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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine binding Source: BHF-UCL
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
  • drug binding Source: Ensembl
  • G-protein coupled amine receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3020. DRD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4926Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8727Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 969ExtracellularSequence Analysis
Transmembranei97 – 11923Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 16325Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini164 – 19229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 27254CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei273 – 29927Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini300 – 31213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei313 – 33725Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini338 – 446109CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • caveola Source: Ensembl
  • ciliary membrane Source: SYSCILIA_CCNET
  • cytosol Source: GOC
  • dendritic shaft Source: Ensembl
  • dendritic spine head Source: Ensembl
  • dendritic spine neck Source: Ensembl
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: BHF-UCL
  • neuronal cell body Source: Ensembl
  • nonmotile primary cilium Source: SYSCILIA_CCNET
  • nucleus Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147.

Chemistry

DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00988. Dopamine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB00353. Methylergometrine.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB00397. Phenylpropanolamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.

Polymorphism and mutation databases

BioMutaiDRD1.
DMDMi118228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446D(1A) dopamine receptorPRO_0000069373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Lipidationi347 – 3471S-palmitoyl cysteine1 Publication
Lipidationi351 – 3511S-palmitoyl cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21728.
PRIDEiP21728.

PTM databases

PhosphoSiteiP21728.

Expressioni

Tissue specificityi

Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

Gene expression databases

BgeeiP21728.
CleanExiHS_DRD1.
GenevisibleiP21728. HS.

Organism-specific databases

HPAiHPA013393.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.By similarity

Protein-protein interaction databases

BioGridi108146. 8 interactions.
MINTiMINT-123019.
STRINGi9606.ENSP00000327652.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728.
SMRiP21728. Positions 29-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21728.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG780RMN.
PhylomeDBiP21728.
TreeFamiTF325181.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP
260 270 280 290 300
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
310 320 330 340 350
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED
410 420 430 440
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,293
Last modified:May 1, 1991 - v1
Checksum:i64E062D765D0DBA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 4381I → M in CAA41734 (PubMed:2168520).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371T → P.
Corresponds to variant rs5327 [ dbSNP | Ensembl ].
VAR_014670
Natural varianti37 – 371T → R.
Corresponds to variant rs5328 [ dbSNP | Ensembl ].
VAR_014671
Natural varianti50 – 501R → S.
Corresponds to variant rs5330 [ dbSNP | Ensembl ].
VAR_014672
Natural varianti81 – 811K → R.1 Publication
VAR_064577
Natural varianti199 – 1991S → A.
Corresponds to variant rs5331 [ dbSNP | Ensembl ].
VAR_014673
Natural varianti259 – 2591S → Y.1 Publication
Corresponds to variant rs74414188 [ dbSNP | Ensembl ].
VAR_064578

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1.
X58987 mRNA. Translation: CAA41734.1.
X55758 Genomic DNA. Translation: CAA39284.1.
S58541 Genomic DNA. Translation: AAB26273.1.
AB065677 Genomic DNA. Translation: BAC05902.1.
AF498961 mRNA. Translation: AAM18131.1.
AK314031 mRNA. Translation: BAG36741.1.
CH471062 Genomic DNA. Translation: EAW61377.1.
BC074978 mRNA. Translation: AAH74978.1.
BC074979 mRNA. Translation: AAH74979.1.
BC096837 mRNA. Translation: AAH96837.1.
CCDSiCCDS4393.1.
PIRiS11377. DYHUD1.
RefSeqiNP_000785.1. NM_000794.3.
UniGeneiHs.2624.

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
GeneIDi1812.
KEGGihsa:1812.
UCSCiuc003mcz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1.
X58987 mRNA. Translation: CAA41734.1.
X55758 Genomic DNA. Translation: CAA39284.1.
S58541 Genomic DNA. Translation: AAB26273.1.
AB065677 Genomic DNA. Translation: BAC05902.1.
AF498961 mRNA. Translation: AAM18131.1.
AK314031 mRNA. Translation: BAG36741.1.
CH471062 Genomic DNA. Translation: EAW61377.1.
BC074978 mRNA. Translation: AAH74978.1.
BC074979 mRNA. Translation: AAH74979.1.
BC096837 mRNA. Translation: AAH96837.1.
CCDSiCCDS4393.1.
PIRiS11377. DYHUD1.
RefSeqiNP_000785.1. NM_000794.3.
UniGeneiHs.2624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728.
SMRiP21728. Positions 29-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108146. 8 interactions.
MINTiMINT-123019.
STRINGi9606.ENSP00000327652.

Chemistry

BindingDBiP21728.
ChEMBLiCHEMBL2096905.
DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00988. Dopamine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB00353. Methylergometrine.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB00397. Phenylpropanolamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi214.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP21728.

Polymorphism and mutation databases

BioMutaiDRD1.
DMDMi118228.

Proteomic databases

PaxDbiP21728.
PRIDEiP21728.

Protocols and materials databases

DNASUi1812.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
GeneIDi1812.
KEGGihsa:1812.
UCSCiuc003mcz.3. human.

Organism-specific databases

CTDi1812.
GeneCardsiGC05M174800.
HGNCiHGNC:3020. DRD1.
HPAiHPA013393.
MIMi126449. gene.
neXtProtiNX_P21728.
PharmGKBiPA147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21728.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG780RMN.
PhylomeDBiP21728.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiDopamine_receptor_D1.
GenomeRNAii1812.
NextBioi7385.
PROiP21728.
SOURCEiSearch...

Gene expression databases

BgeeiP21728.
CleanExiHS_DRD1.
GenevisibleiP21728. HS.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the gene for a human D1 dopamine receptor."
    Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T. Jr., Bates M.D., Caron M.G.
    Nature 347:72-76(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms."
    Ohara K., Ulpian C., Seeman P., Sunahara R.K., van Tol H.H.M., Niznik H.B.
    Neuropsychopharmacology 8:131-135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor."
    Jin H., Xie Z., George S.R., O'Dowd B.F.
    Eur. J. Pharmacol. 386:305-312(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-347 AND CYS-351.
  11. Cited for: VARIANTS ARG-81 AND TYR-259.

Entry informationi

Entry nameiDRD1_HUMAN
AccessioniPrimary (citable) accession number: P21728
Secondary accession number(s): B2RA44, Q4QRJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 22, 2015
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.