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Reviewed, UniProtKB/Swiss-Prot P21781 (FGF7_HUMAN)

Last modified July 22, 2008. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Keratinocyte growth factor
      Short name=KGF
Alternative name(s):
    Fibroblast growth factor 7
      Short name=FGF-7
    Heparin-binding growth factor 7
      Short name=HBGF-7
Gene names
Name: FGF7
Synonyms: KGF
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Subunit structure

Interacts with FGFBP1.

Subcellular location

Secreted.

Tissue specificity

Epithelial cell.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords

   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processepidermis development

Traceable author statement. Source: ProtInc

fibroblast growth factor receptor signaling pathway

Inferred from Experiment. Source: Reactome

positive regulation of cell proliferation Ref.3

Traceable author statement. Source: ProtInc

response to wounding

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from Experiment. Source: Reactome

   Molecular functiongrowth factor activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 3131
Chain32 – 194163Keratinocyte growth factor

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P21781-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: B19192474E6049E2

FASTA19422,509
        10         20         30         40         50         60 
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 

       130        140        150        160        170        180 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 

       190 
KEQKTAHFLP MAIT 

« Hide

References

[1]"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth."
Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.
Science 245:752-755(1989) [PubMed: 2475908] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-50.
[2]"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity."
Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.
Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed: 1664700] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Purification and characterization of a newly identified growth factor specific for epithelial cells."
Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.
Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed: 2915979] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-44.
[4]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]
Cited for: INTERACTION WITH FGFBP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
PIRA36301.
B46289.
RefSeqNP_002000.1.
UniGeneHs.567268

3D structure databases

HSSPHSSP built from PDB template 1QQK based on UniProtKB Q02195.
SMRP21781. Positions 63-194.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4010N.

Genome annotation databases

EnsemblENSG00000140285. Homo sapiens. [Contig view]
GeneID2252.
KEGGhsa:2252.

Organism-specific databases

H-InvDBHIX0008074.
HIX0012227.
HIX0035058.
HIX0041064.
HIX0058650.
HIX0058651.
HIX0058652.
HGNCHGNC:3685. FGF7.
MIM148180. gene.
PharmGKBPA28124.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP21781.
HOVERGENP21781.

Enzyme and pathway databases

ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressP21781.
CleanExHS_FGF7.
GermOnlineENSG00000140285. Homo sapiens.

Family and domain databases

InterProIPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

DrugBankDB00039. Palifermin.
LinkHubP21781.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameFGF7_HUMAN
AccessionPrimary (citable) accession number: P21781
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 22, 2008
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents