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Protein

Thromboxane A2 receptor

Gene

TBXA2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.1 Publication

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: Reactome
  • thromboxane A2 receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006638-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-428930. Thromboxane signalling through TP receptor.
SignaLinkiP21731.
SIGNORiP21731.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:TBXA2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11608. TBXA2R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 52Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini53 – 66CytoplasmicSequence analysisAdd BLAST14
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 106ExtracellularSequence analysisAdd BLAST19
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 149CytoplasmicSequence analysisAdd BLAST21
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 193ExtracellularSequence analysisAdd BLAST21
Transmembranei194 – 219Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini220 – 246CytoplasmicSequence analysisAdd BLAST27
Transmembranei247 – 270Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini271 – 289ExtracellularSequence analysisAdd BLAST19
Transmembranei290 – 311Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini312 – 343CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Bleeding disorder, platelet-type 13 (BDPLT13)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
See also OMIM:614009
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00351560R → L in BDPLT13; does not affect TXA2 binding; defective interaction with G proteins; impairs phospholipase C and adenylyl cyclase activation; isoform 1; has no effect on adenylyl cyclase inhibition; isoform 2. 2 PublicationsCorresponds to variant rs34377097dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi291L → R: Suppresses antagonist binding. 1 Publication1
Mutagenesisi295R → Q: Reduces antagonist binding. 1 Publication1
Mutagenesisi299W → L: Reduces antagonist binding. 1 Publication1
Mutagenesisi299W → R: Reduces antagonist binding. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6915.
MalaCardsiTBXA2R.
MIMi614009. phenotype.
OpenTargetsiENSG00000006638.
Orphaneti220443. Bleeding diathesis due to thromboxane synthesis deficiency.
PharmGKBiPA348.

Chemistry databases

ChEMBLiCHEMBL2069.
DrugBankiDB01207. Ridogrel.
GuidetoPHARMACOLOGYi346.

Polymorphism and mutation databases

BioMutaiTBXA2R.
DMDMi229463010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701381 – 343Thromboxane A2 receptorAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)1
Glycosylationi16N-linked (GlcNAc...)1
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Modified residuei329PhosphoserineCombined sources1
Modified residuei331PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21731.
PeptideAtlasiP21731.
PRIDEiP21731.

PTM databases

iPTMnetiP21731.
PhosphoSitePlusiP21731.
SwissPalmiP21731.

Expressioni

Gene expression databases

BgeeiENSG00000006638.
CleanExiHS_TBXA2R.
ExpressionAtlasiP21731. baseline and differential.
GenevisibleiP21731. HS.

Organism-specific databases

HPAiCAB017631.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131623EBI-2625082,EBI-2211957

Protein-protein interaction databases

BioGridi112777. 35 interactors.
DIPiDIP-41465N.
IntActiP21731. 4 interactors.
MINTiMINT-1512445.
STRINGi9606.ENSP00000393333.

Chemistry databases

BindingDBiP21731.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LBNmodel-A100-265[»]
ProteinModelPortaliP21731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP21731.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG091G0DNT.
PhylomeDBiP21731.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21731-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA
60 70 80 90 100
GARQGGSHTR SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP
110 120 130 140 150
GCRLCRFMGV VMIFFGLSPL LLGAAMASER YLGITRPFSR PAVASQRRAW
160 170 180 190 200
ATVGLVWAAA LALGLLPLLG VGRYTVQYPG SWCFLTLGAE SGDVAFGLLF
210 220 230 240 250
SMLGGLSVGL SFLLNTVSVA TLCHVYHGQE AAQQRPRDSE VEMMAQLLGI
260 270 280 290 300
MVVASVCWLP LLVFIAQTVL RNPPAMSPAG QLSRTTEKEL LIYLRVATWN
310 320 330 340
QILDPWVYIL FRRAVLRRLQ PRLSTRPRSL SLQPQLTQRS GLQ
Length:343
Mass (Da):37,431
Last modified:May 5, 2009 - v3
Checksum:i114A7C3F3F0D35F1
GO
Isoform 2 (identifier: P21731-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     329-343: SLSLQPQLTQRSGLQ → RSLTLWPSLE...PTGKALSRKD

