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P21796

- VDAC1_HUMAN

UniProt

P21796 - VDAC1_HUMAN

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Protein

Voltage-dependent anion-selective channel protein 1

Gene

VDAC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 731Involved in hexokinase bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi242 – 2443NAD
Nucleotide bindingi260 – 2645NAD

GO - Molecular functioni

  1. porin activity Source: UniProtKB-KW
  2. protein kinase binding Source: ParkinsonsUK-UCL
  3. voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  1. anion transport Source: ProtInc
  2. apoptotic process Source: UniProtKB
  3. behavioral fear response Source: Ensembl
  4. epithelial cell differentiation Source: UniProt
  5. learning Source: Ensembl
  6. neuron-neuron synaptic transmission Source: Ensembl
  7. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Apoptosis, Host-virus interaction, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 1
Short name:
VDAC-1
Short name:
hVDAC1
Alternative name(s):
Outer mitochondrial membrane protein porin 1
Plasmalemmal porin
Porin 31HL
Porin 31HM
Gene namesi
Name:VDAC1
Synonyms:VDAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:12669. VDAC1.

Subcellular locationi

Mitochondrion outer membrane 1 Publication. Cell membrane 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. membrane Source: UniProtKB
  3. mitochondrial inner membrane Source: Ensembl
  4. mitochondrial nucleoid Source: BHF-UCL
  5. mitochondrial outer membrane Source: ProtInc
  6. mitochondrion Source: UniProt
  7. nucleus Source: UniProt
  8. plasma membrane Source: UniProtKB-KW
  9. pore complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi193 – 1931S → A: Conformation remains open and constitutively allows cytochrome c efflux. 1 Publication
Mutagenesisi193 – 1931S → E: Conformation remains closed and prevents cytochrome c leakage. 1 Publication

Organism-specific databases

MIMi604492. gene+phenotype.
PharmGKBiPA37292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed7 Publications
Chaini2 – 283282Voltage-dependent anion-selective channel protein 1PRO_0000050499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine5 Publications
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei20 – 201N6-acetyllysine; alternate1 Publication
Modified residuei20 – 201N6-succinyllysine; alternateBy similarity
Modified residuei67 – 671PhosphotyrosineBy similarity
Modified residuei109 – 1091N6-acetyllysineBy similarity
Modified residuei193 – 1931Phosphoserine; by NEK11 Publication
Modified residuei252 – 2521N6-acetyllysineBy similarity
Modified residuei266 – 2661N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP21796.
PaxDbiP21796.
PeptideAtlasiP21796.
PRIDEiP21796.

2D gel databases

DOSAC-COBS-2DPAGEP21796.
OGPiP21796.
REPRODUCTION-2DPAGEIPI00216308.
P21796.
UCD-2DPAGEP21796.

PTM databases

PhosphoSiteiP21796.

Expressioni

Tissue specificityi

Heart, liver and skeletal muscle.

Gene expression databases

BgeeiP21796.
CleanExiHS_VDAC1.
ExpressionAtlasiP21796. baseline and differential.
GenevestigatoriP21796.

Organism-specific databases

HPAiCAB005885.
HPA030780.

Interactioni

Subunit structurei

Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with BOP/C22orf29 (via BH3 domain). Interacts with influenza A virus PB1-F2 protein. Interacts with HK1. The HK1-VDAC1 complex interacts with ATF2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HK1P193672EBI-354158,EBI-713162

Protein-protein interaction databases

BioGridi113259. 66 interactions.
DIPiDIP-32862N.
IntActiP21796. 21 interactions.
MINTiMINT-5002499.
STRINGi9606.ENSP00000265333.

