P21781 (FGF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 7
Short name=FGF-7

Alternative name(s):
Heparin-binding growth factor 7
Short name=HBGF-7
Keratinocyte growth factor

Gene names

Name:	FGF7
Synonyms:	KGF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Ref.4 Ref.6
Subunit structure	Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.4 Ref.5 Ref.6
Subcellular location	Secreted.
Tissue specificity	Epithelial cell.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Heparin-binding
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from direct assay PubMed 17449030. Source: UniProtKB branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara epidermis development Traceable author statement PubMed 7973639. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from genetic interaction Ref.4. Source: MGI hair follicle morphogenesis Inferred from electronic annotation. Source: Compara insulin receptor signaling pathway Traceable author statement. Source: Reactome mesenchymal cell proliferation Inferred from direct assay PubMed 11023837. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from direct assay PubMed 9740653. Source: MGI positive regulation of keratinocyte migration Inferred from direct assay PubMed 17449030. Source: UniProtKB positive regulation of keratinocyte proliferation Inferred from direct assay PubMed 17449030. Source: UniProtKB positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 17449030. Source: UniProtKB protein localization to cell surface Inferred from direct assay PubMed 17449030. Source: UniProtKB regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Inferred from electronic annotation. Source: Compara response to wounding Traceable author statement PubMed 7973639. Source: ProtInc secretion by lung epithelial cell involved in lung growth Inferred from direct assay PubMed 10541313. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome
Molecular_function	chemoattractant activity Inferred from direct assay PubMed 17449030. Source: UniProtKB growth factor activity Traceable author statement Ref.1. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FGFR2	P21802-3	2	EBI-3937699,EBI-6354683

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Ref.1 Ref.3
	Chain	32 – 194	163	Fibroblast growth factor 7		PRO_0000008965
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	59	1	M → T. Corresponds to variant rs34531231 [ dbSNP | Ensembl ].		VAR_049063

Sequences

	Sequence		Length	Mass (Da)
	P21781 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: B19192474E6049E2	FASTA	194	22,509
	10 20 30 40 50 60 MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 70 80 90 100 110 120 GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 130 140 150 160 170 180 MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 190 KEQKTAHFLP MAIT

References

[1]	"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth." Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A. Science 245:752-755(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-50.
[2]	"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity." Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S. Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Purification and characterization of a newly identified growth factor specific for epithelial cells." Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A. Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-44.
[4]	"Receptor specificity of the fibroblast growth factor family." Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR2, FUNCTION IN CELL PROLIFERATION.
[5]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFBP1.
[6]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[7]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60828 mRNA. Translation: AAA63210.1. S81661 mRNA. Translation: AAB21431.1.
IPI	IPI00010403.
PIR	A36301. B46289.
RefSeq	NP_002000.1. NM_002009.3.
UniGene	Hs.567268.
3D structure databases
ProteinModelPortal	P21781.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4010N.
IntAct	P21781. 4 interactions.
STRING	9606.ENSP00000267843.
PTM databases
PhosphoSite	P21781.
Polymorphism databases
DMDM	122756.
Proteomic databases
PaxDb	P21781.
PRIDE	P21781.
Protocols and materials databases
DNASU	2252.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000267843; ENSP00000267843; ENSG00000140285. ENST00000560765; ENSP00000453048; ENSG00000140285.
GeneID	2252.
KEGG	hsa:2252.
UCSC	uc001zxn.3. human.
Organism-specific databases
CTD	2252.
GeneCards	GC15P049715.
H-InvDB	HIX0008074. HIX0035058.
HGNC	HGNC:3685. FGF7.
HPA	HPA043605.
MIM	148180. gene.
neXtProt	NX_P21781.
PharmGKB	PA28124.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG294282.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P21781.
KO	K04358.
OMA	NCSKHER.
OrthoDB	EOG4J9N0V.
PhylomeDB	P21781.
Enzyme and pathway databases
Pathway_Interaction_DB	glypican_3pathway. Glypican 3 network.
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P21781.
Bgee	P21781.
CleanEx	HS_FGF7.
Genevestigator	P21781.
GermOnline	ENSG00000140285. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00039. Palifermin.
GenomeRNAi	2252.
NextBio	9117.
SOURCE	Search...

Entry information

Entry name

FGF7_HUMAN

Accession

Primary (citable) accession number: P21781

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.