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P21754

- ZP3_HUMAN

UniProt

P21754 - ZP3_HUMAN

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Protein

Zona pellucida sperm-binding protein 3

Gene

ZP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

GO - Molecular functioni

  1. acrosin binding Source: UniProtKB
  2. carbohydrate binding Source: UniProtKB
  3. manganese ion transmembrane transporter activity Source: UniProtKB
  4. signal transducer activity Source: UniProtKB
  5. store-operated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. binding of sperm to zona pellucida Source: UniProtKB
  2. blastocyst formation Source: UniProtKB
  3. calcium ion transmembrane transport Source: GOC
  4. egg coat formation Source: UniProtKB
  5. humoral immune response mediated by circulating immunoglobulin Source: UniProtKB
  6. intracellular protein transport Source: UniProtKB
  7. intracellular signal transduction Source: UniProtKB
  8. manganese ion transmembrane transport Source: GOC
  9. manganese ion transport Source: UniProtKB
  10. multicellular organism reproduction Source: Reactome
  11. negative regulation of binding of sperm to zona pellucida Source: UniProtKB
  12. negative regulation of transcription, DNA-templated Source: UniProtKB
  13. oocyte development Source: UniProtKB
  14. phosphatidylinositol-mediated signaling Source: UniProtKB
  15. positive regulation of acrosomal vesicle exocytosis Source: UniProtKB
  16. positive regulation of acrosome reaction Source: UniProtKB
  17. positive regulation of antral ovarian follicle growth Source: UniProtKB
  18. positive regulation of calcium ion import Source: UniProtKB
  19. positive regulation of humoral immune response Source: UniProtKB
  20. positive regulation of inflammatory response Source: UniProtKB
  21. positive regulation of interferon-gamma production Source: UniProtKB
  22. positive regulation of interleukin-4 production Source: UniProtKB
  23. positive regulation of leukocyte migration Source: UniProtKB
  24. positive regulation of ovarian follicle development Source: UniProtKB
  25. positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
  26. positive regulation of protein kinase activity Source: UniProtKB
  27. positive regulation of protein kinase B signaling Source: UniProtKB
  28. positive regulation of T cell proliferation Source: UniProtKB
  29. positive regulation of transcription, DNA-templated Source: UniProtKB
  30. positive regulation of type IV hypersensitivity Source: UniProtKB
  31. protein kinase C signaling Source: UniProtKB
  32. single fertilization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiREACT_163933. Interaction With The Zona Pellucida.

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 3
Alternative name(s):
Sperm receptor
ZP3A/ZP3B
Zona pellucida glycoprotein 3
Short name:
Zp-3
Zona pellucida protein C
Cleaved into the following chain:
Gene namesi
Name:ZP3
Synonyms:ZP3A, ZP3B, ZPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13189. ZP3.

Subcellular locationi

Chain Processed zona pellucida sperm-binding protein 3 : Secretedextracellular spaceextracellular matrix
Note: The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 387365ExtracellularSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Topological domaini409 – 42416CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. extracellular matrix Source: UniProtKB
  4. extracellular region Source: Reactome
  5. extracellular space Source: UniProtKB
  6. Golgi apparatus Source: UniProtKB
  7. integral component of membrane Source: UniProtKB-KW
  8. multivesicular body Source: UniProtKB
  9. outer acrosomal membrane Source: UniProtKB
  10. perinuclear region of cytoplasm Source: UniProtKB
  11. plasma membrane Source: UniProtKB
  12. proteinaceous extracellular matrix Source: UniProtKB-KW
  13. secretory granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 350328Zona pellucida sperm-binding protein 3PRO_0000041709Add
BLAST
Chaini23 – ?Processed zona pellucida sperm-binding protein 3PRO_0000304569
Propeptidei351 – 42474Removed in mature formBy similarityPRO_0000041710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Pyrrolidone carboxylic acid1 Publication
Disulfide bondi46 ↔ 1401 Publication
Disulfide bondi78 ↔ 991 Publication
Glycosylationi125 – 1251N-linked (GlcNAc...)1 Publication
Glycosylationi147 – 1471N-linked (GlcNAc...)1 Publication
Glycosylationi156 – 1561O-linked (GalNAc...)By similarity
Glycosylationi162 – 1621O-linked (GalNAc...)By similarity
Glycosylationi163 – 1631O-linked (GalNAc...)By similarity
Disulfide bondi217 ↔ 2821 Publication
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi239 ↔ 3001 Publication
Glycosylationi272 – 2721N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.1 Publication
N-glycosylated.By similarity
O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP21754.
PRIDEiP21754.

