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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Alternative name(s):
Thymosin beta-9
Cleaved into the following chain:
Gene namesi
Name:TMSB10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 4241Thymosin beta-10PRO_0000034302Add
BLAST
Peptidei2 – 4039Thymosin beta-8PRO_0000034303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei15 – 151N6-acetyllysineBy similarity
Modified residuei21 – 211PhosphothreonineBy similarity
Modified residuei23 – 231PhosphothreonineBy similarity
Modified residuei34 – 341PhosphothreonineBy similarity
Modified residuei39 – 391N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21752.

Expressioni

Tissue specificityi

Distributed in numerous types of tissues, including thymus, spleen, lung, liver and muscle.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007429.

Structurei

Secondary structure

1
42
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2823Combined sources
Beta strandi29 – 313Combined sources
Helixi33 – 419Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HJ0NMR-A2-42[»]
ProteinModelPortaliP21752.
SMRiP21752. Positions 2-42.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21752.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiP21752.
KOiK13785.
OrthoDBiEOG7TJ3MT.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDLGEI NSFDKAKLKK TETQEKNTLP TKETIEQEKQ AK
Length:42
Mass (Da):4,805
Last modified:January 23, 2007 - v2
Checksum:i26D4D58BB76A8909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294616 mRNA. Translation: AAG03074.1.
PIRiB19438.
RefSeqiNP_777048.1. NM_174623.2.
UniGeneiBt.2798.

Genome annotation databases

EnsembliENSBTAT00000007429; ENSBTAP00000007429; ENSBTAG00000005654.
GeneIDi282385.
KEGGibta:282385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294616 mRNA. Translation: AAG03074.1.
PIRiB19438.
RefSeqiNP_777048.1. NM_174623.2.
UniGeneiBt.2798.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HJ0NMR-A2-42[»]
ProteinModelPortaliP21752.
SMRiP21752. Positions 2-42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007429.

Proteomic databases

PaxDbiP21752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007429; ENSBTAP00000007429; ENSBTAG00000005654.
GeneIDi282385.
KEGGibta:282385.

Organism-specific databases

CTDi9168.

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiP21752.
KOiK13785.
OrthoDBiEOG7TJ3MT.

Miscellaneous databases

EvolutionaryTraceiP21752.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bovine thymosin beta-10 full length cDNA sequence."
    Gutierrez-Pabello J.A., Adams L.G.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4."
    Hannappel E., Davoust S., Horecker B.L.
    Proc. Natl. Acad. Sci. U.S.A. 79:1708-1711(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-42, ACETYLATION AT ALA-2.
    Tissue: Thymus.
  3. "Solid phase synthesis of thymosin beta 9."
    Chandramouli N., Bhargava K.K., Incefy G.S., Modak M.J., Merrifield R.B.
    Int. J. Pept. Protein Res. 28:536-541(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS.
  4. "A nuclear magnetic resonance and simulated annealing study of thymosin beta-9 in solution."
    Gallert B., Zarbock J., Voelter W., Holak T.A.
    (In) Schneider C.H., Eberles A.N. (eds.); Peptides 1992, pp.517-518, Escom Science Publishers, Leiden (1993)
    Cited for: STRUCTURE BY NMR.
  5. "Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy."
    Stoll R., Voelter W., Holak T.A.
    Biopolymers 41:623-634(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
    Tissue: Thymus.

Entry informationi

Entry nameiTYB10_BOVIN
AccessioniPrimary (citable) accession number: P21752
Secondary accession number(s): Q9GMC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.