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Protein

Insulin-like growth factor-binding protein 1

Gene

Igfbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functioni

  1. insulin-like growth factor binding Source: RGD
  2. insulin-like growth factor I binding Source: GO_Central
  3. insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

  1. glucose metabolic process Source: RGD
  2. insulin receptor signaling pathway Source: RGD
  3. phosphatidylinositol-mediated signaling Source: RGD
  4. positive regulation of cell growth Source: RGD
  5. regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
  6. tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Gene namesi
Name:Igfbp1
Synonyms:Igfbp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2872. Igfbp1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 272247Insulin-like growth factor-binding protein 1PRO_0000014368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 106PROSITE-ProRule annotation
Modified residuei139 – 1391PhosphoserineBy similarity
Modified residuei157 – 1571PhosphoserineBy similarity
Disulfide bondi189 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation
Disulfide bondi243 ↔ 264PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP21743.

Expressioni

Gene expression databases

GenevestigatoriP21743.

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338.

Structurei

3D structure databases

ProteinModelPortaliP21743.
SMRiP21743. Positions 30-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10982IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 26479Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi259 – 2613Cell attachment site

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44381.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP21743.
OMAiWQCAPCS.
OrthoDBiEOG74N5HG.
PhylomeDBiP21743.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEFLTVVSW PFLILLSFQV RVVAGAPQPW HCAPCTAERL ELCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPLG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVLEP AAPATSSLSG SQHEEAKAAV ASEDELAESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIT DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV QN
Length:272
Mass (Da):29,684
Last modified:June 1, 1994 - v2
Checksum:i12B9F3A42200753D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791R → A (PubMed:1691820).Curated
Sequence conflicti79 – 791R → A (PubMed:7514892).Curated
Sequence conflicti111 – 1122AA → PP (PubMed:1691820).Curated
Sequence conflicti201 – 2011A → R in AAA41382 (PubMed:1283442).Curated
Sequence conflicti265 – 2651H → N (PubMed:1691820).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA. Translation: AAA41380.1.
M89791 mRNA. Translation: AAA41382.1.
L22979 Genomic DNA. Translation: AAA82581.1.
BC078889 mRNA. Translation: AAH78889.1.
PIRiA36082.
RefSeqiNP_037276.1. NM_013144.1.
UniGeneiRn.34026.

Genome annotation databases

EnsembliENSRNOT00000011338; ENSRNOP00000011338; ENSRNOG00000008371.
GeneIDi25685.
KEGGirno:25685.
UCSCiRGD:2872. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA. Translation: AAA41380.1.
M89791 mRNA. Translation: AAA41382.1.
L22979 Genomic DNA. Translation: AAA82581.1.
BC078889 mRNA. Translation: AAH78889.1.
PIRiA36082.
RefSeqiNP_037276.1. NM_013144.1.
UniGeneiRn.34026.

3D structure databases

ProteinModelPortaliP21743.
SMRiP21743. Positions 30-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338.

Protein family/group databases

MEROPSiI31.951.

Proteomic databases

PRIDEiP21743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011338; ENSRNOP00000011338; ENSRNOG00000008371.
GeneIDi25685.
KEGGirno:25685.
UCSCiRGD:2872. rat.

Organism-specific databases

CTDi3484.
RGDi2872. Igfbp1.

Phylogenomic databases

eggNOGiNOG44381.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP21743.
OMAiWQCAPCS.
OrthoDBiEOG74N5HG.
PhylomeDBiP21743.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

NextBioi607667.
PROiP21743.

Gene expression databases

GenevestigatoriP21743.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a rat decidual insulin-like growth factor-binding protein complementary DNA."
    Murphy L.J., Seneviratne C., Ballejo G., Croze F., Kennedy T.G.
    Mol. Endocrinol. 4:329-336(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Decidua.
  2. "The gene encoding rat insulin-like growth factor-binding protein 1 is rapidly and highly induced in regenerating liver."
    Mohn K.L., Melby A.E., Tewari D.S., Laz T.M., Taub R.A.
    Mol. Cell. Biol. 11:1393-1401(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats."
    Ooi G.T., Tseng L.Y.H., Tran M.Q., Rechler M.M.
    Mol. Endocrinol. 6:2219-2228(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene."
    Lacson R.G., Oehler D., Yang E., Goswami R., Unterman T.G.
    Biochim. Biophys. Acta 1218:95-98(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Production of the rat type 1 insulin-like growth factor-binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification, and N-terminal amino acid analysis."
    Unterman T.G., Oehler D.T., Gotway M.B., Morris P.W.
    Endocrinology 127:789-797(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-59.

Entry informationi

Entry nameiIBP1_RAT
AccessioniPrimary (citable) accession number: P21743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 1, 1994
Last modified: April 1, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.