Structurei

Secondary structure

1
283
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 104
Beta strandi26 – 338
Turni36 – 383
Beta strandi40 – 5112
Beta strandi55 – 628
Beta strandi66 – 7611
Turni77 – 793
Beta strandi80 – 889
Beta strandi95 – 1039
Turni105 – 1073
Beta strandi110 – 11910
Beta strandi124 – 13512
Beta strandi137 – 14610
Beta strandi149 – 15810
Turni159 – 1624
Beta strandi167 – 1748
Beta strandi176 – 18510
Turni186 – 1883
Beta strandi189 – 1968
Beta strandi203 – 2119
Beta strandi217 – 22812
Beta strandi231 – 24111
Beta strandi243 – 2508
Beta strandi252 – 2543
Beta strandi256 – 2649
Helixi268 – 2703
Beta strandi274 – 2829

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JK4X-ray4.10A2-283[»]
2K4TNMR-A1-283[»]
ProteinModelPortaliP21796.
SMRiP21796. Positions 2-283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21796.

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 3510Beta stranded
Transmembranei39 – 479Beta stranded
Transmembranei54 – 6411Beta strandedAdd
BLAST
Transmembranei69 – 768Beta stranded
Transmembranei80 – 8910Beta stranded
Transmembranei95 – 10410Beta stranded
Transmembranei111 – 12010Beta stranded
Transmembranei123 – 1308Beta stranded
Transmembranei137 – 1459Beta stranded
Transmembranei150 – 1589Beta stranded
Transmembranei163 – 17513Beta strandedAdd
BLAST
Transmembranei178 – 1858Beta stranded
Transmembranei189 – 19810Beta stranded
Transmembranei202 – 21110Beta stranded
Transmembranei218 – 22710Beta stranded
Transmembranei231 – 2388Beta stranded
Transmembranei242 – 25110Beta stranded
Transmembranei254 – 26310Beta stranded
Transmembranei273 – 28210Beta stranded

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG243169.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiP21796.
KOiK05862.
OMAiYGLMFTE.
PhylomeDBiP21796.
TreeFamiTF315091.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21796-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE
60 70 80 90 100
TTKVTGSLET KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD
110 120 130 140 150
SSFSPNTGKK NAKIKTGYKR EHINLGCDMD FDIAGPSIRG ALVLGYEGWL
160 170 180 190 200
AGYQMNFETA KSRVTQSNFA VGYKTDEFQL HTNVNDGTEF GGSIYQKVNK
210 220 230 240 250
KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS SLIGLGYTQT
260 270 280
LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA
Length:283
Mass (Da):30,773
Last modified:January 23, 2007 - v2
Checksum:i89BA3378B04020D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251Y → L in CAB58127. (PubMed:10772903)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06132 mRNA. Translation: AAA61272.1.
AJ250032
, AJ250033, AJ250034, AJ250035, AJ250036, AJ250037, AJ250038, AJ250039 Genomic DNA. Translation: CAB58127.1.
AF151097
, AF151093, AF151094, AF151095, AF151096 Genomic DNA. Translation: AAD54939.1.
AC005200 Genomic DNA. Translation: AAC24723.1.
AK122953 mRNA. Translation: BAG53816.1.
AC008608 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62281.1.
CH471062 Genomic DNA. Translation: EAW62282.1.
CH471062 Genomic DNA. Translation: EAW62283.1.
CH471062 Genomic DNA. Translation: EAW62285.1.
CH471062 Genomic DNA. Translation: EAW62286.1.
BC008482 mRNA. Translation: AAH08482.1.
BC071168 mRNA. Translation: AAH71168.1.
BC090042 mRNA. Translation: AAH90042.1.
CCDSiCCDS4168.1.
PIRiA44422. MMHUP3.
RefSeqiNP_003365.1. NM_003374.2.
XP_005272132.1. XM_005272075.2.
UniGeneiHs.519320.

Genome annotation databases

EnsembliENST00000265333; ENSP00000265333; ENSG00000213585.
ENST00000395044; ENSP00000378484; ENSG00000213585.
ENST00000395047; ENSP00000378487; ENSG00000213585.
GeneIDi7416.
KEGGihsa:7416.
UCSCiuc003kyp.2. human.

