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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Alternative name(s):
Thymosin beta-9
Cleaved into the following chain:
Gene namesi
Name:TMSB10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000343022 – 42Thymosin beta-10Add BLAST41
PeptideiPRO_00000343032 – 40Thymosin beta-8Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei23PhosphothreonineBy similarity1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21752
PRIDEiP21752

PTM databases

iPTMnetiP21752

Expressioni

Tissue specificityi

Distributed in numerous types of tissues, including thymus, spleen, lung, liver and muscle.

Gene expression databases

BgeeiENSBTAG00000005654

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP21752, 1 interactor
STRINGi9913.ENSBTAP00000007429

Structurei

Secondary structure

142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 28Combined sources23
Beta strandi29 – 31Combined sources3
Helixi33 – 41Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HJ0NMR-A2-42[»]
ProteinModelPortaliP21752
SMRiP21752
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21752

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
HOGENOMiHOG000231370
HOVERGENiHBG012534
InParanoidiP21752
KOiK13785
OrthoDBiEOG091G1AVI

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDLGEI NSFDKAKLKK TETQEKNTLP TKETIEQEKQ AK
Length:42
Mass (Da):4,805
Last modified:January 23, 2007 - v2
Checksum:i26D4D58BB76A8909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294616 mRNA Translation: AAG03074.1
PIRiB19438
RefSeqiNP_777048.1, NM_174623.2
UniGeneiBt.2798

Genome annotation databases

EnsembliENSBTAT00000007429; ENSBTAP00000007429; ENSBTAG00000005654
GeneIDi282385
KEGGibta:282385

Similar proteinsi

Entry informationi

Entry nameiTYB10_BOVIN
AccessioniPrimary (citable) accession number: P21752
Secondary accession number(s): Q9GMC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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