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Protein

Insulin-like growth factor-binding protein 4

Gene

Igfbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
Gene namesi
Name:Igfbp4
Synonyms:Igfbp-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2875 Igfbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001438422 – 254Insulin-like growth factor-binding protein 4Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 53PROSITE-ProRule annotation
Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
Disulfide bondi38 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 56PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation1 Publication
Disulfide bondi74 ↔ 100PROSITE-ProRule annotation1 Publication
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation1 Publication
Disulfide bondi170 ↔ 200PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 222PROSITE-ProRule annotation1 Publication
Disulfide bondi224 ↔ 245PROSITE-ProRule annotation1 Publication
Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21744
PRIDEiP21744

Expressioni

Gene expression databases

BgeeiENSRNOG00000010635
GenevisibleiP21744 RN

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262076, 2 interactors
STRINGi10116.ENSRNOP00000014153

Structurei

3D structure databases

ProteinModelPortaliP21744
SMRiP21744
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini167 – 245Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKZ1 Eukaryota
ENOG4111HXV LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP21744
OMAiKGMPCGV
OrthoDBiEOG091G0EIN
PhylomeDBiP21744
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC
110 120 130 140 150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS
160 170 180 190 200
KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC
210 220 230 240 250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD

SLQE
Length:254
Mass (Da):27,745
Last modified:August 1, 1991 - v2
Checksum:i97D37AC98BD0E787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08276 Genomic DNA No translation available.
AY686592 mRNA Translation: AAT96376.1
BC098750 mRNA Translation: AAH98750.1
PIRiJC1464
RefSeqiNP_001004274.1, NM_001004274.2
UniGeneiRn.160666

Genome annotation databases

EnsembliENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635
GeneIDi360622
KEGGirno:360622
UCSCiRGD:2875 rat

Similar proteinsi

Entry informationi

Entry nameiIBP4_RAT
AccessioniPrimary (citable) accession number: P21744
Secondary accession number(s): Q68J74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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