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P21781

- FGF7_HUMAN

UniProt

P21781 - FGF7_HUMAN

Protein

Fibroblast growth factor 7

Gene

FGF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.2 Publications

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. growth factor activity Source: ProtInc
    3. heparin binding Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. branching involved in salivary gland morphogenesis Source: Ensembl
    3. epidermal growth factor receptor signaling pathway Source: Reactome
    4. epidermis development Source: ProtInc
    5. Fc-epsilon receptor signaling pathway Source: Reactome
    6. fibroblast growth factor receptor signaling pathway Source: MGI
    7. hair follicle morphogenesis Source: Ensembl
    8. innate immune response Source: Reactome
    9. insulin receptor signaling pathway Source: Reactome
    10. mesenchymal cell proliferation Source: UniProtKB
    11. neurotrophin TRK receptor signaling pathway Source: Reactome
    12. phosphatidylinositol-mediated signaling Source: Reactome
    13. positive chemotaxis Source: UniProtKB
    14. positive regulation of cell division Source: UniProtKB-KW
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of epithelial cell proliferation Source: UniProtKB
    17. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
    18. positive regulation of keratinocyte migration Source: UniProtKB
    19. positive regulation of keratinocyte proliferation Source: UniProtKB
    20. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    21. protein localization to cell surface Source: UniProtKB
    22. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
    23. response to wounding Source: ProtInc
    24. secretion by lung epithelial cell involved in lung growth Source: UniProtKB
    25. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiP21781.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 7
    Short name:
    FGF-7
    Alternative name(s):
    Heparin-binding growth factor 7
    Short name:
    HBGF-7
    Keratinocyte growth factor
    Gene namesi
    Name:FGF7
    Synonyms:KGF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:3685. FGF7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31312 PublicationsAdd
    BLAST
    Chaini32 – 194163Fibroblast growth factor 7PRO_0000008965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP21781.
    PRIDEiP21781.

    PTM databases

    PhosphoSiteiP21781.

    Expressioni

    Tissue specificityi

    Epithelial cell.

    Gene expression databases

    ArrayExpressiP21781.
    BgeeiP21781.
    CleanExiHS_FGF7.
    GenevestigatoriP21781.

    Organism-specific databases

    HPAiHPA043605.

    Interactioni

    Subunit structurei

    Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FGFR2P21802-32EBI-3937699,EBI-6354683

    Protein-protein interaction databases

    BioGridi108543. 4 interactions.
    DIPiDIP-4010N.
    IntActiP21781. 4 interactions.
    MINTiMINT-123340.
    STRINGi9606.ENSP00000267843.

    Structurei

    3D structure databases

    ProteinModelPortaliP21781.
    SMRiP21781. Positions 63-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG294282.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP21781.
    KOiK04358.
    OMAiNCSKHER.
    OrthoDBiEOG7992S1.
    PhylomeDBiP21781.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028247. FGF7.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF20. PTHR11486:SF20. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P21781-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE    50
    RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI 100
    RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT 150
    YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT 194
    Length:194
    Mass (Da):22,509
    Last modified:May 1, 1991 - v1
    Checksum:iB19192474E6049E2
    GO
    Isoform 2 (identifier: P21781-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-194: NIMEIRTVAV...TAHFLPMAIT → SK

    Note: No experimental confirmation available.

    Show »
    Length:97
    Mass (Da):11,520
    Checksum:iDDC0FBE2EE78C6DD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591M → T.
    Corresponds to variant rs34531231 [ dbSNP | Ensembl ].
    VAR_049063
    Natural varianti62 – 621G → E.1 Publication
    Corresponds to variant rs17850705 [ dbSNP | Ensembl ].
    VAR_071038

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 19499NIMEI…PMAIT → SK in isoform 2. 1 PublicationVSP_055090Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60828 mRNA. Translation: AAA63210.1.
    S81661 mRNA. Translation: AAB21431.1.
    AK313160 mRNA. Translation: BAG35978.1.
    CR542002 mRNA. Translation: CAG46799.1.
    AC022306 Genomic DNA. No translation available.
    AC025919 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77375.1.
    CH471082 Genomic DNA. Translation: EAW77376.1.
    BC010956 mRNA. Translation: AAH10956.1.
    CCDSiCCDS10131.1. [P21781-1]
    PIRiA36301.
    B46289.
    RefSeqiNP_002000.1. NM_002009.3.
    UniGeneiHs.567268.

