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Protein

Insulin-like growth factor-binding protein 1

Gene

Igfbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • glucose metabolic process Source: RGD
  • insulin receptor signaling pathway Source: RGD
  • phosphatidylinositol-mediated signaling Source: RGD
  • positive regulation of cell growth Source: RGD
  • regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
  • tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiR-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Gene namesi
Name:Igfbp1
Synonyms:Igfbp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2872. Igfbp1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001436826 – 272Insulin-like growth factor-binding protein 1Add BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 106PROSITE-ProRule annotation
Modified residuei139PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei170PhosphothreonineBy similarity1
Modified residuei171PhosphotyrosineBy similarity1
Disulfide bondi189 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation
Disulfide bondi243 ↔ 264PROSITE-ProRule annotation
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP21743.
PRIDEiP21743.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008371.
GenevisibleiP21743. RN.

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338.

Structurei

3D structure databases

ProteinModelPortaliP21743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini186 – 264Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi259 – 261Cell attachment site3

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP21743.
OMAiGQGACVQ.
OrthoDBiEOG091G0EIN.
PhylomeDBiP21743.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEFLTVVSW PFLILLSFQV RVVAGAPQPW HCAPCTAERL ELCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPLG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVLEP AAPATSSLSG SQHEEAKAAV ASEDELAESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIT DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV QN
Length:272
Mass (Da):29,684
Last modified:June 1, 1994 - v2
Checksum:i12B9F3A42200753D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79R → A (PubMed:1691820).Curated1
Sequence conflicti79R → A (PubMed:7514892).Curated1
Sequence conflicti111 – 112AA → PP (PubMed:1691820).Curated2
Sequence conflicti201A → R in AAA41382 (PubMed:1283442).Curated1
Sequence conflicti265H → N (PubMed:1691820).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA. Translation: AAA41380.1.
M89791 mRNA. Translation: AAA41382.1.
L22979 Genomic DNA. Translation: AAA82581.1.
BC078889 mRNA. Translation: AAH78889.1.
PIRiA36082.
RefSeqiNP_037276.1. NM_013144.1.
UniGeneiRn.34026.

Genome annotation databases

EnsembliENSRNOT00000077177; ENSRNOP00000069247; ENSRNOG00000058780.
GeneIDi25685.
KEGGirno:25685.
UCSCiRGD:2872. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58634 mRNA. Translation: AAA41380.1.
M89791 mRNA. Translation: AAA41382.1.
L22979 Genomic DNA. Translation: AAA82581.1.
BC078889 mRNA. Translation: AAH78889.1.
PIRiA36082.
RefSeqiNP_037276.1. NM_013144.1.
UniGeneiRn.34026.

3D structure databases

ProteinModelPortaliP21743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011338.

Protein family/group databases

MEROPSiI31.951.

Proteomic databases

PaxDbiP21743.
PRIDEiP21743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077177; ENSRNOP00000069247; ENSRNOG00000058780.
GeneIDi25685.
KEGGirno:25685.
UCSCiRGD:2872. rat.

Organism-specific databases

CTDi3484.
RGDi2872. Igfbp1.

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP21743.
OMAiGQGACVQ.
OrthoDBiEOG091G0EIN.
PhylomeDBiP21743.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiR-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

PROiP21743.

Gene expression databases

BgeeiENSRNOG00000008371.
GenevisibleiP21743. RN.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP1_RAT
AccessioniPrimary (citable) accession number: P21743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.