Reviewed,
UniProtKB/Swiss-Prot P21730 (C5AR_HUMAN)
Last modified
July 7, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: C5a anaphylatoxin chemotactic receptor Short name=C5a-R Short name=C5aR Alternative name(s): CD_antigen=CD88 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 350 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
| Subcellular location | |
| Post-translational modification | Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 350 | 350 | C5a anaphylatoxin chemotactic receptor | PRO_0000069209 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 37 | 37 | Extracellular Potential | ||||||||
| Transmembrane | 38 – 60 | 23 | 1 Potential | ||||||||
| Topological domain | 61 – 71 | 11 | Cytoplasmic Potential | ||||||||
| Transmembrane | 72 – 94 | 23 | 2 Potential | ||||||||
| Topological domain | 95 – 110 | 16 | Extracellular Potential | ||||||||
| Transmembrane | 111 – 132 | 22 | 3 Potential | ||||||||
| Topological domain | 133 – 153 | 21 | Cytoplasmic Potential | ||||||||
| Transmembrane | 154 – 174 | 21 | 4 Potential | ||||||||
| Topological domain | 175 – 200 | 26 | Extracellular Potential | ||||||||
| Transmembrane | 201 – 226 | 26 | 5 Potential | ||||||||
| Topological domain | 227 – 242 | 16 | Cytoplasmic Potential | ||||||||
| Transmembrane | 243 – 265 | 23 | 6 Potential | ||||||||
| Topological domain | 266 – 282 | 17 | Extracellular Potential | ||||||||
| Transmembrane | 283 – 303 | 21 | 7 Potential | ||||||||
| Topological domain | 304 – 350 | 47 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 11 | 1 | Sulfotyrosine | ||||||||
| Modified residue | 14 | 1 | Sulfotyrosine | ||||||||
| Modified residue | 314 | 1 | Phosphoserine Probable | ||||||||
| Modified residue | 317 | 1 | Phosphoserine Probable | ||||||||
| Modified residue | 327 | 1 | Phosphoserine Probable | ||||||||
| Modified residue | 332 | 1 | Phosphoserine Probable | ||||||||
| Modified residue | 334 | 1 | Phosphoserine Probable | ||||||||
| Modified residue | 338 | 1 | Phosphoserine Probable | ||||||||
| Glycosylation | 5 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 109 ↔ 188 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 2 | 1 | N → D: dbSNP rs4467185. | VAR_049377 | |||||||
| Natural variant | 279 | 1 | N → K: dbSNP rs11880097. | VAR_049378 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells." Boulay F., Mery L., Tardif M., Brouchon L., Vignais P. Biochemistry 30:2993-2999(1991) [PubMed: 2007135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The chemotactic receptor for human C5a anaphylatoxin." Gerard N.P., Gerard C. Nature 349:614-617(1991) [PubMed: 1847994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [3] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ASP-2 AND LYS-279. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [7] | "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene." Gerard N.P., Bao L., Xiao-Ping H., Eddy R.L. Jr., Shows T.B., Gerard C. Biochemistry 32:1243-1250(1993) [PubMed: 8383526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3. |
| [8] | "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo." Giannini E., Brouchon L., Boulay F. J. Biol. Chem. 270:19166-19172(1995) [PubMed: 7642584] [Abstract] Cited for: PHOSPHORYLATION AT SER-314; SER-317; SER-327; SER-332; SER-334 AND SER-338. |
| [9] | "Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor." Farzan M., Schnitzler C.E., Vasilieva N., Leung D., Kuhn J., Gerard C., Gerard N.P., Choe H. J. Exp. Med. 193:1059-1066(2001) [PubMed: 11342590] [Abstract] Cited for: SULFATION AT TYR-11 AND TYR-14. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X57250 mRNA. Translation: CAA40530.1. X58674 Genomic DNA. Translation: CAB37830.1. M62505 mRNA. Translation: AAA62831.1. AY221091 Genomic DNA. Translation: AAO65969.1. BT007358 mRNA. Translation: AAP36022.1. AC099491 Genomic DNA. No translation available. BC008982 mRNA. Translation: AAH08982.1. S56556, S56557 Genomic DNA. Translation: AAD14919.1. | |
| IPI | IPI00010308. |
| PIR | A37963. |
| RefSeq | NP_001727.1. |
| UniGene | Hs.2161 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | P21730. |
Proteomic databases | |
| PRIDE | P21730. |
Genome annotation databases | |
| Ensembl | ENSG00000197405. Homo sapiens. [Contig view] |
| GeneID | 728. |
| KEGG | hsa:728. |
| UCSC | uc002pgj.1. human. |
Organism-specific databases | |
| GeneCards | GC19P052505. |
| H-InvDB | HIX0015270. |
| HGNC | HGNC:1338. C5AR1. |
| HPA | CAB002720. HPA014520. |
| MIM | 113995. gene. |
| Orphanet | 101994. Complement regulatory proteins anomaly. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P21730. |
| HOVERGEN | P21730. |
Enzyme and pathway databases | |
| Reactome | REACT_14797. Signaling by GPCR. |
Gene expression databases | |
| ArrayExpress | P21730. |
| Bgee | P21730. |
| CleanEx | HS_C5AR1. |
| GermOnline | ENSG00000197405. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR002234. Anphylx_rcpt. IPR001274. C5A_anaphtx_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR01104. ANPHYLATOXNR. PR00426. C5ANPHYLTXNR. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 2964. |
| SOURCE | Search... |
Entry information
| Entry name | C5AR_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P21730 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


