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P21695

- GPDA_HUMAN

UniProt

P21695 - GPDA_HUMAN

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene
GPD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Enzyme regulationi

Inhibited by zinc ions and sulfate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NAD
Binding sitei97 – 971NAD
Binding sitei120 – 1201Substrate
Binding sitei153 – 1531NAD; via amide nitrogen
Active sitei204 – 2041Proton acceptor Inferred
Binding sitei269 – 2691NAD
Binding sitei296 – 2961NAD; via amide nitrogen
Binding sitei298 – 2981NAD

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: ProtInc
  2. glycerol-3-phosphate dehydrogenase activity Source: Ensembl
  3. NAD binding Source: Ensembl

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. cellular response to cAMP Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. gluconeogenesis Source: Ensembl
  5. glycerol-3-phosphate catabolic process Source: InterPro
  6. glycerophospholipid biosynthetic process Source: Reactome
  7. NADH oxidation Source: Ensembl
  8. phosphatidic acid biosynthetic process Source: Reactome
  9. phospholipid metabolic process Source: Reactome
  10. small molecule metabolic process Source: Reactome
  11. triglyceride biosynthetic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:HS09586-MONOMER.
ReactomeiREACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.
SABIO-RKP21695.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:GPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4455. GPD1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi614480. phenotype.
Orphaneti300293. Infantile regressive hypertriglyceridemia and hepatosteatosis.
PharmGKBiPA28836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicPRO_0000138079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-succinyllysine By similarity

Proteomic databases

MaxQBiP21695.
PaxDbiP21695.
PRIDEiP21695.

PTM databases

PhosphoSiteiP21695.

Expressioni

Gene expression databases

ArrayExpressiP21695.
BgeeiP21695.
CleanExiHS_GPD1.
GenevestigatoriP21695.

Organism-specific databases

HPAiHPA044620.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109080. 2 interactions.
IntActiP21695. 3 interactions.
MINTiMINT-1429375.
STRINGi9606.ENSP00000301149.

Structurei

Secondary structure

1
349
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96
Helixi13 – 2816
Beta strandi32 – 398
Beta strandi44 – 496
Helixi50 – 578
Turni61 – 633
Beta strandi73 – 786
Helixi79 – 835
Beta strandi87 – 915
Helixi95 – 973
Helixi98 – 1058
Beta strandi114 – 1174
Beta strandi124 – 1285
Helixi132 – 1409
Beta strandi144 – 1485
Helixi153 – 1575
Beta strandi162 – 1676
Helixi171 – 18111
Beta strandi186 – 1927
Helixi194 – 21623
Helixi221 – 24222
Beta strandi243 – 2453
Helixi249 – 2535
Turni255 – 2573
Helixi258 – 26710
Helixi269 – 28012
Helixi284 – 2918
Helixi298 – 31316
Helixi316 – 3183
Helixi320 – 33011
Helixi335 – 3384
Helixi339 – 3435

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WPQX-ray2.50A/B1-349[»]
1X0VX-ray2.30A/B1-349[»]
1X0XX-ray2.75A1-349[»]
ProteinModelPortaliP21695.
SMRiP21695. Positions 1-349.

Miscellaneous databases

EvolutionaryTraceiP21695.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate binding

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiP21695.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
PhylomeDBiP21695.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21695-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL    50
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK 100
ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA 150
NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC 200
GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGPVSSA 250
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP 300
ETARELYSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM 349
Length:349
Mass (Da):37,568
Last modified:March 20, 2007 - v4
Checksum:iCE7B7681103076EF
GO
Isoform 2 (identifier: P21695-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-96: Missing.

Note: No experimental confirmation available.

Show »
Length:326
Mass (Da):35,140
Checksum:i61562929C503DB70
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541I → V.1 Publication
Corresponds to variant rs2232202 [ dbSNP | Ensembl ].
VAR_029492
Natural varianti113 – 1131A → P.1 Publication
Corresponds to variant rs1128867 [ dbSNP | Ensembl ].
VAR_029493
Natural varianti124 – 1241E → K.1 Publication
Corresponds to variant rs34783513 [ dbSNP | Ensembl ].
VAR_067425
Natural varianti197 – 1971V → A.1 Publication
Corresponds to variant rs2232207 [ dbSNP | Ensembl ].
VAR_049220
Natural varianti223 – 2231T → I.1 Publication
VAR_067426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 9623Missing in isoform 2. VSP_045999Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34041 mRNA. Translation: AAA92863.1.
AK130162 mRNA. No translation available.
AC025154 Genomic DNA. No translation available.
BC032234 mRNA. Translation: AAH32234.1.
M36917 Genomic DNA. Translation: AAA35925.1.
CCDSiCCDS58229.1. [P21695-2]
CCDS8799.1. [P21695-1]
PIRiS55920.
RefSeqiNP_001244128.1. NM_001257199.1. [P21695-2]
NP_005267.2. NM_005276.3. [P21695-1]
UniGeneiHs.524418.

