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P21651 (RE107_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Recombination protein 107
Alternative name(s):
Meiotic recombination protein 2
Gene names
Name:REC107
Synonyms:MER2
Ordered Locus Names:YJR021C
ORF Names:J1462
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation. Ref.8

Subunit structure

Interacts with MEI4, REC114 and XRS2. Component of the MER2-MEI4-REC114 complex. Ref.7 Ref.8

Subcellular location

Nucleus. Chromosome. Note: Localizes to chromosomes. Ref.8

Post-translational modification

Phosphorylated during meiotic prophase. Dephosphorylation seems to be dependent on DSB formation. Ref.8

Ontologies

Keywords
   Biological processDNA recombination
Meiosis
   Cellular componentChromosome
Nucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processreciprocal meiotic recombination

Inferred from mutant phenotype PubMed 8536989. Source: SGD

   Cellular_componentcondensed nuclear chromosome

Inferred from direct assay Ref.8. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Recombination protein 107
PRO_0000096421

Experimental info

Sequence conflict2791N → I Ref.1
Sequence conflict2791N → I Ref.2
Sequence conflict284 – 31431DNDDA…LESEL → TMMTLAIG Ref.1
Sequence conflict284 – 31431DNDDA…LESEL → TMMTLAIG Ref.2

Sequences

Sequence LengthMass (Da)Tools
P21651 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 46F426AC0DFDFAD0

FASTA31435,683
        10         20         30         40         50         60 
MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE SDKQILEWAG 

        70         80         90        100        110        120 
KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ DAATNGNVKT LIKDLASQIE 

       130        140        150        160        170        180 
NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV EEISRYNSKI TRHVTNKQHE TEKSMRCTQE 

       190        200        210        220        230        240 
MLFNVGSQLE DVHKVLLSLS KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD 

       250        260        270        280        290        300 
MDEAHDKQRK KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII 

       310 
PWEELRPDTL ESEL 

« Hide

References

« Hide 'large scale' references
[1]"Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation."
Engebrecht J., Hirsch J., Roeder G.S.
Cell 62:927-937(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Meiosis-specific RNA splicing in yeast."
Engebrecht J., Voelkel-Meiman K., Roeder G.S.
Cell 66:1257-1268(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases."
Hani J., Stumpf G., Domdey H.
FEBS Lett. 365:198-202(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 213-314.
Strain: DH484.
[6]"Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2."
Cool M., Malone R.E.
Mol. Cell. Biol. 12:1248-1256(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF REC107 AS MER2.
[7]"Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
Arora C., Kee K., Maleki S., Keeney S.
Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEI4; REC114 AND XRS2.
[8]"Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
Li J., Hooker G.W., Roeder G.S.
Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MEI4 AND REC114, SUBCELLULAR LOCATION, PHOSPHORYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M38340 Genomic DNA. Translation: AAA34772.1.
M60755 mRNA. Translation: AAA34773.1.
X87611 Genomic DNA. Translation: CAA60944.1.
Z49521 Genomic DNA. Translation: CAA89546.1.
Z49519 Genomic DNA. Translation: CAA89545.1.
X85972 Genomic DNA. Translation: CAA59959.1.
BK006943 Genomic DNA. Translation: DAA08811.1.
PIRS55210.
RefSeqNP_012555.1. NM_001181679.1.

3D structure databases

ProteinModelPortalP21651.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33775. 56 interactions.
DIPDIP-5265N.
IntActP21651. 3 interactions.
MINTMINT-523746.
STRING4932.YJR021C.

Proteomic databases

PaxDbP21651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJR021C; YJR021C; YJR021C.
GeneID853478.
KEGGsce:YJR021C.

Organism-specific databases

CYGDYJR021c.
SGDS000003782. REC107.

Phylogenomic databases

eggNOGNOG41190.
OMAMELRENS.
OrthoDBEOG7TJ3TW.

Enzyme and pathway databases

BioCycYEAST:G3O-31661-MONOMER.

Gene expression databases

GenevestigatorP21651.

Family and domain databases

InterProIPR015159. Meiotic_recombination.
[Graphical view]
PfamPF09074. Mer2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974086.

Entry information

Entry nameRE107_YEAST
AccessionPrimary (citable) accession number: P21651
Secondary accession number(s): D6VWJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD