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P21761 (TRFR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thyrotropin-releasing hormone receptor

Short name=TRH-R
Alternative name(s):
Thyroliberin receptor
Gene names
Name:Trhr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Thyrotropin-releasing hormone receptor
PRO_0000070188

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 5123Helical; Name=1; Potential
Topological domain52 – 6110Cytoplasmic Potential
Transmembrane62 – 8322Helical; Name=2; Potential
Topological domain84 – 9916Extracellular Potential
Transmembrane100 – 12122Helical; Name=3; Potential
Topological domain122 – 14423Cytoplasmic Potential
Transmembrane145 – 16824Helical; Name=4; Potential
Topological domain169 – 19325Extracellular Potential
Transmembrane194 – 21522Helical; Name=5; Potential
Topological domain216 – 26651Cytoplasmic Potential
Transmembrane267 – 28822Helical; Name=6; Potential
Topological domain289 – 2968Extracellular Potential
Transmembrane297 – 31923Helical; Name=7; Potential
Topological domain320 – 39374Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 179 By similarity

Sequences

Sequence LengthMass (Da)Tools
P21761 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 8739B75D1A0FCCFC

FASTA39344,559
        10         20         30         40         50         60 
MENDTVSEMN QTELQPQAAV ALEYQVVTIL LVVIICGLGI VGNIMVVLVV MRTKHMRTPT 

        70         80         90        100        110        120 
NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT 

       130        140        150        160        170        180 
IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSIYCMLW FFLLDLNIST YKNAVVVSCG 

       190        200        210        220        230        240 
YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKMWKNDSIH 

       250        260        270        280        290        300 
QNKNLNLNAT NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 

       310        320        330        340        350        360 
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKAANYSV ALNYSVIKES 

       370        380        390 
DRFSTELEDI TVTDTYVSTT KVSFDDTCLA SEN 

« Hide

References

[1]"Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor."
Straub R.E., Frech G.C., Joho R.H., Gershengorn M.C.
Proc. Natl. Acad. Sci. U.S.A. 87:9514-9518(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]"Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells."
Narayanan C.S., Fujimoto J., Geras-Raaka E., Gershengorn M.C.
J. Biol. Chem. 267:17296-17303(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"An alternative splice variant of the mouse TRH receptor mRNA is the major form expressed in the mouse pituitary gland."
Jones K.E., Brubaker J.H., Chin W.W.
J. Mol. Endocrinol. 16:197-204(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-393.
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M59811 mRNA. Translation: AAA40480.1.
M94384 mRNA. Translation: AAA40437.1.
L48936 mRNA. Translation: AAA81559.1.
CCDSCCDS37068.1.
PIRA39251.
RefSeqNP_038724.1. NM_013696.2.
UniGeneMm.309350.

3D structure databases

ProteinModelPortalP21761.
SMRP21761. Positions 26-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000105918.

Chemistry

BindingDBP21761.
ChEMBLCHEMBL2467.
GuidetoPHARMACOLOGY363.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP21761.

Proteomic databases

PRIDEP21761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760.
ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760.
GeneID22045.
KEGGmmu:22045.
UCSCuc007vpo.1. mouse.

Organism-specific databases

CTD7201.
MGIMGI:98824. Trhr.

Phylogenomic databases

eggNOGNOG303917.
HOGENOMHOG000017249.
HOVERGENHBG007549.
InParanoidP21761.
KOK04282.
OMATVVSCGY.
OrthoDBEOG789CCX.
PhylomeDBP21761.
TreeFamTF326170.

Gene expression databases

ArrayExpressP21761.
BgeeP21761.
CleanExMM_TRHR.
GenevestigatorP21761.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301836.
PROP21761.
SOURCESearch...

Entry information

Entry nameTRFR_MOUSE
AccessionPrimary (citable) accession number: P21761
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries