Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thyrotropin-releasing hormone receptor

Gene

Trhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. Activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:Trhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98824. Trhr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 51Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini52 – 61CytoplasmicSequence analysis10
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 99ExtracellularSequence analysisAdd BLAST16
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 144CytoplasmicSequence analysisAdd BLAST23
Transmembranei145 – 168Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini169 – 193ExtracellularSequence analysisAdd BLAST25
Transmembranei194 – 215Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini216 – 266CytoplasmicSequence analysisAdd BLAST51
Transmembranei267 – 288Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini289 – 296ExtracellularSequence analysis8
Transmembranei297 – 319Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini320 – 393CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2467.
GuidetoPHARMACOLOGYi363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701881 – 393Thyrotropin-releasing hormone receptorAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21761.
PRIDEiP21761.

PTM databases

iPTMnetiP21761.
PhosphoSitePlusiP21761.
SwissPalmiP21761.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038760.
CleanExiMM_TRHR.
ExpressionAtlasiP21761. baseline and differential.
GenevisibleiP21761. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036320.

Chemistry databases

BindingDBiP21761.

Structurei

3D structure databases

ProteinModelPortaliP21761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiP21761.
KOiK04282.
OMAiKLCNCKQ.
OrthoDBiEOG091G08BE.
PhylomeDBiP21761.
TreeFamiTF326170.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENDTVSEMN QTELQPQAAV ALEYQVVTIL LVVIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSIYCMLW FFLLDLNIST YKNAVVVSCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SKMWKNDSIH QNKNLNLNAT
260 270 280 290 300
NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKAANYSV
360 370 380 390
ALNYSVIKES DRFSTELEDI TVTDTYVSTT KVSFDDTCLA SEN
Length:393
Mass (Da):44,559
Last modified:May 1, 1991 - v1
Checksum:i8739B75D1A0FCCFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59811 mRNA. Translation: AAA40480.1.
M94384 mRNA. Translation: AAA40437.1.
L48936 mRNA. Translation: AAA81559.1.
CCDSiCCDS37068.1.
PIRiA39251.
RefSeqiNP_038724.1. NM_013696.2.
UniGeneiMm.309350.

Genome annotation databases

EnsembliENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760.
ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760.
GeneIDi22045.
KEGGimmu:22045.
UCSCiuc007vpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59811 mRNA. Translation: AAA40480.1.
M94384 mRNA. Translation: AAA40437.1.
L48936 mRNA. Translation: AAA81559.1.
CCDSiCCDS37068.1.
PIRiA39251.
RefSeqiNP_038724.1. NM_013696.2.
UniGeneiMm.309350.

3D structure databases

ProteinModelPortaliP21761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036320.

Chemistry databases

BindingDBiP21761.
ChEMBLiCHEMBL2467.
GuidetoPHARMACOLOGYi363.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21761.
PhosphoSitePlusiP21761.
SwissPalmiP21761.

Proteomic databases

PaxDbiP21761.
PRIDEiP21761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760.
ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760.
GeneIDi22045.
KEGGimmu:22045.
UCSCiuc007vpo.1. mouse.

Organism-specific databases

CTDi7201.
MGIiMGI:98824. Trhr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiP21761.
KOiK04282.
OMAiKLCNCKQ.
OrthoDBiEOG091G08BE.
PhylomeDBiP21761.
TreeFamiTF326170.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP21761.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038760.
CleanExiMM_TRHR.
ExpressionAtlasiP21761. baseline and differential.
GenevisibleiP21761. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRFR_MOUSE
AccessioniPrimary (citable) accession number: P21761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.