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Protein

Gastrin-releasing peptide receptor

Gene

Grpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • bombesin receptor activity Source: MGI

GO - Biological processi

  • regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:Grpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:95836. Grpr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 63Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 175Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini176 – 209ExtracellularSequence analysisAdd BLAST34
Transmembranei210 – 235Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini236 – 265CytoplasmicSequence analysisAdd BLAST30
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 326Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini327 – 384CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3596.
GuidetoPHARMACOLOGYi39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696631 – 384Gastrin-releasing peptide receptorAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 197PROSITE-ProRule annotation
Lipidationi340S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21729.
PRIDEiP21729.

PTM databases

PhosphoSitePlusiP21729.

Expressioni

Tissue specificityi

Brain (hypothalamus), pancreatic acinar cells, and fibroblasts.

Gene expression databases

BgeeiENSMUSG00000031364.
CleanExiMM_GRPR.
ExpressionAtlasiP21729. baseline and differential.
GenevisibleiP21729. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Oprm1P42866-94EBI-6049651,EBI-6049667

Protein-protein interaction databases

IntActiP21729. 1 interactor.
STRINGi10090.ENSMUSP00000033730.

Chemistry databases

BindingDBiP21729.

Structurei

3D structure databases

ProteinModelPortaliP21729.
SMRiP21729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP21729.
KOiK04169.
OMAiHFIASIC.
OrthoDBiEOG091G085Y.
PhylomeDBiP21729.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNNCSHLN LDVDPFLSCN DTFNQSLSPP KMDNWFHPGF IYVIPAVYGL
60 70 80 90 100
IIVIGLIGNI TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS
110 120 130 140 150
KYLADRWLFG RIGCKLIPFI QLTSVGVSVF TLTALSADRY KAIVRPMDIQ
160 170 180 190 200
ASHALMKICL KAALIWIVSM LLAIPEAVFS DLHPFHVKDT NQTFISCAPY
210 220 230 240 250
PHSNELHPKI HSMASFLVFY VIPLAIISVY YYFIARNLIQ SAYNLPVEGN
260 270 280 290 300
IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML
310 320 330 340 350
HFVTSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPGLMNRSH
360 370 380
STGRSTTCMT SFKSTNPSAT FSLINRNICH EGYV
Length:384
Mass (Da):43,215
Last modified:August 1, 1991 - v2
Checksum:iBF6D60387AA09A2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309R → H (PubMed:1707129).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57922 mRNA. Translation: AAA75650.1.
M61000 mRNA. Translation: AAA37744.1.
CCDSiCCDS30512.1.
PIRiA39003.
RefSeqiNP_032203.1. NM_008177.3.
UniGeneiMm.4687.

Genome annotation databases

EnsembliENSMUST00000033730; ENSMUSP00000033730; ENSMUSG00000031364.
GeneIDi14829.
KEGGimmu:14829.
UCSCiuc009uuu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57922 mRNA. Translation: AAA75650.1.
M61000 mRNA. Translation: AAA37744.1.
CCDSiCCDS30512.1.
PIRiA39003.
RefSeqiNP_032203.1. NM_008177.3.
UniGeneiMm.4687.

3D structure databases

ProteinModelPortaliP21729.
SMRiP21729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21729. 1 interactor.
STRINGi10090.ENSMUSP00000033730.

Chemistry databases

BindingDBiP21729.
ChEMBLiCHEMBL3596.
GuidetoPHARMACOLOGYi39.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP21729.

Proteomic databases

PaxDbiP21729.
PRIDEiP21729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033730; ENSMUSP00000033730; ENSMUSG00000031364.
GeneIDi14829.
KEGGimmu:14829.
UCSCiuc009uuu.1. mouse.

Organism-specific databases

CTDi2925.
MGIiMGI:95836. Grpr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP21729.
KOiK04169.
OMAiHFIASIC.
OrthoDBiEOG091G085Y.
PhylomeDBiP21729.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP21729.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031364.
CleanExiMM_GRPR.
ExpressionAtlasiP21729. baseline and differential.
GenevisibleiP21729. MM.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPR_MOUSE
AccessioniPrimary (citable) accession number: P21729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.