MGI
  51. midbrain development Source: MGI
  52. morphogenesis of embryonic epithelium Source: MGI
  53. multicellular organism growth Source: MGI
  54. negative regulation of cell proliferation Source: MGI
  55. negative regulation of mitosis Source: MGI
  56. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  57. neuromuscular junction development Source: MGI
  58. odontogenesis Source: MGI
  59. orbitofrontal cortex development Source: UniProtKB
  60. organ growth Source: MGI
  61. organ morphogenesis Source: MGI
  62. otic vesicle formation Source: MGI
  63. outflow tract septum morphogenesis Source: MGI
  64. positive regulation of ERK1 and ERK2 cascade Source: MGI
  65. positive regulation of Wnt signaling pathway Source: MGI
  66. positive regulation of canonical Wnt signaling pathway Source: MGI
  67. positive regulation of cardiac muscle cell proliferation Source: MGI
  68. positive regulation of cell cycle Source: UniProtKB
  69. positive regulation of cell division Source: MGI
  70. positive regulation of cell proliferation Source: UniProtKB
  71. positive regulation of epithelial cell proliferation Source: MGI
  72. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  73. positive regulation of mesenchymal cell proliferation Source: MGI
  74. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  75. post-embryonic development Source: MGI
  76. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  77. prostate epithelial cord elongation Source: MGI
  78. prostate gland morphogenesis Source: MGI
  79. pyramidal neuron development Source: UniProtKB
  80. regulation of ERK1 and ERK2 cascade Source: MGI
  81. regulation of branching involved in prostate gland morphogenesis Source: MGI
  82. regulation of cell fate commitment Source: MGI
  83. regulation of cell proliferation Source: MGI
  84. regulation of epithelial cell proliferation Source: MGI
  85. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  86. regulation of morphogenesis of a branching structure Source: MGI
  87. regulation of multicellular organism growth Source: MGI
  88. regulation of smooth muscle cell differentiation Source: MGI
  89. regulation of smoothened signaling pathway Source: MGI
  90. reproductive structure development Source: MGI
  91. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  92. synaptic vesicle transport Source: MGI
  93. ureteric bud development Source: MGI
  94. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
  95. ventricular cardiac muscle tissue morphogenesis Source: MGI
  96. ventricular zone neuroblast division Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Heparin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor 2 (EC:2.7.10.1)
Short name:
FGFR-2
Alternative name(s):
Keratinocyte growth factor receptor
Short name:
KGFR
CD_antigen: CD332
Gene namesi
Name:Fgfr2
Synonyms:Bek, Ect1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Golgi apparatus By similarity. Cytoplasmic vesicle By similarity
Note: Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 377356Extracellular Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Topological domaini399 – 821423Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  3. excitatory synapse Source: UniProtKB
  4. extracellular region Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. nucleus Source: MGI
  7. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality shortly after implantation, due to trophoblast defects, absence of a functional placenta, failure of limb bud formation, plus defects in lung branching and heart development.4 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi769 – 7691Y → F: Abolishes phosphorylation of FRS2 and activation of MAP kinases. 1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 821800Fibroblast growth factor receptor 2
PRO_0000016784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 107 By similarity
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi179 ↔ 231 By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi278 ↔ 342 By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Modified residuei466 – 4661Phosphotyrosine; by autocatalysis By similarity
Modified residuei586 – 5861Phosphotyrosine; by autocatalysis By similarity
Modified residuei588 – 5881Phosphotyrosine; by autocatalysis By similarity
Modified residuei656 – 6561Phosphotyrosine; by autocatalysis By similarity
Modified residuei657 – 6571Phosphotyrosine; by autocatalysis By similarity
Modified residuei769 – 7691Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer By similarity.1 Publication
N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus By similarity.
Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP21803.
PRIDEiP21803.

PTM databases

PhosphoSiteiP21803.

Expressioni

Gene expression databases

CleanExiMM_FGFR2.
GenevestigatoriP21803.

