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P21744

- IBP4_RAT

UniProt

P21744 - IBP4_RAT

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Protein

Insulin-like growth factor-binding protein 4

Gene

Igfbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. insulin-like growth factor binding Source: RGD

GO - Biological processi

  1. inflammatory response Source: RGD
  2. intracellular signal transduction Source: RGD
  3. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  4. positive regulation of MAPK cascade Source: Ensembl
  5. regulation of cell growth Source: Ensembl
  6. regulation of glucose metabolic process Source: Ensembl
  7. type B pancreatic cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_250882. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
Gene namesi
Name:Igfbp4
Synonyms:Igfbp-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi2875. Igfbp4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 254233Insulin-like growth factor-binding protein 4PRO_0000014384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 53PROSITE-ProRule annotation
Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
Disulfide bondi38 ↔ 591 PublicationPROSITE-ProRule annotation
Disulfide bondi44 ↔ 561 PublicationPROSITE-ProRule annotation
Disulfide bondi67 ↔ 801 PublicationPROSITE-ProRule annotation
Disulfide bondi74 ↔ 1001 PublicationPROSITE-ProRule annotation
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi131 ↔ 1381 PublicationPROSITE-ProRule annotation
Disulfide bondi170 ↔ 2001 PublicationPROSITE-ProRule annotation
Disulfide bondi211 ↔ 2221 PublicationPROSITE-ProRule annotation
Disulfide bondi224 ↔ 2451 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21744.
PRIDEiP21744.

Expressioni

Gene expression databases

GenevestigatoriP21744.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Protein-protein interaction databases

BioGridi262076. 2 interactions.
STRINGi10116.ENSRNOP00000014153.

Structurei

3D structure databases

ProteinModelPortaliP21744.
SMRiP21744. Positions 23-113, 168-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 10381IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini167 – 24579Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46496.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP21744.
OMAiKGMPCGV.
OrthoDBiEOG74N5HG.
PhylomeDBiP21744.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR022327. IGFBP-4.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01980. IGFBPFAMILY4.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21744-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC
110 120 130 140 150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS
160 170 180 190 200
KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC
210 220 230 240 250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD

SLQE
Length:254
Mass (Da):27,745
Last modified:August 1, 1991 - v2
Checksum:i97D37AC98BD0E787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08276 Genomic DNA. No translation available.
AY686592 mRNA. Translation: AAT96376.1.
BC098750 mRNA. Translation: AAH98750.1.
PIRiJC1464.
RefSeqiNP_001004274.1. NM_001004274.2.
UniGeneiRn.160666.

Genome annotation databases

EnsembliENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635.
GeneIDi360622.
KEGGirno:360622.
UCSCiRGD:2875. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08276 Genomic DNA. No translation available.
AY686592 mRNA. Translation: AAT96376.1 .
BC098750 mRNA. Translation: AAH98750.1 .
PIRi JC1464.
RefSeqi NP_001004274.1. NM_001004274.2.
UniGenei Rn.160666.

3D structure databases

ProteinModelPortali P21744.
SMRi P21744. Positions 23-113, 168-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 262076. 2 interactions.
STRINGi 10116.ENSRNOP00000014153.

Protein family/group databases

MEROPSi I31.952.

Proteomic databases

PaxDbi P21744.
PRIDEi P21744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014153 ; ENSRNOP00000014153 ; ENSRNOG00000010635 .
GeneIDi 360622.
KEGGi rno:360622.
UCSCi RGD:2875. rat.

Organism-specific databases

CTDi 3487.
RGDi 2875. Igfbp4.

Phylogenomic databases

eggNOGi NOG46496.
GeneTreei ENSGT00550000074457.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P21744.
OMAi KGMPCGV.
OrthoDBi EOG74N5HG.
PhylomeDBi P21744.
TreeFami TF331211.

Enzyme and pathway databases

Reactomei REACT_250882. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

NextBioi 673497.
PROi P21744.

Gene expression databases

Genevestigatori P21744.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR022327. IGFBP-4.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01980. IGFBPFAMILY4.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human."
    Shimasaki S., Uchiyama F., Shimonaka M., Ling N.
    Mol. Endocrinol. 4:1451-1458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of the rat insulin-like growth factor binding protein-4 gene."
    Gao L., Ling N., Shimasaki S.
    Biochem. Biophys. Res. Commun. 190:1053-1059(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  3. "IGFBP3, 4, 5 and 6 expression at the mandibular condylar cartilage during rat growth and development."
    Hajjar D., Ricarte-Filho J.C.M., dos Santos M.F., Kimura E.T.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Mandibular condyle.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "Identification of a novel binding protein for insulin-like growth factors in adult rat serum."
    Shimonaka M., Schroeder R., Shimasaki S., Ling N.
    Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-61.
    Tissue: Serum.
  6. "Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4."
    Chelius D., Baldwin M.A., Lu X., Spencer E.M.
    J. Endocrinol. 168:283-296(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiIBP4_RAT
AccessioniPrimary (citable) accession number: P21744
Secondary accession number(s): Q68J74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3