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P21731

- TA2R_HUMAN

UniProt

P21731 - TA2R_HUMAN

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Protein
Thromboxane A2 receptor
Gene
TBXA2R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.1 Publication

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: Reactome
  2. protein binding Source: UniProtKB
  3. thromboxane A2 receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. blood coagulation Source: Reactome
  3. inflammatory response Source: Ensembl
  4. platelet activation Source: Reactome
  5. positive regulation of angiogenesis Source: Ensembl
  6. positive regulation of blood pressure Source: Ensembl
  7. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  8. positive regulation of smooth muscle contraction Source: Ensembl
  9. positive regulation of vasoconstriction Source: Ensembl
  10. regulation of GTPase activity Source: GOC
  11. response to drug Source: Ensembl
  12. response to lipopolysaccharide Source: Ensembl
  13. response to nutrient Source: Ensembl
  14. second-messenger-mediated signaling Source: Ensembl
  15. thromboxane A2 signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_18425. Prostanoid ligand receptors.
REACT_20647. Thromboxane signalling through TP receptor.
SignaLinkiP21731.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:TBXA2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11608. TBXA2R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed prediction
Add
BLAST
Transmembranei30 – 5223Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini53 – 6614Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini88 – 10619Extracellular Reviewed prediction
Add
BLAST
Transmembranei107 – 12822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini129 – 14921Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17223Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini173 – 19321Extracellular Reviewed prediction
Add
BLAST
Transmembranei194 – 21926Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 24627Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei247 – 27024Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini271 – 28919Extracellular Reviewed prediction
Add
BLAST
Transmembranei290 – 31122Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini312 – 34332Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601R → L in BDPLT13; does not affect TXA2 binding; defective interaction with G proteins; impairs phospholipase C and adenylyl cyclase activation; isoform 1; has no effect on adenylyl cyclase inhibition; isoform 2. 2 Publications
Corresponds to variant rs34377097 [ dbSNP | Ensembl ].
VAR_003515

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi291 – 2911L → R: Suppresses antagonist binding.
Mutagenesisi295 – 2951R → Q: Reduces antagonist binding.
Mutagenesisi299 – 2991W → L: Reduces antagonist binding.
Mutagenesisi299 – 2991W → R: Reduces antagonist binding.

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614009. phenotype.
Orphaneti220443. Bleeding diathesis due to thromboxane synthesis deficiency.
PharmGKBiPA348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Thromboxane A2 receptor
PRO_0000070138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)
Glycosylationi16 – 161N-linked (GlcNAc...)
Disulfide bondi105 ↔ 183 By similarity
Modified residuei329 – 3291Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21731.
PRIDEiP21731.

PTM databases

PhosphoSiteiP21731.

Expressioni

Gene expression databases

ArrayExpressiP21731.
BgeeiP21731.
CleanExiHS_TBXA2R.
GenevestigatoriP21731.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131623EBI-2625082,EBI-2211957

Protein-protein interaction databases

BioGridi112777. 35 interactions.
DIPiDIP-41465N.
IntActiP21731. 4 interactions.
MINTiMINT-1512445.
STRINGi9606.ENSP00000364336.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi101 – 13434
Beta strandi138 – 1403
Turni145 – 1473
Helixi148 – 16417
Helixi166 – 1683
Beta strandi174 – 1774
Turni178 – 1814
Beta strandi182 – 1854
Helixi192 – 1943
Helixi196 – 20611
Helixi209 – 22214
Beta strandi223 – 2286
Turni236 – 2383
Helixi239 – 25517
Helixi256 – 2583
Helixi259 – 2646

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LBNmodel-A100-265[»]
ProteinModelPortaliP21731.
SMRiP21731. Positions 66-177.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263172.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
KOiK04264.
OMAiATLCRVY.
OrthoDBiEOG7TBC2R.
PhylomeDBiP21731.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21731-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA    50
GARQGGSHTR SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP 100
GCRLCRFMGV VMIFFGLSPL LLGAAMASER YLGITRPFSR PAVASQRRAW 150
ATVGLVWAAA LALGLLPLLG VGRYTVQYPG SWCFLTLGAE SGDVAFGLLF 200
SMLGGLSVGL SFLLNTVSVA TLCHVYHGQE AAQQRPRDSE VEMMAQLLGI 250
MVVASVCWLP LLVFIAQTVL RNPPAMSPAG QLSRTTEKEL LIYLRVATWN 300
QILDPWVYIL FRRAVLRRLQ PRLSTRPRSL SLQPQLTQRS GLQ 343
Length:343
Mass (Da):37,431
Last modified:May 5, 2009 - v3
Checksum:i114A7C3F3F0D35F1
GO
Isoform 2 (identifier: P21731-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     329-343: SLSLQPQLTQRSGLQ → RSLTLWPSLE...PTGKALSRKD

