C5a anaphylatoxin chemotactic receptor

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Reviewed, UniProtKB/Swiss-Prot P21730 (C5AR_HUMAN)

Last modified July 7, 2009. Version 95. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    C5a anaphylatoxin chemotactic receptor
      Short name=C5a-R
      Short name=C5aR
Alternative name(s):
    CD_antigen=CD88

Gene names

Name:	C5AR1
Synonyms:	C5AR, C5R1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein Sulfation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW activation of MAPK activity Traceable author statement. Source: ProtInc activation of phospholipase C activity Traceable author statement. Source: ProtInc cellular defense response Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement. Source: ProtInc immune response Traceable author statement. Source: ProtInc sensory perception of chemical stimulus Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	C5a anaphylatoxin receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 350

350

C5a anaphylatoxin chemotactic receptor

PRO_0000069209

Regions

Topological domain

1 – 37

Extracellular Potential

Transmembrane

38 – 60

1 Potential

Topological domain

61 – 71

Cytoplasmic Potential

Transmembrane

72 – 94

2 Potential

Topological domain

95 – 110

Extracellular Potential

Transmembrane

111 – 132

3 Potential

Topological domain

133 – 153

Cytoplasmic Potential

Transmembrane

154 – 174

4 Potential

Topological domain

175 – 200

Extracellular Potential

Transmembrane

201 – 226

5 Potential

Topological domain

227 – 242

Cytoplasmic Potential

Transmembrane

243 – 265

6 Potential

Topological domain

266 – 282

Extracellular Potential

Transmembrane

283 – 303

7 Potential

Topological domain

304 – 350

Cytoplasmic Potential

Amino acid modifications

Modified residue

Sulfotyrosine

Modified residue

Sulfotyrosine

Modified residue

314

Phosphoserine Probable

Modified residue

317

Phosphoserine Probable

Modified residue

327

Phosphoserine Probable

Modified residue

332

Phosphoserine Probable

Modified residue

334

Phosphoserine Probable

Modified residue

338

Phosphoserine Probable

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

109 ↔ 188

By similarity

Natural variations

Natural variant

N → D: dbSNP rs4467185.

VAR_049377

Natural variant

279

N → K: dbSNP rs11880097.

VAR_049378

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Sequences

Sequence

Length

Mass (Da)

Tools

P21730-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: DD1D0D71D327CDD0
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FASTA

350

39,321

        10         20         30         40         50         60 
MNSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW 

        70         80         90        100        110        120 
VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM 

       130        140        150        160        170        180 
YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE 

       190        200        210        220        230        240 
YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT 

       250        260        270        280        290        300 
LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLNK LDSLCVSFAY INCCINPIIY 

       310        320        330        340        350 
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells." Boulay F., Mery L., Tardif M., Brouchon L., Vignais P. Biochemistry 30:2993-2999(1991) [PubMed: 2007135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The chemotactic receptor for human C5a anaphylatoxin." Gerard N.P., Gerard C. Nature 349:614-617(1991) [PubMed: 1847994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ASP-2 AND LYS-279.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene." Gerard N.P., Bao L., Xiao-Ping H., Eddy R.L. Jr., Shows T.B., Gerard C. Biochemistry 32:1243-1250(1993) [PubMed: 8383526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3.
[8]	"Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo." Giannini E., Brouchon L., Boulay F. J. Biol. Chem. 270:19166-19172(1995) [PubMed: 7642584] [Abstract] Cited for: PHOSPHORYLATION AT SER-314; SER-317; SER-327; SER-332; SER-334 AND SER-338.
[9]	"Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor." Farzan M., Schnitzler C.E., Vasilieva N., Leung D., Kuhn J., Gerard C., Gerard N.P., Choe H. J. Exp. Med. 193:1059-1066(2001) [PubMed: 11342590] [Abstract] Cited for: SULFATION AT TYR-11 AND TYR-14.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X57250 mRNA. Translation: CAA40530.1. X58674 Genomic DNA. Translation: CAB37830.1. M62505 mRNA. Translation: AAA62831.1. AY221091 Genomic DNA. Translation: AAO65969.1. BT007358 mRNA. Translation: AAP36022.1. AC099491 Genomic DNA. No translation available. BC008982 mRNA. Translation: AAH08982.1. S56556, S56557 Genomic DNA. Translation: AAD14919.1.
IPI	IPI00010308.
PIR	A37963.
RefSeq	NP_001727.1.
UniGene	Hs.2161
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P21730.
Proteomic databases
PRIDE	P21730.
Genome annotation databases
Ensembl	ENSG00000197405. Homo sapiens. [Contig view]
GeneID	728.
KEGG	hsa:728.
UCSC	uc002pgj.1. human.
Organism-specific databases
GeneCards	GC19P052505.
H-InvDB	HIX0015270.
HGNC	HGNC:1338. C5AR1.
HPA	CAB002720. HPA014520.
MIM	113995. gene.
Orphanet	101994. Complement regulatory proteins anomaly.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P21730.
HOVERGEN	P21730.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P21730.
Bgee	P21730.
CleanEx	HS_C5AR1.
GermOnline	ENSG00000197405. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR002234. Anphylx_rcpt. IPR001274. C5A_anaphtx_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01104. ANPHYLATOXNR. PR00426. C5ANPHYLTXNR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2964.
SOURCE	Search...

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Entry information

Entry name

C5AR_HUMAN

Accession

Primary (citable) accession number: P21730

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	July 7, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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