P21690 (TRPE_SPIAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Spirochaeta aurantia

Taxonomic identifier

147 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Spirochaeta

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	Anthranilate synthase component 1		PRO_0000154112

Sequences

	Sequence		Length	Mass (Da)
	P21690 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 37748386479E3573	FASTA	482	53,699
	10 20 30 40 50 60 MFLFVETIRP QQRGESLLET VIKVVPGERF TPYGLALKLG ARVVLESSSS KKGRDRYSLL 70 80 90 100 110 120 LLQEAFRVAQ EGTEVYFVKD GRRSKVKANH RDILDVLMYF ARQHSDPGQD FPFPAGGVGY 130 140 150 160 170 180 LSFEFCRYCD TIHLNPAKPD PLELPDALFL FGHVFLIYDH YTDLIYLVGL NYKEASIDLE 190 200 210 220 230 240 AALAAVEARV NDGDWSALGS VGAPYDAEVL PQDYDPDETY KANVGAMRQE VIAGNLLQGV 250 260 270 280 290 300 PSRRLLVKTE MPAIEAYRRL RSSNPSPYMF YLDFGDYQLF RASPELHVKV KGGTAEIRPI 310 320 330 340 350 360 AGTRRRGATD AEDRALEAEL LADVKERAEH LMLVDLARND LGRICQPGTV QVKDSYFIER 370 380 390 400 410 420 YSHVMHIVSS VEGRLKDDKT GIDALRASFP AGTVSGAPKI RAIEVIDRLE PVQRRFYSGV 430 440 450 460 470 480 VGHLSPDGSL DTCIAIRSAL KKGDTMVLQA GGGIVFDSNP DRELEETYEK MRATARSLGL EI

References

[1]	"Nucleotide sequence and analysis of a gene encoding anthranilate synthase component I in Spirochaeta aurantia." Brahamsha B., Han C.Y., Crawford I.P., Greenberg E.P. J. Bacteriol. 173:541-548(1991) [PubMed: 1987149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55917 Genomic DNA. Translation: AAA26591.1.
PIR	A39132.
3D structure databases
ProteinModelPortal	P21690.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_SPIAU

Accession

Primary (citable) accession number: P21690

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	September 21, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program