Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P21796 (VDAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 161. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent anion-selective channel protein 1

Short name=VDAC-1
Short name=hVDAC1
Alternative name(s):
Outer mitochondrial membrane protein porin 1
Plasmalemmal porin
Porin 31HL
Porin 31HM
Gene names
Name:VDAC1
Synonyms:VDAC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Ref.17 Ref.18 Ref.34

Subunit structure

Interacts with hexokinases By similarity. Interacts with BCL2L1. Interacts with BOP/C22orf29 (via BH3 domain). Interacts with influenza A virus PB1-F2 protein. Interacts with HK1. The HK1-VDAC1 complex interacts with ATF2 By similarity. Ref.19 Ref.29 Ref.32 Ref.34

Subcellular location

Mitochondrion outer membrane. Cell membrane Ref.15.

Tissue specificity

Heart, liver and skeletal muscle.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Ontologies

Keywords
   Biological processApoptosis
Host-virus interaction
Ion transport
Transport
   Cellular componentCell membrane
Membrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
Transmembrane beta strand
   Molecular functionPorin
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processanion transport

Traceable author statement Ref.1. Source: ProtInc

apoptotic process

Traceable author statement PubMed 10365962. Source: UniProtKB

behavioral fear response

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation

Inferred from expression pattern PubMed 21492153. Source: UniProt

learning

Inferred from electronic annotation. Source: Ensembl

neuron-neuron synaptic transmission

Inferred from electronic annotation. Source: Ensembl

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 20458337. Source: UniProt

membrane

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial inner membrane

Inferred from electronic annotation. Source: Ensembl

mitochondrial nucleoid

Inferred from direct assay PubMed 18063578. Source: BHF-UCL

mitochondrial outer membrane

Traceable author statement Ref.1. Source: ProtInc

mitochondrion

Inferred from direct assay PubMed 20833797. Source: UniProt

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pore complex

Traceable author statement PubMed 9843949. Source: HGNC

   Molecular_functionporin activity

Inferred from electronic annotation. Source: UniProtKB-KW

voltage-gated anion channel activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HK1P193672EBI-354158,EBI-713162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9 Ref.10 Ref.11 Ref.12
Chain2 – 283282Voltage-dependent anion-selective channel protein 1
PRO_0000050499

Regions

Transmembrane26 – 3510Beta stranded
Transmembrane39 – 479Beta stranded
Transmembrane54 – 6411Beta stranded
Transmembrane69 – 768Beta stranded
Transmembrane80 – 8910Beta stranded
Transmembrane95 – 10410Beta stranded
Transmembrane111 – 12010Beta stranded
Transmembrane123 – 1308Beta stranded
Transmembrane137 – 1459Beta stranded
Transmembrane150 – 1589Beta stranded
Transmembrane163 – 17513Beta stranded
Transmembrane178 – 1858Beta stranded
Transmembrane189 – 19810Beta stranded
Transmembrane202 – 21110Beta stranded
Transmembrane218 – 22710Beta stranded
Transmembrane231 – 2388Beta stranded
Transmembrane242 – 25110Beta stranded
Transmembrane254 – 26310Beta stranded
Transmembrane273 – 28210Beta stranded
Nucleotide binding242 – 2443NAD
Nucleotide binding260 – 2645NAD

Sites

Site731Involved in hexokinase binding By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.9 Ref.12 Ref.24 Ref.30 Ref.31
Modified residue131Phosphoserine By similarity
Modified residue201N6-acetyllysine; alternate Ref.25
Modified residue201N6-succinyllysine; alternate By similarity
Modified residue671Phosphotyrosine By similarity
Modified residue1091N6-acetyllysine By similarity
Modified residue2521N6-acetyllysine By similarity
Modified residue2661N6-acetyllysine Ref.25

Experimental info

Sequence conflict2251Y → L in CAB58127. Ref.4

Secondary structure

.................................................. 283
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21796 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 89BA3378B04020D5

FASTA28330,773
        10         20         30         40         50         60 
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET 

        70         80         90        100        110        120 
KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR 

       130        140        150        160        170        180 
EHINLGCDMD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL 

       190        200        210        220        230        240 
HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS 

