P21658 (FGF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 6
Short name=FGF-6

Alternative name(s):
Heparin secretory-transforming protein 2
Short name=HST-2
Short name=HSTF-2
Heparin-binding growth factor 6
Short name=HBGF-6

Gene names

Name:	Fgf6
Synonyms:	Fgf-6, Hstf2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration By similarity.
Subunit structure	Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.
Subcellular location	Secreted › extracellular space.
Tissue specificity	Embryos, adult muscles and adult testis.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cartilage condensation Inferred from genetic interaction PubMed 8565825. Source: MGI fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara myoblast differentiation Inferred from direct assay PubMed 8223280. Source: MGI positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell sarcolemma Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 208	171	Fibroblast growth factor 6		PRO_0000008962
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Disulfide bond	90 ↔ 157		Potential

Sequences

	Sequence		Length	Mass (Da)
	P21658 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: BBF7B9301BB79A1B	FASTA	208	22,798
	10 20 30 40 50 60 MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD SRGWGTLLSR 70 80 90 100 110 120 SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV PPDGRISGTH EENPYSLLEI 130 140 150 160 170 180 STVERGVVSL FGVKSALFIA MNSKGRLYTT PSFHDECKFR ETLLPNNYNA YESDLYRGTY 190 200 IALSKYGRVK RGSKVSPIMT VTHFLPRI

References

[1]	"Isolation and sequence of the murine Fgf6 cDNA." Ollendorf V., Rosnet O., Marics I., Birnbaum D., Delapeyriere O. Biochimie 74:1035-1038(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Embryo.
[2]	"Structure, chromosome mapping and expression of the murine Fgf-6 gene." de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S., Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A., Coulier F., Birnbaum D. Oncogene 5:823-831(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92415 Genomic DNA. Translation: AAA62260.1. M92416 mRNA. Translation: AAA62261.1. X51552 Genomic DNA. Translation: CAA35925.1.
IPI	IPI00379580.
PIR	S14192.
RefSeq	NP_034334.1. NM_010204.1.
UniGene	Mm.3403.
3D structure databases
ProteinModelPortal	P21658.
SMR	P21658. Positions 81-208.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000000187.
PTM databases
PhosphoSite	P21658.
Proteomic databases
PRIDE	P21658.
Protocols and materials databases
DNASU	14177.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
GeneID	14177.
KEGG	mmu:14177.
UCSC	uc009dvo.1. mouse.
Organism-specific databases
CTD	2251.
MGI	MGI:95520. Fgf6.
Phylogenomic databases
eggNOG	NOG320285.
GeneTree	ENSGT00700000104040.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P21658.
KO	K04358.
OMA	EIAGVNW.
OrthoDB	EOG4N8R5V.
Gene expression databases
Bgee	P21658.
CleanEx	MM_FGF6.
Genevestigator	P21658.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285358.
SOURCE	Search...

Entry information

Entry name

FGF6_MOUSE

Accession

Primary (citable) accession number: P21658

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program