Show »
Length:407
Mass (Da):44,205
Checksum:i461D60349704E7AB
GO

Sequence cautioni

The sequence AAA58957.1 differs from that shown. Reason: Frameshift at position 329.
Isoform 2 : The sequence AAA58957.1 differs from that shown. Reason: Frameshift at positions 330 and 386.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601R → L in BDPLT13; does not affect TXA2 binding; defective interaction with G proteins; impairs phospholipase C and adenylyl cyclase activation; isoform 1; has no effect on adenylyl cyclase inhibition; isoform 2. 2 Publications
Corresponds to variant rs34377097 [ dbSNP | Ensembl ].
VAR_003515
Natural varianti68 – 681C → S.
Corresponds to variant rs5743 [ dbSNP | Ensembl ].
VAR_014688
Natural varianti80 – 801V → E.
Corresponds to variant rs5744 [ dbSNP | Ensembl ].
VAR_014689
Natural varianti94 – 941E → V.
Corresponds to variant rs5746 [ dbSNP | Ensembl ].
VAR_014690
Natural varianti160 – 1601A → T.
Corresponds to variant rs5749 [ dbSNP | Ensembl ].
VAR_014691
Natural varianti176 – 1761V → E.
Corresponds to variant rs5750 [ dbSNP | Ensembl ].
VAR_014692
Natural varianti217 – 2171V → I.
Corresponds to variant rs5751 [ dbSNP | Ensembl ].
VAR_014693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 34315SLSLQ…RSGLQ → RSLTLWPSLEYSGTISAHCN LRLPGSSDSRASASRAAGIT GVSHCARPCMLFDPEFDLLA GVQLLPFEPPTGKALSRKD in isoform 2.
VSP_001925Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631V → W AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38081 mRNA. Translation: BAA07274.1.
D15056 Genomic DNA. Translation: BAA03649.1.
U11271 mRNA. Translation: AAA58957.1. Frameshift.
U27325 mRNA. Translation: AAA68608.1.
AY429110 mRNA. Translation: AAR07905.1.
DQ268653 Genomic DNA. Translation: ABB72549.1.
AC005175 Genomic DNA. Translation: AAC24302.1.
AC005175 Genomic DNA. Translation: AAC24303.1.
CH471139 Genomic DNA. Translation: EAW69301.1.
BC074749 mRNA. Translation: AAH74749.1.
BC074750 mRNA. Translation: AAH74750.1.
CCDSiCCDS42467.1. [P21731-3]
CCDS54198.1. [P21731-2]
PIRiA49117.
A53959.
A56194.
T02670.
RefSeqiNP_001051.1. NM_001060.5. [P21731-3]
NP_963998.2. NM_201636.2. [P21731-2]
UniGeneiHs.442530.

Genome annotation databases

EnsembliENST00000375190; ENSP00000364336; ENSG00000006638. [P21731-3]
ENST00000411851; ENSP00000393333; ENSG00000006638. [P21731-2]
GeneIDi6915.
KEGGihsa:6915.
UCSCiuc002lyg.2. human. [P21731-3]
uc021umv.1. human. [P21731-2]

Polymorphism databases

DMDMi229463010.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38081 mRNA. Translation: BAA07274.1 .
D15056 Genomic DNA. Translation: BAA03649.1 .
U11271 mRNA. Translation: AAA58957.1 . Frameshift.
U27325 mRNA. Translation: AAA68608.1 .
AY429110 mRNA. Translation: AAR07905.1 .
DQ268653 Genomic DNA. Translation: ABB72549.1 .
AC005175 Genomic DNA. Translation: AAC24302.1 .
AC005175 Genomic DNA. Translation: AAC24303.1 .
CH471139 Genomic DNA. Translation: EAW69301.1 .
BC074749 mRNA. Translation: AAH74749.1 .
BC074750 mRNA. Translation: AAH74750.1 .
CCDSi CCDS42467.1. [P21731-3 ]
CCDS54198.1. [P21731-2 ]
PIRi A49117.
A53959.
A56194.
T02670.
RefSeqi NP_001051.1. NM_001060.5. [P21731-3 ]
NP_963998.2. NM_201636.2. [P21731-2 ]
UniGenei Hs.442530.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LBN model - A 100-265 [» ]
ProteinModelPortali P21731.
SMRi P21731. Positions 66-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112777. 35 interactions.
DIPi DIP-41465N.
IntActi P21731. 4 interactions.
MINTi MINT-1512445.
STRINGi 9606.ENSP00000364336.

