ID   FGF6_MOUSE              Reviewed;         208 AA.
AC   P21658;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   24-JAN-2024, entry version 166.
DE   RecName: Full=Fibroblast growth factor 6;
DE            Short=FGF-6;
DE   AltName: Full=Heparin secretory-transforming protein 2;
DE            Short=HST-2;
DE            Short=HSTF-2;
DE   AltName: Full=Heparin-binding growth factor 6;
DE            Short=HBGF-6;
DE   Flags: Precursor;
GN   Name=Fgf6; Synonyms=Fgf-6, Hstf2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Embryo;
RX   PubMed=1477139; DOI=10.1016/0300-9084(92)90025-a;
RA   Ollendorf V., Rosnet O., Marics I., Birnbaum D., Delapeyriere O.;
RT   "Isolation and sequence of the murine Fgf6 cDNA.";
RL   Biochimie 74:1035-1038(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.
RX   PubMed=2193291;
RA   de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S.,
RA   Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A.,
RA   Coulier F., Birnbaum D.;
RT   "Structure, chromosome mapping and expression of the murine Fgf-6 gene.";
RL   Oncogene 5:823-831(1990).
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation, cell differentiation, angiogenesis and myogenesis, and
CC       is required for normal muscle regeneration. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFR1, FGFR2 and FGFR4. Affinity between
CC       fibroblast growth factors (FGFs) and their receptors is increased by
CC       heparan sulfate glycosaminoglycans that function as coreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Embryos, adult muscles and adult testis.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; M92415; AAA62260.1; -; Genomic_DNA.
DR   EMBL; M92416; AAA62261.1; -; mRNA.
DR   EMBL; X51552; CAA35925.1; -; Genomic_DNA.
DR   CCDS; CCDS20561.1; -.
DR   PIR; S14192; S14192.
DR   RefSeq; NP_034334.1; NM_010204.1.
DR   AlphaFoldDB; P21658; -.
DR   SMR; P21658; -.
DR   STRING; 10090.ENSMUSP00000000187; -.
DR   GlyCosmos; P21658; 1 site, No reported glycans.
DR   GlyGen; P21658; 1 site.
DR   iPTMnet; P21658; -.
DR   PhosphoSitePlus; P21658; -.
DR   PaxDb; 10090-ENSMUSP00000000187; -.
DR   Antibodypedia; 41814; 212 antibodies from 22 providers.
DR   DNASU; 14177; -.
DR   Ensembl; ENSMUST00000000187.7; ENSMUSP00000000187.6; ENSMUSG00000000183.7.
DR   GeneID; 14177; -.
DR   KEGG; mmu:14177; -.
DR   UCSC; uc009dvo.1; mouse.
DR   AGR; MGI:95520; -.
DR   CTD; 2251; -.
DR   MGI; MGI:95520; Fgf6.
DR   VEuPathDB; HostDB:ENSMUSG00000000183; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000157821; -.
DR   HOGENOM; CLU_081609_4_1_1; -.
DR   InParanoid; P21658; -.
DR   OMA; RISGAHN; -.
DR   OrthoDB; 2883843at2759; -.
DR   PhylomeDB; P21658; -.
DR   TreeFam; TF317805; -.
DR   Reactome; R-MMU-109704; PI3K Cascade.
DR   Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR   Reactome; R-MMU-190373; FGFR1c ligand binding and activation.
DR   Reactome; R-MMU-190375; FGFR2c ligand binding and activation.
DR   Reactome; R-MMU-5654219; Phospholipase C-mediated cascade: FGFR1.
DR   Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR   Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR   Reactome; R-MMU-5654687; Downstream signaling of activated FGFR1.
DR   Reactome; R-MMU-5654688; SHC-mediated cascade:FGFR1.
DR   Reactome; R-MMU-5654689; PI-3K cascade:FGFR1.
DR   Reactome; R-MMU-5654693; FRS-mediated FGFR1 signaling.
DR   Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR   Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR   Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR   Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR   Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR   Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR   Reactome; R-MMU-5654726; Negative regulation of FGFR1 signaling.
DR   Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   BioGRID-ORCS; 14177; 0 hits in 78 CRISPR screens.
DR   PRO; PR:P21658; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P21658; Protein.
DR   Bgee; ENSMUSG00000000183; Expressed in mesenchyme of tongue and 43 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; ISO:MGI.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0001502; P:cartilage condensation; IGI:MGI.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR   GO; GO:0045445; P:myoblast differentiation; IDA:MGI.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   CDD; cd00058; FGF; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR   PANTHER; PTHR11486:SF25; FIBROBLAST GROWTH FACTOR 6; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
DR   Genevisible; P21658; MM.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Growth factor; Mitogen; Proto-oncogene; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..208
FT                   /note="Fibroblast growth factor 6"
FT                   /id="PRO_0000008962"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..157
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   208 AA;  22798 MW;  BBF7B9301BB79A1B CRC64;
     MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD SRGWGTLLSR
     SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV PPDGRISGTH EENPYSLLEI
     STVERGVVSL FGVKSALFIA MNSKGRLYTT PSFHDECKFR ETLLPNNYNA YESDLYRGTY
     IALSKYGRVK RGSKVSPIMT VTHFLPRI
//