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Protein

Protein MrkE

Gene

mrkE

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of fimbrial expression.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fimbrium biogenesis, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MrkE
Gene namesi
Name:mrkE
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811401 – 269Protein MrkEAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1104-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP21649.

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_02737.

Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi59 – 63Combined sources5
Helixi67 – 80Combined sources14
Beta strandi84 – 90Combined sources7
Helixi92 – 101Combined sources10
Beta strandi105 – 109Combined sources5
Beta strandi114 – 116Combined sources3
Helixi118 – 125Combined sources8
Beta strandi133 – 139Combined sources7
Helixi144 – 149Combined sources6
Beta strandi153 – 159Combined sources7
Helixi162 – 178Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QV0X-ray2.40A/B52-183[»]
ProteinModelPortaliP21649.
SMRiP21649.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 173Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini197 – 269HTH LytTR-typePROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 1 HTH LytTR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DY9. Bacteria.
COG3279. LUCA.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGNKIGLLN VHHRVKLLYG EGLHIRNLTP GTEIAFYVPN NSTPQGDGVA
60 70 80 90 100
VVMSGEKMKV IIVEDEFLAQ QELSWLINTH SQMEIVGSFD DGLDVLKFLQ
110 120 130 140 150
HNKVDAIFLD INIPSLDGVL LAQNISQFAH KPFIVFITAW KEHAVEAFEL
160 170 180 190 200
EAFDYILKPY QESRIINMLQ KLTTAWEQQN NAASGLASAA PRENDTINLI
210 220 230 240 250
KDERIIVTSI HDIYYAEAHE KMTFVYTRRE SFVMPMNITE FVPDALNIAA
260
SGQSKFLLTV AQVSIANRF
Length:269
Mass (Da):30,290
Last modified:May 1, 1991 - v1
Checksum:i416003BC3650E938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55912 Genomic DNA. Translation: AAA25092.1.
PIRiA39142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55912 Genomic DNA. Translation: AAA25092.1.
PIRiA39142.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QV0X-ray2.40A/B52-183[»]
ProteinModelPortaliP21649.
SMRiP21649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_02737.

Proteomic databases

PRIDEiP21649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DY9. Bacteria.
COG3279. LUCA.

Miscellaneous databases

EvolutionaryTraceiP21649.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRKE_KLEPN
AccessioniPrimary (citable) accession number: P21649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.