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P21762

- TSAA_HELPY

UniProt

P21762 - TSAA_HELPY

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Protein

Probable peroxiredoxin

Gene

tsaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491By similarity

GO - Molecular functioni

  1. peroxidase activity Source: UniProtKB-KW
  2. peroxiredoxin activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciHPY:HP1563-MONOMER.
BRENDAi1.11.1.15. 2605.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peroxiredoxin (EC:1.11.1.15)
Alternative name(s):
26 kDa antigen
Thioredoxin reductase
Gene namesi
Name:tsaA
Ordered Locus Names:HP_1563
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Probable peroxiredoxinPRO_0000135144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 – 49Interchain (with C-169)By similarity
Disulfide bondi169 – 169Interchain (with C-49)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP21762.

Interactioni

Subunit structurei

Decameric ring of 5 homodimers; disulfide-linked. The rings have an approximate diameter of 125 A and a central hole of 55 A (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-3646N.
IntActiP21762. 3 interactions.
MINTiMINT-165908.
STRINGi85962.HP1563.

Structurei

3D structure databases

ProteinModelPortaliP21762.
SMRiP21762. Positions 1-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 161160ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0450.
KOiK03386.
OMAiPGAETIK.
OrthoDBiEOG67X1XH.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21762-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVTKLAPDF KAPAVLGNNE VDEHFELSKN LGKNGAILFF WPKDFTFVCP
60 70 80 90 100
TEIIAFDKRV KDFQEKGFNV IGVSIDSEQV HFAWKNTPVE KGGIGQVTFP
110 120 130 140 150
MVADITKSIS RDYDVLFEEA IALRGAFLID KNMKVRHAVI NDLPLGRNAD
160 170 180 190
EMLRMVDALL HFEEHGEVCP AGWRKGDKGM KATHQGVAEY LKENSIKL
Length:198
Mass (Da):22,236
Last modified:November 1, 1997 - v3
Checksum:i599E2FF491CEA0BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361A → V in AAA18984. (PubMed:1987145)Curated
Sequence conflicti64 – 641Q → H in AAA18984. (PubMed:1987145)Curated
Sequence conflicti98 – 981T → S in AAA18984. (PubMed:1987145)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55507 Unassigned DNA. Translation: AAA18984.1.
AE000511 Genomic DNA. Translation: AAD08603.1.
PIRiC64715.
RefSeqiNP_208354.1. NC_000915.1.
YP_006935490.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08603; AAD08603; HP_1563.
GeneIDi13870783.
899728.
KEGGiheo:C694_08100.
hpy:HP1563.
PATRICi20594553. VBIHelPyl33062_1644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55507 Unassigned DNA. Translation: AAA18984.1 .
AE000511 Genomic DNA. Translation: AAD08603.1 .
PIRi C64715.
RefSeqi NP_208354.1. NC_000915.1.
YP_006935490.1. NC_018939.1.

3D structure databases

ProteinModelPortali P21762.
SMRi P21762. Positions 1-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3646N.
IntActi P21762. 3 interactions.
MINTi MINT-165908.
STRINGi 85962.HP1563.

Proteomic databases

PRIDEi P21762.

Protocols and materials databases

DNASUi 899728.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08603 ; AAD08603 ; HP_1563 .
GeneIDi 13870783.
899728.
KEGGi heo:C694_08100.
hpy:HP1563.
PATRICi 20594553. VBIHelPyl33062_1644.

Phylogenomic databases

eggNOGi COG0450.
KOi K03386.
OMAi PGAETIK.
OrthoDBi EOG67X1XH.

Enzyme and pathway databases

BioCyci HPY:HP1563-MONOMER.
BRENDAi 1.11.1.15. 2605.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000239. AHPC. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori."
    O'Toole P.W., Logan S.M., Kostrzynska M., Wadstrom T., Trust T.J.
    J. Bacteriol. 173:505-513(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTSAA_HELPY
AccessioniPrimary (citable) accession number: P21762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3