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P21699 (NSS_TOSV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein NS-S
Gene names
Name:NSS
OrganismToscana virus (Tos)
Taxonomic identifier11590 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents the establishment of the host antiviral state by interfering with beta interferon (IFN-beta) production. Interacts with host DDX58 and targets it for proteasomal degradation, thereby inhibiting DDX58-mediated signaling pathway. Ref.2

Subunit structure

Interacts with host DDX58; this interaction targets DDX58 to proteasomal degradation. Ref.2

Sequence similarities

Belongs to the phlebovirus NS-S protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DDX58O957863EBI-6693910,EBI-995350From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Non-structural protein NS-S
PRO_0000221981

Sequences

Sequence LengthMass (Da)Tools
P21699 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: EEA752F082D9A411

FASTA31636,678
        10         20         30         40         50         60 
MQSRAVILKY RSGSGHKRSL PRFYIDCDLD TFDFEKDCSL IENEFPIYIN NYKVVYKSKP 

        70         80         90        100        110        120 
TLSHFLIEKE FPAVLGPGMI SAVRTRLYEP TMRELYQESI HQLKRSNKKY LLSALRWPTG 

       130        140        150        160        170        180 
IPTLEFIDYY FEELLFLSEF DPGSIQRYLK LLVKASGLYN STNEEQIVEI HRRVLIEGKK 

       190        200        210        220        230        240 
HGLTAFDLPG NDILGDICVV QAARVTRLVA KTFSKMTRDT HLMIYFSISP VELVLSKLDK 

       250        260        270        280        290        300 
KGDKRAKAKG LMSMSAARSY DYFMRTDLGF RETALSTFWA KDWPTPQETI LSDKRCLKED 

       310 
MRVTKWLPSP PHYPPL 

« Hide

References

[1]"Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
Virology 180:738-753(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."
Gori-Savellini G., Valentini M., Cusi M.G.
J. Virol. 87:6660-6667(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HOST DDX58.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53794 Genomic RNA. Translation: CAA37802.1.
PIRMNVUTV. A38552.
RefSeqYP_089667.1. NC_006318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP21699. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3077269.

Family and domain databases

InterProIPR024376. RVFV_non-structural.
[Graphical view]
PfamPF11073. NSs. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSS_TOSV
AccessionPrimary (citable) accession number: P21699
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families