Interactioni

Subunit structurei

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, FGF10, FGF17, FGF18 and FGF22 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19 and FGF21. Interacts with PLCG1, GRB2 and PAK4 By similarity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ncam1P135952EBI-6286942,EBI-774943

Protein-protein interaction databases

BioGridi199657. 2 interactions.
DIPiDIP-6038N.
IntActiP21803. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 525
Beta strandi58 – 614
Beta strandi69 – 746
Beta strandi77 – 793
Beta strandi83 – 886
Beta strandi91 – 944
Helixi99 – 1013
Beta strandi103 – 1108
Beta strandi115 – 12410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWUX-ray2.90A/B45-127[»]
ProteinModelPortaliP21803.
SMRiP21803. Positions 47-363, 462-801.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 125101Ig-like C2-type 1
Add
BLAST
Domaini154 – 24794Ig-like C2-type 2
Add
BLAST
Domaini256 – 358103Ig-like C2-type 3
Add
BLAST
Domaini481 – 770290Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 17818Heparin-binding By similarity
Add
BLAST

Domaini

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Alternative splicing events affecting the third Ig-like domain are crucial for ligand selectivity By similarity.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000263410.
HOVERGENiHBG000345.
InParanoidiP21803.
KOiK05093.
PhylomeDBiP21803.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P21803-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY    50
VVAPGESLEL QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR 100
DSGLYACTAA RTVDSETWIF MVNVTDAISS GDDEDDTDSS EDVVSENRSN 150
QRAPYWTNTE KMEKRLHACP AANTVKFRCP AGGNPTSTMR WLKNGKEFKQ 200
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVE 250
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK 300
NGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI 350
SFHSAWLTVL PAPVREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVIFCRM 400
KTTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR 450
LSSTADTPML AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA 500
VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGKHKNIINL 550
LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 600
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD 650
INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG 700
GSPYPGIPVE ELFKLLKEGH RMDKPTNCTN ELYMMMRDCW HAVPSQRPTF 750
KQLVEDLDRI LTLTTNEEYL DLTQPLEQYS PSYPDTSSSC SSGDDSVFSP 800
DPMPYEPCLP QYPHINGSVK T 821
Length:821
Mass (Da):91,984
Last modified:November 1, 1997 - v4
Checksum:iFCDB28ADD61F4414
GO
Isoform Short (identifier: P21803-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-37: E → G
     38-152: Missing.
     314-361: AAGVNTTDKE...FHSAWLTVLP → HSGINSSNAE...AWLTVLPKQQ

Show »
Length:707
Mass (Da):79,531
Checksum:iE57F5804B12F667C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 371E → G in isoform Short.
VSP_002985
Alternative sequencei38 – 152115Missing in isoform Short.
VSP_002986Add
BLAST
Alternative sequencei314 – 36148AAGVN…LTVLP → HSGINSSNAEVLALFNVTEM DAGEYICKVSNYIGQANQSA WLTVLPKQQ in isoform Short.
VSP_002987Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531A → V in CAA39083. 1 Publication
Sequence conflicti55 – 562GE → RG in CAA39083. 1 Publication
Sequence conflicti90 – 901E → R in CAA39083. 1 Publication
Sequence conflicti119 – 1191I → Y in CAA39083. 1 Publication
Sequence conflicti142 – 1432DV → R in CAA39083. 1 Publication
Sequence conflicti169 – 1691C → V in CAA39083. 1 Publication
Sequence conflicti169 – 1691C → V in AAA39377. 1 Publication
Sequence conflicti187 – 1871S → P in CAA39083. 1 Publication
Sequence conflicti187 – 1871S → P in AAA39377. 1 Publication
Sequence conflicti214 – 2141W → R in CAA39083. 1 Publication
Sequence conflicti229 – 2291Y → I in CAA39083. 1 Publication
Sequence conflicti275 – 2751E → R in CAA39083. 1 Publication
Sequence conflicti301 – 3011N → Y in CAA39083. 1 Publication
Sequence conflicti301 – 3011N → Y in AAA39377. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55441 mRNA. Translation: CAA39083.1.
M63503 mRNA. Translation: AAA39377.1.
M86441 mRNA. Translation: AAA37286.1.
Y16152 Genomic DNA. Translation: CAA76098.1.
Y16167 Genomic DNA. Translation: CAA76099.1.
M23362 mRNA. Translation: AAA37285.1.
PIRiA38429.
A44142. TVMSBK.
S17295.
RefSeqiNP_034337.2. NM_010207.2.
NP_963895.2. NM_201601.2.
UniGeneiMm.16340.

