ID   FGF7_HUMAN              Reviewed;         194 AA.
AC   P21781;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-JAN-2012, entry version 111.
DE   RecName: Full=Keratinocyte growth factor;
DE            Short=KGF;
DE   AltName: Full=Fibroblast growth factor 7;
DE            Short=FGF-7;
DE   AltName: Full=Heparin-binding growth factor 7;
DE            Short=HBGF-7;
DE   Flags: Precursor;
GN   Name=FGF7; Synonyms=KGF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-50.
RX   MEDLINE=89368897; PubMed=2475908; DOI=10.1126/science.2475908;
RA   Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.;
RT   "Human KGF is FGF-related with properties of a paracrine effector of
RT   epithelial cell growth.";
RL   Science 245:752-755(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92152720; PubMed=1664700;
RX   DOI=10.1111/j.1749-6632.1991.tb49018.x;
RA   Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W.,
RA   Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.;
RT   "Keratinocyte growth factor. A fibroblast growth factor family member
RT   with unusual target cell specificity.";
RL   Ann. N. Y. Acad. Sci. 638:62-77(1991).
RN   [3]
RP   PROTEIN SEQUENCE OF 32-44.
RX   MEDLINE=89128865; PubMed=2915979; DOI=10.1073/pnas.86.3.802;
RA   Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S.,
RA   Aaronson S.A.;
RT   "Purification and characterization of a newly identified growth factor
RT   specific for epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989).
RN   [4]
RP   INTERACTION WITH FGFR2, AND FUNCTION IN CELL PROLIFERATION.
RX   PubMed=8663044; DOI=10.1074/jbc.271.25.15292;
RA   Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A.,
RA   Coulier F., Gao G., Goldfarb M.;
RT   "Receptor specificity of the fibroblast growth factor family.";
RL   J. Biol. Chem. 271:15292-15297(1996).
RN   [5]
RP   INTERACTION WITH FGFBP1.
RX   PubMed=15806171; DOI=10.1038/sj.onc.1208560;
RA   Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A.,
RA   Werner S.;
RT   "The fibroblast growth factor binding protein is a novel interaction
RT   partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
RT   implications for epithelial repair.";
RL   Oncogene 24:5269-5277(2005).
RN   [6]
RP   INTERACTION WITH FGFR2, AND FUNCTION IN STIMULATION OF CELL
RP   PROLIFERATION.
RX   PubMed=16597617; DOI=10.1074/jbc.M601252200;
RA   Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M.,
RA   Ornitz D.M.;
RT   "Receptor specificity of the fibroblast growth factor family. The
RT   complete mammalian FGF family.";
RL   J. Biol. Chem. 281:15694-15700(2006).
RN   [7]
RP   REVIEW.
RX   PubMed=20094046; DOI=10.1038/nrc2780;
RA   Turner N., Grose R.;
RT   "Fibroblast growth factor signalling: from development to cancer.";
RL   Nat. Rev. Cancer 10:116-129(2010).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation and cell differentiation. Required
CC       for normal branching morphogenesis. Growth factor active on
CC       keratinocytes. Possible major paracrine effector of normal
CC       epithelial cell proliferation.
CC   -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity
CC       between fibroblast growth factors (FGFs) and their receptors is
CC       increased by heparan sulfate glycosaminoglycans that function as
CC       coreceptors.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Epithelial cell.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; M60828; AAA63210.1; -; mRNA.
DR   EMBL; S81661; AAB21431.1; -; mRNA.
DR   IPI; IPI00010403; -.
DR   PIR; A36301; A36301.
DR   PIR; B46289; B46289.
DR   RefSeq; NP_002000.1; NM_002009.3.
DR   UniGene; Hs.567268; -.
DR   ProteinModelPortal; P21781; -.
DR   SMR; P21781; 63-194.
DR   DIP; DIP-4010N; -.
DR   IntAct; P21781; 2.
DR   STRING; P21781; -.
DR   PhosphoSite; P21781; -.
DR   DMDM; 122756; -.
DR   PRIDE; P21781; -.
DR   Ensembl; ENST00000267843; ENSP00000267843; ENSG00000140285.
DR   GeneID; 2252; -.
DR   KEGG; hsa:2252; -.
DR   UCSC; uc001zxn.1; human.
DR   CTD; 2252; -.
DR   GeneCards; GC15P049715; -.
DR   H-InvDB; HIX0012227; -.
DR   HGNC; HGNC:3685; FGF7.
DR   HPA; HPA043605; -.
DR   MIM; 148180; gene.
DR   neXtProt; NX_P21781; -.
DR   PharmGKB; PA28124; -.
DR   eggNOG; prNOG07447; -.
DR   HOGENOM; HBG715603; -.
DR   HOVERGEN; HBG007580; -.
DR   InParanoid; P21781; -.
DR   OMA; MAANVNC; -.
DR   OrthoDB; EOG4J9N0V; -.
DR   PhylomeDB; P21781; -.
DR   Pathway_Interaction_DB; glypican_3pathway; Glypican 3 network.
DR   Reactome; REACT_111102; Signal Transduction.
DR   DrugBank; DB00039; Palifermin.
DR   NextBio; 9117; -.
DR   ArrayExpress; P21781; -.
DR   Bgee; P21781; -.
DR   CleanEx; HS_FGF7; -.
DR   Genevestigator; P21781; -.
DR   GermOnline; ENSG00000140285; Homo sapiens.
DR   GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0010463; P:mesenchymal cell proliferation; IDA:UniProtKB.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IDA:MGI.
DR   GO; GO:0051549; P:positive regulation of keratinocyte migration; IDA:UniProtKB.
DR   GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IDA:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
DR   GO; GO:0034394; P:protein localization at cell surface; IDA:UniProtKB.
DR   GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IDA:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002209; GF_heparin-bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Glycoprotein;
KW   Growth factor; Heparin-binding; Mitogen; Polymorphism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     31
FT   CHAIN        32    194       Keratinocyte growth factor.
FT                                /FTId=PRO_0000008965.
FT   CARBOHYD     45     45       N-linked (GlcNAc...) (Potential).
FT   VARIANT      59     59       M -> T (in dbSNP:rs34531231).
FT                                /FTId=VAR_049063.
SQ   SEQUENCE   194 AA;  22509 MW;  B19192474E6049E2 CRC64;
     MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
     GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA
     MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK
     KEQKTAHFLP MAIT
//