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Reviewed, UniProtKB/Swiss-Prot P21781 (FGF7_HUMAN)

Last modified February 9, 2010. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Keratinocyte growth factor
      Short name=KGF
Alternative name(s):
    Fibroblast growth factor 7
      Short name=FGF-7
    Heparin-binding growth factor 7
      Short name=HBGF-7
Gene names
Name: FGF7
Synonyms: KGF
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Subunit structure

Interacts with FGFBP1. Ref.4

Subcellular location

Secreted.

Tissue specificity

Epithelial cell.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Ref.1 Ref.3
Chain32 – 194163Keratinocyte growth factor
PRO_0000008965

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential

Natural variations

Natural variant591M → T: dbSNP rs34531231.
VAR_049063

Sequences

Sequence LengthMass (Da)Tools
P21781-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: B19192474E6049E2

FASTA19422,509
        10         20         30         40         50         60 
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 

       130        140        150        160        170        180 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 

       190 
KEQKTAHFLP MAIT 

« Hide

References

[1]"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth."
Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.
Science 245:752-755(1989) [PubMed: 2475908] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-50.
[2]"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity."
Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.
Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed: 1664700] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Purification and characterization of a newly identified growth factor specific for epithelial cells."
Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.
Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed: 2915979] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-44.
[4]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]
Cited for: INTERACTION WITH FGFBP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
IPIIPI00010403.
PIRA36301.
B46289.
RefSeqNP_002000.1.
UniGeneHs.567268

3D structure databases

SMRP21781. Positions 63-194.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4010N.
STRINGP21781.

Genome annotation databases

EnsemblENST00000267843; ENSP00000267843; ENSG00000140285; Homo sapiens. [Genome view]
GeneID2252.
KEGGhsa:2252.
UCSCuc001zxn.1. human.

Organism-specific databases

CTD2252.
GeneCardsGC09M046628.
GC15P047502.
GC15P047503.
H-InvDBHIX0008074.
HIX0012227.
HIX0035058.
HIX0041064.
HIX0058650.
HIX0058651.
HIX0058652.
HGNCHGNC:3685. FGF7.
MIM148180. gene.
PharmGKBPA28124.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07447.
HOGENOMHBG715603.
HOVERGENP21781.
InParanoidP21781.
OMAPEQMAAN.
PhylomeDBP21781.

Enzyme and pathway databases

Pathway_Interaction_DBglypican_3pathway. Glypican 3 network.
ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressP21781.
BgeeP21781.
CleanExHS_FGF7.
GenevestigatorP21781.
GermOnlineENSG00000140285. Homo sapiens.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00039. Palifermin.
NextBio9117.
SOURCESearch...

Entry information

Entry nameFGF7_HUMAN
AccessionPrimary (citable) accession number: P21781
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 9, 2010
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents