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P21761

- TRFR_MOUSE

UniProt

P21761 - TRFR_MOUSE

Protein

Thyrotropin-releasing hormone receptor

Gene

Trhr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. thyrotropin-releasing hormone receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyrotropin-releasing hormone receptor
    Short name:
    TRH-R
    Alternative name(s):
    Thyroliberin receptor
    Gene namesi
    Name:Trhr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:98824. Trhr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Thyrotropin-releasing hormone receptorPRO_0000070188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP21761.

    PTM databases

    PhosphoSiteiP21761.

    Expressioni

    Gene expression databases

    ArrayExpressiP21761.
    BgeeiP21761.
    CleanExiMM_TRHR.
    GenevestigatoriP21761.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105918.

    Structurei

    3D structure databases

    ProteinModelPortaliP21761.
    SMRiP21761. Positions 26-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6110CytoplasmicSequence Analysis
    Topological domaini84 – 9916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19325ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 26651CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 2968ExtracellularSequence Analysis
    Topological domaini320 – 39374CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5123Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16824Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31923Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303917.
    HOGENOMiHOG000017249.
    HOVERGENiHBG007549.
    InParanoidiP21761.
    KOiK04282.
    OMAiTVVSCGY.
    OrthoDBiEOG789CCX.
    PhylomeDBiP21761.
    TreeFamiTF326170.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002120. TRH_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00751. THYROLIBRINR.
    PR01846. TRHRFAMILY.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENDTVSEMN QTELQPQAAV ALEYQVVTIL LVVIICGLGI VGNIMVVLVV    50
    MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC 100
    ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW 150
    AFTSIYCMLW FFLLDLNIST YKNAVVVSCG YKISRNYYSP IYLMDFGVFY 200
    VVPMILATVL YGFIARILFL NPIPSDPKEN SKMWKNDSIH QNKNLNLNAT 250
    NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 300
    FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKAANYSV 350
    ALNYSVIKES DRFSTELEDI TVTDTYVSTT KVSFDDTCLA SEN 393
    Length:393
    Mass (Da):44,559
    Last modified:May 1, 1991 - v1
    Checksum:i8739B75D1A0FCCFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59811 mRNA. Translation: AAA40480.1.
    M94384 mRNA. Translation: AAA40437.1.
    L48936 mRNA. Translation: AAA81559.1.
    CCDSiCCDS37068.1.
    PIRiA39251.
    RefSeqiNP_038724.1. NM_013696.2.
    UniGeneiMm.309350.

    Genome annotation databases

    EnsembliENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760.
    ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760.
    GeneIDi22045.
    KEGGimmu:22045.
    UCSCiuc007vpo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59811 mRNA. Translation: AAA40480.1 .
    M94384 mRNA. Translation: AAA40437.1 .
    L48936 mRNA. Translation: AAA81559.1 .
    CCDSi CCDS37068.1.
    PIRi A39251.
    RefSeqi NP_038724.1. NM_013696.2.
    UniGenei Mm.309350.

    3D structure databases

    ProteinModelPortali P21761.
    SMRi P21761. Positions 26-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105918.

    Chemistry

    BindingDBi P21761.
    ChEMBLi CHEMBL2467.
    GuidetoPHARMACOLOGYi 363.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21761.

    Proteomic databases

    PRIDEi P21761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038856 ; ENSMUSP00000036320 ; ENSMUSG00000038760 .
    ENSMUST00000110289 ; ENSMUSP00000105918 ; ENSMUSG00000038760 .
    GeneIDi 22045.
    KEGGi mmu:22045.
    UCSCi uc007vpo.1. mouse.

    Organism-specific databases

    CTDi 7201.
    MGIi MGI:98824. Trhr.

    Phylogenomic databases

    eggNOGi NOG303917.
    HOGENOMi HOG000017249.
    HOVERGENi HBG007549.
    InParanoidi P21761.
    KOi K04282.
    OMAi TVVSCGY.
    OrthoDBi EOG789CCX.
    PhylomeDBi P21761.
    TreeFami TF326170.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 301836.
    PROi P21761.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21761.
    Bgeei P21761.
    CleanExi MM_TRHR.
    Genevestigatori P21761.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002120. TRH_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00751. THYROLIBRINR.
    PR01846. TRHRFAMILY.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor."
      Straub R.E., Frech G.C., Joho R.H., Gershengorn M.C.
      Proc. Natl. Acad. Sci. U.S.A. 87:9514-9518(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells."
      Narayanan C.S., Fujimoto J., Geras-Raaka E., Gershengorn M.C.
      J. Biol. Chem. 267:17296-17303(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "An alternative splice variant of the mouse TRH receptor mRNA is the major form expressed in the mouse pituitary gland."
      Jones K.E., Brubaker J.H., Chin W.W.
      J. Mol. Endocrinol. 16:197-204(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-393.
      Tissue: Pituitary.

    Entry informationi

    Entry nameiTRFR_MOUSE
    AccessioniPrimary (citable) accession number: P21761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3