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Protein

Follistatin

Gene

Fst

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

  • activin binding Source: RGD
  • heparan sulfate proteoglycan binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2473224 Antagonism of Activin by Follistatin

Protein family/group databases

MEROPSiI01.966

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:Fst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2633 Fst

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001010630 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotationBy similarity
Disulfide bondi42 ↔ 88PROSITE-ProRule annotationBy similarity
Disulfide bondi56 ↔ 91PROSITE-ProRule annotationBy similarity
Disulfide bondi95 ↔ 106By similarity
Disulfide bondi100 ↔ 116By similarity
Disulfide bondi118 ↔ 150By similarity
Disulfide bondi122 ↔ 143By similarity
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 164By similarity
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi173 ↔ 189By similarity
Disulfide bondi192 ↔ 225By similarity
Disulfide bondi196 ↔ 218By similarity
Disulfide bondi207 ↔ 239By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi250 ↔ 267By similarity
Disulfide bondi270 ↔ 302By similarity
Disulfide bondi274 ↔ 295By similarity
Disulfide bondi284 ↔ 316By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21674
PRIDEiP21674

PTM databases

PhosphoSitePlusiP21674

Expressioni

Gene expression databases

BgeeiENSRNOG00000011631
GenevisibleiP21674 RN

Interactioni

Subunit structurei

Monomer.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
INHBAP084762EBI-5746973,EBI-8077140From Homo sapiens.

GO - Molecular functioni

  • heparan sulfate proteoglycan binding Source: RGD

Protein-protein interaction databases

IntActiP21674, 2 interactors
MINTiP21674
STRINGi10116.ENSRNOP00000015680

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi104 – 108Combined sources5
Beta strandi114 – 118Combined sources5
Helixi122 – 124Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi138 – 141Combined sources4
Helixi142 – 151Combined sources10
Beta strandi158 – 162Combined sources5
Beta strandi166 – 168Combined sources3
Beta strandi178 – 181Combined sources4
Beta strandi185 – 190Combined sources6
Beta strandi200 – 202Combined sources3
Beta strandi206 – 208Combined sources3
Beta strandi213 – 216Combined sources4
Helixi217 – 227Combined sources11
Beta strandi233 – 238Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LR7X-ray1.50A93-165[»]
1LR8X-ray2.10A93-165[»]
1LR9X-ray2.50A93-165[»]
2ARPX-ray2.00F93-241[»]
ProteinModelPortaliP21674
SMRiP21674
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21674

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F Eukaryota
ENOG410YM8Q LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiP21674
KOiK04661
OMAiDEAVCAS
OrthoDBiEOG091G09I0
PhylomeDBiP21674
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 3 hits
SMARTiView protein in SMART
SM00274 FOLN, 3 hits
SM00280 KAZAL, 3 hits
SUPFAMiSSF100895 SSF100895, 3 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 3 hits
PS51364 TB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPS
210 220 230 240 250
SSEQSLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
GGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EETEEEEEEE DQDYSFPISS TLEW
Length:344
Mass (Da):37,838
Last modified:May 1, 1991 - v1
Checksum:i864244CF05436552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31591
, M31586, M31587, M31588, M31589, M31590 Genomic DNA Translation: AAB60704.1
S58913 Genomic DNA Translation: AAP13905.1
PIRiI57698
RefSeqiNP_036693.1, NM_012561.2
UniGeneiRn.162557
Rn.2743

Genome annotation databases

EnsembliENSRNOT00000015680; ENSRNOP00000015680; ENSRNOG00000011631
GeneIDi24373
KEGGirno:24373

Similar proteinsi

Entry informationi

Entry nameiFST_RAT
AccessioniPrimary (citable) accession number: P21674
Secondary accession number(s): Q80XW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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