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Reviewed, UniProtKB/Swiss-Prot P21796 (VDAC1_HUMAN)

Last modified January 19, 2010. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Voltage-dependent anion-selective channel protein 1
      Short name=VDAC-1
      Short name=hVDAC1
Alternative name(s):
    Outer mitochondrial membrane protein porin 1
    Plasmalemmal porin
    Porin 31HL
    Porin 31HM
Gene names
Name: VDAC1
Synonyms: VDAC
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Ref.17 Ref.18 Ref.33

Subunit structure

Interacts with hexokinases By similarity. Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein. Ref.33 Ref.21

Subcellular location

Mitochondrion outer membrane. Cell membrane Ref.15.

Tissue specificity

Heart, liver and skeletal muscle.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9 Ref.10 Ref.11 Ref.12
Chain2 – 283282Voltage-dependent anion-selective channel protein 1
PRO_0000050499

Regions

Transmembrane26 – 3510Transmembrane beta-strand
Transmembrane39 – 479Transmembrane beta-strand
Transmembrane54 – 6411Transmembrane beta-strand
Transmembrane69 – 768Transmembrane beta-strand
Transmembrane80 – 8910Transmembrane beta-strand
Transmembrane95 – 10410Transmembrane beta-strand
Transmembrane111 – 12010Transmembrane beta-strand
Transmembrane123 – 1308Transmembrane beta-strand
Transmembrane137 – 1459Transmembrane beta-strand
Transmembrane150 – 1589Transmembrane beta-strand
Transmembrane163 – 17513Transmembrane beta-strand
Transmembrane178 – 1858Transmembrane beta-strand
Transmembrane189 – 19810Transmembrane beta-strand
Transmembrane202 – 21110Transmembrane beta-strand
Transmembrane218 – 22710Transmembrane beta-strand
Transmembrane231 – 2388Transmembrane beta-strand
Transmembrane242 – 25110Transmembrane beta-strand
Transmembrane254 – 26310Transmembrane beta-strand
Transmembrane273 – 28210Transmembrane beta-strand
Nucleotide binding242 – 2443NAD
Nucleotide binding260 – 2645NAD

Sites

Site731Involved in hexokinase binding By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.9 Ref.12 Ref.30
Modified residue131Phosphoserine By similarity
Modified residue201N6-acetyllysine Ref.31
Modified residue281N6-acetyllysine Ref.31
Modified residue611N6-acetyllysine Ref.31
Modified residue671Phosphotyrosine Ref.24
Modified residue1011Phosphoserine Ref.28
Modified residue1041Phosphoserine Ref.30 Ref.28 Ref.19 Ref.22 Ref.23 Ref.25 Ref.26 Ref.27
Modified residue1071Phosphothreonine Ref.25
Modified residue1371Phosphoserine By similarity
Modified residue1951Phosphotyrosine Ref.20
Modified residue2241N6-acetyllysine Ref.31
Modified residue2661N6-acetyllysine Ref.31

Experimental info

Sequence conflict2251Y → L in CAB58127. Ref.4

Secondary structure

....................................... 283
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21796-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 89BA3378B04020D5

FASTA28330,773
        10         20         30         40         50         60 
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET 

        70         80         90        100        110        120 
KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR 

       130        140        150        160        170        180 
EHINLGCDMD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL 

       190        200        210        220        230        240 
HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS 

