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P21743 (IBP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 1

Short name=IBP-1
Short name=IGF-binding protein 1
Short name=IGFBP-1
Gene names
Name:Igfbp1
Synonyms:Igfbp-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration By similarity.

Subunit structure

Binds equally well IGF1 and IGF2.

Subcellular location

Secreted.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.6
Chain26 – 272247Insulin-like growth factor-binding protein 1
PRO_0000014368

Regions

Domain28 – 10982IGFBP N-terminal
Domain186 – 26479Thyroglobulin type-1
Motif259 – 2613Cell attachment site

Amino acid modifications

Modified residue1391Phosphoserine By similarity
Modified residue1571Phosphoserine By similarity
Disulfide bond73 ↔ 86 By similarity
Disulfide bond80 ↔ 106 By similarity
Disulfide bond189 ↔ 219 By similarity
Disulfide bond230 ↔ 241 By similarity
Disulfide bond243 ↔ 264 By similarity

Experimental info

Sequence conflict791R → A Ref.1
Sequence conflict791R → A Ref.4
Sequence conflict111 – 1122AA → PP Ref.1
Sequence conflict2011A → R in AAA41382. Ref.3
Sequence conflict2651H → N Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21743 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: 12B9F3A42200753D

FASTA27229,684
        10         20         30         40         50         60 
MPEFLTVVSW PFLILLSFQV RVVAGAPQPW HCAPCTAERL ELCPPVPASC PEISRPAGCG 

        70         80         90        100        110        120 
CCPTCALPLG AACGVATARC AQGLSCRALP GEPRPLHALT RGQGACVLEP AAPATSSLSG 

       130        140        150        160        170        180 
SQHEEAKAAV ASEDELAESP EMTEEQLLDS FHLMAPSRED QPILWNAIST YSSMRAREIT 

       190        200        210        220        230        240 
DLKKWKEPCQ RELYKVLERL AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL 

       250        260        270 
CWCVYPWSGK KIPGSLETRG DPNCHQYFNV QN 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a rat decidual insulin-like growth factor-binding protein complementary DNA."
Murphy L.J., Seneviratne C., Ballejo G., Croze F., Kennedy T.G.
Mol. Endocrinol. 4:329-336(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Decidua.
[2]"The gene encoding rat insulin-like growth factor-binding protein 1 is rapidly and highly induced in regenerating liver."
Mohn K.L., Melby A.E., Tewari D.S., Laz T.M., Taub R.A.
Mol. Cell. Biol. 11:1393-1401(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats."
Ooi G.T., Tseng L.Y.H., Tran M.Q., Rechler M.M.
Mol. Endocrinol. 6:2219-2228(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene."
Lacson R.G., Oehler D., Yang E., Goswami R., Unterman T.G.
Biochim. Biophys. Acta 1218:95-98(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[6]"Production of the rat type 1 insulin-like growth factor-binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification, and N-terminal amino acid analysis."
Unterman T.G., Oehler D.T., Gotway M.B., Morris P.W.
Endocrinology 127:789-797(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-59.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58634 mRNA. Translation: AAA41380.1.
M89791 mRNA. Translation: AAA41382.1.
L22979 Genomic DNA. Translation: AAA82581.1.
BC078889 mRNA. Translation: AAH78889.1.
PIRA36082.
RefSeqNP_037276.1. NM_013144.1.
UniGeneRn.34026.

3D structure databases

ProteinModelPortalP21743.
SMRP21743. Positions 30-108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011338.

Protein family/group databases

MEROPSI31.951.

Proteomic databases

PRIDEP21743.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011338; ENSRNOP00000011338; ENSRNOG00000008371.
GeneID25685.
KEGGrno:25685.
UCSCRGD:2872. rat.

Organism-specific databases

CTD3484.
RGD2872. Igfbp1.

Phylogenomic databases

eggNOGNOG44381.
GeneTreeENSGT00550000074457.
HOGENOMHOG000253012.
HOVERGENHBG002631.
OMAMCALPLG.
OrthoDBEOG74N5HG.
PhylomeDBP21743.
TreeFamTF331211.

Gene expression databases

GenevestigatorP21743.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607667.
PROP21743.

Entry information

Entry nameIBP1_RAT
AccessionPrimary (citable) accession number: P21743
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families