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Protein

Epididymal secretory glutathione peroxidase

Gene

Gpx5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Protein family/group databases

PeroxiBasei5578. MmGPx05.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory glutathione peroxidase (EC:1.11.1.9)
Alternative name(s):
Epididymis-specific glutathione peroxidase-like protein
Short name:
EGLP
Glutathione peroxidase 5
Short name:
GPx-5
Short name:
GSHPx-5
Major androgen-regulated protein
arMEP24
Gene namesi
Name:Gpx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:104886. Gpx5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: WormBase
  • sperm plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 221200Epididymal secretory glutathione peroxidasePRO_0000013078Add
BLAST

Proteomic databases

PaxDbiP21765.
PRIDEiP21765.

PTM databases

PhosphoSiteiP21765.

Expressioni

Tissue specificityi

Epididymis.

Gene expression databases

BgeeiENSMUSG00000004344.
CleanExiMM_GPX5.
ExpressionAtlasiP21765. baseline and differential.
GenevisibleiP21765. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004456.

Structurei

3D structure databases

ProteinModelPortaliP21765.
SMRiP21765. Positions 31-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiP21765.
KOiK00432.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTELRVFYL VPLLLASYVQ TTPRPEKMKM DCYKDVKGTI YDYEALSLNG
60 70 80 90 100
KEHIPFKQYA GKHVLFVNVA TYCGLTIQYP ELNALQEDLK PFGLVILGFP
110 120 130 140 150
CNQFGKQEPG DNLEILPGLK YVRPGKGFLP NFQLFAKGDV NGENEQKIFT
160 170 180 190 200
FLKRSCPHPS ETVVMSKHTF WEPIKVHDIR WNFEKFLVGP DGIPVMRWFH
210 220
QAPVSTVKSD IMAYLSHFKT I
Length:221
Mass (Da):25,393
Last modified:October 3, 2012 - v3
Checksum:i99FF8A2FECABFC9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531H → D in AAA37729 (PubMed:8469239).Curated
Sequence conflicti60 – 601A → R in AAA37729 (PubMed:8469239).Curated
Sequence conflicti60 – 601A → R in CAA37796 (PubMed:2263479).Curated
Sequence conflicti170 – 1701F → S in AAA37729 (PubMed:8469239).Curated
Sequence conflicti170 – 1701F → S in CAA37796 (PubMed:2263479).Curated
Sequence conflicti193 – 1931I → V in AAA37729 (PubMed:8469239).Curated
Sequence conflicti193 – 1931I → V in CAA37796 (PubMed:2263479).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68896 Genomic DNA. Translation: AAA37729.1.
AC124460 Genomic DNA. No translation available.
X53780 mRNA. Translation: CAA37796.1.
CCDSiCCDS26270.1.
PIRiA47367.
RefSeqiNP_034473.2. NM_010343.2.
UniGeneiMm.1332.

Genome annotation databases

EnsembliENSMUST00000004456; ENSMUSP00000004456; ENSMUSG00000004344.
GeneIDi14780.
KEGGimmu:14780.
UCSCiuc007ppz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68896 Genomic DNA. Translation: AAA37729.1.
AC124460 Genomic DNA. No translation available.
X53780 mRNA. Translation: CAA37796.1.
CCDSiCCDS26270.1.
PIRiA47367.
RefSeqiNP_034473.2. NM_010343.2.
UniGeneiMm.1332.

3D structure databases

ProteinModelPortaliP21765.
SMRiP21765. Positions 31-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004456.

Protein family/group databases

PeroxiBasei5578. MmGPx05.

PTM databases

PhosphoSiteiP21765.

Proteomic databases

PaxDbiP21765.
PRIDEiP21765.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004456; ENSMUSP00000004456; ENSMUSG00000004344.
GeneIDi14780.
KEGGimmu:14780.
UCSCiuc007ppz.2. mouse.

Organism-specific databases

CTDi2880.
MGIiMGI:104886. Gpx5.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiP21765.
KOiK00432.

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiP21765.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004344.
CleanExiMM_GPX5.
ExpressionAtlasiP21765. baseline and differential.
GenevisibleiP21765. MM.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX5_MOUSE
AccessioniPrimary (citable) accession number: P21765
Secondary accession number(s): E9QK84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.