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P21699

- NSS_TOSV

UniProt

P21699 - NSS_TOSV

Protein

Non-structural protein NS-S

Gene

NSS

Organism
Toscana virus (Tos)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Prevents the establishment of the host antiviral state by interfering with beta interferon (IFN-beta) production. Interacts with host DDX58 and targets it for proteasomal degradation, thereby inhibiting DDX58-mediated signaling pathway.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. suppression by virus of host RIG-I activity Source: UniProtKB

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:NSS
    OrganismiToscana virus (Tos)
    Taxonomic identifieri11590 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Phlebotomus perniciosus [TaxID: 13204]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Non-structural protein NS-SPRO_0000221981Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with host DDX58; this interaction targets DDX58 to proteasomal degradation.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX58O957863EBI-6693910,EBI-995350From a different organism.

    Protein-protein interaction databases

    IntActiP21699. 1 interaction.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phlebovirus NS-S protein family.Curated

    Family and domain databases

    InterProiIPR024376. RVFV_non-structural.
    [Graphical view]
    PfamiPF11073. NSs. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSRAVILKY RSGSGHKRSL PRFYIDCDLD TFDFEKDCSL IENEFPIYIN    50
    NYKVVYKSKP TLSHFLIEKE FPAVLGPGMI SAVRTRLYEP TMRELYQESI 100
    HQLKRSNKKY LLSALRWPTG IPTLEFIDYY FEELLFLSEF DPGSIQRYLK 150
    LLVKASGLYN STNEEQIVEI HRRVLIEGKK HGLTAFDLPG NDILGDICVV 200
    QAARVTRLVA KTFSKMTRDT HLMIYFSISP VELVLSKLDK KGDKRAKAKG 250
    LMSMSAARSY DYFMRTDLGF RETALSTFWA KDWPTPQETI LSDKRCLKED 300
    MRVTKWLPSP PHYPPL 316
    Length:316
    Mass (Da):36,678
    Last modified:May 1, 1991 - v1
    Checksum:iEEA752F082D9A411
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53794 Genomic RNA. Translation: CAA37802.1.
    PIRiA38552. MNVUTV.
    RefSeqiYP_089667.1. NC_006318.1.

    Genome annotation databases

    GeneIDi3077269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53794 Genomic RNA. Translation: CAA37802.1 .
    PIRi A38552. MNVUTV.
    RefSeqi YP_089667.1. NC_006318.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21699. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3077269.

    Family and domain databases

    InterProi IPR024376. RVFV_non-structural.
    [Graphical view ]
    Pfami PF11073. NSs. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
      Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
      Virology 180:738-753(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."
      Gori-Savellini G., Valentini M., Cusi M.G.
      J. Virol. 87:6660-6667(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HOST DDX58.

    Entry informationi

    Entry nameiNSS_TOSV
    AccessioniPrimary (citable) accession number: P21699
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3