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Protein

Fibroblast growth factor 7

Gene

FGF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.2 Publications

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • growth factor activity Source: ProtInc
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • epidermal growth factor receptor signaling pathway Source: Reactome
  • epidermis development Source: ProtInc
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • hair follicle morphogenesis Source: Ensembl
  • innate immune response Source: Reactome
  • insulin receptor signaling pathway Source: Reactome
  • mesenchymal cell proliferation Source: UniProtKB
  • neurotrophin TRK receptor signaling pathway Source: Reactome
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive chemotaxis Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • positive regulation of keratinocyte migration Source: UniProtKB
  • positive regulation of keratinocyte proliferation Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • protein localization to cell surface Source: UniProtKB
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
  • response to wounding Source: ProtInc
  • secretion by lung epithelial cell involved in lung growth Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_120863. Activated point mutants of FGFR2.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_75829. PIP3 activates AKT signaling.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP21781.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:FGF7
Synonyms:KGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:3685. FGF7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28124.

Polymorphism and mutation databases

BioMutaiFGF7.
DMDMi122756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31312 PublicationsAdd
BLAST
Chaini32 – 194163Fibroblast growth factor 7PRO_0000008965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP21781.
PRIDEiP21781.

PTM databases

PhosphoSiteiP21781.

Expressioni

Tissue specificityi

Epithelial cell.

Gene expression databases

BgeeiP21781.
CleanExiHS_FGF7.
ExpressionAtlasiP21781. baseline and differential.
GenevisibleiP21781. HS.

Organism-specific databases

HPAiHPA043605.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P21802-32EBI-3937699,EBI-6354683

Protein-protein interaction databases

BioGridi108543. 4 interactions.
DIPiDIP-4010N.
IntActiP21781. 4 interactions.
MINTiMINT-123340.
STRINGi9606.ENSP00000267843.

Structurei

3D structure databases

ProteinModelPortaliP21781.
SMRiP21781. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG294282.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21781.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
PhylomeDBiP21781.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21781-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,509
Last modified:May 1, 1991 - v1
Checksum:iB19192474E6049E2
GO
Isoform 2 (identifier: P21781-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-194: NIMEIRTVAV...TAHFLPMAIT → SK

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,520
Checksum:iDDC0FBE2EE78C6DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591M → T.
Corresponds to variant rs34531231 [ dbSNP | Ensembl ].
VAR_049063
Natural varianti62 – 621G → E.1 Publication
Corresponds to variant rs17850705 [ dbSNP | Ensembl ].
VAR_071038

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 19499NIMEI…PMAIT → SK in isoform 2. 1 PublicationVSP_055090Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
AK313160 mRNA. Translation: BAG35978.1.
CR542002 mRNA. Translation: CAG46799.1.
AC022306 Genomic DNA. No translation available.
AC025919 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77375.1.
CH471082 Genomic DNA. Translation: EAW77376.1.
BC010956 mRNA. Translation: AAH10956.1.
CCDSiCCDS10131.1. [P21781-1]
PIRiA36301.
B46289.
RefSeqiNP_002000.1. NM_002009.3. [P21781-1]
UniGeneiHs.567268.

Genome annotation databases

EnsembliENST00000267843; ENSP00000267843; ENSG00000140285. [P21781-1]
ENST00000560270; ENSP00000454205; ENSG00000140285. [P21781-2]
ENST00000560765; ENSP00000453048; ENSG00000140285. [P21781-1]
ENST00000614567; ENSP00000478148; ENSG00000140285. [P21781-1]
GeneIDi2252.
KEGGihsa:2252.
UCSCiuc001zxn.3. human. [P21781-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
AK313160 mRNA. Translation: BAG35978.1.
CR542002 mRNA. Translation: CAG46799.1.
AC022306 Genomic DNA. No translation available.
AC025919 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77375.1.
CH471082 Genomic DNA. Translation: EAW77376.1.
BC010956 mRNA. Translation: AAH10956.1.
CCDSiCCDS10131.1. [P21781-1]
PIRiA36301.
B46289.
RefSeqiNP_002000.1. NM_002009.3. [P21781-1]
UniGeneiHs.567268.

3D structure databases

ProteinModelPortaliP21781.
SMRiP21781. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108543. 4 interactions.
DIPiDIP-4010N.
IntActiP21781. 4 interactions.
MINTiMINT-123340.
STRINGi9606.ENSP00000267843.

Chemistry

BindingDBiP21781.
ChEMBLiCHEMBL3286071.

PTM databases

PhosphoSiteiP21781.

Polymorphism and mutation databases

BioMutaiFGF7.
DMDMi122756.

Proteomic databases

PaxDbiP21781.
PRIDEiP21781.

Protocols and materials databases

DNASUi2252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267843; ENSP00000267843; ENSG00000140285. [P21781-1]
ENST00000560270; ENSP00000454205; ENSG00000140285. [P21781-2]
ENST00000560765; ENSP00000453048; ENSG00000140285. [P21781-1]
ENST00000614567; ENSP00000478148; ENSG00000140285. [P21781-1]
GeneIDi2252.
KEGGihsa:2252.
UCSCiuc001zxn.3. human. [P21781-1]

Organism-specific databases

CTDi2252.
GeneCardsiGC15P049715.
H-InvDBHIX0008074.
HIX0035058.
HGNCiHGNC:3685. FGF7.
HPAiHPA043605.
MIMi148180. gene.
neXtProtiNX_P21781.
PharmGKBiPA28124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG294282.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21781.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
PhylomeDBiP21781.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_120863. Activated point mutants of FGFR2.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_75829. PIP3 activates AKT signaling.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP21781.

Miscellaneous databases

GeneWikiiFGF7.
GenomeRNAii2252.
NextBioi35525170.
PROiP21781.
SOURCEiSearch...

Gene expression databases

BgeeiP21781.
CleanExiHS_FGF7.
ExpressionAtlasiP21781. baseline and differential.
GenevisibleiP21781. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth."
    Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.
    Science 245:752-755(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 32-50.
  2. "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity."
    Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.
    Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-62.
    Tissue: Brain.
  8. "Purification and characterization of a newly identified growth factor specific for epithelial cells."
    Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-44.
  9. Cited for: INTERACTION WITH FGFR2, FUNCTION IN CELL PROLIFERATION.
  10. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
    Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
    Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFBP1.
  11. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  12. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF7_HUMAN
AccessioniPrimary (citable) accession number: P21781
Secondary accession number(s): H0YNY5, Q6FGV5, Q96FG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 24, 2015
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.