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P21651

- RE107_YEAST

UniProt

P21651 - RE107_YEAST

Protein

Recombination protein 107

Gene

REC107

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.1 Publication

    GO - Biological processi

    1. reciprocal meiotic recombination Source: SGD

    Keywords - Biological processi

    DNA recombination, Meiosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31661-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Recombination protein 107
    Alternative name(s):
    Meiotic recombination protein 2
    Gene namesi
    Name:REC107
    Synonyms:MER2
    Ordered Locus Names:YJR021C
    ORF Names:J1462
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR021c.
    SGDiS000003782. REC107.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication
    Note: Localizes to chromosomes.

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: SGD

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Recombination protein 107PRO_0000096421Add
    BLAST

    Post-translational modificationi

    Phosphorylated during meiotic prophase. Dephosphorylation seems to be dependent on DSB formation.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP21651.

    Expressioni

    Gene expression databases

    GenevestigatoriP21651.

    Interactioni

    Subunit structurei

    Interacts with MEI4, REC114 and XRS2. Component of the MER2-MEI4-REC114 complex.2 Publications

    Protein-protein interaction databases

    BioGridi33775. 56 interactions.
    DIPiDIP-5265N.
    IntActiP21651. 3 interactions.
    MINTiMINT-523746.
    STRINGi4932.YJR021C.

    Structurei

    3D structure databases

    ProteinModelPortaliP21651.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG41190.
    OMAiMELRENS.
    OrthoDBiEOG7TJ3TW.

    Family and domain databases

    InterProiIPR015159. Meiotic_recombination.
    [Graphical view]
    PfamiPF09074. Mer2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21651-1 [UniParc]FASTAAdd to Basket

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    MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE    50
    SDKQILEWAG KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ 100
    DAATNGNVKT LIKDLASQIE NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV 150
    EEISRYNSKI TRHVTNKQHE TEKSMRCTQE MLFNVGSQLE DVHKVLLSLS 200
    KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD MDEAHDKQRK 250
    KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII 300
    PWEELRPDTL ESEL 314
    Length:314
    Mass (Da):35,683
    Last modified:November 1, 1995 - v2
    Checksum:i46F426AC0DFDFAD0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti279 – 2791N → I(PubMed:2203538)Curated
    Sequence conflicti279 – 2791N → I(PubMed:1840507)Curated
    Sequence conflicti284 – 31431DNDDA…LESEL → TMMTLAIG(PubMed:2203538)CuratedAdd
    BLAST
    Sequence conflicti284 – 31431DNDDA…LESEL → TMMTLAIG(PubMed:1840507)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38340 Genomic DNA. Translation: AAA34772.1.
    M60755 mRNA. Translation: AAA34773.1.
    X87611 Genomic DNA. Translation: CAA60944.1.
    Z49521 Genomic DNA. Translation: CAA89546.1.
    Z49519 Genomic DNA. Translation: CAA89545.1.
    X85972 Genomic DNA. Translation: CAA59959.1.
    BK006943 Genomic DNA. Translation: DAA08811.1.
    PIRiS55210.
    RefSeqiNP_012555.1. NM_001181679.1.

    Genome annotation databases

    EnsemblFungiiYJR021C; YJR021C; YJR021C.
    GeneIDi853478.
    KEGGisce:YJR021C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38340 Genomic DNA. Translation: AAA34772.1 .
    M60755 mRNA. Translation: AAA34773.1 .
    X87611 Genomic DNA. Translation: CAA60944.1 .
    Z49521 Genomic DNA. Translation: CAA89546.1 .
    Z49519 Genomic DNA. Translation: CAA89545.1 .
    X85972 Genomic DNA. Translation: CAA59959.1 .
    BK006943 Genomic DNA. Translation: DAA08811.1 .
    PIRi S55210.
    RefSeqi NP_012555.1. NM_001181679.1.

    3D structure databases

    ProteinModelPortali P21651.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33775. 56 interactions.
    DIPi DIP-5265N.
    IntActi P21651. 3 interactions.
    MINTi MINT-523746.
    STRINGi 4932.YJR021C.

    Proteomic databases

    PaxDbi P21651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR021C ; YJR021C ; YJR021C .
    GeneIDi 853478.
    KEGGi sce:YJR021C.

    Organism-specific databases

    CYGDi YJR021c.
    SGDi S000003782. REC107.

    Phylogenomic databases

    eggNOGi NOG41190.
    OMAi MELRENS.
    OrthoDBi EOG7TJ3TW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31661-MONOMER.

    Miscellaneous databases

    NextBioi 974086.

    Gene expression databases

    Genevestigatori P21651.

    Family and domain databases

    InterProi IPR015159. Meiotic_recombination.
    [Graphical view ]
    Pfami PF09074. Mer2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation."
      Engebrecht J., Hirsch J., Roeder G.S.
      Cell 62:927-937(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases."
      Hani J., Stumpf G., Domdey H.
      FEBS Lett. 365:198-202(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 213-314.
      Strain: DH484.
    6. "Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2."
      Cool M., Malone R.E.
      Mol. Cell. Biol. 12:1248-1256(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF REC107 AS MER2.
    7. "Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
      Arora C., Kee K., Maleki S., Keeney S.
      Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEI4; REC114 AND XRS2.
    8. "Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
      Li J., Hooker G.W., Roeder G.S.
      Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MEI4 AND REC114, SUBCELLULAR LOCATION, PHOSPHORYLATION.

    Entry informationi

    Entry nameiRE107_YEAST
    AccessioniPrimary (citable) accession number: P21651
    Secondary accession number(s): D6VWJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3