    Genome annotation databases

    EnsembliENST00000267843; ENSP00000267843; ENSG00000140285. [P21781-1]
    ENST00000560270; ENSP00000454205; ENSG00000140285. [P21781-2]
    ENST00000560765; ENSP00000453048; ENSG00000140285. [P21781-1]
    GeneIDi2252.
    KEGGihsa:2252.
    UCSCiuc001zxn.3. human. [P21781-1]

    Polymorphism databases

    DMDMi122756.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60828 mRNA. Translation: AAA63210.1 .
    S81661 mRNA. Translation: AAB21431.1 .
    AK313160 mRNA. Translation: BAG35978.1 .
    CR542002 mRNA. Translation: CAG46799.1 .
    AC022306 Genomic DNA. No translation available.
    AC025919 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77375.1 .
    CH471082 Genomic DNA. Translation: EAW77376.1 .
    BC010956 mRNA. Translation: AAH10956.1 .
    CCDSi CCDS10131.1. [P21781-1 ]
    PIRi A36301.
    B46289.
    RefSeqi NP_002000.1. NM_002009.3.
    UniGenei Hs.567268.

    3D structure databases

    ProteinModelPortali P21781.
    SMRi P21781. Positions 63-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108543. 4 interactions.
    DIPi DIP-4010N.
    IntActi P21781. 4 interactions.
    MINTi MINT-123340.
    STRINGi 9606.ENSP00000267843.

    Chemistry

    DrugBanki DB00039. Palifermin.

    PTM databases

    PhosphoSitei P21781.

    Polymorphism databases

    DMDMi 122756.

    Proteomic databases

    PaxDbi P21781.
    PRIDEi P21781.

    Protocols and materials databases

    DNASUi 2252.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267843 ; ENSP00000267843 ; ENSG00000140285 . [P21781-1 ]
    ENST00000560270 ; ENSP00000454205 ; ENSG00000140285 . [P21781-2 ]
    ENST00000560765 ; ENSP00000453048 ; ENSG00000140285 . [P21781-1 ]
    GeneIDi 2252.
    KEGGi hsa:2252.
    UCSCi uc001zxn.3. human. [P21781-1 ]

    Organism-specific databases

    CTDi 2252.
    GeneCardsi GC15P049715.
    H-InvDB HIX0008074.
    HIX0035058.
    HGNCi HGNC:3685. FGF7.
    HPAi HPA043605.
    MIMi 148180. gene.
    neXtProti NX_P21781.
    PharmGKBi PA28124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294282.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P21781.
    KOi K04358.
    OMAi NCSKHER.
    OrthoDBi EOG7992S1.
    PhylomeDBi P21781.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki P21781.

    Miscellaneous databases

    GeneWikii FGF7.
    GenomeRNAii 2252.
    NextBioi 35525170.
    PROi P21781.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21781.
    Bgeei P21781.
    CleanExi HS_FGF7.
    Genevestigatori P21781.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028247. FGF7.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF20. PTHR11486:SF20. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth."
      Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.
      Science 245:752-755(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 32-50.
    2. "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity."
      Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.
      Ann. N. Y. Acad. Sci. 638:62-77(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-62.
      Tissue: Brain.
    8. "Purification and characterization of a newly identified growth factor specific for epithelial cells."
      Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-44.
    9. Cited for: INTERACTION WITH FGFR2, FUNCTION IN CELL PROLIFERATION.
    10. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
      Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
      Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFBP1.
    11. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    12. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF7_HUMAN
    AccessioniPrimary (citable) accession number: P21781
    Secondary accession number(s): H0YNY5, Q6FGV5, Q96FG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3