Chemistry

BindingDBi P21731.
ChEMBLi CHEMBL2069.
DrugBanki DB01207. Ridogrel.
GuidetoPHARMACOLOGYi 346.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21731.

Polymorphism databases

DMDMi 229463010.

Proteomic databases

PaxDbi P21731.
PRIDEi P21731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375190 ; ENSP00000364336 ; ENSG00000006638 . [P21731-3 ]
ENST00000411851 ; ENSP00000393333 ; ENSG00000006638 . [P21731-2 ]
GeneIDi 6915.
KEGGi hsa:6915.
UCSCi uc002lyg.2. human. [P21731-3 ]
uc021umv.1. human. [P21731-2 ]

Organism-specific databases

CTDi 6915.
GeneCardsi GC19M003594.
H-InvDB HIX0202922.
HGNCi HGNC:11608. TBXA2R.
MIMi 188070. gene.
614009. phenotype.
neXtProti NX_P21731.
Orphaneti 220443. Bleeding diathesis due to thromboxane synthesis deficiency.
PharmGKBi PA348.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263172.
HOGENOMi HOG000015238.
HOVERGENi HBG108543.
KOi K04264.
OMAi ATLCRVY.
OrthoDBi EOG7TBC2R.
PhylomeDBi P21731.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_18425. Prostanoid ligand receptors.
REACT_20647. Thromboxane signalling through TP receptor.
SignaLinki P21731.

Miscellaneous databases

ChiTaRSi TBXA2R. human.
GeneWikii Thromboxane_receptor.
GenomeRNAii 6915.
NextBioi 27045.
PROi P21731.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21731.
Bgeei P21731.
CleanExi HS_TBXA2R.
Genevestigatori P21731.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of cDNA for a human thromboxane A2 receptor."
    Hirata M., Hayashi Y., Ushikubi F., Yokota Y., Kageyama R., Nakanishi S., Narumiya S.
    Nature 349:617-620(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
    Tissue: Placenta.
  2. "Characterization and chromosomal mapping of the human thromboxane A2 receptor gene."
    Nuesing R.M., Hirata M., Kakizuka A., Eki T., Ozawa K., Narumiya S.
    J. Biol. Chem. 268:25253-25259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor."
    Raychowdhury M.K., Yukawa M., Collins L.J., McGrail S.H., Kent K.C., Ware J.A.
    J. Biol. Chem. 269:19256-19261(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
    Tissue: Endothelial cell and Placenta.
  4. "Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells."
    D'Angelo D.D., Davis M.G., Ali S., Dorn G.W. II
    J. Pharmacol. Exp. Ther. 271:1034-1041(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. NIEHS SNPs program
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  10. "Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation."
    Hirata T., Ushikubi F., Kakizuka A., Okuma M., Narumiya S.
    J. Clin. Invest. 97:949-956(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 329-343 (ISOFORMS 1 AND 2), FUNCTION, ALTERNATIVE SPLICING, CHARACTERIZATION OF VARIANT BDPLT13 LEU-60.
    Tissue: Platelet.
  11. "Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites."
    Funk C.D., Furci L., Moran N., Fitzgerald G.A.
    Mol. Pharmacol. 44:934-939(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  12. "Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes."
    Sasaki M., Sukegawa J., Miyosawa K., Yanagisawa T., Ohkubo S., Nakahata N.
    Prostaglandins Other Lipid Mediat. 83:237-249(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSMA3.
  13. "RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)."
    Parent A., Laroche G., Hamelin E., Parent J.L.
    Traffic 9:394-407(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GNB2L1.
  14. "Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor."
    Tokue S., Sasaki M., Nakahata N.
    Prostaglandins Other Lipid Mediat. 89:8-15(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RPGRIP1L.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder."
    Hirata T., Kakizuka A., Ushikubi F., Fuse I., Okuma M., Narumiya S.
    J. Clin. Invest. 94:1662-1667(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BDPLT13 LEU-60, CHARACTERIZATION OF VARIANT BDPLT13 LEU-60.

Entry informationi

Entry nameiTA2R_HUMAN
AccessioniPrimary (citable) accession number: P21731
Secondary accession number(s): O75228
, Q6DK52, Q9UCY1, Q9UCY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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