       250        260        270        280 
SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
Blachly-Dyson E., Zambronicz E.B., Yu W.H., Adams V., McCabe E.R., Adelman J.P., Colombini M., Forte M.A.
J. Biol. Chem. 268:1835-1841(1993) [PubMed: 8420959] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human VDAC cDNA."
Blachly-Dyson E., Forte M.A.
Biophys. J. 59:216A-216A(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[3]"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
Mamm. Genome 10:1041-1042(1999) [PubMed: 10501981] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: a tool for porin deficiency analysis."
Messina A., Guarino F., Oliva M., van den Heuvel L.P., Smeitink J., De Pinto V.
Biochem. Biophys. Res. Commun. 270:787-792(2000) [PubMed: 10772903] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed: 15372022] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Skin.
[9]"Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)."
Kayser H., Kratzin H.D., Thinnes F.P., Goetz H., Schmidt W.E., Eckart K., Hilschmann N.
Biol. Chem. Hoppe-Seyler 370:1265-1278(1989) [PubMed: 2559745] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: Lymphocyte.
[10]"Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical."
Juergens L., Ilsemann P., Kratzin H.D., Hesse D., Eckart K., Thinnes F.P., Hilschmann N.
Biol. Chem. Hoppe-Seyler 372:455-463(1991) [PubMed: 1657034] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: Skeletal muscle.
[11]Hein A., Kiafard Z., Hesse D., Hesse J.-O., Zimmermann B., Kratzin H.D., Schulz H., Reiss J., Thinnes F.P., Goetz H., Hilschmann N.
Submitted (DEC-1997) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-283.
Tissue: B-cell.
[12]Bienvenut W.V.
Submitted (MAR-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-12; 21-61; 64-74; 94-110; 121-139; 162-174; 225-236 AND 257-274, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[13]Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 75-93; 175-197 AND 201-218, MASS SPECTROMETRY.
Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[14]"Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel."
Thomas L., Blachly-Dyson E., Colombini M., Forte M.A.
Proc. Natl. Acad. Sci. U.S.A. 90:5446-5449(1993) [PubMed: 7685903] [Abstract]
Cited for: MUTAGENESIS.
[15]"Subcellular localization of human voltage-dependent anion channel isoforms."
Yu W.H., Wolfgang W., Forte M.A.
J. Biol. Chem. 270:13998-14006(1995) [PubMed: 7539795] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[16]"Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation."
Stadtmueller U., Eben-Brunnen J., Schmid A., Hesse D., Klebert S., Kratzin H.D., Hesse J., Zimmermann B., Reymann S., Thinnes F.P., Benz R., Goetz H., Hilschmann N.
Biol. Chem. 380:1461-1466(1999) [PubMed: 10661876] [Abstract]
Cited for: CHARACTERIZATION, PARTIAL PROTEIN SEQUENCE.
[17]"Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy?"
Thinnes F.P., Walter G., Hellmann K.P., Hellmann T., Merker R., Kiafard Z., Eben-Brunnen J., Schwarzer C., Goetz H., Hilschmann N.
Pflugers Arch. 443:S111-S116(2001) [PubMed: 11845315] [Abstract]
Cited for: FUNCTION.
[18]"Study of PTPC composition during apoptosis for identification of viral protein target."
Verrier F., Mignotte B., Jan G., Brenner C.
Ann. N. Y. Acad. Sci. 1010:126-142(2003) [PubMed: 15033708] [Abstract]
Cited for: FUNCTION IN APOPTOSIS.
[19]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
Tissue: Epithelium.
[20]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-195, MASS SPECTROMETRY.
[21]"Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
PLoS Pathog. 1:40-54(2005) [PubMed: 16201016] [Abstract]
Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
[22]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
Tissue: Epithelium.
[23]"Phosphoproteome analysis of the human mitotic spindle."
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
Tissue: Epithelium.
[24]"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer."
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. expand/collapse author list , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-67, MASS SPECTROMETRY.
[25]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND THR-107, MASS SPECTROMETRY.
[26]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
Tissue: Platelet.
[27]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
[28]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-104, MASS SPECTROMETRY.
[29]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[30]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, MASS SPECTROMETRY.
[31]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20; LYS-28; LYS-61; LYS-224 AND LYS-266, MASS SPECTROMETRY.
[32]"Structure of the human voltage-dependent anion channel."
Bayrhuber M., Meins T., Habeck M., Becker S., Giller K., Villinger S., Vonrhein C., Griesinger C., Zweckstetter M., Zeth K.
Proc. Natl. Acad. Sci. U.S.A. 105:15370-15375(2008) [PubMed: 18832158] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF 2-283, STRUCTURE BY NMR.
[33]"Solution structure of the integral human membrane protein VDAC-1 in detergent micelles."
Hiller S., Garces R.G., Malia T.J., Orekhov V.Y., Colombini M., Wagner G.
Science 321:1206-1210(2008) [PubMed: 18755977] [Abstract]
Cited for: STRUCTURE BY NMR, FUNCTION, INTERACTION WITH BCL2L1, NADH BINDING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L06132 mRNA. Translation: AAA61272.1.
AJ250032 expand/collapse EMBL AC list , AJ250033, AJ250034, AJ250035, AJ250036, AJ250037, AJ250038, AJ250039 Genomic DNA. Translation: CAB58127.1.
AF151097 expand/collapse EMBL AC list , AF151093, AF151094, AF151095, AF151096 Genomic DNA. Translation: AAD54939.1.
AC005200 Genomic DNA. Translation: AAC24723.1.
AK122953 mRNA. Translation: BAG53816.1.
AC008608 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62281.1.
BC008482 mRNA. Translation: AAH08482.1.
BC071168 mRNA. Translation: AAH71168.1.
BC090042 mRNA. Translation: AAH90042.1.
IPIIPI00216308.
PIRMMHUP3. A44422.
RefSeqNP_003365.1.
UniGeneHs.519320
Hs.709372

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JK4X-ray4.10A2-283[»]
2K4TNMR-A1-283[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-32862N.
IntActP21796. 27 interactions.
STRINGP21796.

PTM databases

PhosphoSiteP21796.

2-D gel databases

DOSAC-COBS-2DPAGEP21796.
OGPP21796.
REPRODUCTION-2DPAGEIPI00216308.
P21796.

Proteomic databases

PeptideAtlasP21796.
PRIDEP21796.

Genome annotation databases

EnsemblENST00000265333; ENSP00000265333; ENSG00000213585; Homo sapiens. [Genome view]
ENST00000395044; ENSP00000378484; ENSG00000213585; Homo sapiens. [Genome view]
ENST00000395047; ENSP00000378487; ENSG00000213585; Homo sapiens. [Genome view]
GeneID7416.
KEGGhsa:7416.
UCSCuc003kyp.1. human.

Organism-specific databases

CTD7416.
GeneCardsGC05M133336.
H-InvDBHIX0005171.
HGNCHGNC:12669. VDAC1.
HPACAB005885.
MIM604492. gene+phenotype.
PharmGKBPA37292.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10452.
HOGENOMHBG396026.
HOVERGENP21796.
InParanoidP21796.
OMAQKMAVPP.
OrthoDBEOG92FW36.
PhylomeDBP21796.

Gene expression databases

ArrayExpressP21796.
BgeeP21796.
CleanExHS_VDAC1.
GenevestigatorP21796.
GermOnlineENSG00000073905. Homo sapiens.

Family and domain databases

InterProIPR001925. Porin_Euk.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01375. Dihydroxyaluminium.
NextBio29038.
SOURCESearch...

Entry information

Entry nameVDAC1_HUMAN
AccessionPrimary (citable) accession number: P21796
Secondary accession number(s): B3KVK4 expand/collapse secondary AC list , Q5FVE7, Q9UIQ5, Q9UPL0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents