Cytochrome b - Akodon torques (Cloud forest grass mouse)

Contribute

Send feedback

Read comments (?) or add your own

P21721 (CYB_AKOTO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	MT-CYB
Synonyms:	COB, CYTB, MTCYB

Encoded on

Mitochondrion

Organism

Akodon torques (Cloud forest grass mouse)

Taxonomic identifier

10078 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Sigmodontinae › Akodon

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 379

379

Cytochrome b

PRO_0000060557

Regions

Transmembrane

33 – 53

Helical; Potential

Transmembrane

89 – 109

Helical; Potential

Transmembrane

115 – 135

Helical; Potential

Transmembrane

150 – 170

Helical; Potential

Transmembrane

178 – 198

Helical; Potential

Transmembrane

229 – 249

Helical; Potential

Transmembrane

288 – 308

Helical; Potential

Transmembrane

323 – 343

Helical; Potential

Transmembrane

346 – 366

Helical; Potential

Sites

Metal binding

Iron 1 (heme b562 axial ligand)

Metal binding

Iron 2 (heme b566 axial ligand)

Metal binding

182

Iron 1 (heme b562 axial ligand)

Metal binding

196

Iron 2 (heme b566 axial ligand)

Natural variations

Natural variant

108

V → A in strain: Isolate MVZ 174053 and Isolate MVZ 174054.

Natural variant

115

V → I in strain: Isolate MVZ 174053 and Isolate MVZ 174054.

Sequences

Sequence

Length

Mass (Da)

Tools

P21721 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 4C94CF8A92CCC34F
Show »

FASTA

379

42,611

        10         20         30         40         50         60 
MKILRKNHPL LKIVNHSFID LPTPSNISSW WNFGSLLGVC LMIQILTGLF LAMHYTSDTT 

        70         80         90        100        110        120 
TAFSSVAHIC RDVNYGWLIR YLHANGASMF FICLFIHVGR GIYYGSYVLS ETWNVGIILF 

       130        140        150        160        170        180 
LTTMATAFVG YVLPWGQMSF WGATVITNLL SAIPYIGSTL VEWIWGGFSV DKATLTRFFA 

       190        200        210        220        230        240 
FHFILPFIIT AFALVHLLFL HETGSNNPSG LNSDSDKIPF HPYYTIKDLL GIFLLLLVLM 

       250        260        270        280        290        300 
ILALFFPDVL GDPDNFTPAN PLNTPAHIKP EWYFLFAYAI LRSIPNKLGG VLALILSILI 

       310        320        330        340        350        360 
LAAFPLLNTS KQHGLIFRPV TQTIYWTFIA NLLVLTWIGG QPVEYPFTMI GQIASITYFT 

       370 
IIIILMPVSN TIENNIIKL

« Hide

References

[1]	Smith M.F. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"The diversification of South American murid rodents: evidence from mitochondrial DNA sequence data for the akodontine tribe." Smith M.F., Patton J.L. Biol. J. Linn. Soc. Lond. 50:149-177(1993) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-267. Tissue: Liver.
[3]	"Variation in mitochondrial cytochrome b sequence in natural populations of South American akodontine rodents (Muridae: Sigmodontinae)." Smith M.F., Patton J.L. Mol. Biol. Evol. 8:85-103(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-133. Strain: Isolate MVZ 171720, Isolate MVZ 171721, Isolate MVZ 174053 and Isolate MVZ 174054. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M35700 Genomic DNA. Translation: AAA18897.2. M35701 Genomic DNA. Translation: AAA31624.1. M35702 Genomic DNA. Translation: AAA31625.1.
PIR	G23725.
3D structure databases
ProteinModelPortal	P21721.
SMR	P21721. Positions 1-378.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG017694.
Family and domain databases
InterPro	IPR016175. Cyt_b/b6. IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR016174. Di-haem_cyt_TM. [Graphical view]
PANTHER	PTHR19271. PTHR19271. 1 hit.
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81648. Cytochrome_b/b6_C. 1 hit. SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYB_AKOTO

Accession

Primary (citable) accession number: P21721

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents