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Protein

37S ribosomal protein S28, mitochondrial

Gene

MRPS28

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 6960 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29893-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S28, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS15m1 Publication
Gene namesi
Name:MRPS28
Ordered Locus Names:YDR337W
ORF Names:D9651.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR337W
SGDiS000002745 MRPS28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33Mitochondrion1 PublicationAdd BLAST33
ChainiPRO_000003061334 – 28637S ribosomal protein S28, mitochondrialAdd BLAST253

Post-translational modificationi

The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).1 Publication

Proteomic databases

MaxQBiP21771
PaxDbiP21771
PRIDEiP21771

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.3 Publications

Protein-protein interaction databases

BioGridi32394, 120 interactors
DIPiDIP-3889N
IntActiP21771, 9 interactors
MINTiP21771
STRINGi4932.YDR337W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25OO34-286[»]
5MREelectron microscopy3.75OO34-286[»]
5MRFelectron microscopy4.97OO34-286[»]
ProteinModelPortaliP21771
SMRiP21771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000248865
InParanoidiP21771
KOiK02956
OMAiDRRYMQD
OrthoDBiEOG092C3VY1

Family and domain databases

CDDicd00353 Ribosomal_S15p_S13e, 1 hit
HAMAPiMF_01343_B Ribosomal_S15_B, 1 hit
InterProiView protein in InterPro
IPR000589 Ribosomal_S15
IPR005290 Ribosomal_S15_bac-type
IPR009068 S15_NS1_RNA-bd
PANTHERiPTHR23321 PTHR23321, 2 hits
PfamiView protein in Pfam
PF00312 Ribosomal_S15, 1 hit
SMARTiView protein in SMART
SM01387 Ribosomal_S15, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
TIGRFAMsiTIGR00952 S15_bact, 1 hit
PROSITEiView protein in PROSITE
PS00362 RIBOSOMAL_S15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVGRNAIL NLRISLCPLF MGKRSFVSSP VSNSAKAVKF LKAQRRKQKN
60 70 80 90 100
EAKQATLKAS TDKVDPVLGR ADTPFITRIM AELKEPLVLS KGYNIEEVDK
110 120 130 140 150
FLAAIESAKR ERAELSGLNT EVVGIEDIEK LEDRREAILR ILSMRNSENK
160 170 180 190 200
NAIKMAVELA RKEFERFPGD TGSSEVQAAC MTVRIQNMAN HIKEHRKDFA
210 220 230 240 250
NTRNLRILVQ QRQAILRYLK RDNPEKYYWT IQKLGLNDAA ITDEFNMDRR
260 270 280
YMQDYEFFGD KILIRDSKKV ANQKRKEIRK QKRATF
Length:286
Mass (Da):33,057
Last modified:May 1, 1991 - v1
Checksum:iA3134D0896DB4CF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55977 Genomic DNA Translation: CAA39447.1
M38016 Genomic DNA Translation: AAA74730.1
U51032 Genomic DNA Translation: AAB64773.1
AY557743 Genomic DNA Translation: AAS56069.1
BK006938 Genomic DNA Translation: DAA12179.1
PIRiS12797
RefSeqiNP_010624.3, NM_001180645.3

Genome annotation databases

EnsemblFungiiYDR337W; YDR337W; YDR337W
GeneIDi851937
KEGGisce:YDR337W

Similar proteinsi

Entry informationi

Entry nameiRT28_YEAST
AccessioniPrimary (citable) accession number: P21771
Secondary accession number(s): D6VSW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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