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Reviewed, UniProtKB/Swiss-Prot P21778 (K6PF2_THET8)

Last modified June 16, 2009. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    6-phosphofructokinase isozyme 2
      Short name=Phosphofructokinase 2
      Short name=PFK2
    EC=2.7.1.11
Alternative name(s):
    Phosphohexokinase 2
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length25 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP MF_00339

Enzyme regulation

In contrast with PFK1 this enzyme is not affected by phosphoenolpyruvate. HAMAP MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP MF_00339

Subunit structure

Homotetramer. HAMAP MF_00339

Subcellular location

Cytoplasm. HAMAP MF_00339

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular function6-phosphofructokinase activity

Inferred from electronic annotation. Source: HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›25›256-phosphofructokinase isozyme 2 HAMAP MF_00339
PRO_0000112002

Regions

Nucleotide binding21 – 255ATP By similarity

Experimental info

Non-terminal residue251

Sequences

Sequence LengthMass (Da)Tools
P21778-1 [UniParc].

Last modified April 12, 2005. Version 3.
Checksum: E7AEC8D6110EBA46

FASTA252,557
        10         20 
MKRIGVLTSG GDSPGMNAAI RAVVR 

« Hide

References

[1]"Phosphoenolpyruvate-insensitive phosphofructokinase isozyme from Thermus thermophilus HB8."
Xu J., Oshima T., Yoshida M.
J. Biochem. 109:199-203(1991) [PubMed: 1830879] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases

HSSPHSSP built from PDB template 3PFK based on UniProtKB P00512.
ModBaseSearch...

Family and domain databases

HAMAPMF_00339.
[Tree]
InterProIPR000023. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PROSITEPS00433. PHOSPHOFRUCTOKINASE. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF2_THET8
AccessionPrimary (citable) accession number: P21778
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 12, 2005
Last modified: June 16, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents