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Protein

Non-structural protein NS-S

Gene

NSS

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibits host general transcription by inhibiting host basal transcription factor TFIIH.1 Publication

GO - Biological processi

  1. negative stranded viral RNA replication Source: CACAO
  2. suppression by virus of host gene expression Source: CACAO
  3. suppression by virus of host transcription Source: CACAO
  4. suppression by virus of host transcription initiation from RNA polymerase II promoter Source: CACAO
  5. suppression by virus of host type I interferon production Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:NSS
OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
Taxonomic identifieri11589 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
ProteomesiUP000002477 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Non-structural protein NS-SPRO_0000221979Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP21698. 26 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the phlebovirus NS-S protein family.Curated

Family and domain databases

InterProiIPR024376. RVFV_non-structural.
[Graphical view]
PfamiPF11073. NSs. 1 hit.
[Graphical view]
PIRSFiPIRSF003956. NS-S_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

P21698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPVISVD LQSGRRVVSV EYFRGDGPPR IPYSMVGPCC VFLMHHRPSH
60 70 80 90 100
EVRLRFSDFY NVGEFPYRVG LGDFASNVAP PPAKPFQRLI DLIGHMTLSD
110 120 130 140 150
FTRFPNLKEA ISWPLGEPSL AFFDLSSTRV HRNDDIRRDQ IATLAMRSCK
160 170 180 190 200
ITNDLEDSFA GLHRMIATEA ILRGIDLCLL PGFDLMYEVA HVQCVRLLQA
210 220 230 240 250
AKEDISNAVV PNSALIVLME ESLMLRSSLP SMMGRNNWIP VIPPIPDVEM
260
ESEEESDDDG FVEVD
Length:265
Mass (Da):29,903
Last modified:May 1, 1991 - v1
Checksum:iEF2608D29CEB6C84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53771 Genomic RNA. Translation: CAA37788.1.
PIRiC38552. MNVURV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53771 Genomic RNA. Translation: CAA37788.1.
PIRiC38552. MNVURV.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21698. 26 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR024376. RVFV_non-structural.
[Graphical view]
PfamiPF11073. NSs. 1 hit.
[Graphical view]
PIRSFiPIRSF003956. NS-S_PhleboV. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
    Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
    Virology 180:738-753(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62."
    Kalveram B., Lihoradova O., Ikegami T.
    J. Virol. 85:6234-6243(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNSS_RVFVZ
AccessioniPrimary (citable) accession number: P21698
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 29, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.