Genome annotation databases

GeneIDi14183.
KEGGimmu:14183.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55441 mRNA. Translation: CAA39083.1 .
M63503 mRNA. Translation: AAA39377.1 .
M86441 mRNA. Translation: AAA37286.1 .
Y16152 Genomic DNA. Translation: CAA76098.1 .
Y16167 Genomic DNA. Translation: CAA76099.1 .
M23362 mRNA. Translation: AAA37285.1 .
PIRi A38429.
A44142. TVMSBK.
S17295.
RefSeqi NP_034337.2. NM_010207.2.
NP_963895.2. NM_201601.2.
UniGenei Mm.16340.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HWU X-ray 2.90 A/B 45-127 [» ]
ProteinModelPortali P21803.
SMRi P21803. Positions 47-363, 462-801.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199657. 2 interactions.
DIPi DIP-6038N.
IntActi P21803. 2 interactions.

Chemistry

ChEMBLi CHEMBL2111391.

PTM databases

PhosphoSitei P21803.

Proteomic databases

PaxDbi P21803.
PRIDEi P21803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14183.
KEGGi mmu:14183.

Organism-specific databases

CTDi 2263.
MGIi MGI:95523. Fgfr2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000263410.
HOVERGENi HBG000345.
InParanoidi P21803.
KOi K05093.
PhylomeDBi P21803.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 3474.

Miscellaneous databases

ChiTaRSi FGFR2. mouse.
NextBioi 285386.
PROi P21803.
SOURCEi Search...

Gene expression databases

CleanExi MM_FGFR2.
Genevestigatori P21803.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfami PF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000628. FGFR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors."
    Raz V., Kelman Z., Avivi A., Neufeld G., Givol D., Yarden Y.
    Oncogene 6:753-760(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Strain: BALB/c.
    Tissue: Brain.
  2. "Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop."
    Miki T., Fleming T.P., Bottaro D.P., Rubin J.S., Ron D., Aaronson S.A.
    Science 251:72-75(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  3. "Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin."
    Mansukhani A., Dell'Era P., Moscatelli D., Kornbluth S., Hanafusa H., Basilico C.
    Proc. Natl. Acad. Sci. U.S.A. 89:3305-3309(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Brain and Liver.
  4. "Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3."
    Twigg S.R.F., Burns H.D., Oldridge M., Heath J.K., Wilkie A.O.M.
    Hum. Mol. Genet. 7:685-691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG).
  5. "Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries."
    Kornbluth S., Paulson K.E., Hanafusa H.
    Mol. Cell. Biol. 8:5541-5544(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 477-821.
    Tissue: Liver.
  6. "Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)."
    Orr-Urtreger A., Bedford M.T., Burakova T., Arman E., Zimmer Y., Yayon A., Givol D., Lonai P.
    Dev. Biol. 158:475-486(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: INTERACTION WITH FGF1; FGF2; FGF3; FGF4; FGF6; FGF7 AND FGF9, FUNCTION IN CELL PROLIFERATION.
  8. "Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction."
    Xu X., Weinstein M., Li C., Naski M., Cohen R.I., Ornitz D.M., Leder P., Deng C.
    Development 125:753-765(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development."
    Arman E., Haffner-Krausz R., Chen Y., Heath J.K., Lonai P.
    Proc. Natl. Acad. Sci. U.S.A. 95:5082-5087(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  10. "Fgfr2 is required for limb outgrowth and lung-branching morphogenesis."
    Arman E., Haffner-Krausz R., Gorivodsky M., Lonai P.
    Proc. Natl. Acad. Sci. U.S.A. 96:11895-11899(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  11. "Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts."
    Mansukhani A., Bellosta P., Sahni M., Basilico C.
    J. Cell Biol. 149:1297-1308(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The IIIc alternative of Fgfr2 is a positive regulator of bone formation."
    Eswarakumar V.P., Monsonego-Ornan E., Pines M., Antonopoulou I., Morriss-Kay G.M., Lonai P.
    Development 129:3783-3793(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  13. "Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis."
    Ceridono M., Belleudi F., Ceccarelli S., Torrisi M.R.
    Biochem. Biophys. Res. Commun. 327:523-532(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL PROLIFERATION AND ACTIVATION OF SIGNALING PATHWAYS, MUTAGENESIS OF TYR-769, PHOSPHORYLATION AT TYR-769, INTERACTION WITH PLCG1.

Entry informationi

Entry nameiFGFR2_MOUSE
AccessioniPrimary (citable) accession number: P21803
Secondary accession number(s): O55141, Q00389, Q61342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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