Insulin-like growth factor-binding protein 4 precursor

Contribute

Send feedback

Read comments (?) or add your own

P21744 (IBP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Insulin-like growth factor-binding protein 4
Short name=IBP-4
Short name=IGF-binding protein 4
Short name=IGFBP-4

Gene names

Name:	Igfbp4
Synonyms:	Igfbp-4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subunit structure	Binds IGF2 more than IGF1.
Subcellular location	Secreted.
Sequence similarities	Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Growth factor binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from expression pattern PubMed 11145587. Source: RGD intracellular signal transduction Traceable author statement PubMed 12193414. Source: RGD positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of insulin-like growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of cell growth Inferred from electronic annotation. Source: Compara regulation of glucose metabolic process Inferred from electronic annotation. Source: Compara type B pancreatic cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	insulin-like growth factor binding Traceable author statement PubMed 11145587 Ref.2. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Ref.5

Chain

22 – 254

233

Insulin-like growth factor-binding protein 4

PRO_0000014384

Regions

Domain

23 – 103

IGFBP N-terminal

Domain

167 – 245

Thyroglobulin type-1

Amino acid modifications

Glycosylation

125

N-linked (GlcNAc...) Potential

Disulfide bond

27 ↔ 53

By similarity

Disulfide bond

30 ↔ 55

By similarity

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Sequences

Sequence

Length

Mass (Da)

Tools

P21744 [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: 97D37AC98BD0E787
Show »

FASTA

254

27,745

        10         20         30         40         50         60 
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA 

        70         80         90        100        110        120 
LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC TELSEIEAIQ ESLQTSDKDE 

       130        140        150        160        170        180 
SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS KMKVVGTPRE EPRPVPQGSC QSELHRALER 

       190        200        210        220        230        240 
LAASQSRTHE DLFIIPIPNC DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK 

       250 
GELDCHQLAD SLQE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human." Shimasaki S., Uchiyama F., Shimonaka M., Ling N. Mol. Endocrinol. 4:1451-1458(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure of the rat insulin-like growth factor binding protein-4 gene." Gao L., Ling N., Shimasaki S. Biochem. Biophys. Res. Commun. 190:1053-1059(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
[3]	"IGFBP3, 4, 5 and 6 expression at the mandibular condylar cartilage during rat growth and development." Hajjar D., Ricarte-Filho J.C.M., dos Santos M.F., Kimura E.T. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Mandibular condyle.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"Identification of a novel binding protein for insulin-like growth factors in adult rat serum." Shimonaka M., Schroeder R., Shimasaki S., Ling N. Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-61. Tissue: Serum.
[6]	"Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4." Chelius D., Baldwin M.A., Lu X., Spencer E.M. J. Endocrinol. 168:283-296(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08276 Genomic DNA. No translation available. AY686592 mRNA. Translation: AAT96376.1. BC098750 mRNA. Translation: AAH98750.1.
IPI	IPI00206239.
PIR	JC1464.
RefSeq	NP_001004274.1. NM_001004274.2.
UniGene	Rn.160666.
3D structure databases
ProteinModelPortal	P21744.
SMR	P21744. Positions 23-113, 168-246.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014153.
Proteomic databases
PaxDb	P21744.
PRIDE	P21744.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014153; ENSRNOP00000014153; ENSRNOG00000010635.
GeneID	360622.
KEGG	rno:360622.
UCSC	RGD:2875. rat.
Organism-specific databases
CTD	3487.
RGD	2875. Igfbp4.
Phylogenomic databases
eggNOG	NOG46496.
GeneTree	ENSGT00550000074457.
HOGENOM	HOG000253012.
HOVERGEN	HBG002631.
InParanoid	P21744.
OMA	KGMPCGV.
OrthoDB	EOG4FR0SF.
Gene expression databases
Genevestigator	P21744.
GermOnline	ENSRNOG00000010635. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.40.20. 1 hit. 4.10.800.10. 1 hit.
InterPro	IPR009030. Growth_fac_rcpt_N_dom. IPR022327. IGFBP-4. IPR000867. IGFBP-like. IPR009168. IGFBP1-6. IPR022321. IGFBP_1-6_chordata. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000716. Thyroglobulin_1. [Graphical view]
PANTHER	PTHR11551. PTHR11551. 1 hit.
Pfam	PF00219. IGFBP. 1 hit. PF00086. Thyroglobulin_1. 1 hit. [Graphical view]
PRINTS	PR01976. IGFBPFAMILY. PR01980. IGFBPFAMILY4.
SMART	SM00121. IB. 1 hit. SM00211. TY. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF57610. Thyroglobulin_1. 1 hit.
PROSITE	PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	673497.

Entry information

Entry name

IBP4_RAT

Accession

Primary (citable) accession number: P21744
Secondary accession number(s): Q68J74

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 29, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents