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P21762 (TSAA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable peroxiredoxin

EC=1.11.1.15
Alternative name(s):
26 kDa antigen
Thioredoxin reductase
Gene names
Name:tsaA
Ordered Locus Names:HP_1563
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Subunit structure

Decameric ring of 5 homodimers; disulfide-linked. The rings have an approximate diameter of 125 A and a central hole of 55 A By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the AhpC/TSA family.

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   Molecular functionAntioxidant
Oxidoreductase
Peroxidase
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionperoxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

peroxiredoxin activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Probable peroxiredoxin
PRO_0000135144

Regions

Domain2 – 161160Thioredoxin

Sites

Active site491 By similarity

Amino acid modifications

Disulfide bond49Interchain (with C-169) By similarity
Disulfide bond169Interchain (with C-49) By similarity

Experimental info

Sequence conflict361A → V in AAA18984. Ref.1
Sequence conflict641Q → H in AAA18984. Ref.1
Sequence conflict981T → S in AAA18984. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21762 [UniParc].

Last modified November 1, 1997. Version 3.
Checksum: 599E2FF491CEA0BC

FASTA19822,236
        10         20         30         40         50         60 
MLVTKLAPDF KAPAVLGNNE VDEHFELSKN LGKNGAILFF WPKDFTFVCP TEIIAFDKRV 

        70         80         90        100        110        120 
KDFQEKGFNV IGVSIDSEQV HFAWKNTPVE KGGIGQVTFP MVADITKSIS RDYDVLFEEA 

       130        140        150        160        170        180 
IALRGAFLID KNMKVRHAVI NDLPLGRNAD EMLRMVDALL HFEEHGEVCP AGWRKGDKGM 

       190 
KATHQGVAEY LKENSIKL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori."
O'Toole P.W., Logan S.M., Kostrzynska M., Wadstrom T., Trust T.J.
J. Bacteriol. 173:505-513(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-46.
[2]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55507 Unassigned DNA. Translation: AAA18984.1.
AE000511 Genomic DNA. Translation: AAD08603.1.
PIRC64715.
RefSeqNP_208354.1. NC_000915.1.
YP_006935490.1. NC_018939.1.

3D structure databases

ProteinModelPortalP21762.
SMRP21762. Positions 1-175.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3646N.
IntActP21762. 3 interactions.
MINTMINT-165908.
STRING85962.HP1563.

Proteomic databases

PRIDEP21762.

Protocols and materials databases

DNASU899728.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08603; AAD08603; HP_1563.
GeneID13870783.
899728.
KEGGheo:C694_08100.
hpy:HP1563.
PATRIC20594553. VBIHelPyl33062_1644.

Phylogenomic databases

eggNOGCOG0450.
KOK03386.
OMANWTPGEK.
OrthoDBEOG67X1XH.
ProtClustDBCLSK496569.

Enzyme and pathway databases

BioCycHPY:HP1563-MONOMER.
BRENDA1.11.1.15. 2605.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFPIRSF000239. AHPC. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTSAA_HELPY
AccessionPrimary (citable) accession number: P21762
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names