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P21730

- C5AR1_HUMAN

UniProt

P21730 - C5AR1_HUMAN

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Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5AR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  1. C5a anaphylatoxin receptor activity Source: UniProtKB
  2. complement component C5a receptor activity Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: ProtInc
  2. activation of phospholipase C activity Source: ProtInc
  3. apoptotic process Source: Ensembl
  4. cell proliferation in hindbrain Source: Ensembl
  5. cellular defense response Source: ProtInc
  6. chemotaxis Source: ProtInc
  7. complement component C5a signaling pathway Source: GOC
  8. defense response to Gram-positive bacterium Source: Ensembl
  9. immune response Source: ProtInc
  10. inflammatory response Source: Ensembl
  11. mRNA transcription from RNA polymerase II promoter Source: UniProtKB
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. neutrophil chemotaxis Source: Ensembl
  14. organ regeneration Source: Ensembl
  15. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  16. positive regulation of epithelial cell proliferation Source: UniProtKB
  17. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  18. response to lipopolysaccharide Source: Ensembl
  19. response to peptidoglycan Source: Ensembl
  20. sensory perception of chemical stimulus Source: ProtInc
  21. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP21730.

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 1
Alternative name(s):
C5a anaphylatoxin chemotactic receptor
Short name:
C5a-R
Short name:
C5aR
CD_antigen: CD88
Gene namesi
Name:C5AR1
Synonyms:C5AR, C5R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1338. C5AR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei38 – 6023Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei72 – 9423Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 15321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 20026ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22626Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26523Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 35047CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. basolateral plasma membrane Source: UniProtKB
  3. cell surface Source: Ensembl
  4. integral component of plasma membrane Source: ProtInc
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350C5a anaphylatoxin chemotactic receptor 1PRO_0000069209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Modified residuei11 – 111Sulfotyrosine1 Publication
Modified residuei14 – 141Sulfotyrosine1 Publication
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation
Modified residuei314 – 3141Phosphoserine1 Publication
Modified residuei317 – 3171Phosphoserine1 Publication
Modified residuei327 – 3271Phosphoserine1 Publication
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei338 – 3381Phosphoserine1 Publication

Post-translational modificationi

Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP21730.
PRIDEiP21730.

PTM databases

PhosphoSiteiP21730.

Expressioni

Gene expression databases

BgeeiP21730.
CleanExiHS_C5AR1.
GenevestigatoriP21730.

Organism-specific databases

HPAiCAB002720.
HPA014520.

Interactioni

Subunit structurei

Interacts with ARRB1 and ARRB2.By similarity

Protein-protein interaction databases

BioGridi107189. 6 interactions.
IntActiP21730. 1 interaction.
STRINGi9606.ENSP00000347197.

Structurei

3D structure databases

ProteinModelPortaliP21730.
SMRiP21730. Positions 32-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151055.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiP21730.
KOiK04010.
OMAiYINCCIN.
PhylomeDBiP21730.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF28. PTHR24225:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21730-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV
60 70 80 90 100
GVLGNALVVW VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH
110 120 130 140 150
HWPFGGAACS ILPSLILLNM YASILLLATI SADRFLLVFK PIWCQNFRGA
160 170 180 190 200
GLAWIACAVA WGLALLLTIP SFLYRVVREE YFPPKVLCGV DYSHDKRRER
210 220 230 240 250
AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT LKVVVAVVAS
260 270 280 290 300
FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY
310 320 330 340 350
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV
Length:350
Mass (Da):39,336
Last modified:November 2, 2010 - v2
Checksum:i9334BB39A2C96D3D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21D → N.6 Publications
Corresponds to variant rs4467185 [ dbSNP | Ensembl ].
VAR_049377
Natural varianti279 – 2791K → N.5 Publications
Corresponds to variant rs11880097 [ dbSNP | Ensembl ].
VAR_049378

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62505 mRNA. Translation: AAA62831.1.
X57250 mRNA. Translation: CAA40530.1.
X58674 Genomic DNA. Translation: CAB37830.1.
AY221091 Genomic DNA. Translation: AAO65969.1.
BT007358 mRNA. Translation: AAP36022.1.
AC099491 Genomic DNA. No translation available.
BC008982 mRNA. Translation: AAH08982.1.
S56556, S56557 Genomic DNA. Translation: AAD14919.1.
CCDSiCCDS33063.1.
PIRiA37963.
RefSeqiNP_001727.1. NM_001736.3.
UniGeneiHs.2161.

