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Protein

Transcriptional activator protein DAL81

Gene

DAL81

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi150 – 179Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

  • nitrogen catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of gamma-aminobutyric acid catabolic process Source: SGD
  • positive regulation of nitrogen utilization Source: GO_Central
  • positive regulation of urea catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31442-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein DAL81
Alternative name(s):
Regulatory protein UGA35
Gene namesi
Name:DAL81
Synonyms:DURL, UGA35
Ordered Locus Names:YIR023W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR023W.
SGDiS000001462. DAL81.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149471 – 970Transcriptional activator protein DAL81Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21657.
PRIDEiP21657.

PTM databases

iPTMnetiP21657.

Interactioni

Protein-protein interaction databases

BioGridi35014. 91 interactors.
DIPiDIP-5733N.
IntActiP21657. 4 interactors.
MINTiMINT-4490459.

Structurei

3D structure databases

ProteinModelPortaliP21657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 50Asn-richAdd BLAST27
Compositional biasi73 – 88Poly-GlnAdd BLAST16
Compositional biasi127 – 139Asn-richAdd BLAST13
Compositional biasi227 – 237Poly-GlnAdd BLAST11

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000094358.
InParanoidiP21657.
OMAiNNWVLCS.
OrthoDBiEOG092C0PA0.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPHQSPADN AASPTKSVKA TTKNSSTNNN VNSNNSNNNS NHDILNFNDN
60 70 80 90 100
YTTILQHLAN DHPNILREKG GSQQQQHQQQ QQQQQQQQQQ QQQQSLDTLL
110 120 130 140 150
HHYQSLLSKS DNAIAFDDNV SNSADHNGSN SNNNNNNNDI SSPGNLMGSC
160 170 180 190 200
NQCRLKKTKC NYFPDLGNCL ECETSRTKCT FSIAPNYLKR TSSGANNNMP
210 220 230 240 250
TSSNSKRMKN FEDYSNRLPS SMLYRHQQQQ QQQQQQQRIQ YPRSSFFVGP
260 270 280 290 300
ASVFDLNLTK HVRLDNVDQI QLSKTLSLRK VSPTAQFILQ DDFDTTLHSK
310 320 330 340 350
QEYEVDLVEN LVHPHGHLLV EIFFKLIHPF LPILHERVFL EKYSRSYREL
360 370 380 390 400
TAPLLASIYS LALQYWDFHP ALLGFPKPDV TAQLNNIALE TFYARVGRPK
410 420 430 440 450
LSIIQTGLLI LQCRSECHNN WVLCSSVVAL AEELGLGVEC NDWKLPKWEK
460 470 480 490 500
DLRKRLAWAV WLMDKWCALN EGRQSHLILG RNWMIKLLNF DDFPLNSPTI
510 520 530 540 550
LNSLQNDQSG SSPSSSNDVK NHQIAFGNLP IFNINPTLED FKNGTLMFQQ
560 570 580 590 600
MVSLSIILGE IMDTFYTQGS MTINKSIEQV LKLAKPLQLK LREWYHSLPK
610 620 630 640 650
NLSMSYATPQ KLNSNSTLTL AYFATEITLH RKIICALNPQ TPKELVQVCR
660 670 680 690 700
TAARTRLVAA IEFIRDLKNE HINAFWYNCS TGNLMLIGTF AALLYVTSAT
710 720 730 740 750
KEEAMIFRDY VRNYTWVLKI GSKYFDKLSN ALNNMHLLFA QIPGLLTDEP
760 770 780 790 800
VVVSPNSNIN SVNPQRSGVQ SQIPIQFNVG SPAMTEQGSP LNQWKNLPQE
810 820 830 840 850
ILQQLNSFPN GTTSTTTPVN PTSRQTQLES QGSPAINSAN NNSNNTPLPF
860 870 880 890 900
APNKSSKKTS QSSPNVTPSH MSRHPPSNTS SPRVNSSTNV NSNTQMNASP
910 920 930 940 950
LTSINETRQE SGDAADEKTA GRERTANEES STELKDDNPN SNQETSATGN
960 970
QTIKMNDDKN VTINTRETPL
Length:970
Mass (Da):109,174
Last modified:February 1, 1995 - v3
Checksum:i9FEBD271A18AFC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77 – 82Missing in AAA35192 (PubMed:1999281).Curated6
Sequence conflicti465K → R in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti497S → L in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti507D → G in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti760N → S in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti785T → A in AAA34557 (PubMed:1990272).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63498 Genomic DNA. Translation: AAA35192.1.
M60415 Genomic DNA. Translation: AAA34557.1.
Z38061 Genomic DNA. Translation: CAA86183.1.
BK006942 Genomic DNA. Translation: DAA08570.1.
PIRiS48485.
RefSeqiNP_012289.3. NM_001179545.3.

Genome annotation databases

EnsemblFungiiYIR023W; YIR023W; YIR023W.
GeneIDi854841.
KEGGisce:YIR023W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63498 Genomic DNA. Translation: AAA35192.1.
M60415 Genomic DNA. Translation: AAA34557.1.
Z38061 Genomic DNA. Translation: CAA86183.1.
BK006942 Genomic DNA. Translation: DAA08570.1.
PIRiS48485.
RefSeqiNP_012289.3. NM_001179545.3.

3D structure databases

ProteinModelPortaliP21657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35014. 91 interactors.
DIPiDIP-5733N.
IntActiP21657. 4 interactors.
MINTiMINT-4490459.

PTM databases

iPTMnetiP21657.

Proteomic databases

MaxQBiP21657.
PRIDEiP21657.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR023W; YIR023W; YIR023W.
GeneIDi854841.
KEGGisce:YIR023W.

Organism-specific databases

EuPathDBiFungiDB:YIR023W.
SGDiS000001462. DAL81.

Phylogenomic databases

HOGENOMiHOG000094358.
InParanoidiP21657.
OMAiNNWVLCS.
OrthoDBiEOG092C0PA0.

Enzyme and pathway databases

BioCyciYEAST:G3O-31442-MONOMER.

Miscellaneous databases

PROiP21657.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAL81_YEAST
AccessioniPrimary (citable) accession number: P21657
Secondary accession number(s): D6VVV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.