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P21744 (IBP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 4

Short name=IBP-4
Short name=IGF-binding protein 4
Short name=IGFBP-4
Gene names
Name:Igfbp4
Synonyms:Igfbp-4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit structure

Binds IGF2 more than IGF1.

Subcellular location

Secreted.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.5
Chain22 – 254233Insulin-like growth factor-binding protein 4
PRO_0000014384

Regions

Domain23 – 10381IGFBP N-terminal
Domain167 – 24579Thyroglobulin type-1

Amino acid modifications

Glycosylation1251N-linked (GlcNAc...) Potential
Disulfide bond27 ↔ 53 By similarity
Disulfide bond30 ↔ 55 By similarity
Disulfide bond38 ↔ 59 Ref.6
Disulfide bond44 ↔ 56 Ref.6
Disulfide bond67 ↔ 80 Ref.6
Disulfide bond74 ↔ 100 Ref.6
Disulfide bond131 ↔ 138 Ref.6
Disulfide bond170 ↔ 200 Ref.6
Disulfide bond211 ↔ 222 Ref.6
Disulfide bond224 ↔ 245 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P21744 [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: 97D37AC98BD0E787

FASTA25427,745
        10         20         30         40         50         60 
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA 

        70         80         90        100        110        120 
LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC TELSEIEAIQ ESLQTSDKDE 

       130        140        150        160        170        180 
SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS KMKVVGTPRE EPRPVPQGSC QSELHRALER 

       190        200        210        220        230        240 
LAASQSRTHE DLFIIPIPNC DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK 

       250 
GELDCHQLAD SLQE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human."
Shimasaki S., Uchiyama F., Shimonaka M., Ling N.
Mol. Endocrinol. 4:1451-1458(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structure of the rat insulin-like growth factor binding protein-4 gene."
Gao L., Ling N., Shimasaki S.
Biochem. Biophys. Res. Commun. 190:1053-1059(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
[3]"IGFBP3, 4, 5 and 6 expression at the mandibular condylar cartilage during rat growth and development."
Hajjar D., Ricarte-Filho J.C.M., dos Santos M.F., Kimura E.T.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Mandibular condyle.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[5]"Identification of a novel binding protein for insulin-like growth factors in adult rat serum."
Shimonaka M., Schroeder R., Shimasaki S., Ling N.
Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-61.
Tissue: Serum.
[6]"Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4."
Chelius D., Baldwin M.A., Lu X., Spencer E.M.
J. Endocrinol. 168:283-296(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08276 Genomic DNA. No translation available.
AY686592 mRNA. Translation: AAT96376.1.
BC098750 mRNA. Translation: AAH98750.1.
PIRJC1464.
RefSeqNP_001004274.1. NM_001004274.2.
UniGeneRn.160666.

3D structure databases

ProteinModelPortalP21744.
SMRP21744. Positions 23-113, 168-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid262076. 2 interactions.
STRING10116.ENSRNOP00000014153.

Proteomic databases

PaxDbP21744.
PRIDEP21744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635.
GeneID360622.
KEGGrno:360622.
UCSCRGD:2875. rat.

Organism-specific databases

CTD3487.
RGD2875. Igfbp4.

Phylogenomic databases

eggNOGNOG46496.
GeneTreeENSGT00550000074457.
HOGENOMHOG000253012.
HOVERGENHBG002631.
InParanoidP21744.
OMAKGMPCGV.
OrthoDBEOG74N5HG.
PhylomeDBP21744.
TreeFamTF331211.

Gene expression databases

GenevestigatorP21744.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR022327. IGFBP-4.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01980. IGFBPFAMILY4.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio673497.
PROP21744.

Entry information

Entry nameIBP4_RAT
AccessionPrimary (citable) accession number: P21744
Secondary accession number(s): Q68J74
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families