P21689 (TRPE_PSESS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Pseudomonas syringae pv. savastanoi

Taxonomic identifier

29438 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Anthranilate synthase component 1		PRO_0000154108

Sequences

	Sequence		Length	Mass (Da)
	P21689 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: A38E81931331F6BB	FASTA	505	56,084
	10 20 30 40 50 60 MNREEFLRLA AEGYNRIPLA RETLADFDTP LSIYLKLADQ PNSYLLESVQ GGEKWGRYSI 70 80 90 100 110 120 IGLPCRTVMR VHGHHVSVTH DGVEIESLDV EDPLDFVETF KARYNVPTIA GLPRFNGGLV 130 140 150 160 170 180 GYFGYDCVRY VEKRLANCPN PDPLGVPDIL LMVSDAVVVF DNLAGKMHAI VLVDPAQQDA 190 200 210 220 230 240 YARGVAQLDE LMHKLRQPIT PRRGLDLDRA PRADPVFRSS FTQGDYEAAV DTIKQYILAG 250 260 270 280 290 300 DVMQVVPSQR MSIDFKAAPI DLYRALRCFN PTPYMYFFNF GDFHVVGSSP EVLVRVEDNL 310 320 330 340 350 360 ITVRPIAGTR PRGATEEADL ALEEDLLSDH KEIAEHLMLI DLGRNDVGRV SEIGTVKLTE 370 380 390 400 410 420 KMVIERYSNV MHIVSNVTGQ LKNGLTAMDA LRAILPAGTL SGAPKIRAME IIDELEPVKR 430 440 450 460 470 480 GVYGGAVGYM AWNGNMDTAI AIRTAVIKNG ELHVQAGGGI VADSVPVLEW EETLNKRRAM 490 500 VGSAWWPWPR RLPRVEQACC SGNER

References

[1]	"Molecular characterization and expression analysis of the anthranilate synthase gene of Pseudomonas syringae subsp. savastanoi." da Costa e Silva O., Kosuge T. J. Bacteriol. 173:463-471(1991) [PubMed: 1987141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55911 Genomic DNA. Translation: AAA26016.1.
PIR	A39128.
3D structure databases
ProteinModelPortal	P21689.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_PSESS

Accession

Primary (citable) accession number: P21689

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	September 21, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program