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P21699

- NSS_TOSV

UniProt

P21699 - NSS_TOSV

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Protein
Non-structural protein NS-S
Gene
NSS
Organism
Toscana virus (Tos)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents the establishment of the host antiviral state by interfering with beta interferon (IFN-beta) production. Interacts with host DDX58 and targets it for proteasomal degradation, thereby inhibiting DDX58-mediated signaling pathway.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. suppression by virus of host RIG-I activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:NSS
OrganismiToscana virus (Tos)
Taxonomic identifieri11590 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Non-structural protein NS-S
PRO_0000221981Add
BLAST

Interactioni

Subunit structurei

Interacts with host DDX58; this interaction targets DDX58 to proteasomal degradation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX58O957863EBI-6693910,EBI-995350From a different organism.

Protein-protein interaction databases

IntActiP21699. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024376. RVFV_non-structural.
[Graphical view]
PfamiPF11073. NSs. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21699-1 [UniParc]FASTAAdd to Basket

« Hide

MQSRAVILKY RSGSGHKRSL PRFYIDCDLD TFDFEKDCSL IENEFPIYIN    50
NYKVVYKSKP TLSHFLIEKE FPAVLGPGMI SAVRTRLYEP TMRELYQESI 100
HQLKRSNKKY LLSALRWPTG IPTLEFIDYY FEELLFLSEF DPGSIQRYLK 150
LLVKASGLYN STNEEQIVEI HRRVLIEGKK HGLTAFDLPG NDILGDICVV 200
QAARVTRLVA KTFSKMTRDT HLMIYFSISP VELVLSKLDK KGDKRAKAKG 250
LMSMSAARSY DYFMRTDLGF RETALSTFWA KDWPTPQETI LSDKRCLKED 300
MRVTKWLPSP PHYPPL 316
Length:316
Mass (Da):36,678
Last modified:May 1, 1991 - v1
Checksum:iEEA752F082D9A411
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53794 Genomic RNA. Translation: CAA37802.1.
PIRiA38552. MNVUTV.
RefSeqiYP_089667.1. NC_006318.1.

Genome annotation databases

GeneIDi3077269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53794 Genomic RNA. Translation: CAA37802.1 .
PIRi A38552. MNVUTV.
RefSeqi YP_089667.1. NC_006318.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

IntActi P21699. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077269.

Family and domain databases

InterProi IPR024376. RVFV_non-structural.
[Graphical view ]
Pfami PF11073. NSs. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
    Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
    Virology 180:738-753(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Toscana Virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I."
    Gori-Savellini G., Valentini M., Cusi M.G.
    J. Virol. 87:6660-6667(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HOST DDX58.

Entry informationi

Entry nameiNSS_TOSV
AccessioniPrimary (citable) accession number: P21699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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