Genome annotation databases

EnsembliENST00000301149; ENSP00000301149; ENSG00000167588. [P21695-1]
ENST00000548814; ENSP00000446768; ENSG00000167588. [P21695-2]
GeneIDi2819.
KEGGihsa:2819.
UCSCiuc001rvz.4. human. [P21695-1]

Polymorphism databases

DMDMi134047785.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34041 mRNA. Translation: AAA92863.1 .
AK130162 mRNA. No translation available.
AC025154 Genomic DNA. No translation available.
BC032234 mRNA. Translation: AAH32234.1 .
M36917 Genomic DNA. Translation: AAA35925.1 .
CCDSi CCDS58229.1. [P21695-2 ]
CCDS8799.1. [P21695-1 ]
PIRi S55920.
RefSeqi NP_001244128.1. NM_001257199.1. [P21695-2 ]
NP_005267.2. NM_005276.3. [P21695-1 ]
UniGenei Hs.524418.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WPQ X-ray 2.50 A/B 1-349 [» ]
1X0V X-ray 2.30 A/B 1-349 [» ]
1X0X X-ray 2.75 A 1-349 [» ]
ProteinModelPortali P21695.
SMRi P21695. Positions 1-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109080. 2 interactions.
IntActi P21695. 3 interactions.
MINTi MINT-1429375.
STRINGi 9606.ENSP00000301149.

Chemistry

DrugBanki DB00157. NADH.

PTM databases

PhosphoSitei P21695.

Polymorphism databases

DMDMi 134047785.

Proteomic databases

MaxQBi P21695.
PaxDbi P21695.
PRIDEi P21695.

Protocols and materials databases

DNASUi 2819.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301149 ; ENSP00000301149 ; ENSG00000167588 . [P21695-1 ]
ENST00000548814 ; ENSP00000446768 ; ENSG00000167588 . [P21695-2 ]
GeneIDi 2819.
KEGGi hsa:2819.
UCSCi uc001rvz.4. human. [P21695-1 ]

Organism-specific databases

CTDi 2819.
GeneCardsi GC12P050497.
HGNCi HGNC:4455. GPD1.
HPAi HPA044620.
MIMi 138420. gene.
614480. phenotype.
neXtProti NX_P21695.
Orphaneti 300293. Infantile regressive hypertriglyceridemia and hepatosteatosis.
PharmGKBi PA28836.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0240.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi P21695.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
PhylomeDBi P21695.
TreeFami TF300836.

Enzyme and pathway databases

BioCyci MetaCyc:HS09586-MONOMER.
Reactomei REACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.
SABIO-RK P21695.

Miscellaneous databases

EvolutionaryTracei P21695.
GenomeRNAii 2819.
NextBioi 11107.
PROi P21695.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21695.
Bgeei P21695.
CleanExi HS_GPD1.
Genevestigatori P21695.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase."
    Menaya J., Gonzalez-Manchon C., Parrilla R., Ayuso M.S.
    Biochim. Biophys. Acta 1262:91-94(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-113.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Macrophage.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  5. "Sequence conservation and structural organization of the glycerol-3-phosphate dehydrogenase promoter in mice and humans."
    Gwynn B., Lyford K.L., Birkenmeier E.H.
    Mol. Cell. Biol. 10:5244-5256(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
    Tissue: Fetal liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1."
    Basel-Vanagaite L., Zevit N., Zahav A.H., Guo L., Parathath S., Pasmanik-Chor M., McIntyre A.D., Wang J., Albin-Kaplanski A., Hartman C., Marom D., Zeharia A., Badir A., Shoerman O., Simon A.J., Rechavi G., Shohat M., Hegele R.A., Fisher E.A., Shamir R.
    Am. J. Hum. Genet. 90:49-60(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HTGTI, VARIANTS VAL-54; LYS-124; ALA-197 AND ILE-223.
  8. "Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)."
    Ou X., Ji C., Han X., Zhao X., Li X., Mao Y., Wong L.-L., Bartlam M., Rao Z.
    J. Mol. Biol. 357:858-869(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH NAD, SUBUNIT, ENZYME REGULATION.

Entry informationi

Entry nameiGPDA_HUMAN
AccessioniPrimary (citable) accession number: P21695
Secondary accession number(s): F8W1L5, Q8N1B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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