PTM databases

PhosphoSiteiP21754.

Expressioni

Tissue specificityi

Oocytes.

Gene expression databases

BgeeiP21754.
CleanExiHS_ZP3.
ExpressionAtlasiP21754. baseline.
GenevestigatoriP21754.

Organism-specific databases

HPAiHPA054061.

Interactioni

Subunit structurei

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.By similarity

Protein-protein interaction databases

BioGridi113565. 9 interactions.
STRINGi9606.ENSP00000378326.

Structurei

3D structure databases

ProteinModelPortaliP21754.
SMRiP21754. Positions 41-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 307263ZPPROSITE-ProRule annotationAdd
BLAST

Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Sequence similaritiesi

Belongs to the ZP domain family. ZPC subfamily.Curated
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43042.
GeneTreeiENSGT00530000063482.
HOGENOMiHOG000220813.
HOVERGENiHBG007985.
InParanoidiP21754.
OMAiLMEEDWG.
OrthoDBiEOG773XG3.
PhylomeDBiP21754.
TreeFamiTF331369.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform ZP3A (identifier: P21754-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT
60 70 80 90 100
LMVMVSKDLF GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG
110 120 130 140 150
NSMQVTDDAL VYSTFLLHDP RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS
160 170 180 190 200
QAILPTWLPF RTTVFSEEKL TFSLRLMEEN WNAEKRSPTF HLGDAAHLQA
210 220 230 240 250
EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL VDGLTDASSA
260 270 280 290 300
FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC
310 320 330 340 350
SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN
360 370 380 390 400
RRHVTEEADV TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL
410 420
TLTAVILVLT RRCRTASHPV SASE
Length:424
Mass (Da):47,018
Last modified:July 7, 2009 - v2
Checksum:i0F3CCDA2427C0E3A
GO
Isoform ZP3B (identifier: P21754-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-372: PLIFLDRRG → ATDLPGQEW
     373-424: Missing.

Note: Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids.

Show »
Length:372
Mass (Da):41,469
Checksum:iAB7BD85572DB7B4A
GO
Isoform 3 (identifier: P21754-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Show »
Length:373
Mass (Da):41,272
Checksum:i2CF838B25DC801C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451R → T in CAA40095. (PubMed:1478648)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311G → R.
Corresponds to variant rs2286428 [ dbSNP | Ensembl ].
VAR_058011
Natural varianti315 – 3151S → P.4 Publications
Corresponds to variant rs2906999 [ dbSNP | Ensembl ].
VAR_058012
Natural varianti340 – 3401M → V.
Corresponds to variant rs2906997 [ dbSNP | Ensembl ].
VAR_058013

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 3. 2 PublicationsVSP_037556Add
BLAST
Alternative sequencei364 – 3729PLIFLDRRG → ATDLPGQEW in isoform ZP3B. 1 PublicationVSP_006949
Alternative sequencei373 – 42452Missing in isoform ZP3B. 1 PublicationVSP_006950Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60504 mRNA. Translation: AAA61336.1.
X56777 mRNA. Translation: CAA40095.1.
AK292763 mRNA. Translation: BAF85452.1.
AC005522 Genomic DNA. No translation available.
BC113949 mRNA. Translation: AAI13950.2.
CCDSiCCDS47618.1. [P21754-1]
CCDS5586.1. [P21754-3]
PIRiA36000.
RefSeqiNP_001103824.1. NM_001110354.1. [P21754-1]
NP_009086.4. NM_007155.5. [P21754-3]
UniGeneiHs.656137.

