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Protein

Non-structural protein NS-S

Gene

NSS

Organism
Toscana virus (Tos)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Prevents the establishment of the host antiviral state by interfering with beta interferon (IFN-beta) production. Interacts with host DDX58 and targets it for proteasomal degradation, thereby inhibiting DDX58-mediated signaling pathway.1 Publication

GO - Biological processi

  1. suppression by virus of host RIG-I activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:NSS
OrganismiToscana virus (Tos)
Taxonomic identifieri11590 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Non-structural protein NS-SPRO_0000221981Add
BLAST

Interactioni

Subunit structurei

Interacts with host DDX58; this interaction targets DDX58 to proteasomal degradation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX58O957863EBI-6693910,EBI-995350From a different organism.

Protein-protein interaction databases

IntActiP21699. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the phlebovirus NS-S protein family.Curated

Family and domain databases

InterProiIPR024376. RVFV_non-structural.
[Graphical view]
PfamiPF11073. NSs. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSRAVILKY RSGSGHKRSL PRFYIDCDLD TFDFEKDCSL IENEFPIYIN
60 70 80 90 100
NYKVVYKSKP TLSHFLIEKE FPAVLGPGMI SAVRTRLYEP TMRELYQESI
110 120 130 140 150
HQLKRSNKKY LLSALRWPTG IPTLEFIDYY FEELLFLSEF DPGSIQRYLK
160 170 180 190 200
LLVKASGLYN STNEEQIVEI HRRVLIEGKK HGLTAFDLPG NDILGDICVV
210 220 230 240 250
QAARVTRLVA KTFSKMTRDT HLMIYFSISP VELVLSKLDK KGDKRAKAKG
260 270 280 290 300
LMSMSAARSY DYFMRTDLGF RETALSTFWA KDWPTPQETI LSDKRCLKED
310
MRVTKWLPSP PHYPPL
Length:316
Mass (Da):36,678
Last modified:April 30, 1991 - v1
Checksum:iEEA752F082D9A411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53794 Genomic RNA. Translation: CAA37802.1.
PIRiA38552. MNVUTV.
RefSeqiYP_089667.1. NC_006318.1.

Genome annotation databases

GeneIDi3077269.
KEGGivg:3077269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53794 Genomic RNA. Translation: CAA37802.1.
PIRiA38552. MNVUTV.
RefSeqiYP_089667.1. NC_006318.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21699. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077269.
KEGGivg:3077269.

Family and domain databases

InterProiIPR024376. RVFV_non-structural.
[Graphical view]
PfamiPF11073. NSs. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
    Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
    Virology 180:738-753(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."
    Gori-Savellini G., Valentini M., Cusi M.G.
    J. Virol. 87:6660-6667(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HOST DDX58.

Entry informationi

Entry nameiNSS_TOSV
AccessioniPrimary (citable) accession number: P21699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 1991
Last sequence update: April 30, 1991
Last modified: March 31, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.