Genome annotation databases

EnsembliENST00000355085; ENSP00000347197; ENSG00000197405.
GeneIDi728.
KEGGihsa:728.
UCSCiuc002pgj.1. human.

Polymorphism databases

DMDMi311033355.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62505 mRNA. Translation: AAA62831.1 .
X57250 mRNA. Translation: CAA40530.1 .
X58674 Genomic DNA. Translation: CAB37830.1 .
AY221091 Genomic DNA. Translation: AAO65969.1 .
BT007358 mRNA. Translation: AAP36022.1 .
AC099491 Genomic DNA. No translation available.
BC008982 mRNA. Translation: AAH08982.1 .
S56556 , S56557 Genomic DNA. Translation: AAD14919.1 .
CCDSi CCDS33063.1.
PIRi A37963.
RefSeqi NP_001727.1. NM_001736.3.
UniGenei Hs.2161.

3D structure databases

ProteinModelPortali P21730.
SMRi P21730. Positions 32-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107189. 6 interactions.
IntActi P21730. 1 interaction.
STRINGi 9606.ENSP00000347197.

Chemistry

BindingDBi P21730.
ChEMBLi CHEMBL2373.
GuidetoPHARMACOLOGYi 32.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21730.

Polymorphism databases

DMDMi 311033355.

Proteomic databases

PaxDbi P21730.
PRIDEi P21730.

Protocols and materials databases

DNASUi 728.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355085 ; ENSP00000347197 ; ENSG00000197405 .
GeneIDi 728.
KEGGi hsa:728.
UCSCi uc002pgj.1. human.

Organism-specific databases

CTDi 728.
GeneCardsi GC19P047813.
HGNCi HGNC:1338. C5AR1.
HPAi CAB002720.
HPA014520.
MIMi 113995. gene.
neXtProti NX_P21730.
PharmGKBi PA25920.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151055.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
HOVERGENi HBG107547.
InParanoidi P21730.
KOi K04010.
OMAi YINCCIN.
PhylomeDBi P21730.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P21730.

Miscellaneous databases

ChiTaRSi C5AR1. human.
GeneWikii C5a_receptor.
GenomeRNAii 728.
NextBioi 2964.
PROi P21730.
SOURCEi Search...

Gene expression databases

Bgeei P21730.
CleanExi HS_C5AR1.
Genevestigatori P21730.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF28. PTHR24225:SF28. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01104. ANPHYLATOXNR.
PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells."
    Boulay F., Mery L., Tardif M., Brouchon L., Vignais P.
    Biochemistry 30:2993-2999(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND ASN-279.
  2. "The chemotactic receptor for human C5a anaphylatoxin."
    Gerard N.P., Gerard C.
    Nature 349:614-617(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ASN-2 AND ASN-279.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
    Tissue: Brain.
  7. "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene."
    Gerard N.P., Bao L., Xiao-Ping H., Eddy R.L. Jr., Shows T.B., Gerard C.
    Biochemistry 32:1243-1250(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3, VARIANT ASN-2.
  8. "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo."
    Giannini E., Brouchon L., Boulay F.
    J. Biol. Chem. 270:19166-19172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-314; SER-317; SER-327; SER-332; SER-334 AND SER-338.
  9. "Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor."
    Farzan M., Schnitzler C.E., Vasilieva N., Leung D., Kuhn J., Gerard C., Gerard N.P., Choe H.
    J. Exp. Med. 193:1059-1066(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SULFATION AT TYR-11 AND TYR-14.

Entry informationi

Entry nameiC5AR1_HUMAN
AccessioniPrimary (citable) accession number: P21730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3