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P21684 (CRTE_PANAN) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase
Short name=GGPP synthase
EC=2.5.1.29
Alternative name(s):
Farnesyltranstransferase
Gene names
Name:crtE
OrganismPantoea ananas (Erwinia uredovora)
Taxonomic identifier553 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pantoea

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
   Biological processCarotenoid biosynthesis
Isoprene biosynthesis
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processcarotenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionfarnesyltranstransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Geranylgeranyl pyrophosphate synthase
PRO_0000123993

Sites

Metal binding941Magnesium 1 By similarity
Metal binding941Magnesium 2 By similarity
Metal binding1001Magnesium 1 By similarity
Metal binding1001Magnesium 2 By similarity
Metal binding2301Magnesium 3 By similarity
Binding site531Isopentenyl diphosphate By similarity
Binding site561Isopentenyl diphosphate By similarity
Binding site871Isopentenyl diphosphate By similarity
Binding site1051Farnesyl diphosphate By similarity
Binding site1061Isopentenyl diphosphate By similarity
Binding site1891Farnesyl diphosphate By similarity
Binding site1901Farnesyl diphosphate By similarity
Binding site2271Farnesyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P21684 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: CADB04699D2EBA4A

FASTA30232,583
        10         20         30         40         50         60 
MTVCAKKHVH LTRDAAEQLL ADIDRRLDQL LPVEGERDVV GAAMREGALA PGKRIRPMLL 

        70         80         90        100        110        120 
LLTARDLGCA VSHDGLLDLA CAVEMVHAAS LILDDMPCMD DAKLRRGRPT IHSHYGEHVA 

       130        140        150        160        170        180 
ILAAVALLSK AFGVIADADG LTPLAKNRAV SELSNAIGMQ GLVQGQFKDL SEGDKPRSAE 

       190        200        210        220        230        240 
AILMTNHFKT STLFCASMQM ASIVANASSE ARDCLHRFSL DLGQAFQLLD DLTDGMTDTG 

       250        260        270        280        290        300 
KDSNQDAGKS TLVNLLGPRA VEERLRQHLQ LASEHLSAAC QHGHATQHFI QAWFDKKLAA 


VS

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References

[1]"Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli."
Misawa N., Nakagawa M., Kobayashi K., Yamano S., Izawa Y., Nakamura K., Harashima K.
J. Bacteriol. 172:6704-6712(1990) [PubMed: 2254247] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 20D3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D90087 Genomic DNA. Translation: BAA14124.1.
PIRA37802.

3D structure databases

ProteinModelPortalP21684.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRTE_PANAN
AccessionPrimary (citable) accession number: P21684
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 21, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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