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P21658 (FGF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 6

Short name=FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name=HST-2
Short name=HSTF-2
Heparin-binding growth factor 6
Short name=HBGF-6
Gene names
Name:Fgf6
Synonyms:Fgf-6, Hstf2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration By similarity.

Subunit structure

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.

Subcellular location

Secretedextracellular space.

Tissue specificity

Embryos, adult muscles and adult testis.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 208171Fibroblast growth factor 6
PRO_0000008962

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 157 Potential

Sequences

Sequence LengthMass (Da)Tools
P21658 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: BBF7B9301BB79A1B

FASTA20822,798
        10         20         30         40         50         60 
MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV PPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVKSALFIA MNSKGRLYTT PSFHDECKFR ETLLPNNYNA YESDLYRGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI 

« Hide

References

[1]"Isolation and sequence of the murine Fgf6 cDNA."
Ollendorf V., Rosnet O., Marics I., Birnbaum D., Delapeyriere O.
Biochimie 74:1035-1038(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Embryo.
[2]"Structure, chromosome mapping and expression of the murine Fgf-6 gene."
de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S., Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A., Coulier F., Birnbaum D.
Oncogene 5:823-831(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92415 Genomic DNA. Translation: AAA62260.1.
M92416 mRNA. Translation: AAA62261.1.
X51552 Genomic DNA. Translation: CAA35925.1.
CCDSCCDS20561.1.
PIRS14192.
RefSeqNP_034334.1. NM_010204.1.
UniGeneMm.3403.

3D structure databases

ProteinModelPortalP21658.
SMRP21658. Positions 81-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000000187.

PTM databases

PhosphoSiteP21658.

Proteomic databases

PRIDEP21658.

Protocols and materials databases

DNASU14177.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
GeneID14177.
KEGGmmu:14177.
UCSCuc009dvo.1. mouse.

Organism-specific databases

CTD2251.
MGIMGI:95520. Fgf6.

Phylogenomic databases

eggNOGNOG320285.
GeneTreeENSGT00730000110487.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP21658.
KOK04358.
OMAEIAGVNW.
OrthoDBEOG7992S1.
PhylomeDBP21658.
TreeFamTF317805.

Gene expression databases

BgeeP21658.
CleanExMM_FGF6.
GenevestigatorP21658.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285358.
PROP21658.
SOURCESearch...

Entry information

Entry nameFGF6_MOUSE
AccessionPrimary (citable) accession number: P21658
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot