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P21761

- TRFR_MOUSE

UniProt

P21761 - TRFR_MOUSE

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Protein
Thyrotropin-releasing hormone receptor
Gene
Trhr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. thyrotropin-releasing hormone receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:Trhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:98824. Trhr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed prediction
Add
BLAST
Transmembranei29 – 5123Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini52 – 6110Cytoplasmic Reviewed prediction
Transmembranei62 – 8322Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini84 – 9916Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12122Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14423Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei145 – 16824Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini169 – 19325Extracellular Reviewed prediction
Add
BLAST
Transmembranei194 – 21522Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini216 – 26651Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei267 – 28822Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini289 – 2968Extracellular Reviewed prediction
Transmembranei297 – 31923Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini320 – 39374Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Thyrotropin-releasing hormone receptor
PRO_0000070188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 179 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21761.

PTM databases

PhosphoSiteiP21761.

Expressioni

Gene expression databases

ArrayExpressiP21761.
BgeeiP21761.
CleanExiMM_TRHR.
GenevestigatoriP21761.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105918.

Structurei

3D structure databases

ProteinModelPortaliP21761.
SMRiP21761. Positions 26-346.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303917.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiP21761.
KOiK04282.
OMAiTVVSCGY.
OrthoDBiEOG789CCX.
PhylomeDBiP21761.
TreeFamiTF326170.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21761-1 [UniParc]FASTAAdd to Basket

« Hide

MENDTVSEMN QTELQPQAAV ALEYQVVTIL LVVIICGLGI VGNIMVVLVV    50
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC 100
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW 150
AFTSIYCMLW FFLLDLNIST YKNAVVVSCG YKISRNYYSP IYLMDFGVFY 200
VVPMILATVL YGFIARILFL NPIPSDPKEN SKMWKNDSIH QNKNLNLNAT 250
NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 300
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKAANYSV 350
ALNYSVIKES DRFSTELEDI TVTDTYVSTT KVSFDDTCLA SEN 393
Length:393
Mass (Da):44,559
Last modified:May 1, 1991 - v1
Checksum:i8739B75D1A0FCCFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59811 mRNA. Translation: AAA40480.1.
M94384 mRNA. Translation: AAA40437.1.
L48936 mRNA. Translation: AAA81559.1.
CCDSiCCDS37068.1.
PIRiA39251.
RefSeqiNP_038724.1. NM_013696.2.
UniGeneiMm.309350.

Genome annotation databases

EnsembliENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760.
ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760.
GeneIDi22045.
KEGGimmu:22045.
UCSCiuc007vpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59811 mRNA. Translation: AAA40480.1 .
M94384 mRNA. Translation: AAA40437.1 .
L48936 mRNA. Translation: AAA81559.1 .
CCDSi CCDS37068.1.
PIRi A39251.
RefSeqi NP_038724.1. NM_013696.2.
UniGenei Mm.309350.

3D structure databases

ProteinModelPortali P21761.
SMRi P21761. Positions 26-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000105918.

Chemistry

BindingDBi P21761.
ChEMBLi CHEMBL2467.
GuidetoPHARMACOLOGYi 363.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21761.

Proteomic databases

PRIDEi P21761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038856 ; ENSMUSP00000036320 ; ENSMUSG00000038760 .
ENSMUST00000110289 ; ENSMUSP00000105918 ; ENSMUSG00000038760 .
GeneIDi 22045.
KEGGi mmu:22045.
UCSCi uc007vpo.1. mouse.

Organism-specific databases

CTDi 7201.
MGIi MGI:98824. Trhr.

Phylogenomic databases

eggNOGi NOG303917.
HOGENOMi HOG000017249.
HOVERGENi HBG007549.
InParanoidi P21761.
KOi K04282.
OMAi TVVSCGY.
OrthoDBi EOG789CCX.
PhylomeDBi P21761.
TreeFami TF326170.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 301836.
PROi P21761.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21761.
Bgeei P21761.
CleanExi MM_TRHR.
Genevestigatori P21761.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor."
    Straub R.E., Frech G.C., Joho R.H., Gershengorn M.C.
    Proc. Natl. Acad. Sci. U.S.A. 87:9514-9518(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells."
    Narayanan C.S., Fujimoto J., Geras-Raaka E., Gershengorn M.C.
    J. Biol. Chem. 267:17296-17303(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "An alternative splice variant of the mouse TRH receptor mRNA is the major form expressed in the mouse pituitary gland."
    Jones K.E., Brubaker J.H., Chin W.W.
    J. Mol. Endocrinol. 16:197-204(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-393.
    Tissue: Pituitary.

Entry informationi

Entry nameiTRFR_MOUSE
AccessioniPrimary (citable) accession number: P21761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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