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P21781 (FGF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 7

Short name=FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name=HBGF-7
Keratinocyte growth factor
Gene names
Name:FGF7
Synonyms:KGF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Ref.9 Ref.11

Subunit structure

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.9 Ref.10 Ref.11

Subcellular location

Secreted.

Tissue specificity

Epithelial cell.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandHeparin-binding
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

actin cytoskeleton reorganization

Inferred from direct assay PubMed 17449030. Source: UniProtKB

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

epidermis development

Traceable author statement PubMed 7973639. Source: ProtInc

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction Ref.9. Source: MGI

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

mesenchymal cell proliferation

Inferred from direct assay PubMed 11023837. Source: UniProtKB

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive chemotaxis

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from genetic interaction Ref.9. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 15690149. Source: UniProtKB

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from direct assay PubMed 9740653. Source: MGI

positive regulation of keratinocyte migration

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of keratinocyte proliferation

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 17449030. Source: UniProtKB

protein localization to cell surface

Inferred from direct assay PubMed 17449030. Source: UniProtKB

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Inferred from electronic annotation. Source: Ensembl

response to wounding

Traceable author statement PubMed 7973639. Source: ProtInc

secretion by lung epithelial cell involved in lung growth

Inferred from direct assay PubMed 10541313. Source: UniProtKB

signal transduction

Non-traceable author statement Ref.1. Source: ProtInc

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

   Molecular_functionchemoattractant activity

Inferred from direct assay PubMed 17449030. Source: UniProtKB

growth factor activity

Traceable author statement Ref.1. Source: ProtInc

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 1309608. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FGFR2P21802-32EBI-3937699,EBI-6354683

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P21781-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P21781-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-194: NIMEIRTVAV...TAHFLPMAIT → SK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Ref.1 Ref.8
Chain32 – 194163Fibroblast growth factor 7
PRO_0000008965

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence96 – 19499NIMEI…PMAIT → SK in isoform 2.
VSP_055090
Natural variant591M → T.
Corresponds to variant rs34531231 [ dbSNP | Ensembl ].
VAR_049063
Natural variant621G → E. Ref.7
Corresponds to variant rs17850705 [ dbSNP | Ensembl ].
VAR_071038

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: B19192474E6049E2

FASTA19422,509
        10         20         30         40         50         60 
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 

       130        140        150        160        170        180 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 

       190 
KEQKTAHFLP MAIT 

« Hide

Isoform 2 [UniParc].

Checksum: DDC0FBE2EE78C6DD
Show »

FASTA9711,520

References

« Hide 'large scale' references
[1]"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth."
Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.
Science 245:752-755(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 32-50.
[2]"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity."
Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.
Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-62.
Tissue: Brain.
[8]"Purification and characterization of a newly identified growth factor specific for epithelial cells."
Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.
Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-44.
[9]"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR2, FUNCTION IN CELL PROLIFERATION.
[10]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFBP1.
[11]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[12]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
AK313160 mRNA. Translation: BAG35978.1.
CR542002 mRNA. Translation: CAG46799.1.
AC022306 Genomic DNA. No translation available.
AC025919 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77375.1.
CH471082 Genomic DNA. Translation: EAW77376.1.
BC010956 mRNA. Translation: AAH10956.1.
CCDSCCDS10131.1.
PIRA36301.
B46289.
RefSeqNP_002000.1. NM_002009.3.
UniGeneHs.567268.

3D structure databases

ProteinModelPortalP21781.
SMRP21781. Positions 63-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108543. 4 interactions.
DIPDIP-4010N.
IntActP21781. 4 interactions.
MINTMINT-123340.
STRING9606.ENSP00000267843.

Chemistry

DrugBankDB00039. Palifermin.

PTM databases

PhosphoSiteP21781.

Polymorphism databases

DMDM122756.

Proteomic databases

PaxDbP21781.
PRIDEP21781.

Protocols and materials databases

DNASU2252.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267843; ENSP00000267843; ENSG00000140285.
ENST00000560270; ENSP00000454205; ENSG00000140285.
ENST00000560765; ENSP00000453048; ENSG00000140285.
GeneID2252.
KEGGhsa:2252.
UCSCuc001zxn.3. human.

Organism-specific databases

CTD2252.
GeneCardsGC15P049715.
H-InvDBHIX0008074.
HIX0035058.
HGNCHGNC:3685. FGF7.
HPAHPA043605.
MIM148180. gene.
neXtProtNX_P21781.
PharmGKBPA28124.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294282.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP21781.
KOK04358.
OMANCSKHER.
OrthoDBEOG7992S1.
PhylomeDBP21781.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkP21781.

Gene expression databases

ArrayExpressP21781.
BgeeP21781.
CleanExHS_FGF7.
GenevestigatorP21781.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGF7.
GenomeRNAi2252.
NextBio9117.
PROP21781.
SOURCESearch...

Entry information

Entry nameFGF7_HUMAN
AccessionPrimary (citable) accession number: P21781
Secondary accession number(s): H0YNY5, Q6FGV5, Q96FG5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM