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Protein

Follistatin

Gene

Fst

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

  • activin binding Source: RGD
  • heparan sulfate proteoglycan binding Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2473224. Antagonism of Activin by Follistatin.

Protein family/group databases

MEROPSiI01.966.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:Fst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2633. Fst.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001010630 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
Disulfide bondi56 ↔ 91PROSITE-ProRule annotation
Disulfide bondi95 ↔ 106
Disulfide bondi100 ↔ 116
Disulfide bondi118 ↔ 150
Disulfide bondi122 ↔ 143
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi132 ↔ 164
Disulfide bondi168 ↔ 179
Disulfide bondi173 ↔ 189
Disulfide bondi192 ↔ 225
Disulfide bondi196 ↔ 218
Disulfide bondi207 ↔ 239
Disulfide bondi270 ↔ 302PROSITE-ProRule annotation
Disulfide bondi274 ↔ 295PROSITE-ProRule annotation
Disulfide bondi284 ↔ 316PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21674.
PRIDEiP21674.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011631.
GenevisibleiP21674. RN.

Interactioni

Subunit structurei

Monomer.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
INHBAP084762EBI-5746973,EBI-8077140From a different organism.

GO - Molecular functioni

  • activin binding Source: RGD

Protein-protein interaction databases

IntActiP21674. 2 interactors.
MINTiMINT-1787002.
STRINGi10116.ENSRNOP00000015680.

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi104 – 108Combined sources5
Beta strandi114 – 118Combined sources5
Helixi122 – 124Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi138 – 141Combined sources4
Helixi142 – 151Combined sources10
Beta strandi158 – 162Combined sources5
Beta strandi166 – 168Combined sources3
Beta strandi178 – 181Combined sources4
Beta strandi185 – 190Combined sources6
Beta strandi200 – 202Combined sources3
Beta strandi206 – 208Combined sources3
Beta strandi213 – 216Combined sources4
Helixi217 – 227Combined sources11
Beta strandi233 – 238Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LR7X-ray1.50A93-165[»]
1LR8X-ray2.10A93-165[»]
1LR9X-ray2.50A93-165[»]
2ARPX-ray2.00F93-241[»]
ProteinModelPortaliP21674.
SMRiP21674.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Sequence similaritiesi

Contains 3 follistatin-like domains.Curated
Contains 3 Kazal-like domains.PROSITE-ProRule annotation
Contains 1 TB (TGF-beta binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP21674.
KOiK04661.
OMAiEAVCASD.
OrthoDBiEOG091G09I0.
PhylomeDBiP21674.
TreeFamiTF106409.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPS
210 220 230 240 250
SSEQSLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
GGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EETEEEEEEE DQDYSFPISS TLEW
Length:344
Mass (Da):37,838
Last modified:May 1, 1991 - v1
Checksum:i864244CF05436552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31591
, M31586, M31587, M31588, M31589, M31590 Genomic DNA. Translation: AAB60704.1.
S58913 Genomic DNA. Translation: AAP13905.1.
PIRiI57698.
RefSeqiNP_036693.1. NM_012561.2.
UniGeneiRn.162557.
Rn.2743.

Genome annotation databases

EnsembliENSRNOT00000015680; ENSRNOP00000015680; ENSRNOG00000011631.
GeneIDi24373.
KEGGirno:24373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31591
, M31586, M31587, M31588, M31589, M31590 Genomic DNA. Translation: AAB60704.1.
S58913 Genomic DNA. Translation: AAP13905.1.
PIRiI57698.
RefSeqiNP_036693.1. NM_012561.2.
UniGeneiRn.162557.
Rn.2743.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LR7X-ray1.50A93-165[»]
1LR8X-ray2.10A93-165[»]
1LR9X-ray2.50A93-165[»]
2ARPX-ray2.00F93-241[»]
ProteinModelPortaliP21674.
SMRiP21674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21674. 2 interactors.
MINTiMINT-1787002.
STRINGi10116.ENSRNOP00000015680.

Protein family/group databases

MEROPSiI01.966.

Proteomic databases

PaxDbiP21674.
PRIDEiP21674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015680; ENSRNOP00000015680; ENSRNOG00000011631.
GeneIDi24373.
KEGGirno:24373.

Organism-specific databases

CTDi10468.
RGDi2633. Fst.

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP21674.
KOiK04661.
OMAiEAVCASD.
OrthoDBiEOG091G09I0.
PhylomeDBiP21674.
TreeFamiTF106409.

Enzyme and pathway databases

ReactomeiR-RNO-2473224. Antagonism of Activin by Follistatin.

Miscellaneous databases

EvolutionaryTraceiP21674.
PROiP21674.

Gene expression databases

BgeeiENSRNOG00000011631.
GenevisibleiP21674. RN.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFST_RAT
AccessioniPrimary (citable) accession number: P21674
Secondary accession number(s): Q80XW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.