Polymorphism databases

DMDMi130683.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06132 mRNA. Translation: AAA61272.1 .
AJ250032
, AJ250033 , AJ250034 , AJ250035 , AJ250036 , AJ250037 , AJ250038 , AJ250039 Genomic DNA. Translation: CAB58127.1 .
AF151097
, AF151093 , AF151094 , AF151095 , AF151096 Genomic DNA. Translation: AAD54939.1 .
AC005200 Genomic DNA. Translation: AAC24723.1 .
AK122953 mRNA. Translation: BAG53816.1 .
AC008608 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62281.1 .
CH471062 Genomic DNA. Translation: EAW62282.1 .
CH471062 Genomic DNA. Translation: EAW62283.1 .
CH471062 Genomic DNA. Translation: EAW62285.1 .
CH471062 Genomic DNA. Translation: EAW62286.1 .
BC008482 mRNA. Translation: AAH08482.1 .
BC071168 mRNA. Translation: AAH71168.1 .
BC090042 mRNA. Translation: AAH90042.1 .
CCDSi CCDS4168.1.
PIRi A44422. MMHUP3.
RefSeqi NP_003365.1. NM_003374.2.
XP_005272132.1. XM_005272075.2.
UniGenei Hs.519320.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JK4 X-ray 4.10 A 2-283 [» ]
2K4T NMR - A 1-283 [» ]
ProteinModelPortali P21796.
SMRi P21796. Positions 2-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113259. 66 interactions.
DIPi DIP-32862N.
IntActi P21796. 21 interactions.
MINTi MINT-5002499.
STRINGi 9606.ENSP00000265333.

Chemistry

DrugBanki DB01375. Dihydroxyaluminium.

PTM databases

PhosphoSitei P21796.

Polymorphism databases

DMDMi 130683.

2D gel databases

DOSAC-COBS-2DPAGE P21796.
OGPi P21796.
REPRODUCTION-2DPAGE IPI00216308.
P21796.
UCD-2DPAGE P21796.

Proteomic databases

MaxQBi P21796.
PaxDbi P21796.
PeptideAtlasi P21796.
PRIDEi P21796.

Protocols and materials databases

DNASUi 7416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265333 ; ENSP00000265333 ; ENSG00000213585 .
ENST00000395044 ; ENSP00000378484 ; ENSG00000213585 .
ENST00000395047 ; ENSP00000378487 ; ENSG00000213585 .
GeneIDi 7416.
KEGGi hsa:7416.
UCSCi uc003kyp.2. human.

Organism-specific databases

CTDi 7416.
GeneCardsi GC05M133307.
H-InvDB HIX0056260.
HGNCi HGNC:12669. VDAC1.
HPAi CAB005885.
HPA030780.
MIMi 604492. gene+phenotype.
neXtProti NX_P21796.
PharmGKBi PA37292.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243169.
GeneTreei ENSGT00390000011336.
HOGENOMi HOG000188277.
HOVERGENi HBG054036.
InParanoidi P21796.
KOi K05862.
OMAi YGLMFTE.
PhylomeDBi P21796.
TreeFami TF315091.

Enzyme and pathway databases

Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

EvolutionaryTracei P21796.
GeneWikii VDAC1.
GenomeRNAii 7416.
NextBioi 29038.
PROi P21796.
SOURCEi Search...

Gene expression databases

Bgeei P21796.
CleanExi HS_VDAC1.
ExpressionAtlasi P21796. baseline and differential.
Genevestigatori P21796.

