Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 6

Gene

Fgf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.By similarity

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cartilage condensation Source: MGI
  3. fibroblast growth factor receptor signaling pathway Source: MGI
  4. myoblast differentiation Source: MGI
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_345290. Signaling by activated point mutants of FGFR1.
REACT_349060. Activated point mutants of FGFR2.
REACT_354830. FGFR1c ligand binding and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:Fgf6
Synonyms:Fgf-6, Hstf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95520. Fgf6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 208171Fibroblast growth factor 6PRO_0000008962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 ↔ 157Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21658.

PTM databases

PhosphoSiteiP21658.

Expressioni

Tissue specificityi

Embryos, adult muscles and adult testis.

Gene expression databases

BgeeiP21658.
CleanExiMM_FGF6.
GenevestigatoriP21658.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000187.

Structurei

3D structure databases

ProteinModelPortaliP21658.
SMRiP21658. Positions 81-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320285.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21658.
KOiK04358.
OMAiRLQGTLW.
OrthoDBiEOG7992S1.
PhylomeDBiP21658.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
PPDGRISGTH EENPYSLLEI STVERGVVSL FGVKSALFIA MNSKGRLYTT
160 170 180 190 200
PSFHDECKFR ETLLPNNYNA YESDLYRGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,798
Last modified:November 1, 1995 - v2
Checksum:iBBF7B9301BB79A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92415 Genomic DNA. Translation: AAA62260.1.
M92416 mRNA. Translation: AAA62261.1.
X51552 Genomic DNA. Translation: CAA35925.1.
CCDSiCCDS20561.1.
PIRiS14192.
RefSeqiNP_034334.1. NM_010204.1.
UniGeneiMm.3403.

Genome annotation databases

EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
GeneIDi14177.
KEGGimmu:14177.
UCSCiuc009dvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92415 Genomic DNA. Translation: AAA62260.1.
M92416 mRNA. Translation: AAA62261.1.
X51552 Genomic DNA. Translation: CAA35925.1.
CCDSiCCDS20561.1.
PIRiS14192.
RefSeqiNP_034334.1. NM_010204.1.
UniGeneiMm.3403.

3D structure databases

ProteinModelPortaliP21658.
SMRiP21658. Positions 81-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000187.

PTM databases

PhosphoSiteiP21658.

Proteomic databases

PRIDEiP21658.

Protocols and materials databases

DNASUi14177.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
GeneIDi14177.
KEGGimmu:14177.
UCSCiuc009dvo.1. mouse.

Organism-specific databases

CTDi2251.
MGIiMGI:95520. Fgf6.

Phylogenomic databases

eggNOGiNOG320285.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP21658.
KOiK04358.
OMAiRLQGTLW.
OrthoDBiEOG7992S1.
PhylomeDBiP21658.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_345290. Signaling by activated point mutants of FGFR1.
REACT_349060. Activated point mutants of FGFR2.
REACT_354830. FGFR1c ligand binding and activation.

Miscellaneous databases

NextBioi285358.
PROiP21658.
SOURCEiSearch...

Gene expression databases

BgeeiP21658.
CleanExiMM_FGF6.
GenevestigatoriP21658.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028242. FGF6.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF25. PTHR11486:SF25. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Embryo.
  2. "Structure, chromosome mapping and expression of the murine Fgf-6 gene."
    de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S., Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A., Coulier F., Birnbaum D.
    Oncogene 5:823-831(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.

Entry informationi

Entry nameiFGF6_MOUSE
AccessioniPrimary (citable) accession number: P21658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: April 1, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.