Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

Gene

gpd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121NADBy similarity1
Binding sitei144NAD; via amide nitrogenBy similarity1
Binding sitei144SubstrateBy similarity1
Binding sitei177NAD; via amide nitrogenBy similarity1
Active sitei232Proton acceptorBy similarity1
Binding sitei296NADBy similarity1
Binding sitei325NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 34NADBy similarity6

GO - Molecular functioni

  • glycerol-3-phosphate dehydrogenase [NAD+] activity Source: PomBase
  • NAD binding Source: InterPro
  • protein homodimerization activity Source: InterPro

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • cellular water homeostasis Source: PomBase
  • glycerol-3-phosphate catabolic process Source: InterPro
  • glycerol biosynthetic process Source: PomBase
  • NADH oxidation Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-SPO-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 (EC:1.1.1.8)
Alternative name(s):
GPDH-C
Short name:
GPD-C
Gene namesi
Name:gpd1
ORF Names:SPBC215.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC215.05
PomBaseiSPBC215.05 gpd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380951 – 385Glycerol-3-phosphate dehydrogenase [NAD(+)] 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376Phosphoserine1 Publication1
Modified residuei382Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21696
PaxDbiP21696
PRIDEiP21696

PTM databases

iPTMnetiP21696
SwissPalmiP21696

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276983, 44 interactors
STRINGi4896.SPBC215.05.1

Structurei

3D structure databases

ProteinModelPortaliP21696
SMRiP21696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni296 – 297Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855
InParanoidiP21696
KOiK00006
OMAiWLCKGFE
OrthoDBiEOG092C3ZQP
PhylomeDBiP21696

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

P21696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYGQQGVS AANIDSIRPK KRLSIGVVGS GNWGTAIAKI CGENARAHGH
60 70 80 90 100
HFRSKVRMWV FEEEIEYKGE KRKLTEVFNE AHENVKYLPG IECPPNVIAV
110 120 130 140 150
PDVREVARRA DILVFVVPHQ FIERVCDQMV GLIRPGAVGI SCIKGVAVSK
160 170 180 190 200
EGVRLYSEVI SEKLGIYCGV LSGANVANEV AREQFCETTI GFNPPNEVDI
210 220 230 240 250
PREQIAAVFD RPYFSVVSVD DVAGVALGGA LKNVVAMAVG FADGLEWGGN
260 270 280 290 300
TKAAIMRRGL LEMQKFATTF FDSDPRTMVE QSCGIADLVT SCLGGRNNRC
310 320 330 340 350
AEAFVKTGKS LETLEKELLG GQLLQGAATS KDVHEFLLTK DMVKDFPLFT
360 370 380
AVYNISYEDM DPKDLIIVLQ PLKEDSENEG GTETE
Length:385
Mass (Da):41,995
Last modified:January 11, 2001 - v2
Checksum:i8061C294196516E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 56SKV → GKG in CAA39630 (PubMed:2263480).Curated3
Sequence conflicti126 – 127CD → WH in CAA39630 (PubMed:2263480).Curated2
Sequence conflicti153Missing in CAA39630 (PubMed:2263480).Curated1
Sequence conflicti154R → S in CAA39630 (PubMed:2263480).Curated1
Sequence conflicti209F → S in CAA39630 (PubMed:2263480).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56162 Genomic DNA Translation: CAA39630.1
CU329671 Genomic DNA Translation: CAA22119.1
D50796 Genomic DNA Translation: BAA09424.1
PIRiT39895
RefSeqiNP_596682.1, NM_001022605.2

Genome annotation databases

EnsemblFungiiSPBC215.05.1; SPBC215.05.1:pep; SPBC215.05
GeneIDi2540455
KEGGispo:SPBC215.05

Similar proteinsi

Entry informationi

Entry nameiGPD1_SCHPO
AccessioniPrimary (citable) accession number: P21696
Secondary accession number(s): O94310, P78927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health