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Protein

Fibroblast growth factor 7

Gene

FGF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • epidermis development Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • hair follicle morphogenesis Source: Ensembl
  • MAPK cascade Source: Reactome
  • mesenchymal cell proliferation Source: UniProtKB
  • positive chemotaxis Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • positive regulation of keratinocyte migration Source: UniProtKB
  • positive regulation of keratinocyte proliferation Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: Reactome
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • protein localization to cell surface Source: UniProtKB
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
  • response to wounding Source: ProtInc
  • secretion by lung epithelial cell involved in lung growth Source: UniProtKB
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP21781

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:FGF7
Synonyms:KGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140285.9
HGNCiHGNC:3685 FGF7
MIMi148180 gene
neXtProtiNX_P21781

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2252
OpenTargetsiENSG00000140285
PharmGKBiPA28124

Chemistry databases

ChEMBLiCHEMBL3286071

Polymorphism and mutation databases

BioMutaiFGF7
DMDMi122756

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 312 PublicationsAdd BLAST31
ChainiPRO_000000896532 – 194Fibroblast growth factor 7Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP21781
PeptideAtlasiP21781
PRIDEiP21781

PTM databases

iPTMnetiP21781
PhosphoSitePlusiP21781

Expressioni

Tissue specificityi

Epithelial cell.

Gene expression databases

BgeeiENSG00000140285
CleanExiHS_FGF7
ExpressionAtlasiP21781 baseline and differential
GenevisibleiP21781 HS

Organism-specific databases

HPAiHPA043605

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P21802-32EBI-3937699,EBI-6354683

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • fibroblast growth factor receptor binding Source: InterPro
  • growth factor activity Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

Protein-protein interaction databases

BioGridi108543, 4 interactors
DIPiDIP-4010N
IntActiP21781, 4 interactors
STRINGi9606.ENSP00000267843

Chemistry databases

BindingDBiP21781

Structurei

3D structure databases

ProteinModelPortaliP21781
SMRiP21781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP21781
KOiK04358
OMAiCSKHERH
OrthoDBiEOG091G0NAY
PhylomeDBiP21781
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028247 FGF7
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF20 PTHR11486:SF20, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21781-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,509
Last modified:May 1, 1991 - v1
Checksum:iB19192474E6049E2
GO
Isoform 2 (identifier: P21781-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-194: NIMEIRTVAV...TAHFLPMAIT → SK

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,520
Checksum:iDDC0FBE2EE78C6DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04906359M → T. Corresponds to variant dbSNP:rs34531231Ensembl.1
Natural variantiVAR_07103862G → E1 PublicationCorresponds to variant dbSNP:rs17850705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05509096 – 194NIMEI…PMAIT → SK in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60828 mRNA Translation: AAA63210.1
S81661 mRNA Translation: AAB21431.1
AK313160 mRNA Translation: BAG35978.1
CR542002 mRNA Translation: CAG46799.1
AC022306 Genomic DNA No translation available.
AC025919 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77375.1
CH471082 Genomic DNA Translation: EAW77376.1
BC010956 mRNA Translation: AAH10956.1
CCDSiCCDS10131.1 [P21781-1]
PIRiA36301
B46289
RefSeqiNP_002000.1, NM_002009.3 [P21781-1]
UniGeneiHs.567268

Genome annotation databases

EnsembliENST00000267843; ENSP00000267843; ENSG00000140285 [P21781-1]
ENST00000560270; ENSP00000454205; ENSG00000140285 [P21781-2]
ENST00000560765; ENSP00000453048; ENSG00000140285 [P21781-1]
ENST00000614567; ENSP00000478148; ENSG00000140285 [P21781-1]
GeneIDi2252
KEGGihsa:2252
UCSCiuc001zxn.3 human [P21781-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGF7_HUMAN
AccessioniPrimary (citable) accession number: P21781
Secondary accession number(s): H0YNY5, Q6FGV5, Q96FG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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