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P21744

- IBP4_RAT

UniProt

P21744 - IBP4_RAT

Protein

Insulin-like growth factor-binding protein 4

Gene

Igfbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. insulin-like growth factor binding Source: RGD

    GO - Biological processi

    1. inflammatory response Source: RGD
    2. intracellular signal transduction Source: RGD
    3. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    4. positive regulation of MAPK cascade Source: Ensembl
    5. regulation of cell growth Source: Ensembl
    6. regulation of glucose metabolic process Source: Ensembl
    7. type B pancreatic cell proliferation Source: Ensembl

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Short name:
    IBP-4
    Short name:
    IGF-binding protein 4
    Short name:
    IGFBP-4
    Gene namesi
    Name:Igfbp4
    Synonyms:Igfbp-4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi2875. Igfbp4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 254233Insulin-like growth factor-binding protein 4PRO_0000014384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 53PROSITE-ProRule annotation
    Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi38 ↔ 591 PublicationPROSITE-ProRule annotation
    Disulfide bondi44 ↔ 561 PublicationPROSITE-ProRule annotation
    Disulfide bondi67 ↔ 801 PublicationPROSITE-ProRule annotation
    Disulfide bondi74 ↔ 1001 PublicationPROSITE-ProRule annotation
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi131 ↔ 1381 PublicationPROSITE-ProRule annotation
    Disulfide bondi170 ↔ 2001 PublicationPROSITE-ProRule annotation
    Disulfide bondi211 ↔ 2221 PublicationPROSITE-ProRule annotation
    Disulfide bondi224 ↔ 2451 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP21744.
    PRIDEiP21744.

    Expressioni

    Gene expression databases

    GenevestigatoriP21744.

    Interactioni

    Subunit structurei

    Binds IGF2 more than IGF1.

    Protein-protein interaction databases

    BioGridi262076. 2 interactions.
    STRINGi10116.ENSRNOP00000014153.

    Structurei

    3D structure databases

    ProteinModelPortaliP21744.
    SMRiP21744. Positions 23-113, 168-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 10381IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 24579Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46496.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP21744.
    OMAiKGMPCGV.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP21744.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR022327. IGFBP-4.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01980. IGFBPFAMILY4.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21744-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE    50
    PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC 100
    TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS 150
    KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC 200
    DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD 250
    SLQE 254
    Length:254
    Mass (Da):27,745
    Last modified:August 1, 1991 - v2
    Checksum:i97D37AC98BD0E787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08276 Genomic DNA. No translation available.
    AY686592 mRNA. Translation: AAT96376.1.
    BC098750 mRNA. Translation: AAH98750.1.
    PIRiJC1464.
    RefSeqiNP_001004274.1. NM_001004274.2.
    UniGeneiRn.160666.

    Genome annotation databases

    EnsembliENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635.
    GeneIDi360622.
    KEGGirno:360622.
    UCSCiRGD:2875. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08276 Genomic DNA. No translation available.
    AY686592 mRNA. Translation: AAT96376.1 .
    BC098750 mRNA. Translation: AAH98750.1 .
    PIRi JC1464.
    RefSeqi NP_001004274.1. NM_001004274.2.
    UniGenei Rn.160666.

    3D structure databases

    ProteinModelPortali P21744.
    SMRi P21744. Positions 23-113, 168-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 262076. 2 interactions.
    STRINGi 10116.ENSRNOP00000014153.

    Proteomic databases

    PaxDbi P21744.
    PRIDEi P21744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014153 ; ENSRNOP00000014153 ; ENSRNOG00000010635 .
    GeneIDi 360622.
    KEGGi rno:360622.
    UCSCi RGD:2875. rat.

    Organism-specific databases

    CTDi 3487.
    RGDi 2875. Igfbp4.

    Phylogenomic databases

    eggNOGi NOG46496.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P21744.
    OMAi KGMPCGV.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P21744.
    TreeFami TF331211.

    Miscellaneous databases

    NextBioi 673497.
    PROi P21744.

    Gene expression databases

    Genevestigatori P21744.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR022327. IGFBP-4.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01980. IGFBPFAMILY4.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human."
      Shimasaki S., Uchiyama F., Shimonaka M., Ling N.
      Mol. Endocrinol. 4:1451-1458(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure of the rat insulin-like growth factor binding protein-4 gene."
      Gao L., Ling N., Shimasaki S.
      Biochem. Biophys. Res. Commun. 190:1053-1059(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
    3. "IGFBP3, 4, 5 and 6 expression at the mandibular condylar cartilage during rat growth and development."
      Hajjar D., Ricarte-Filho J.C.M., dos Santos M.F., Kimura E.T.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Mandibular condyle.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    5. "Identification of a novel binding protein for insulin-like growth factors in adult rat serum."
      Shimonaka M., Schroeder R., Shimasaki S., Ling N.
      Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-61.
      Tissue: Serum.
    6. "Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4."
      Chelius D., Baldwin M.A., Lu X., Spencer E.M.
      J. Endocrinol. 168:283-296(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.

    Entry informationi

    Entry nameiIBP4_RAT
    AccessioniPrimary (citable) accession number: P21744
    Secondary accession number(s): Q68J74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3