Family and domain databases

Gene3Di 2.40.160.10. 1 hit.
InterProi IPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view ]
Pfami PF01459. Porin_3. 1 hit.
[Graphical view ]
PRINTSi PR00185. EUKARYTPORIN.
PROSITEi PS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
    Blachly-Dyson E., Zambronicz E.B., Yu W.H., Adams V., McCabe E.R., Adelman J.P., Colombini M., Forte M.A.
    J. Biol. Chem. 268:1835-1841(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human VDAC cDNA."
    Blachly-Dyson E., Forte M.A.
    Biophys. J. 59:216A-216A(1991)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  3. "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
    Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
    Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: a tool for porin deficiency analysis."
    Messina A., Guarino F., Oliva M., van den Heuvel L.P., Smeitink J., De Pinto V.
    Biochem. Biophys. Res. Commun. 270:787-792(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  9. "Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)."
    Kayser H., Kratzin H.D., Thinnes F.P., Goetz H., Schmidt W.E., Eckart K., Hilschmann N.
    Biol. Chem. Hoppe-Seyler 370:1265-1278(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-283.
    Tissue: Lymphocyte.
  10. "Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical."
    Juergens L., Ilsemann P., Kratzin H.D., Hesse D., Eckart K., Thinnes F.P., Hilschmann N.
    Biol. Chem. Hoppe-Seyler 372:455-463(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-283.
    Tissue: Skeletal muscle.
  11. Cited for: PROTEIN SEQUENCE OF 2-283.
    Tissue: B-cell.
  12. Bienvenut W.V.
    Submitted (MAR-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12; 21-61; 64-74; 94-110; 121-139; 162-174; 225-236 AND 257-274, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  13. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 75-93; 175-197 AND 201-218, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  14. "Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel."
    Thomas L., Blachly-Dyson E., Colombini M., Forte M.A.
    Proc. Natl. Acad. Sci. U.S.A. 90:5446-5449(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  15. "Subcellular localization of human voltage-dependent anion channel isoforms."
    Yu W.H., Wolfgang W., Forte M.A.
    J. Biol. Chem. 270:13998-14006(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. "Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation."
    Stadtmueller U., Eben-Brunnen J., Schmid A., Hesse D., Klebert S., Kratzin H.D., Hesse J., Zimmermann B., Reymann S., Thinnes F.P., Benz R., Goetz H., Hilschmann N.
    Biol. Chem. 380:1461-1466(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, PARTIAL PROTEIN SEQUENCE.
  17. "Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy?"
    Thinnes F.P., Walter G., Hellmann K.P., Hellmann T., Merker R., Kiafard Z., Eben-Brunnen J., Schwarzer C., Goetz H., Hilschmann N.
    Pflugers Arch. 443:S111-S116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "Study of PTPC composition during apoptosis for identification of viral protein target."
    Verrier F., Mignotte B., Jan G., Brenner C.
    Ann. N. Y. Acad. Sci. 1010:126-142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN APOPTOSIS.
  19. "Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
    Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
    PLoS Pathog. 1:40-54(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
  20. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. "Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1."
    Chen Y., Gaczynska M., Osmulski P., Polci R., Riley D.J.
    Biochem. Biophys. Res. Commun. 394:798-803(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-193, MUTAGENESIS OF SER-193.
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  28. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  30. "PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."
    Lau E., Kluger H., Varsano T., Lee K., Scheffler I., Rimm D.L., Ideker T., Ronai Z.A.
    Cell 148:543-555(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATF2 AND HK1.
  31. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  32. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  33. "Human Bop is a novel BH3-only member of the Bcl-2 protein family."
    Zhang X., Weng C., Li Y., Wang X., Jiang C., Li X., Xu Y., Chen Q., Pan L., Tang H.
    Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BOP/C22ORF29.
  34. Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF 2-283, STRUCTURE BY NMR.
  35. "Solution structure of the integral human membrane protein VDAC-1 in detergent micelles."
    Hiller S., Garces R.G., Malia T.J., Orekhov V.Y., Colombini M., Wagner G.
    Science 321:1206-1210(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, FUNCTION, INTERACTION WITH BCL2L1, NADH-BINDING.

Entry informationi

Entry nameiVDAC1_HUMAN
AccessioniPrimary (citable) accession number: P21796
Secondary accession number(s): B3KVK4
, D3DQ93, Q5FVE7, Q9UIQ5, Q9UPL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3