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Protein

Thyrotropin-releasing hormone receptor

Gene

Trhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. Activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:Trhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98824 Trhr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 51Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini52 – 61CytoplasmicSequence analysis10
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 99ExtracellularSequence analysisAdd BLAST16
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 144CytoplasmicSequence analysisAdd BLAST23
Transmembranei145 – 168Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini169 – 193ExtracellularSequence analysisAdd BLAST25
Transmembranei194 – 215Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini216 – 266CytoplasmicSequence analysisAdd BLAST51
Transmembranei267 – 288Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini289 – 296ExtracellularSequence analysis8
Transmembranei297 – 319Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini320 – 393CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2467
GuidetoPHARMACOLOGYi363

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701881 – 393Thyrotropin-releasing hormone receptorAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21761
PRIDEiP21761

PTM databases

iPTMnetiP21761
PhosphoSitePlusiP21761
SwissPalmiP21761

Expressioni

Gene expression databases

BgeeiENSMUSG00000038760
CleanExiMM_TRHR
ExpressionAtlasiP21761 baseline and differential
GenevisibleiP21761 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036320

Chemistry databases

BindingDBiP21761

Structurei

3D structure databases

ProteinModelPortaliP21761
SMRiP21761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000017249
HOVERGENiHBG007549
InParanoidiP21761
KOiK04282
OMAiEYQVVTI
OrthoDBiEOG091G08BE
PhylomeDBiP21761
TreeFamiTF326170

Family and domain databases

CDDicd14995 7tmA_TRH-R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002120 TRH_rcpt_1
PANTHERiPTHR24243:SF115 PTHR24243:SF115, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00751 THYROLIBRINR
PR01846 TRHRFAMILY
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P21761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENDTVSEMN QTELQPQAAV ALEYQVVTIL LVVIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSIYCMLW FFLLDLNIST YKNAVVVSCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SKMWKNDSIH QNKNLNLNAT
260 270 280 290 300
NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKAANYSV
360 370 380 390
ALNYSVIKES DRFSTELEDI TVTDTYVSTT KVSFDDTCLA SEN
Length:393
Mass (Da):44,559
Last modified:May 1, 1991 - v1
Checksum:i8739B75D1A0FCCFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59811 mRNA Translation: AAA40480.1
M94384 mRNA Translation: AAA40437.1
L48936 mRNA Translation: AAA81559.1
CCDSiCCDS37068.1
PIRiA39251
RefSeqiNP_038724.1, NM_013696.2
UniGeneiMm.309350

Genome annotation databases

EnsembliENSMUST00000038856; ENSMUSP00000036320; ENSMUSG00000038760
ENSMUST00000110289; ENSMUSP00000105918; ENSMUSG00000038760
ENSMUST00000226626; ENSMUSP00000154650; ENSMUSG00000038760
GeneIDi22045
KEGGimmu:22045
UCSCiuc007vpo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRFR_MOUSE
AccessioniPrimary (citable) accession number: P21761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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