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P21729

- GRPR_MOUSE

UniProt

P21729 - GRPR_MOUSE

Protein

Gastrin-releasing peptide receptor

Gene

Grpr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. bombesin receptor activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of cell proliferation Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin-releasing peptide receptor
    Short name:
    GRP-R
    Alternative name(s):
    GRP-preferring bombesin receptor
    Gene namesi
    Name:Grpr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:95836. Grpr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Gastrin-releasing peptide receptorPRO_0000069663Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 197PROSITE-ProRule annotation
    Lipidationi340 – 3401S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP21729.

    PTM databases

    PhosphoSiteiP21729.

    Expressioni

    Tissue specificityi

    Brain (hypothalamus), pancreatic acinar cells, and fibroblasts.

    Gene expression databases

    BgeeiP21729.
    CleanExiMM_GRPR.
    GenevestigatoriP21729.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Oprm1P42866-94EBI-6049651,EBI-6049667

    Protein-protein interaction databases

    IntActiP21729. 1 interaction.
    STRINGi10090.ENSMUSP00000033730.

    Structurei

    3D structure databases

    ProteinModelPortaliP21729.
    SMRiP21729. Positions 11-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 26530CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 38458CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6324Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9720Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17522Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei210 – 23526Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32627Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328649.
    HOGENOMiHOG000230781.
    HOVERGENiHBG004898.
    InParanoidiP21729.
    KOiK04169.
    OMAiCNISNHS.
    OrthoDBiEOG73V6KG.
    PhylomeDBiP21729.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001556. Bombsn_rcpt.
    IPR001966. Gastrin_pep_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00358. BOMBESINR.
    PR00640. GASTRINRELPR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21729-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPNNCSHLN LDVDPFLSCN DTFNQSLSPP KMDNWFHPGF IYVIPAVYGL    50
    IIVIGLIGNI TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS 100
    KYLADRWLFG RIGCKLIPFI QLTSVGVSVF TLTALSADRY KAIVRPMDIQ 150
    ASHALMKICL KAALIWIVSM LLAIPEAVFS DLHPFHVKDT NQTFISCAPY 200
    PHSNELHPKI HSMASFLVFY VIPLAIISVY YYFIARNLIQ SAYNLPVEGN 250
    IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML 300
    HFVTSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPGLMNRSH 350
    STGRSTTCMT SFKSTNPSAT FSLINRNICH EGYV 384
    Length:384
    Mass (Da):43,215
    Last modified:August 1, 1991 - v2
    Checksum:iBF6D60387AA09A2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti309 – 3091R → H(PubMed:1707129)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57922 mRNA. Translation: AAA75650.1.
    M61000 mRNA. Translation: AAA37744.1.
    CCDSiCCDS30512.1.
    PIRiA39003.
    RefSeqiNP_032203.1. NM_008177.2.
    UniGeneiMm.4687.

    Genome annotation databases

    EnsembliENSMUST00000033730; ENSMUSP00000033730; ENSMUSG00000031364.
    GeneIDi14829.
    KEGGimmu:14829.
    UCSCiuc009uuu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57922 mRNA. Translation: AAA75650.1 .
    M61000 mRNA. Translation: AAA37744.1 .
    CCDSi CCDS30512.1.
    PIRi A39003.
    RefSeqi NP_032203.1. NM_008177.2.
    UniGenei Mm.4687.

    3D structure databases

    ProteinModelPortali P21729.
    SMRi P21729. Positions 11-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21729. 1 interaction.
    STRINGi 10090.ENSMUSP00000033730.

    Chemistry

    BindingDBi P21729.
    ChEMBLi CHEMBL3596.
    GuidetoPHARMACOLOGYi 39.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21729.

    Proteomic databases

    PRIDEi P21729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033730 ; ENSMUSP00000033730 ; ENSMUSG00000031364 .
    GeneIDi 14829.
    KEGGi mmu:14829.
    UCSCi uc009uuu.1. mouse.

    Organism-specific databases

    CTDi 2925.
    MGIi MGI:95836. Grpr.

    Phylogenomic databases

    eggNOGi NOG328649.
    HOGENOMi HOG000230781.
    HOVERGENi HBG004898.
    InParanoidi P21729.
    KOi K04169.
    OMAi CNISNHS.
    OrthoDBi EOG73V6KG.
    PhylomeDBi P21729.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 287043.
    PROi P21729.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21729.
    CleanExi MM_GRPR.
    Genevestigatori P21729.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001556. Bombsn_rcpt.
    IPR001966. Gastrin_pep_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00358. BOMBESINR.
    PR00640. GASTRINRELPR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells."
      Battey J.F., Way J.M., Corjay M.H., Shapira H., Kusano K., Harkins R., Wu J.M., Slattery T., Mann E., Feldman R.I.
      Proc. Natl. Acad. Sci. U.S.A. 88:395-399(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Swiss.
      Tissue: Fibroblast.
    2. "Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor."
      Spindel E.R., Giladi E., Brehm P., Goodman R.H., Segerson T.P.
      Mol. Endocrinol. 4:1956-1963(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
      Tissue: Fibroblast.
    3. "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides."
      Giladi E., Nagalla S.R., Spindel E.R.
      J. Mol. Neurosci. 4:41-54(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGRPR_MOUSE
    AccessioniPrimary (citable) accession number: P21729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3