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Protein

Macrophage scavenger receptor types I and II

Gene

MSR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

ReactomeiR-BTA-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage scavenger receptor types I and II
Alternative name(s):
Macrophage acetylated LDL receptor I and II
CD_antigen: CD204
Gene namesi
Name:MSR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050CytoplasmicSequence analysisAdd
BLAST
Transmembranei51 – 7626Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini77 – 453377ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

LDL, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Macrophage scavenger receptor types I and IIPRO_0000181626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineBy similarity
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi377 ↔ 441PROSITE-ProRule annotation
Disulfide bondi390 ↔ 451PROSITE-ProRule annotation
Disulfide bondi421 ↔ 431PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21758.

Expressioni

Gene expression databases

ExpressionAtlasiP21758. baseline and differential.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003751.

Structurei

3D structure databases

DisProtiDP00246.
ProteinModelPortaliP21758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini272 – 34372Collagen-likeAdd
BLAST
Domaini352 – 452101SRCRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 10832SpacerCuratedAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili194 – 25562Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 collagen-like domain.Curated
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK8A. Eukaryota.
ENOG410YQBT. LUCA.
GeneTreeiENSGT00840000129711.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiP21758.
KOiK06558.
OMAiDQRFNDV.
OrthoDBiEOG7V1FQV.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003543. Macro_scav_rcpt.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF03523. Macscav_rec. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR01408. MACSCAVRCPTR.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P21758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQWDDFPDQ QEDTDSCTES VKFDARSVTA LLPPHPKNGP TLQERMKSYK
60 70 80 90 100
TALITLYLIV FVVLVPIIGI VAAQLLKWET KNCTVGSVNA DISPSPEGKG
110 120 130 140 150
NGSEDEMRFR EAVMERMSNM ESRIQYLSDN EANLLDAKNF QNFSITTDQR
160 170 180 190 200
FNDVLFQLNS LLSSIQEHEN IIGDISKSLV GLNTTVLDLQ FSIETLNGRV
210 220 230 240 250
QENAFKQQEE MRKLEERIYN ASAEIKSLDE KQVYLEQEIK GEMKLLNNIT
260 270 280 290 300
NDLRLKDWEH SQTLKNITLL QGPPGPPGEK GDRGPPGQNG IPGFPGLIGT
310 320 330 340 350
PGLKGDRGIS GLPGVRGFPG PMGKTGKPGL NGQKGQKGEK GSGSMQRQSN
360 370 380 390 400
TVRLVGGSGP HEGRVEIFHE GQWGTVCDDR WELRGGLVVC RSLGYKGVQS
410 420 430 440 450
VHKRAYFGKG TGPIWLNEVF CFGKESSIEE CRIRQWGVRA CSHDEDAGVT

CTT
Length:453
Mass (Da):50,057
Last modified:May 1, 1991 - v1
Checksum:i77A0EFEE48B00A21
GO
Isoform II (identifier: P21758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-349: QS → PG
     350-453: Missing.

Show »
Length:349
Mass (Da):38,457
Checksum:iAEA193A6FDE7A01A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei348 – 3492QS → PG in isoform II. 1 PublicationVSP_006227
Alternative sequencei350 – 453104Missing in isoform II. 1 PublicationVSP_006228Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51689 mRNA. Translation: CAA35987.1.
X54183 mRNA. Translation: CAA38108.1.
BC142250 mRNA. Translation: AAI42251.1.
PIRiS08276.
S08278.
RefSeqiNP_001106711.1. NM_001113240.1. [P21758-1]
NP_776538.1. NM_174113.2. [P21758-2]
UniGeneiBt.4482.

Genome annotation databases

EnsembliENSBTAT00000003751; ENSBTAP00000003751; ENSBTAG00000002885. [P21758-1]
ENSBTAT00000003755; ENSBTAP00000003755; ENSBTAG00000002885. [P21758-2]
GeneIDi281311.
KEGGibta:281311.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51689 mRNA. Translation: CAA35987.1.
X54183 mRNA. Translation: CAA38108.1.
BC142250 mRNA. Translation: AAI42251.1.
PIRiS08276.
S08278.
RefSeqiNP_001106711.1. NM_001113240.1. [P21758-1]
NP_776538.1. NM_174113.2. [P21758-2]
UniGeneiBt.4482.

3D structure databases

DisProtiDP00246.
ProteinModelPortaliP21758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003751.

Proteomic databases

PaxDbiP21758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003751; ENSBTAP00000003751; ENSBTAG00000002885. [P21758-1]
ENSBTAT00000003755; ENSBTAP00000003755; ENSBTAG00000002885. [P21758-2]
GeneIDi281311.
KEGGibta:281311.

Organism-specific databases

CTDi4481.

Phylogenomic databases

eggNOGiENOG410IK8A. Eukaryota.
ENOG410YQBT. LUCA.
GeneTreeiENSGT00840000129711.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiP21758.
KOiK06558.
OMAiDQRFNDV.
OrthoDBiEOG7V1FQV.
TreeFamiTF330855.

Enzyme and pathway databases

ReactomeiR-BTA-3000480. Scavenging by Class A Receptors.

Gene expression databases

ExpressionAtlasiP21758. baseline and differential.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003543. Macro_scav_rcpt.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF03523. Macscav_rec. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR01408. MACSCAVRCPTR.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils."
    Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., Krieger M.
    Nature 343:531-535(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I), PARTIAL PROTEIN SEQUENCE.
    Tissue: Lung.
  2. "Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II."
    Rohrer L., Freeman M., Kodama T., Penman M., Krieger M.
    Nature 343:570-572(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II).
    Tissue: Lung.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiMSRE_BOVIN
AccessioniPrimary (citable) accession number: P21758
Secondary accession number(s): A5PJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.