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P21658

- FGF6_MOUSE

UniProt

P21658 - FGF6_MOUSE

Protein

Fibroblast growth factor 6

Gene

Fgf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.By similarity

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cartilage condensation Source: MGI
    3. fibroblast growth factor receptor signaling pathway Source: Ensembl
    4. myoblast differentiation Source: MGI
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 6
    Short name:
    FGF-6
    Alternative name(s):
    Heparin secretory-transforming protein 2
    Short name:
    HST-2
    Short name:
    HSTF-2
    Heparin-binding growth factor 6
    Short name:
    HBGF-6
    Gene namesi
    Name:Fgf6
    Synonyms:Fgf-6, Hstf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:95520. Fgf6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 208171Fibroblast growth factor 6PRO_0000008962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 ↔ 157Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP21658.

    PTM databases

    PhosphoSiteiP21658.

    Expressioni

    Tissue specificityi

    Embryos, adult muscles and adult testis.

    Gene expression databases

    BgeeiP21658.
    CleanExiMM_FGF6.
    GenevestigatoriP21658.

    Interactioni

    Subunit structurei

    Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000000187.

    Structurei

    3D structure databases

    ProteinModelPortaliP21658.
    SMRiP21658. Positions 81-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320285.
    GeneTreeiENSGT00730000110487.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP21658.
    KOiK04358.
    OMAiEIAGVNW.
    OrthoDBiEOG7992S1.
    PhylomeDBiP21658.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028242. FGF6.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF25. PTHR11486:SF25. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD    50
    SRGWGTLLSR SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV 100
    PPDGRISGTH EENPYSLLEI STVERGVVSL FGVKSALFIA MNSKGRLYTT 150
    PSFHDECKFR ETLLPNNYNA YESDLYRGTY IALSKYGRVK RGSKVSPIMT 200
    VTHFLPRI 208
    Length:208
    Mass (Da):22,798
    Last modified:November 1, 1995 - v2
    Checksum:iBBF7B9301BB79A1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92415 Genomic DNA. Translation: AAA62260.1.
    M92416 mRNA. Translation: AAA62261.1.
    X51552 Genomic DNA. Translation: CAA35925.1.
    CCDSiCCDS20561.1.
    PIRiS14192.
    RefSeqiNP_034334.1. NM_010204.1.
    UniGeneiMm.3403.

    Genome annotation databases

    EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
    GeneIDi14177.
    KEGGimmu:14177.
    UCSCiuc009dvo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92415 Genomic DNA. Translation: AAA62260.1 .
    M92416 mRNA. Translation: AAA62261.1 .
    X51552 Genomic DNA. Translation: CAA35925.1 .
    CCDSi CCDS20561.1.
    PIRi S14192.
    RefSeqi NP_034334.1. NM_010204.1.
    UniGenei Mm.3403.

    3D structure databases

    ProteinModelPortali P21658.
    SMRi P21658. Positions 81-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000000187.

    PTM databases

    PhosphoSitei P21658.

    Proteomic databases

    PRIDEi P21658.

    Protocols and materials databases

    DNASUi 14177.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000187 ; ENSMUSP00000000187 ; ENSMUSG00000000183 .
    GeneIDi 14177.
    KEGGi mmu:14177.
    UCSCi uc009dvo.1. mouse.

    Organism-specific databases

    CTDi 2251.
    MGIi MGI:95520. Fgf6.

    Phylogenomic databases

    eggNOGi NOG320285.
    GeneTreei ENSGT00730000110487.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P21658.
    KOi K04358.
    OMAi EIAGVNW.
    OrthoDBi EOG7992S1.
    PhylomeDBi P21658.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285358.
    PROi P21658.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21658.
    CleanExi MM_FGF6.
    Genevestigatori P21658.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028242. FGF6.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF25. PTHR11486:SF25. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Embryo.
    2. "Structure, chromosome mapping and expression of the murine Fgf-6 gene."
      de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S., Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A., Coulier F., Birnbaum D.
      Oncogene 5:823-831(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.

    Entry informationi

    Entry nameiFGF6_MOUSE
    AccessioniPrimary (citable) accession number: P21658
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3