Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 7

Gene

FGF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • epidermis development Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • hair follicle morphogenesis Source: Ensembl
  • interleukin-7-mediated signaling pathway Source: Reactome
  • MAPK cascade Source: Reactome
  • mesenchymal cell proliferation Source: UniProtKB
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive chemotaxis Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • positive regulation of keratinocyte migration Source: UniProtKB
  • positive regulation of keratinocyte proliferation Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • protein localization to cell surface Source: UniProtKB
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
  • response to wounding Source: ProtInc
  • secretion by lung epithelial cell involved in lung growth Source: UniProtKB
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-190377. FGFR2b ligand binding and activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiP21781.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:FGF7
Synonyms:KGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140285.9.
HGNCiHGNC:3685. FGF7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2252.
OpenTargetsiENSG00000140285.
PharmGKBiPA28124.

Chemistry databases

ChEMBLiCHEMBL3286071.

Polymorphism and mutation databases

BioMutaiFGF7.
DMDMi122756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 312 PublicationsAdd BLAST31
ChainiPRO_000000896532 – 194Fibroblast growth factor 7Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP21781.
PeptideAtlasiP21781.
PRIDEiP21781.

PTM databases

iPTMnetiP21781.
PhosphoSitePlusiP21781.

Expressioni

Tissue specificityi

Epithelial cell.

Gene expression databases

BgeeiENSG00000140285.
CleanExiHS_FGF7.
ExpressionAtlasiP21781. baseline and differential.
GenevisibleiP21781. HS.

Organism-specific databases

HPAiHPA043605.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P21802-32EBI-3937699,EBI-6354683

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: InterPro
  • growth factor activity Source: ProtInc

Protein-protein interaction databases

BioGridi108543. 4 interactors.
DIPiDIP-4010N.
IntActiP21781. 4 interactors.
MINTiMINT-123340.
STRINGi9606.ENSP00000267843.

Chemistry databases

BindingDBiP21781.

Structurei

3D structure databases

ProteinModelPortaliP21781.
SMRiP21781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21781.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG091G0NAY.
PhylomeDBiP21781.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF94. PTHR11486:SF94. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21781-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,509
Last modified:May 1, 1991 - v1
Checksum:iB19192474E6049E2
GO
Isoform 2 (identifier: P21781-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-194: NIMEIRTVAV...TAHFLPMAIT → SK

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,520
Checksum:iDDC0FBE2EE78C6DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04906359M → T. Corresponds to variant dbSNP:rs34531231Ensembl.1
Natural variantiVAR_07103862G → E1 PublicationCorresponds to variant dbSNP:rs17850705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05509096 – 194NIMEI…PMAIT → SK in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60828 mRNA. Translation: AAA63210.1.
S81661 mRNA. Translation: AAB21431.1.
AK313160 mRNA. Translation: BAG35978.1.
CR542002 mRNA. Translation: CAG46799.1.
AC022306 Genomic DNA. No translation available.
AC025919 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77375.1.
CH471082 Genomic DNA. Translation: EAW77376.1.
BC010956 mRNA. Translation: AAH10956.1.
CCDSiCCDS10131.1. [P21781-1]
PIRiA36301.
B46289.
RefSeqiNP_002000.1. NM_002009.3. [P21781-1]
UniGeneiHs.567268.

Genome annotation databases

EnsembliENST00000267843; ENSP00000267843; ENSG00000140285. [P21781-1]
ENST00000560270; ENSP00000454205; ENSG00000140285. [P21781-2]
ENST00000560765; ENSP00000453048; ENSG00000140285. [P21781-1]
ENST00000614567; ENSP00000478148; ENSG00000140285. [P21781-1]
GeneIDi2252.
KEGGihsa:2252.
UCSCiuc001zxn.3. human. [P21781-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGF7_HUMAN
AccessioniPrimary (citable) accession number: P21781
Secondary accession number(s): H0YNY5, Q6FGV5, Q96FG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 27, 2017
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families