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P21698

- NSS_RVFVZ

UniProt

P21698 - NSS_RVFVZ

Protein

Non-structural protein NS-S

Gene

NSS

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Inhibits host general transcription by inhibiting host basal transcription factor TFIIH.1 Publication

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:NSS
    OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
    Taxonomic identifieri11589 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Bos taurus x Bison bison (beefalo) [TaxID: 297284]
    Camelus bactrianus (Bactrian camel) [TaxID: 9837]
    Capra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Ovis aries (Sheep) [TaxID: 9940]
    Phlebotomus papatasi (Sandfly) [TaxID: 29031]
    ProteomesiUP000002477: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Non-structural protein NS-SPRO_0000221979Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP21698. 26 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phlebovirus NS-S protein family.Curated

    Family and domain databases

    InterProiIPR024376. RVFV_non-structural.
    [Graphical view]
    PfamiPF11073. NSs. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003956. NS-S_PhleboV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21698-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFPVISVD LQSGRRVVSV EYFRGDGPPR IPYSMVGPCC VFLMHHRPSH    50
    EVRLRFSDFY NVGEFPYRVG LGDFASNVAP PPAKPFQRLI DLIGHMTLSD 100
    FTRFPNLKEA ISWPLGEPSL AFFDLSSTRV HRNDDIRRDQ IATLAMRSCK 150
    ITNDLEDSFA GLHRMIATEA ILRGIDLCLL PGFDLMYEVA HVQCVRLLQA 200
    AKEDISNAVV PNSALIVLME ESLMLRSSLP SMMGRNNWIP VIPPIPDVEM 250
    ESEEESDDDG FVEVD 265
    Length:265
    Mass (Da):29,903
    Last modified:May 1, 1991 - v1
    Checksum:iEF2608D29CEB6C84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53771 Genomic RNA. Translation: CAA37788.1.
    PIRiC38552. MNVURV.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53771 Genomic RNA. Translation: CAA37788.1 .
    PIRi C38552. MNVURV.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21698. 26 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR024376. RVFV_non-structural.
    [Graphical view ]
    Pfami PF11073. NSs. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003956. NS-S_PhleboV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses."
      Giorgi C., Accardi L., Nicoletti L., Gro M.C., Takehara K., Hilditch C., Morikawa S., Bishop D.H.L.
      Virology 180:738-753(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62."
      Kalveram B., Lihoradova O., Ikegami T.
      J. Virol. 85:6234-6243(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNSS_RVFVZ
    AccessioniPrimary (citable) accession number: P21698
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3