Reviewed, UniProtKB/Swiss-Prot P21781 (FGF7_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratinocyte growth factor
      Short name=KGF
Alternative name(s):
    Fibroblast growth factor 7
      Short name=FGF-7
    Heparin-binding growth factor 7
      Short name=HBGF-7

Gene names

Name:	FGF7
Synonyms:	KGF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Subunit structure	Interacts with FGFBP1. Ref.4
Subcellular location	Secreted.
Tissue specificity	Epithelial cell.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell proliferation Inferred from electronic annotation. Source: UniProtKB-KW epidermis development Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome positive regulation of epithelial cell proliferation Inferred from direct assay. Source: MGI response to wounding Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from Experiment. Source: Reactome
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Ref.1 Ref.3
	Chain	32 – 194	163	Keratinocyte growth factor		PRO_0000008965
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	59	1	M → T: dbSNP rs34531231.		VAR_049063

Sequences

	Sequence		Length	Mass (Da)
	P21781-1 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: B19192474E6049E2	FASTA	194	22,509
	10 20 30 40 50 60 MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 70 80 90 100 110 120 GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 130 140 150 160 170 180 MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 190 KEQKTAHFLP MAIT

References

[1]	"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth." Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A. Science 245:752-755(1989) [PubMed: 2475908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-50.
[2]	"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity." Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S. Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed: 1664700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Purification and characterization of a newly identified growth factor specific for epithelial cells." Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A. Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed: 2915979] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-44.
[4]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract] Cited for: INTERACTION WITH FGFBP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M60828 mRNA. Translation: AAA63210.1. S81661 mRNA. Translation: AAB21431.1.
IPI	IPI00010403.
PIR	A36301. B46289.
RefSeq	NP_002000.1.
UniGene	Hs.567268
3D structure databases
HSSP	HSSP built from PDB template 1QQK based on UniProtKB Q02195.
SMR	P21781. Positions 63-194.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4010N.
Genome annotation databases
Ensembl	ENSG00000140285. Homo sapiens. [Contig view]
GeneID	2252.
KEGG	hsa:2252.
Organism-specific databases
GeneCards	GC09M046628. GC15P047502. GC15P047503.
H-InvDB	HIX0008074. HIX0012227. HIX0035058. HIX0041064. HIX0058650. HIX0058651. HIX0058652.
HGNC	HGNC:3685. FGF7.
MIM	148180. gene.
PharmGKB	PA28124.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P21781.
HOVERGEN	P21781.
OMA	P21781. PEQMAAN.
Enzyme and pathway databases
Pathway_Interaction_DB	glypican_3pathway. Glypican 3 network.
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	P21781.
Bgee	P21781.
CleanEx	HS_FGF7.
GermOnline	ENSG00000140285. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00039. Palifermin.
NextBio	9117.
SOURCE	Search...

Entry information

Entry name

FGF7_HUMAN

Accession

Primary (citable) accession number: P21781

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)