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P21728

- DRD1_HUMAN

UniProt

P21728 - DRD1_HUMAN

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Protein
D(1A) dopamine receptor
Gene
DRD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. dopamine binding Source: BHF-UCL
  2. dopamine neurotransmitter receptor activity Source: MGI
  3. dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
  4. protein binding Source: BHF-UCL

GO - Biological processi

  1. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: BHF-UCL
  2. activation of adenylate cyclase activity Source: BHF-UCL
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  4. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  5. adult walking behavior Source: BHF-UCL
  6. astrocyte development Source: Ensembl
  7. behavioral fear response Source: Ensembl
  8. behavioral response to cocaine Source: Ensembl
  9. cellular response to catecholamine stimulus Source: BHF-UCL
  10. cerebral cortex GABAergic interneuron migration Source: BHF-UCL
  11. conditioned taste aversion Source: Ensembl
  12. dentate gyrus development Source: Ensembl
  13. dopamine metabolic process Source: BHF-UCL
  14. dopamine transport Source: Ensembl
  15. glucose import Source: Ensembl
  16. grooming behavior Source: Ensembl
  17. habituation Source: Ensembl
  18. long term synaptic depression Source: Ensembl
  19. long-term synaptic potentiation Source: Ensembl
  20. maternal behavior Source: Ensembl
  21. mating behavior Source: BHF-UCL
  22. memory Source: Ensembl
  23. neuronal action potential Source: Ensembl
  24. operant conditioning Source: Ensembl
  25. peristalsis Source: Ensembl
  26. phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
  27. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  28. positive regulation of cAMP biosynthetic process Source: BHF-UCL
  29. positive regulation of cell migration Source: BHF-UCL
  30. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  31. positive regulation of potassium ion transport Source: BHF-UCL
  32. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
  33. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  34. prepulse inhibition Source: BHF-UCL
  35. protein import into nucleus Source: Ensembl
  36. regulation of dopamine metabolic process Source: Ensembl
  37. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
  38. response to amphetamine Source: Ensembl
  39. response to drug Source: BHF-UCL
  40. sensitization Source: Ensembl
  41. striatum development Source: Ensembl
  42. synapse assembly Source: BHF-UCL
  43. synaptic transmission, dopaminergic Source: Ensembl
  44. temperature homeostasis Source: Ensembl
  45. transmission of nerve impulse Source: BHF-UCL
  46. vasodilation Source: InterPro
  47. visual learning Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3020. DRD1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity
Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4926Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini50 – 6011Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei61 – 8727Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini88 – 969Extracellular Reviewed prediction
Transmembranei97 – 11923Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei139 – 16325Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini164 – 19229Extracellular Reviewed prediction
Add
BLAST
Transmembranei193 – 21826Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 27254Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei273 – 29927Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini300 – 31213Extracellular Reviewed prediction
Add
BLAST
Transmembranei313 – 33725Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini338 – 446109Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: BHF-UCL
  3. nucleus Source: Ensembl
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446D(1A) dopamine receptor
PRO_0000069373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 186 By similarity
Lipidationi347 – 3471S-palmitoyl cysteine1 Publication
Lipidationi351 – 3511S-palmitoyl cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21728.
PRIDEiP21728.

PTM databases

PhosphoSiteiP21728.

Expressioni

Tissue specificityi

Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

Gene expression databases

BgeeiP21728.
CleanExiHS_DRD1.
GenevestigatoriP21728.

Organism-specific databases

HPAiHPA013393.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus By similarity. Interacts with DRD1IP.

Protein-protein interaction databases

BioGridi108146. 6 interactions.
MINTiMINT-123019.
STRINGi9606.ENSP00000327652.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728.
SMRiP21728. Positions 29-345.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21728.
KOiK04144.
OMAiSPTTFDV.
OrthoDBiEOG780RMN.
PhylomeDBiP21728.
TreeFamiTF325181.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21728-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR    50
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV 100
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL 150
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV 200
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP 250
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS 300
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL 350
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED 400
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT 446
Length:446
Mass (Da):49,293
Last modified:May 1, 1991 - v1
Checksum:i64E062D765D0DBA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371T → P.
Corresponds to variant rs5327 [ dbSNP | Ensembl ].
VAR_014670
Natural varianti37 – 371T → R.
Corresponds to variant rs5328 [ dbSNP | Ensembl ].
VAR_014671
Natural varianti50 – 501R → S.
Corresponds to variant rs5330 [ dbSNP | Ensembl ].
VAR_014672
Natural varianti81 – 811K → R.1 Publication
VAR_064577
Natural varianti199 – 1991S → A.
Corresponds to variant rs5331 [ dbSNP | Ensembl ].
VAR_014673
Natural varianti259 – 2591S → Y.1 Publication
Corresponds to variant rs74414188 [ dbSNP | Ensembl ].
VAR_064578

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 4381I → M in CAA41734. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1.
X58987 mRNA. Translation: CAA41734.1.
X55758 Genomic DNA. Translation: CAA39284.1.
S58541 Genomic DNA. Translation: AAB26273.1.
AB065677 Genomic DNA. Translation: BAC05902.1.
AF498961 mRNA. Translation: AAM18131.1.
AK314031 mRNA. Translation: BAG36741.1.
CH471062 Genomic DNA. Translation: EAW61377.1.
BC074978 mRNA. Translation: AAH74978.1.
BC074979 mRNA. Translation: AAH74979.1.
BC096837 mRNA. Translation: AAH96837.1.
CCDSiCCDS4393.1.
PIRiS11377. DYHUD1.
RefSeqiNP_000785.1. NM_000794.3.
UniGeneiHs.2624.

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
GeneIDi1812.
KEGGihsa:1812.
UCSCiuc003mcz.3. human.

Polymorphism databases

DMDMi118228.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1 .
X58987 mRNA. Translation: CAA41734.1 .
X55758 Genomic DNA. Translation: CAA39284.1 .
S58541 Genomic DNA. Translation: AAB26273.1 .
AB065677 Genomic DNA. Translation: BAC05902.1 .
AF498961 mRNA. Translation: AAM18131.1 .
AK314031 mRNA. Translation: BAG36741.1 .
CH471062 Genomic DNA. Translation: EAW61377.1 .
BC074978 mRNA. Translation: AAH74978.1 .
BC074979 mRNA. Translation: AAH74979.1 .
BC096837 mRNA. Translation: AAH96837.1 .
CCDSi CCDS4393.1.
PIRi S11377. DYHUD1.
RefSeqi NP_000785.1. NM_000794.3.
UniGenei Hs.2624.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OZ5 model - A 1-446 [» ]
ProteinModelPortali P21728.
SMRi P21728. Positions 29-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108146. 6 interactions.
MINTi MINT-123019.
STRINGi 9606.ENSP00000327652.

Chemistry

BindingDBi P21728.
ChEMBLi CHEMBL2111341.
DrugBanki DB01063. Acetophenazine.
DB00915. Amantadine.
DB00714. Apomorphine.
DB01038. Carphenazine.
DB01239. Chlorprothixene.
DB00363. Clozapine.
DB00907. Cocaine.
DB00988. Dopamine.
DB00800. Fenoldopam.
DB00875. Flupenthixol.
DB00623. Fluphenazine.
DB00502. Haloperidol.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB00353. Methylergonovine.
DB00805. Minaprine.
DB00334. Olanzapine.
DB00061. Pegademase bovine.
DB01186. Pergolide.
DB00850. Perphenazine.
DB00433. Prochlorperazine.
DB00420. Promazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00372. Thiethylperazine.
DB00679. Thioridazine.
DB00508. Triflupromazine.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi 214.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21728.

Polymorphism databases

DMDMi 118228.

Proteomic databases

PaxDbi P21728.
PRIDEi P21728.

Protocols and materials databases

DNASUi 1812.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393752 ; ENSP00000377353 ; ENSG00000184845 .
GeneIDi 1812.
KEGGi hsa:1812.
UCSCi uc003mcz.3. human.

Organism-specific databases

CTDi 1812.
GeneCardsi GC05M174800.
HGNCi HGNC:3020. DRD1.
HPAi HPA013393.
MIMi 126449. gene.
neXtProti NX_P21728.
PharmGKBi PA147.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262978.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P21728.
KOi K04144.
OMAi SPTTFDV.
OrthoDBi EOG780RMN.
PhylomeDBi P21728.
TreeFami TF325181.

Enzyme and pathway databases

Reactomei REACT_16968. Dopamine receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Dopamine_receptor_D1.
GenomeRNAii 1812.
NextBioi 7385.
PROi P21728.
SOURCEi Search...

Gene expression databases

Bgeei P21728.
CleanExi HS_DRD1.
Genevestigatori P21728.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the gene for a human D1 dopamine receptor."
    Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T. Jr., Bates M.D., Caron M.G.
    Nature 347:72-76(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms."
    Ohara K., Ulpian C., Seeman P., Sunahara R.K., van Tol H.H.M., Niznik H.B.
    Neuropsychopharmacology 8:131-135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor."
    Jin H., Xie Z., George S.R., O'Dowd B.F.
    Eur. J. Pharmacol. 386:305-312(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-347 AND CYS-351.
  11. Cited for: VARIANTS ARG-81 AND TYR-259.

Entry informationi

Entry nameiDRD1_HUMAN
AccessioniPrimary (citable) accession number: P21728
Secondary accession number(s): B2RA44, Q4QRJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 3, 2014
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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