Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Outer dense fiber protein 1

Gene

Odf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 1
Alternative name(s):
Protein RT7
RTS 5/1
Gene namesi
Name:Odf1
Synonyms:Odf27, Odfp, Rt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3228. Odf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580271 – 245Outer dense fiber protein 1Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21769.

PTM databases

iPTMnetiP21769.
PhosphoSitePlusiP21769.

Expressioni

Tissue specificityi

Testis. Specifically located to the round spermatid layer and to the luminally-oriented cytoplasm of elongated spermatids.

Developmental stagei

First detected in 30-day old rats after which, levels increase during spermatid elongation. Levels decrease at the time of spermatid assembly and disappear just before spermiation.

Gene expression databases

BgeeiENSRNOG00000006578.
GenevisibleiP21769. RN.

Interactioni

Subunit structurei

Interacts with SPAG4 and KLC3.2 Publications

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008700.

Structurei

3D structure databases

ProteinModelPortaliP21769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 3815
Repeati74 – 7825

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 782 X 5 AA repeats of [RC]-C-L-C-DAdd BLAST45
Regioni195 – 233C-X-P repeat regionAdd BLAST39

Domaini

The C-terminal contains many C-X-P repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHKT. Eukaryota.
ENOG4111C5F. LUCA.
GeneTreeiENSGT00440000038909.
HOGENOMiHOG000290650.
HOVERGENiHBG007863.
InParanoidiP21769.
OMAiCYPCASP.
OrthoDBiEOG091G0QI9.
PhylomeDBiP21769.
TreeFamiTF337986.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.

Sequencei

Sequence statusi: Complete.

P21769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALSCLLDS VRRDIKKVDR ELRQLRCIDE ISSRCLCDLY MHPYCCCDLH
60 70 80 90 100
PYPYCLCYSK RSRSCGLCDL YYPCCLCDYK LYCLRPSLRS LERLRRTTNR
110 120 130 140 150
ILASSCCSSN ILGSVNVCGF EPDQVKVRVK DGKVCVSAER ENRYDCLGSK
160 170 180 190 200
KYSYMNICKE FSLPPCVDEK DVTYSYGLGS CVKIESPCYP CTSPCNPCNP
210 220 230 240
CSPCSPCGPC GPCGPCGPCG PCGPCDPCNP CYPCGSRFSC RKMIL
Length:245
Mass (Da):27,351
Last modified:November 1, 1997 - v2
Checksum:i3111C776213A7381
GO

Sequence cautioni

The sequence AAA42091 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88 – 90LRS → SAA in AAA42086 (PubMed:1699827).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88759 mRNA. Translation: AAA03066.1.
M88762 Genomic DNA. Translation: AAA42091.1. Different initiation.
M88762 Genomic DNA. Translation: AAA42092.1. Sequence problems.
BC078708 mRNA. Translation: AAH78708.1.
U09021 mRNA. Translation: AAA67872.1.
M58677 mRNA. Translation: AAA42086.1.
PIRiA43905.
RefSeqiNP_077040.2. NM_024126.5.
UniGeneiRn.9850.

Genome annotation databases

EnsembliENSRNOT00000008700; ENSRNOP00000008700; ENSRNOG00000006578.
GeneIDi24610.
KEGGirno:24610.
UCSCiRGD:3228. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88759 mRNA. Translation: AAA03066.1.
M88762 Genomic DNA. Translation: AAA42091.1. Different initiation.
M88762 Genomic DNA. Translation: AAA42092.1. Sequence problems.
BC078708 mRNA. Translation: AAH78708.1.
U09021 mRNA. Translation: AAA67872.1.
M58677 mRNA. Translation: AAA42086.1.
PIRiA43905.
RefSeqiNP_077040.2. NM_024126.5.
UniGeneiRn.9850.

3D structure databases

ProteinModelPortaliP21769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008700.

PTM databases

iPTMnetiP21769.
PhosphoSitePlusiP21769.

Proteomic databases

PaxDbiP21769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008700; ENSRNOP00000008700; ENSRNOG00000006578.
GeneIDi24610.
KEGGirno:24610.
UCSCiRGD:3228. rat.

Organism-specific databases

CTDi4956.
RGDi3228. Odf1.

Phylogenomic databases

eggNOGiENOG410IHKT. Eukaryota.
ENOG4111C5F. LUCA.
GeneTreeiENSGT00440000038909.
HOGENOMiHOG000290650.
HOVERGENiHBG007863.
InParanoidiP21769.
OMAiCYPCASP.
OrthoDBiEOG091G0QI9.
PhylomeDBiP21769.
TreeFamiTF337986.

Miscellaneous databases

PROiP21769.

Gene expression databases

BgeeiENSRNOG00000006578.
GenevisibleiP21769. RN.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiODFP1_RAT
AccessioniPrimary (citable) accession number: P21769
Secondary accession number(s): Q62652
, Q63390, Q63534, Q63535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.