Show »
Length:407
Mass (Da):44,205
Checksum:i461D60349704E7AB
GO

Sequence cautioni

The sequence AAA58957 differs from that shown. Reason: Frameshift at position 329.Curated
Isoform 2 : The sequence AAA58957 differs from that shown. Reason: Frameshift at positions 330 and 386.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263V → W AA sequence (PubMed:1825698).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00351560R → L in BDPLT13; does not affect TXA2 binding; defective interaction with G proteins; impairs phospholipase C and adenylyl cyclase activation; isoform 1; has no effect on adenylyl cyclase inhibition; isoform 2. 2 PublicationsCorresponds to variant rs34377097dbSNPEnsembl.1
Natural variantiVAR_01468868C → S.Corresponds to variant rs5743dbSNPEnsembl.1
Natural variantiVAR_01468980V → E.Corresponds to variant rs5744dbSNPEnsembl.1
Natural variantiVAR_01469094E → V.Corresponds to variant rs5746dbSNPEnsembl.1
Natural variantiVAR_014691160A → T.Corresponds to variant rs5749dbSNPEnsembl.1
Natural variantiVAR_014692176V → E.Corresponds to variant rs5750dbSNPEnsembl.1
Natural variantiVAR_014693217V → I.Corresponds to variant rs5751dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001925329 – 343SLSLQ…RSGLQ → RSLTLWPSLEYSGTISAHCN LRLPGSSDSRASASRAAGIT GVSHCARPCMLFDPEFDLLA GVQLLPFEPPTGKALSRKD in isoform 2. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38081 mRNA. Translation: BAA07274.1.
D15056 Genomic DNA. Translation: BAA03649.1.
U11271 mRNA. Translation: AAA58957.1. Frameshift.
U27325 mRNA. Translation: AAA68608.1.
AY429110 mRNA. Translation: AAR07905.1.
DQ268653 Genomic DNA. Translation: ABB72549.1.
AC005175 Genomic DNA. Translation: AAC24302.1.
AC005175 Genomic DNA. Translation: AAC24303.1.
CH471139 Genomic DNA. Translation: EAW69301.1.
BC074749 mRNA. Translation: AAH74749.1.
BC074750 mRNA. Translation: AAH74750.1.
CCDSiCCDS42467.1. [P21731-3]
CCDS54198.1. [P21731-2]
PIRiA49117.
A53959.
A56194.
T02670.
RefSeqiNP_001051.1. NM_001060.5. [P21731-3]
NP_963998.2. NM_201636.2. [P21731-2]
XP_011526516.1. XM_011528214.2. [P21731-3]
UniGeneiHs.442530.

Genome annotation databases

EnsembliENST00000375190; ENSP00000364336; ENSG00000006638. [P21731-3]
ENST00000411851; ENSP00000393333; ENSG00000006638. [P21731-2]
GeneIDi6915.
KEGGihsa:6915.
UCSCiuc002lyg.3. human. [P21731-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38081 mRNA. Translation: BAA07274.1.
D15056 Genomic DNA. Translation: BAA03649.1.
U11271 mRNA. Translation: AAA58957.1. Frameshift.
U27325 mRNA. Translation: AAA68608.1.
AY429110 mRNA. Translation: AAR07905.1.
DQ268653 Genomic DNA. Translation: ABB72549.1.
AC005175 Genomic DNA. Translation: AAC24302.1.
AC005175 Genomic DNA. Translation: AAC24303.1.
CH471139 Genomic DNA. Translation: EAW69301.1.
BC074749 mRNA. Translation: AAH74749.1.
BC074750 mRNA. Translation: AAH74750.1.
CCDSiCCDS42467.1. [P21731-3]
CCDS54198.1. [P21731-2]
PIRiA49117.
A53959.
A56194.
T02670.
RefSeqiNP_001051.1. NM_001060.5. [P21731-3]
NP_963998.2. NM_201636.2. [P21731-2]
XP_011526516.1. XM_011528214.2. [P21731-3]
UniGeneiHs.442530.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LBNmodel-A100-265[»]
ProteinModelPortaliP21731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112777. 35 interactors.
DIPiDIP-41465N.
IntActiP21731. 4 interactors.
MINTiMINT-1512445.
STRINGi9606.ENSP00000393333.

Chemistry databases

BindingDBiP21731.
ChEMBLiCHEMBL2069.
DrugBankiDB01207. Ridogrel.
GuidetoPHARMACOLOGYi346.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21731.
PhosphoSitePlusiP21731.
SwissPalmiP21731.

Polymorphism and mutation databases

BioMutaiTBXA2R.
DMDMi229463010.

Proteomic databases

PaxDbiP21731.
PeptideAtlasiP21731.
PRIDEiP21731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375190; ENSP00000364336; ENSG00000006638. [P21731-3]
ENST00000411851; ENSP00000393333; ENSG00000006638. [P21731-2]
GeneIDi6915.
KEGGihsa:6915.
UCSCiuc002lyg.3. human. [P21731-3]

Organism-specific databases

CTDi6915.
DisGeNETi6915.
GeneCardsiTBXA2R.
H-InvDBHIX0202922.
HGNCiHGNC:11608. TBXA2R.
HPAiCAB017631.
MalaCardsiTBXA2R.
MIMi188070. gene.
614009. phenotype.
neXtProtiNX_P21731.
OpenTargetsiENSG00000006638.
Orphaneti220443. Bleeding diathesis due to thromboxane synthesis deficiency.
PharmGKBiPA348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP21731.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG091G0DNT.
PhylomeDBiP21731.
TreeFamiTF324982.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006638-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-428930. Thromboxane signalling through TP receptor.
SignaLinkiP21731.
SIGNORiP21731.

Miscellaneous databases

ChiTaRSiTBXA2R. human.
GeneWikiiThromboxane_receptor.
GenomeRNAii6915.
PROiP21731.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006638.
CleanExiHS_TBXA2R.
ExpressionAtlasiP21731. baseline and differential.
GenevisibleiP21731. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R_HUMAN
AccessioniPrimary (citable) accession number: P21731
Secondary accession number(s): O75228
, Q6DK52, Q9UCY1, Q9UCY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 178 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.