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P21658

- FGF6_MOUSE

UniProt

P21658 - FGF6_MOUSE

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Protein

Fibroblast growth factor 6

Gene

Fgf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.By similarity

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cartilage condensation Source: MGI
  3. fibroblast growth factor receptor signaling pathway Source: Ensembl
  4. myoblast differentiation Source: MGI
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:Fgf6
Synonyms:Fgf-6, Hstf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:95520. Fgf6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 208171Fibroblast growth factor 6PRO_0000008962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 ↔ 157Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21658.

PTM databases

PhosphoSiteiP21658.

Expressioni

Tissue specificityi

Embryos, adult muscles and adult testis.

Gene expression databases

BgeeiP21658.
CleanExiMM_FGF6.
GenevestigatoriP21658.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000187.

Structurei

3D structure databases

ProteinModelPortaliP21658.
SMRiP21658. Positions 81-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320285.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21658.
KOiK04358.
OMAiEIAGVNW.
OrthoDBiEOG7992S1.
PhylomeDBiP21658.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21658-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
PPDGRISGTH EENPYSLLEI STVERGVVSL FGVKSALFIA MNSKGRLYTT
160 170 180 190 200
PSFHDECKFR ETLLPNNYNA YESDLYRGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,798
Last modified:November 1, 1995 - v2
Checksum:iBBF7B9301BB79A1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92415 Genomic DNA. Translation: AAA62260.1.
M92416 mRNA. Translation: AAA62261.1.
X51552 Genomic DNA. Translation: CAA35925.1.
CCDSiCCDS20561.1.
PIRiS14192.
RefSeqiNP_034334.1. NM_010204.1.
UniGeneiMm.3403.

Genome annotation databases

EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
GeneIDi14177.
KEGGimmu:14177.
UCSCiuc009dvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92415 Genomic DNA. Translation: AAA62260.1 .
M92416 mRNA. Translation: AAA62261.1 .
X51552 Genomic DNA. Translation: CAA35925.1 .
CCDSi CCDS20561.1.
PIRi S14192.
RefSeqi NP_034334.1. NM_010204.1.
UniGenei Mm.3403.

3D structure databases

ProteinModelPortali P21658.
SMRi P21658. Positions 81-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000187.

PTM databases

PhosphoSitei P21658.

Proteomic databases

PRIDEi P21658.

Protocols and materials databases

DNASUi 14177.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000187 ; ENSMUSP00000000187 ; ENSMUSG00000000183 .
GeneIDi 14177.
KEGGi mmu:14177.
UCSCi uc009dvo.1. mouse.

Organism-specific databases

CTDi 2251.
MGIi MGI:95520. Fgf6.

Phylogenomic databases

eggNOGi NOG320285.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P21658.
KOi K04358.
OMAi EIAGVNW.
OrthoDBi EOG7992S1.
PhylomeDBi P21658.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

NextBioi 285358.
PROi P21658.
SOURCEi Search...

Gene expression databases

Bgeei P21658.
CleanExi MM_FGF6.
Genevestigatori P21658.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Embryo.
  2. "Structure, chromosome mapping and expression of the murine Fgf-6 gene."
    de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S., Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A., Coulier F., Birnbaum D.
    Oncogene 5:823-831(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.

Entry informationi

Entry nameiFGF6_MOUSE
AccessioniPrimary (citable) accession number: P21658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3