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Protein

Recombination protein 107

Gene

REC107

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.1 Publication

GO - Biological processi

  • reciprocal meiotic recombination Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31661-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Recombination protein 107
Alternative name(s):
Meiotic recombination protein 2
Gene namesi
Name:REC107
Synonyms:MER2
Ordered Locus Names:YJR021C
ORF Names:J1462
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR021C.
SGDiS000003782. REC107.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication

  • Note: Localizes to chromosomes.

GO - Cellular componenti

  • condensed nuclear chromosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964211 – 314Recombination protein 107Add BLAST314

Post-translational modificationi

Phosphorylated during meiotic prophase. Dephosphorylation seems to be dependent on DSB formation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP21651.

PTM databases

iPTMnetiP21651.

Interactioni

Subunit structurei

Interacts with MEI4, REC114 and XRS2. Component of the MER2-MEI4-REC114 complex.2 Publications

Protein-protein interaction databases

BioGridi33775. 56 interactors.
DIPiDIP-5265N.
IntActiP21651. 3 interactors.
MINTiMINT-523746.

Structurei

3D structure databases

ProteinModelPortaliP21651.
SMRiP21651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP21651.
OrthoDBiEOG092C3GZC.

Family and domain databases

InterProiIPR015159. Rec107.
[Graphical view]
PfamiPF09074. Mer2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE
60 70 80 90 100
SDKQILEWAG KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ
110 120 130 140 150
DAATNGNVKT LIKDLASQIE NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV
160 170 180 190 200
EEISRYNSKI TRHVTNKQHE TEKSMRCTQE MLFNVGSQLE DVHKVLLSLS
210 220 230 240 250
KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD MDEAHDKQRK
260 270 280 290 300
KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII
310
PWEELRPDTL ESEL
Length:314
Mass (Da):35,683
Last modified:November 1, 1995 - v2
Checksum:i46F426AC0DFDFAD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279N → I (PubMed:2203538).Curated1
Sequence conflicti279N → I (PubMed:1840507).Curated1
Sequence conflicti284 – 314DNDDA…LESEL → TMMTLAIG (PubMed:2203538).CuratedAdd BLAST31
Sequence conflicti284 – 314DNDDA…LESEL → TMMTLAIG (PubMed:1840507).CuratedAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38340 Genomic DNA. Translation: AAA34772.1.
M60755 mRNA. Translation: AAA34773.1.
X87611 Genomic DNA. Translation: CAA60944.1.
Z49521 Genomic DNA. Translation: CAA89546.1.
Z49519 Genomic DNA. Translation: CAA89545.1.
X85972 Genomic DNA. Translation: CAA59959.1.
BK006943 Genomic DNA. Translation: DAA08811.1.
PIRiS55210.
RefSeqiNP_012555.1. NM_001181679.1.

Genome annotation databases

EnsemblFungiiYJR021C; YJR021C; YJR021C.
GeneIDi853478.
KEGGisce:YJR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38340 Genomic DNA. Translation: AAA34772.1.
M60755 mRNA. Translation: AAA34773.1.
X87611 Genomic DNA. Translation: CAA60944.1.
Z49521 Genomic DNA. Translation: CAA89546.1.
Z49519 Genomic DNA. Translation: CAA89545.1.
X85972 Genomic DNA. Translation: CAA59959.1.
BK006943 Genomic DNA. Translation: DAA08811.1.
PIRiS55210.
RefSeqiNP_012555.1. NM_001181679.1.

3D structure databases

ProteinModelPortaliP21651.
SMRiP21651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33775. 56 interactors.
DIPiDIP-5265N.
IntActiP21651. 3 interactors.
MINTiMINT-523746.

PTM databases

iPTMnetiP21651.

Proteomic databases

PRIDEiP21651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR021C; YJR021C; YJR021C.
GeneIDi853478.
KEGGisce:YJR021C.

Organism-specific databases

EuPathDBiFungiDB:YJR021C.
SGDiS000003782. REC107.

Phylogenomic databases

InParanoidiP21651.
OrthoDBiEOG092C3GZC.

Enzyme and pathway databases

BioCyciYEAST:G3O-31661-MONOMER.

Miscellaneous databases

PROiP21651.

Family and domain databases

InterProiIPR015159. Rec107.
[Graphical view]
PfamiPF09074. Mer2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRE107_YEAST
AccessioniPrimary (citable) accession number: P21651
Secondary accession number(s): D6VWJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.