Genome annotation databases

EnsembliENST00000336517; ENSP00000337310; ENSG00000188372. [P21754-3]
ENST00000394857; ENSP00000378326; ENSG00000188372. [P21754-1]
GeneIDi7784.
KEGGihsa:7784.
UCSCiuc003ufc.4. human. [P21754-1]

Polymorphism databases

DMDMi251757420.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular chastity - Issue 93 of April 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60504 mRNA. Translation: AAA61336.1 .
X56777 mRNA. Translation: CAA40095.1 .
AK292763 mRNA. Translation: BAF85452.1 .
AC005522 Genomic DNA. No translation available.
BC113949 mRNA. Translation: AAI13950.2 .
CCDSi CCDS47618.1. [P21754-1 ]
CCDS5586.1. [P21754-3 ]
PIRi A36000.
RefSeqi NP_001103824.1. NM_001110354.1. [P21754-1 ]
NP_009086.4. NM_007155.5. [P21754-3 ]
UniGenei Hs.656137.

3D structure databases

ProteinModelPortali P21754.
SMRi P21754. Positions 41-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113565. 9 interactions.
STRINGi 9606.ENSP00000378326.

PTM databases

PhosphoSitei P21754.

Polymorphism databases

DMDMi 251757420.

Proteomic databases

PaxDbi P21754.
PRIDEi P21754.

Protocols and materials databases

DNASUi 7784.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336517 ; ENSP00000337310 ; ENSG00000188372 . [P21754-3 ]
ENST00000394857 ; ENSP00000378326 ; ENSG00000188372 . [P21754-1 ]
GeneIDi 7784.
KEGGi hsa:7784.
UCSCi uc003ufc.4. human. [P21754-1 ]

Organism-specific databases

CTDi 7784.
GeneCardsi GC07P076026.
HGNCi HGNC:13189. ZP3.
HPAi HPA054061.
MIMi 182889. gene.
neXtProti NX_P21754.
PharmGKBi PA37757.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43042.
GeneTreei ENSGT00530000063482.
HOGENOMi HOG000220813.
HOVERGENi HBG007985.
InParanoidi P21754.
OMAi LMEEDWG.
OrthoDBi EOG773XG3.
PhylomeDBi P21754.
TreeFami TF331369.

Enzyme and pathway databases

Reactomei REACT_163933. Interaction With The Zona Pellucida.

Miscellaneous databases

GeneWikii ZP3.
GenomeRNAii 7784.
NextBioi 30137.
PROi P21754.
SOURCEi Search...

Gene expression databases

Bgeei P21754.
CleanExi HS_ZP3.
ExpressionAtlasi P21754. baseline.
Genevestigatori P21754.

Family and domain databases

InterProi IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZP3A), VARIANT PRO-315.
  2. "Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations."
    van Duin M., Polman J.E., Verkoelen C.C., Bunschoten H., Meyerink J.H., Olijve W., Aitken R.J.
    Genomics 14:1064-1070(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ZP3A AND ZP3B), VARIANT PRO-315.
    Tissue: Ovary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-315.
    Tissue: Lung.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-315.
    Tissue: Brain.
  6. "Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells."
    Zhao M., Boja E.S., Hoodbhoy T., Nawrocki J., Kaufman J.B., Kresge N., Ghirlando R., Shiloach J., Pannell L., Levine R.L., Fales H.M., Dean J.
    Biochemistry 43:12090-12104(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIGNAL SEQUENCE CLEAVAGE SITE, PYROGLUTAMATE FORMATION AT GLU-23, PROTEOLYTIC PROCESSING, DISULFIDE BONDS, GLYCOSYLATION AT ASN-125; ASN-147 AND ASN-272.

Entry informationi

Entry nameiZP3_HUMAN
AccessioniPrimary (citable) accession number: P21754
Secondary accession number(s): Q06633, Q29RW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3