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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Alternative name(s):
Thymosin beta-9
Cleaved into the following chain:
Gene namesi
Name:TMSB10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000343022 – 42Thymosin beta-10Add BLAST41
PeptideiPRO_00000343032 – 40Thymosin beta-8Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei23PhosphothreonineBy similarity1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21752.
PRIDEiP21752.

Expressioni

Tissue specificityi

Distributed in numerous types of tissues, including thymus, spleen, lung, liver and muscle.

Gene expression databases

BgeeiENSBTAG00000005654.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007429.

Structurei

Secondary structure

142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 28Combined sources23
Beta strandi29 – 31Combined sources3
Helixi33 – 41Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HJ0NMR-A2-42[»]
ProteinModelPortaliP21752.
SMRiP21752.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21752.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiP21752.
KOiK13785.
OrthoDBiEOG091G1AVI.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDLGEI NSFDKAKLKK TETQEKNTLP TKETIEQEKQ AK
Length:42
Mass (Da):4,805
Last modified:January 23, 2007 - v2
Checksum:i26D4D58BB76A8909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294616 mRNA. Translation: AAG03074.1.
PIRiB19438.
RefSeqiNP_777048.1. NM_174623.2.
UniGeneiBt.2798.

Genome annotation databases

EnsembliENSBTAT00000007429; ENSBTAP00000007429; ENSBTAG00000005654.
GeneIDi282385.
KEGGibta:282385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294616 mRNA. Translation: AAG03074.1.
PIRiB19438.
RefSeqiNP_777048.1. NM_174623.2.
UniGeneiBt.2798.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HJ0NMR-A2-42[»]
ProteinModelPortaliP21752.
SMRiP21752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007429.

Proteomic databases

PaxDbiP21752.
PRIDEiP21752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007429; ENSBTAP00000007429; ENSBTAG00000005654.
GeneIDi282385.
KEGGibta:282385.

Organism-specific databases

CTDi9168.

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiP21752.
KOiK13785.
OrthoDBiEOG091G1AVI.

Miscellaneous databases

EvolutionaryTraceiP21752.

Gene expression databases

BgeeiENSBTAG00000005654.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYB10_BOVIN
AccessioniPrimary (citable) accession number: P21752
Secondary accession number(s): Q9GMC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.