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Protein

Probable peroxiredoxin

Gene

tsaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciHPY:HP1563-MONOMER.
BRENDAi1.11.1.15. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peroxiredoxin (EC:1.11.1.15)
Alternative name(s):
26 kDa antigen
Thioredoxin reductase
Gene namesi
Name:tsaA
Ordered Locus Names:HP_1563
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351441 – 198Probable peroxiredoxinAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49Interchain (with C-169)By similarity
Disulfide bondi169Interchain (with C-49)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP21762.

Interactioni

Subunit structurei

Decameric ring of 5 homodimers; disulfide-linked. The rings have an approximate diameter of 125 A and a central hole of 55 A (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-3646N.
IntActiP21762. 3 interactors.
MINTiMINT-165908.
STRINGi85962.HP1563.

Structurei

3D structure databases

ProteinModelPortaliP21762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 161ThioredoxinPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the AhpC/TSA family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105D3R. Bacteria.
COG0450. LUCA.
KOiK03386.
OMAiNWTPGEK.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTKLAPDF KAPAVLGNNE VDEHFELSKN LGKNGAILFF WPKDFTFVCP
60 70 80 90 100
TEIIAFDKRV KDFQEKGFNV IGVSIDSEQV HFAWKNTPVE KGGIGQVTFP
110 120 130 140 150
MVADITKSIS RDYDVLFEEA IALRGAFLID KNMKVRHAVI NDLPLGRNAD
160 170 180 190
EMLRMVDALL HFEEHGEVCP AGWRKGDKGM KATHQGVAEY LKENSIKL
Length:198
Mass (Da):22,236
Last modified:November 1, 1997 - v3
Checksum:i599E2FF491CEA0BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36A → V in AAA18984 (PubMed:1987145).Curated1
Sequence conflicti64Q → H in AAA18984 (PubMed:1987145).Curated1
Sequence conflicti98T → S in AAA18984 (PubMed:1987145).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55507 Unassigned DNA. Translation: AAA18984.1.
AE000511 Genomic DNA. Translation: AAD08603.1.
PIRiC64715.
RefSeqiNP_208354.1. NC_000915.1.
WP_000961643.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08603; AAD08603; HP_1563.
GeneIDi899728.
KEGGiheo:C694_08100.
hpy:HP1563.
PATRICi20594553. VBIHelPyl33062_1644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55507 Unassigned DNA. Translation: AAA18984.1.
AE000511 Genomic DNA. Translation: AAD08603.1.
PIRiC64715.
RefSeqiNP_208354.1. NC_000915.1.
WP_000961643.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP21762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3646N.
IntActiP21762. 3 interactors.
MINTiMINT-165908.
STRINGi85962.HP1563.

Proteomic databases

PaxDbiP21762.

Protocols and materials databases

DNASUi899728.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08603; AAD08603; HP_1563.
GeneIDi899728.
KEGGiheo:C694_08100.
hpy:HP1563.
PATRICi20594553. VBIHelPyl33062_1644.

Phylogenomic databases

eggNOGiENOG4105D3R. Bacteria.
COG0450. LUCA.
KOiK03386.
OMAiNWTPGEK.

Enzyme and pathway databases

BioCyciHPY:HP1563-MONOMER.
BRENDAi1.11.1.15. 2604.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSAA_HELPY
AccessioniPrimary (citable) accession number: P21762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.