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P21730

- C5AR1_HUMAN

UniProt

P21730 - C5AR1_HUMAN

Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5AR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

    GO - Molecular functioni

    1. C5a anaphylatoxin receptor activity Source: UniProtKB
    2. complement component C5a receptor activity Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: ProtInc
    2. activation of phospholipase C activity Source: ProtInc
    3. apoptotic process Source: Ensembl
    4. cell proliferation in hindbrain Source: Ensembl
    5. cellular defense response Source: ProtInc
    6. chemotaxis Source: ProtInc
    7. complement component C5a signaling pathway Source: GOC
    8. defense response to Gram-positive bacterium Source: Ensembl
    9. immune response Source: ProtInc
    10. inflammatory response Source: Ensembl
    11. mRNA transcription from RNA polymerase II promoter Source: UniProtKB
    12. negative regulation of neuron apoptotic process Source: Ensembl
    13. neutrophil chemotaxis Source: Ensembl
    14. organ regeneration Source: Ensembl
    15. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    16. positive regulation of epithelial cell proliferation Source: UniProtKB
    17. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    18. response to lipopolysaccharide Source: Ensembl
    19. response to peptidoglycan Source: Ensembl
    20. sensory perception of chemical stimulus Source: ProtInc
    21. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP21730.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 1
    Alternative name(s):
    C5a anaphylatoxin chemotactic receptor
    Short name:
    C5a-R
    Short name:
    C5aR
    CD_antigen: CD88
    Gene namesi
    Name:C5AR1
    Synonyms:C5AR, C5R1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1338. C5AR1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: UniProtKB
    2. basolateral plasma membrane Source: UniProtKB
    3. cell surface Source: Ensembl
    4. integral component of plasma membrane Source: ProtInc
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25920.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350C5a anaphylatoxin chemotactic receptor 1PRO_0000069209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Modified residuei11 – 111Sulfotyrosine1 Publication
    Modified residuei14 – 141Sulfotyrosine1 Publication
    Disulfide bondi109 ↔ 188PROSITE-ProRule annotation
    Modified residuei314 – 3141Phosphoserine1 Publication
    Modified residuei317 – 3171Phosphoserine1 Publication
    Modified residuei327 – 3271Phosphoserine1 Publication
    Modified residuei332 – 3321Phosphoserine1 Publication
    Modified residuei334 – 3341Phosphoserine1 Publication
    Modified residuei338 – 3381Phosphoserine1 Publication

    Post-translational modificationi

    Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

    Proteomic databases

    PaxDbiP21730.
    PRIDEiP21730.

    PTM databases

    PhosphoSiteiP21730.

    Expressioni

    Gene expression databases

    BgeeiP21730.
    CleanExiHS_C5AR1.
    GenevestigatoriP21730.

    Organism-specific databases

    HPAiCAB002720.
    HPA014520.

    Interactioni

    Subunit structurei

    Interacts with ARRB1 and ARRB2.By similarity

    Protein-protein interaction databases

    BioGridi107189. 6 interactions.
    IntActiP21730. 1 interaction.
    STRINGi9606.ENSP00000347197.

    Structurei

    3D structure databases

    ProteinModelPortaliP21730.
    SMRiP21730. Positions 32-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 11016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 20026ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 35047CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6023Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9423Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22626Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26523Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151055.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107547.
    InParanoidiP21730.
    KOiK04010.
    OMAiYINCCIN.
    PhylomeDBiP21730.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF28. PTHR24225:SF28. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01104. ANPHYLATOXNR.
    PR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21730-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV    50
    GVLGNALVVW VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH 100
    HWPFGGAACS ILPSLILLNM YASILLLATI SADRFLLVFK PIWCQNFRGA 150
    GLAWIACAVA WGLALLLTIP SFLYRVVREE YFPPKVLCGV DYSHDKRRER 200
    AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT LKVVVAVVAS 250
    FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY 300
    VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV 350
    Length:350
    Mass (Da):39,336
    Last modified:November 2, 2010 - v2
    Checksum:i9334BB39A2C96D3D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21D → N.6 Publications
    Corresponds to variant rs4467185 [ dbSNP | Ensembl ].
    VAR_049377
    Natural varianti279 – 2791K → N.5 Publications
    Corresponds to variant rs11880097 [ dbSNP | Ensembl ].
    VAR_049378

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62505 mRNA. Translation: AAA62831.1.
    X57250 mRNA. Translation: CAA40530.1.
    X58674 Genomic DNA. Translation: CAB37830.1.
    AY221091 Genomic DNA. Translation: AAO65969.1.
    BT007358 mRNA. Translation: AAP36022.1.
    AC099491 Genomic DNA. No translation available.
    BC008982 mRNA. Translation: AAH08982.1.
    S56556, S56557 Genomic DNA. Translation: AAD14919.1.
    CCDSiCCDS33063.1.
    PIRiA37963.
    RefSeqiNP_001727.1. NM_001736.3.
    UniGeneiHs.2161.

