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P21762

- TSAA_HELPY

UniProt

P21762 - TSAA_HELPY

Protein

Probable peroxiredoxin

Gene

tsaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491By similarity

    GO - Molecular functioni

    1. peroxidase activity Source: UniProtKB-KW
    2. peroxiredoxin activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase, Peroxidase

    Enzyme and pathway databases

    BioCyciHPY:HP1563-MONOMER.
    BRENDAi1.11.1.15. 2605.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable peroxiredoxin (EC:1.11.1.15)
    Alternative name(s):
    26 kDa antigen
    Thioredoxin reductase
    Gene namesi
    Name:tsaA
    Ordered Locus Names:HP_1563
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Probable peroxiredoxinPRO_0000135144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 – 49Interchain (with C-169)By similarity
    Disulfide bondi169 – 169Interchain (with C-49)By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP21762.

    Interactioni

    Subunit structurei

    Decameric ring of 5 homodimers; disulfide-linked. The rings have an approximate diameter of 125 A and a central hole of 55 A By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-3646N.
    IntActiP21762. 3 interactions.
    MINTiMINT-165908.
    STRINGi85962.HP1563.

    Structurei

    3D structure databases

    ProteinModelPortaliP21762.
    SMRiP21762. Positions 1-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 161160ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AhpC/TSA family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0450.
    KOiK03386.
    OMAiPGAETIK.
    OrthoDBiEOG67X1XH.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000866. AhpC/TSA.
    IPR024706. Peroxiredoxin_AhpC-typ.
    IPR019479. Peroxiredoxin_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF10417. 1-cysPrx_C. 1 hit.
    PF00578. AhpC-TSA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000239. AHPC. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21762-1 [UniParc]FASTAAdd to Basket

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    MLVTKLAPDF KAPAVLGNNE VDEHFELSKN LGKNGAILFF WPKDFTFVCP    50
    TEIIAFDKRV KDFQEKGFNV IGVSIDSEQV HFAWKNTPVE KGGIGQVTFP 100
    MVADITKSIS RDYDVLFEEA IALRGAFLID KNMKVRHAVI NDLPLGRNAD 150
    EMLRMVDALL HFEEHGEVCP AGWRKGDKGM KATHQGVAEY LKENSIKL 198
    Length:198
    Mass (Da):22,236
    Last modified:November 1, 1997 - v3
    Checksum:i599E2FF491CEA0BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361A → V in AAA18984. (PubMed:1987145)Curated
    Sequence conflicti64 – 641Q → H in AAA18984. (PubMed:1987145)Curated
    Sequence conflicti98 – 981T → S in AAA18984. (PubMed:1987145)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55507 Unassigned DNA. Translation: AAA18984.1.
    AE000511 Genomic DNA. Translation: AAD08603.1.
    PIRiC64715.
    RefSeqiNP_208354.1. NC_000915.1.
    YP_006935490.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08603; AAD08603; HP_1563.
    GeneIDi13870783.
    899728.
    KEGGiheo:C694_08100.
    hpy:HP1563.
    PATRICi20594553. VBIHelPyl33062_1644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55507 Unassigned DNA. Translation: AAA18984.1 .
    AE000511 Genomic DNA. Translation: AAD08603.1 .
    PIRi C64715.
    RefSeqi NP_208354.1. NC_000915.1.
    YP_006935490.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P21762.
    SMRi P21762. Positions 1-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3646N.
    IntActi P21762. 3 interactions.
    MINTi MINT-165908.
    STRINGi 85962.HP1563.

    Proteomic databases

    PRIDEi P21762.

    Protocols and materials databases

    DNASUi 899728.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08603 ; AAD08603 ; HP_1563 .
    GeneIDi 13870783.
    899728.
    KEGGi heo:C694_08100.
    hpy:HP1563.
    PATRICi 20594553. VBIHelPyl33062_1644.

    Phylogenomic databases

    eggNOGi COG0450.
    KOi K03386.
    OMAi PGAETIK.
    OrthoDBi EOG67X1XH.

    Enzyme and pathway databases

    BioCyci HPY:HP1563-MONOMER.
    BRENDAi 1.11.1.15. 2605.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000866. AhpC/TSA.
    IPR024706. Peroxiredoxin_AhpC-typ.
    IPR019479. Peroxiredoxin_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF10417. 1-cysPrx_C. 1 hit.
    PF00578. AhpC-TSA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000239. AHPC. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori."
      O'Toole P.W., Logan S.M., Kostrzynska M., Wadstrom T., Trust T.J.
      J. Bacteriol. 173:505-513(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-46.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiTSAA_HELPY
    AccessioniPrimary (citable) accession number: P21762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3