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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine binding Source: BHF-UCL
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33099-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3020. DRD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 49Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 87Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini88 – 96ExtracellularSequence analysis9
Transmembranei97 – 119Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 163Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini164 – 192ExtracellularSequence analysisAdd BLAST29
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

  • ciliary membrane Source: SYSCILIA_CCNET
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: BHF-UCL
  • non-motile cilium Source: SYSCILIA_CCNET
  • nucleus Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1812.
OpenTargetsiENSG00000184845.
PharmGKBiPA147.

Chemistry databases

ChEMBLiCHEMBL2056.
DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00988. Dopamine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB00353. Methylergometrine.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB00397. Phenylpropanolamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi214.

Polymorphism and mutation databases

BioMutaiDRD1.
DMDMi118228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693731 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteine1 Publication1
Lipidationi351S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21728.
PRIDEiP21728.

PTM databases

iPTMnetiP21728.
PhosphoSitePlusiP21728.
SwissPalmiP21728.

Expressioni

Tissue specificityi

Detected in caudate, nucleus accumbens and in the olfactory tubercle.1 Publication

Gene expression databases

BgeeiENSG00000184845.
CleanExiHS_DRD1.
GenevisibleiP21728. HS.

Organism-specific databases

HPAiHPA013393.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.By similarity

Protein-protein interaction databases

BioGridi108146. 8 interactors.
MINTiMINT-123019.
STRINGi9606.ENSP00000327652.

Chemistry databases

BindingDBiP21728.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728.
SMRiP21728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21728.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
PhylomeDBiP21728.
TreeFamiTF325181.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP
260 270 280 290 300
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
310 320 330 340 350
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED
410 420 430 440
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,293
Last modified:May 1, 1991 - v1
Checksum:i64E062D765D0DBA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti438I → M in CAA41734 (PubMed:2168520).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01467037T → P.Corresponds to variant rs5327dbSNPEnsembl.1
Natural variantiVAR_01467137T → R.Corresponds to variant rs5328dbSNPEnsembl.1
Natural variantiVAR_01467250R → S.Corresponds to variant rs5330dbSNPEnsembl.1
Natural variantiVAR_06457781K → R.1 Publication1
Natural variantiVAR_014673199S → A.Corresponds to variant rs5331dbSNPEnsembl.1
Natural variantiVAR_064578259S → Y.1 PublicationCorresponds to variant rs74414188dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1.
X58987 mRNA. Translation: CAA41734.1.
X55758 Genomic DNA. Translation: CAA39284.1.
S58541 Genomic DNA. Translation: AAB26273.1.
AB065677 Genomic DNA. Translation: BAC05902.1.
AF498961 mRNA. Translation: AAM18131.1.
AK314031 mRNA. Translation: BAG36741.1.
CH471062 Genomic DNA. Translation: EAW61377.1.
BC074978 mRNA. Translation: AAH74978.1.
BC074979 mRNA. Translation: AAH74979.1.
BC096837 mRNA. Translation: AAH96837.1.
CCDSiCCDS4393.1.
PIRiS11377. DYHUD1.
RefSeqiNP_000785.1. NM_000794.3.
UniGeneiHs.2624.

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
GeneIDi1812.
KEGGihsa:1812.
UCSCiuc003mcz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55760 Genomic DNA. Translation: CAA39286.1.
X58987 mRNA. Translation: CAA41734.1.
X55758 Genomic DNA. Translation: CAA39284.1.
S58541 Genomic DNA. Translation: AAB26273.1.
AB065677 Genomic DNA. Translation: BAC05902.1.
AF498961 mRNA. Translation: AAM18131.1.
AK314031 mRNA. Translation: BAG36741.1.
CH471062 Genomic DNA. Translation: EAW61377.1.
BC074978 mRNA. Translation: AAH74978.1.
BC074979 mRNA. Translation: AAH74979.1.
BC096837 mRNA. Translation: AAH96837.1.
CCDSiCCDS4393.1.
PIRiS11377. DYHUD1.
RefSeqiNP_000785.1. NM_000794.3.
UniGeneiHs.2624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZ5model-A1-446[»]
ProteinModelPortaliP21728.
SMRiP21728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108146. 8 interactors.
MINTiMINT-123019.
STRINGi9606.ENSP00000327652.

Chemistry databases

BindingDBiP21728.
ChEMBLiCHEMBL2056.
DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB00988. Dopamine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB00353. Methylergometrine.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB00397. Phenylpropanolamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi214.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21728.
PhosphoSitePlusiP21728.
SwissPalmiP21728.

Polymorphism and mutation databases

BioMutaiDRD1.
DMDMi118228.

Proteomic databases

PaxDbiP21728.
PRIDEiP21728.

Protocols and materials databases

DNASUi1812.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393752; ENSP00000377353; ENSG00000184845.
GeneIDi1812.
KEGGihsa:1812.
UCSCiuc003mcz.4. human.

Organism-specific databases

CTDi1812.
DisGeNETi1812.
GeneCardsiDRD1.
HGNCiHGNC:3020. DRD1.
HPAiHPA013393.
MIMi126449. gene.
neXtProtiNX_P21728.
OpenTargetsiENSG00000184845.
PharmGKBiPA147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP21728.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
PhylomeDBiP21728.
TreeFamiTF325181.

Enzyme and pathway databases

BioCyciZFISH:G66-33099-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiDopamine_receptor_D1.
GenomeRNAii1812.
PROiP21728.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184845.
CleanExiHS_DRD1.
GenevisibleiP21728. HS.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD1_HUMAN
AccessioniPrimary (citable) accession number: P21728
Secondary accession number(s): B2RA44, Q4QRJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 30, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.