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P21651

- RE107_YEAST

UniProt

P21651 - RE107_YEAST

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Protein

Recombination protein 107

Gene
REC107, MER2, YJR021C, J1462
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.1 Publication

GO - Biological processi

  1. reciprocal meiotic recombination Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31661-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Recombination protein 107
Alternative name(s):
Meiotic recombination protein 2
Gene namesi
Name:REC107
Synonyms:MER2
Ordered Locus Names:YJR021C
ORF Names:J1462
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR021c.
SGDiS000003782. REC107.

Subcellular locationi

Nucleus. Chromosome
Note: Localizes to chromosomes.1 Publication

GO - Cellular componenti

  1. condensed nuclear chromosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Recombination protein 107PRO_0000096421Add
BLAST

Post-translational modificationi

Phosphorylated during meiotic prophase. Dephosphorylation seems to be dependent on DSB formation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21651.

Expressioni

Gene expression databases

GenevestigatoriP21651.

Interactioni

Subunit structurei

Interacts with MEI4, REC114 and XRS2. Component of the MER2-MEI4-REC114 complex.2 Publications

Protein-protein interaction databases

BioGridi33775. 56 interactions.
DIPiDIP-5265N.
IntActiP21651. 3 interactions.
MINTiMINT-523746.
STRINGi4932.YJR021C.

Structurei

3D structure databases

ProteinModelPortaliP21651.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41190.
OMAiMELRENS.
OrthoDBiEOG7TJ3TW.

Family and domain databases

InterProiIPR015159. Meiotic_recombination.
[Graphical view]
PfamiPF09074. Mer2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21651-1 [UniParc]FASTAAdd to Basket

« Hide

MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE    50
SDKQILEWAG KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ 100
DAATNGNVKT LIKDLASQIE NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV 150
EEISRYNSKI TRHVTNKQHE TEKSMRCTQE MLFNVGSQLE DVHKVLLSLS 200
KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD MDEAHDKQRK 250
KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII 300
PWEELRPDTL ESEL 314
Length:314
Mass (Da):35,683
Last modified:November 1, 1995 - v2
Checksum:i46F426AC0DFDFAD0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791N → I1 Publication
Sequence conflicti279 – 2791N → I1 Publication
Sequence conflicti284 – 31431DNDDA…LESEL → TMMTLAIG1 PublicationAdd
BLAST
Sequence conflicti284 – 31431DNDDA…LESEL → TMMTLAIG1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M38340 Genomic DNA. Translation: AAA34772.1.
M60755 mRNA. Translation: AAA34773.1.
X87611 Genomic DNA. Translation: CAA60944.1.
Z49521 Genomic DNA. Translation: CAA89546.1.
Z49519 Genomic DNA. Translation: CAA89545.1.
X85972 Genomic DNA. Translation: CAA59959.1.
BK006943 Genomic DNA. Translation: DAA08811.1.
PIRiS55210.
RefSeqiNP_012555.1. NM_001181679.1.

Genome annotation databases

EnsemblFungiiYJR021C; YJR021C; YJR021C.
GeneIDi853478.
KEGGisce:YJR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M38340 Genomic DNA. Translation: AAA34772.1 .
M60755 mRNA. Translation: AAA34773.1 .
X87611 Genomic DNA. Translation: CAA60944.1 .
Z49521 Genomic DNA. Translation: CAA89546.1 .
Z49519 Genomic DNA. Translation: CAA89545.1 .
X85972 Genomic DNA. Translation: CAA59959.1 .
BK006943 Genomic DNA. Translation: DAA08811.1 .
PIRi S55210.
RefSeqi NP_012555.1. NM_001181679.1.

3D structure databases

ProteinModelPortali P21651.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33775. 56 interactions.
DIPi DIP-5265N.
IntActi P21651. 3 interactions.
MINTi MINT-523746.
STRINGi 4932.YJR021C.

Proteomic databases

PaxDbi P21651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR021C ; YJR021C ; YJR021C .
GeneIDi 853478.
KEGGi sce:YJR021C.

Organism-specific databases

CYGDi YJR021c.
SGDi S000003782. REC107.

Phylogenomic databases

eggNOGi NOG41190.
OMAi MELRENS.
OrthoDBi EOG7TJ3TW.

Enzyme and pathway databases

BioCyci YEAST:G3O-31661-MONOMER.

Miscellaneous databases

NextBioi 974086.

Gene expression databases

Genevestigatori P21651.

Family and domain databases

InterProi IPR015159. Meiotic_recombination.
[Graphical view ]
Pfami PF09074. Mer2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation."
    Engebrecht J., Hirsch J., Roeder G.S.
    Cell 62:927-937(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases."
    Hani J., Stumpf G., Domdey H.
    FEBS Lett. 365:198-202(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 213-314.
    Strain: DH484.
  6. "Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2."
    Cool M., Malone R.E.
    Mol. Cell. Biol. 12:1248-1256(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF REC107 AS MER2.
  7. "Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
    Arora C., Kee K., Maleki S., Keeney S.
    Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEI4; REC114 AND XRS2.
  8. "Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
    Li J., Hooker G.W., Roeder G.S.
    Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MEI4 AND REC114, SUBCELLULAR LOCATION, PHOSPHORYLATION.

Entry informationi

Entry nameiRE107_YEAST
AccessioniPrimary (citable) accession number: P21651
Secondary accession number(s): D6VWJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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