       250        260        270        280 
SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
Blachly-Dyson E., Zambronicz E.B., Yu W.H., Adams V., McCabe E.R., Adelman J.P., Colombini M., Forte M.A.
J. Biol. Chem. 268:1835-1841(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human VDAC cDNA."
Blachly-Dyson E., Forte M.A.
Biophys. J. 59:216A-216A(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[3]"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: a tool for porin deficiency analysis."
Messina A., Guarino F., Oliva M., van den Heuvel L.P., Smeitink J., De Pinto V.
Biochem. Biophys. Res. Commun. 270:787-792(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Skin.
[9]"Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)."
Kayser H., Kratzin H.D., Thinnes F.P., Goetz H., Schmidt W.E., Eckart K., Hilschmann N.
Biol. Chem. Hoppe-Seyler 370:1265-1278(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: Lymphocyte.
[10]"Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical."
Juergens L., Ilsemann P., Kratzin H.D., Hesse D., Eckart K., Thinnes F.P., Hilschmann N.
Biol. Chem. Hoppe-Seyler 372:455-463(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: Skeletal muscle.
[11]Hein A., Kiafard Z., Hesse D., Hesse J.-O., Zimmermann B., Kratzin H.D., Schulz H., Reiss J., Thinnes F.P., Goetz H., Hilschmann N.
Submitted (DEC-1997) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: B-cell.
[12]Bienvenut W.V.
Submitted (MAR-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-12; 21-61; 64-74; 94-110; 121-139; 162-174; 225-236 AND 257-274, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[13]Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 75-93; 175-197 AND 201-218, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[14]"Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel."
Thomas L., Blachly-Dyson E., Colombini M., Forte M.A.
Proc. Natl. Acad. Sci. U.S.A. 90:5446-5449(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS.
[15]"Subcellular localization of human voltage-dependent anion channel isoforms."
Yu W.H., Wolfgang W., Forte M.A.
J. Biol. Chem. 270:13998-14006(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[16]"Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation."
Stadtmueller U., Eben-Brunnen J., Schmid A., Hesse D., Klebert S., Kratzin H.D., Hesse J., Zimmermann B., Reymann S., Thinnes F.P., Benz R., Goetz H., Hilschmann N.
Biol. Chem. 380:1461-1466(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, PARTIAL PROTEIN SEQUENCE.
[17]"Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy?"
Thinnes F.P., Walter G., Hellmann K.P., Hellmann T., Merker R., Kiafard Z., Eben-Brunnen J., Schwarzer C., Goetz H., Hilschmann N.
Pflugers Arch. 443:S111-S116(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Study of PTPC composition during apoptosis for identification of viral protein target."
Verrier F., Mignotte B., Jan G., Brenner C.
Ann. N. Y. Acad. Sci. 1010:126-142(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN APOPTOSIS.
[19]"Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
PLoS Pathog. 1:40-54(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
[20]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[21]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[22]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[23]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[24]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[25]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[26]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[27]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[28]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[29]"PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."
Lau E., Kluger H., Varsano T., Lee K., Scheffler I., Rimm D.L., Ideker T., Ronai Z.A.
Cell 148:543-555(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATF2 AND HK1.
[30]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[31]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[32]"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Zhang X., Weng C., Li Y., Wang X., Jiang C., Li X., Xu Y., Chen Q., Pan L., Tang H.
Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BOP/C22ORF29.
[33]"Structure of the human voltage-dependent anion channel."
Bayrhuber M., Meins T., Habeck M., Becker S., Giller K., Villinger S., Vonrhein C., Griesinger C., Zweckstetter M., Zeth K.
Proc. Natl. Acad. Sci. U.S.A. 105:15370-15375(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF 2-283, STRUCTURE BY NMR.
[34]"Solution structure of the integral human membrane protein VDAC-1 in detergent micelles."
Hiller S., Garces R.G., Malia T.J., Orekhov V.Y., Colombini M., Wagner G.
Science 321:1206-1210(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, FUNCTION, INTERACTION WITH BCL2L1, NADH-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L06132 mRNA. Translation: AAA61272.1.
AJ250032 expand/collapse EMBL AC list , AJ250033, AJ250034, AJ250035, AJ250036, AJ250037, AJ250038, AJ250039 Genomic DNA. Translation: CAB58127.1.
AF151097 expand/collapse EMBL AC list , AF151093, AF151094, AF151095, AF151096 Genomic DNA. Translation: AAD54939.1.
AC005200 Genomic DNA. Translation: AAC24723.1.
AK122953 mRNA. Translation: BAG53816.1.
AC008608 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62281.1.
CH471062 Genomic DNA. Translation: EAW62282.1.
CH471062 Genomic DNA. Translation: EAW62283.1.
CH471062 Genomic DNA. Translation: EAW62285.1.
CH471062 Genomic DNA. Translation: EAW62286.1.
BC008482 mRNA. Translation: AAH08482.1.
BC071168 mRNA. Translation: AAH71168.1.
BC090042 mRNA. Translation: AAH90042.1.
PIRMMHUP3. A44422.
RefSeqNP_003365.1. NM_003374.2.
XP_005272132.1. XM_005272075.2.
UniGeneHs.519320.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JK4X-ray4.10A2-283[»]
2K4TNMR-A1-283[»]
ProteinModelPortalP21796.
SMRP21796. Positions 2-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113259. 56 interactions.
DIPDIP-32862N.
IntActP21796. 19 interactions.
MINTMINT-5002499.
STRING9606.ENSP00000265333.

Chemistry

DrugBankDB01375. Dihydroxyaluminium.

PTM databases

PhosphoSiteP21796.

Polymorphism databases

DMDM130683.

2D gel databases

DOSAC-COBS-2DPAGEP21796.
OGPP21796.
REPRODUCTION-2DPAGEIPI00216308.
P21796.
UCD-2DPAGEP21796.

Proteomic databases

PaxDbP21796.
PeptideAtlasP21796.
PRIDEP21796.

Protocols and materials databases

DNASU7416.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265333; ENSP00000265333; ENSG00000213585.
ENST00000395044; ENSP00000378484; ENSG00000213585.
ENST00000395047; ENSP00000378487; ENSG00000213585.
GeneID7416.
KEGGhsa:7416.
UCSCuc003kyp.2. human.

Organism-specific databases

CTD7416.
GeneCardsGC05M133307.
H-InvDBHIX0056260.
HGNCHGNC:12669. VDAC1.
HPACAB005885.
HPA030780.
MIM604492. gene+phenotype.
neXtProtNX_P21796.
PharmGKBPA37292.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG243169.
HOGENOMHOG000188277.
HOVERGENHBG054036.
InParanoidP21796.
KOK05862.
OMAYGLMFTE.
PhylomeDBP21796.
TreeFamTF315091.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressP21796.
BgeeP21796.
CleanExHS_VDAC1.
GenevestigatorP21796.

Family and domain databases

Gene3D2.40.160.10. 1 hit.
InterProIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP21796.
GeneWikiVDAC1.
GenomeRNAi7416.
NextBio29038.
PROP21796.
SOURCESearch...

Entry information

Entry nameVDAC1_HUMAN
AccessionPrimary (citable) accession number: P21796
Secondary accession number(s): B3KVK4 expand/collapse secondary AC list , D3DQ93, Q5FVE7, Q9UIQ5, Q9UPL0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM