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P21728

- DRD1_HUMAN

UniProt

P21728 - DRD1_HUMAN

Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. dopamine binding Source: BHF-UCL
    2. dopamine neurotransmitter receptor activity Source: MGI
    3. dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL
    4. protein binding Source: BHF-UCL

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: BHF-UCL
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    4. adult walking behavior Source: BHF-UCL
    5. astrocyte development Source: Ensembl
    6. behavioral fear response Source: Ensembl
    7. behavioral response to cocaine Source: Ensembl
    8. cellular response to catecholamine stimulus Source: BHF-UCL
    9. cerebral cortex GABAergic interneuron migration Source: BHF-UCL
    10. conditioned taste aversion Source: Ensembl
    11. dentate gyrus development Source: Ensembl
    12. dopamine metabolic process Source: BHF-UCL
    13. dopamine transport Source: Ensembl
    14. glucose import Source: Ensembl
    15. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: BHF-UCL
    16. grooming behavior Source: Ensembl
    17. habituation Source: Ensembl
    18. long term synaptic depression Source: Ensembl
    19. long-term synaptic potentiation Source: Ensembl
    20. maternal behavior Source: Ensembl
    21. mating behavior Source: BHF-UCL
    22. memory Source: Ensembl
    23. neuronal action potential Source: Ensembl
    24. operant conditioning Source: Ensembl
    25. peristalsis Source: Ensembl
    26. phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
    27. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
    28. positive regulation of cAMP biosynthetic process Source: BHF-UCL
    29. positive regulation of cell migration Source: BHF-UCL
    30. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
    31. positive regulation of potassium ion transport Source: BHF-UCL
    32. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
    33. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
    34. prepulse inhibition Source: BHF-UCL
    35. protein import into nucleus Source: Ensembl
    36. regulation of dopamine metabolic process Source: Ensembl
    37. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
    38. response to amphetamine Source: Ensembl
    39. response to drug Source: BHF-UCL
    40. sensitization Source: Ensembl
    41. striatum development Source: Ensembl
    42. synapse assembly Source: BHF-UCL
    43. synaptic transmission, dopaminergic Source: Ensembl
    44. temperature homeostasis Source: Ensembl
    45. transmission of nerve impulse Source: BHF-UCL
    46. vasodilation Source: InterPro
    47. visual learning Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16968. Dopamine receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(1A) dopamine receptor
    Alternative name(s):
    Dopamine D1 receptor
    Gene namesi
    Name:DRD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3020. DRD1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
    Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: BHF-UCL
    3. nucleus Source: Ensembl
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446D(1A) dopamine receptorPRO_0000069373Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
    Lipidationi347 – 3471S-palmitoyl cysteine1 Publication
    Lipidationi351 – 3511S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP21728.
    PRIDEiP21728.

    PTM databases

    PhosphoSiteiP21728.

    Expressioni

    Tissue specificityi

    Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

    Gene expression databases

    BgeeiP21728.
    CleanExiHS_DRD1.
    GenevestigatoriP21728.

    Organism-specific databases

    HPAiHPA013393.

    Interactioni

    Subunit structurei

    Interacts with DNAJC14 via its C-terminus By similarity. Interacts with DRD1IP.By similarity

    Protein-protein interaction databases

    BioGridi108146. 6 interactions.
    MINTiMINT-123019.
    STRINGi9606.ENSP00000327652.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OZ5model-A1-446[»]
    ProteinModelPortaliP21728.
    SMRiP21728. Positions 29-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 969ExtracellularSequence Analysis
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 27254CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini300 – 31213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini338 – 446109CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4926Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8727Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11923Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 16325Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29927Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei313 – 33725Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262978.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP21728.
    KOiK04144.
    OMAiSPTTFDV.
    OrthoDBiEOG780RMN.
    PhylomeDBiP21728.
    TreeFamiTF325181.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001413. Dopamine_D1_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00565. DOPAMINED1AR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21728-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR    50
    FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV 100
    AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL 150
    SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV 200
    ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP 250
    VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS 300
    GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL 350
    CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED 400
    LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT 446
    Length:446
    Mass (Da):49,293
    Last modified:May 1, 1991 - v1
    Checksum:i64E062D765D0DBA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti438 – 4381I → M in CAA41734. (PubMed:2168520)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371T → P.
    Corresponds to variant rs5327 [ dbSNP | Ensembl ].
    VAR_014670
    Natural varianti37 – 371T → R.
    Corresponds to variant rs5328 [ dbSNP | Ensembl ].
    VAR_014671
    Natural varianti50 – 501R → S.
    Corresponds to variant rs5330 [ dbSNP | Ensembl ].
    VAR_014672
    Natural varianti81 – 811K → R.1 Publication
    VAR_064577
    Natural varianti199 – 1991S → A.
    Corresponds to variant rs5331 [ dbSNP | Ensembl ].
    VAR_014673
    Natural varianti259 – 2591S → Y.1 Publication
    Corresponds to variant rs74414188 [ dbSNP | Ensembl ].
    VAR_064578

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55760 Genomic DNA. Translation: CAA39286.1.
    X58987 mRNA. Translation: CAA41734.1.
    X55758 Genomic DNA. Translation: CAA39284.1.
    S58541 Genomic DNA. Translation: AAB26273.1.
    AB065677 Genomic DNA. Translation: BAC05902.1.
    AF498961 mRNA. Translation: AAM18131.1.
    AK314031 mRNA. Translation: BAG36741.1.
    CH471062 Genomic DNA. Translation: EAW61377.1.
    BC074978 mRNA. Translation: AAH74978.1.
    BC074979 mRNA. Translation: AAH74979.1.
    BC096837 mRNA. Translation: AAH96837.1.
    CCDSiCCDS4393.1.
    PIRiS11377. DYHUD1.
    RefSeqiNP_000785.1. NM_000794.3.
    UniGeneiHs.2624.

    Genome annotation databases

    EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
    GeneIDi1812.
    KEGGihsa:1812.
    UCSCiuc003mcz.3. human.

    Polymorphism databases

    DMDMi118228.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55760 Genomic DNA. Translation: CAA39286.1 .
    X58987 mRNA. Translation: CAA41734.1 .
    X55758 Genomic DNA. Translation: CAA39284.1 .
    S58541 Genomic DNA. Translation: AAB26273.1 .
    AB065677 Genomic DNA. Translation: BAC05902.1 .
    AF498961 mRNA. Translation: AAM18131.1 .
    AK314031 mRNA. Translation: BAG36741.1 .
    CH471062 Genomic DNA. Translation: EAW61377.1 .
    BC074978 mRNA. Translation: AAH74978.1 .
    BC074979 mRNA. Translation: AAH74979.1 .
    BC096837 mRNA. Translation: AAH96837.1 .
    CCDSi CCDS4393.1.
    PIRi S11377. DYHUD1.
    RefSeqi NP_000785.1. NM_000794.3.
    UniGenei Hs.2624.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OZ5 model - A 1-446 [» ]
    ProteinModelPortali P21728.
    SMRi P21728. Positions 29-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108146. 6 interactions.
    MINTi MINT-123019.
    STRINGi 9606.ENSP00000327652.

    Chemistry

    BindingDBi P21728.
    ChEMBLi CHEMBL2111341.
    DrugBanki DB01063. Acetophenazine.
    DB00915. Amantadine.
    DB00714. Apomorphine.
    DB01038. Carphenazine.
    DB01239. Chlorprothixene.
    DB00363. Clozapine.
    DB00907. Cocaine.
    DB00988. Dopamine.
    DB00800. Fenoldopam.
    DB00875. Flupenthixol.
    DB00623. Fluphenazine.
    DB00502. Haloperidol.
    DB01235. Levodopa.
    DB00589. Lisuride.
    DB00408. Loxapine.
    DB00353. Methylergonovine.
    DB00805. Minaprine.
    DB00334. Olanzapine.
    DB00061. Pegademase bovine.
    DB01186. Pergolide.
    DB00850. Perphenazine.
    DB00433. Prochlorperazine.
    DB00420. Promazine.
    DB00777. Propiomazine.
    DB01224. Quetiapine.
    DB00372. Thiethylperazine.
    DB00679. Thioridazine.
    DB00508. Triflupromazine.
    DB01624. Zuclopenthixol.
    GuidetoPHARMACOLOGYi 214.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21728.

    Polymorphism databases

    DMDMi 118228.

    Proteomic databases

    PaxDbi P21728.
    PRIDEi P21728.

    Protocols and materials databases

    DNASUi 1812.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393752 ; ENSP00000377353 ; ENSG00000184845 .
    GeneIDi 1812.
    KEGGi hsa:1812.
    UCSCi uc003mcz.3. human.

    Organism-specific databases

    CTDi 1812.
    GeneCardsi GC05M174800.
    HGNCi HGNC:3020. DRD1.
    HPAi HPA013393.
    MIMi 126449. gene.
    neXtProti NX_P21728.
    PharmGKBi PA147.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262978.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P21728.
    KOi K04144.
    OMAi SPTTFDV.
    OrthoDBi EOG780RMN.
    PhylomeDBi P21728.
    TreeFami TF325181.

    Enzyme and pathway databases

    Reactomei REACT_16968. Dopamine receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Dopamine_receptor_D1.
    GenomeRNAii 1812.
    NextBioi 7385.
    PROi P21728.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21728.
    CleanExi HS_DRD1.
    Genevestigatori P21728.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001413. Dopamine_D1_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00565. DOPAMINED1AR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of the gene for a human D1 dopamine receptor."
      Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T. Jr., Bates M.D., Caron M.G.
      Nature 347:72-76(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms."
      Ohara K., Ulpian C., Seeman P., Sunahara R.K., van Tol H.H.M., Niznik H.B.
      Neuropsychopharmacology 8:131-135(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor."
      Jin H., Xie Z., George S.R., O'Dowd B.F.
      Eur. J. Pharmacol. 386:305-312(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-347 AND CYS-351.
    11. Cited for: VARIANTS ARG-81 AND TYR-259.

    Entry informationi

    Entry nameiDRD1_HUMAN
    AccessioniPrimary (citable) accession number: P21728
    Secondary accession number(s): B2RA44, Q4QRJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 157 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3