    Genome annotation databases

    EnsembliENST00000355085; ENSP00000347197; ENSG00000197405.
    GeneIDi728.
    KEGGihsa:728.
    UCSCiuc002pgj.1. human.

    Polymorphism databases

    DMDMi311033355.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62505 mRNA. Translation: AAA62831.1 .
    X57250 mRNA. Translation: CAA40530.1 .
    X58674 Genomic DNA. Translation: CAB37830.1 .
    AY221091 Genomic DNA. Translation: AAO65969.1 .
    BT007358 mRNA. Translation: AAP36022.1 .
    AC099491 Genomic DNA. No translation available.
    BC008982 mRNA. Translation: AAH08982.1 .
    S56556 , S56557 Genomic DNA. Translation: AAD14919.1 .
    CCDSi CCDS33063.1.
    PIRi A37963.
    RefSeqi NP_001727.1. NM_001736.3.
    UniGenei Hs.2161.

    3D structure databases

    ProteinModelPortali P21730.
    SMRi P21730. Positions 32-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107189. 6 interactions.
    IntActi P21730. 1 interaction.
    STRINGi 9606.ENSP00000347197.

    Chemistry

    BindingDBi P21730.
    ChEMBLi CHEMBL2373.
    GuidetoPHARMACOLOGYi 32.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21730.

    Polymorphism databases

    DMDMi 311033355.

    Proteomic databases

    PaxDbi P21730.
    PRIDEi P21730.

    Protocols and materials databases

    DNASUi 728.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355085 ; ENSP00000347197 ; ENSG00000197405 .
    GeneIDi 728.
    KEGGi hsa:728.
    UCSCi uc002pgj.1. human.

    Organism-specific databases

    CTDi 728.
    GeneCardsi GC19P047813.
    HGNCi HGNC:1338. C5AR1.
    HPAi CAB002720.
    HPA014520.
    MIMi 113995. gene.
    neXtProti NX_P21730.
    PharmGKBi PA25920.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151055.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107547.
    InParanoidi P21730.
    KOi K04010.
    OMAi YINCCIN.
    PhylomeDBi P21730.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P21730.

    Miscellaneous databases

    ChiTaRSi C5AR1. human.
    GeneWikii C5a_receptor.
    GenomeRNAii 728.
    NextBioi 2964.
    PROi P21730.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21730.
    CleanExi HS_C5AR1.
    Genevestigatori P21730.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF28. PTHR24225:SF28. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01104. ANPHYLATOXNR.
    PR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells."
      Boulay F., Mery L., Tardif M., Brouchon L., Vignais P.
      Biochemistry 30:2993-2999(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND ASN-279.
    2. "The chemotactic receptor for human C5a anaphylatoxin."
      Gerard N.P., Gerard C.
      Nature 349:614-617(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ASN-2 AND ASN-279.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-2 AND ASN-279.
      Tissue: Brain.
    7. "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene."
      Gerard N.P., Bao L., Xiao-Ping H., Eddy R.L. Jr., Shows T.B., Gerard C.
      Biochemistry 32:1243-1250(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3, VARIANT ASN-2.
    8. "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo."
      Giannini E., Brouchon L., Boulay F.
      J. Biol. Chem. 270:19166-19172(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-314; SER-317; SER-327; SER-332; SER-334 AND SER-338.
    9. "Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor."
      Farzan M., Schnitzler C.E., Vasilieva N., Leung D., Kuhn J., Gerard C., Gerard N.P., Choe H.
      J. Exp. Med. 193:1059-1066(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SULFATION AT TYR-11 AND TYR-14.

    Entry informationi

    Entry nameiC5AR1_HUMAN
    AccessioniPrimary (citable) accession number: P21730
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3