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P21638

- COBH_PSEDE

UniProt

P21638 - COBH_PSEDE

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Protein
Precorrin-8X methylmutase
Gene
cobH
Organism
Pseudomonas denitrificans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid.

Catalytic activityi

Precorrin-8X = hydrogenobyrinate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431

GO - Molecular functioni

  1. precorrin-8X methylmutase activity Source: InterPro

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-115.
RETL1328306-WGS:GSTH-6323-MONOMER.
UniPathwayiUPA00148; UER00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Precorrin-8X methylmutase (EC:5.4.99.61)
Alternative name(s):
HBA synthase
Precorrin isomerase
Gene namesi
Name:cobH
OrganismiPseudomonas denitrificans
Taxonomic identifieri43306 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Precorrin-8X methylmutase
PRO_0000135926Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2415
Beta strandi28 – 303
Helixi32 – 4514
Helixi48 – 536
Beta strandi54 – 563
Helixi60 – 6910
Beta strandi74 – 785
Helixi79 – 846
Helixi87 – 893
Beta strandi96 – 983
Helixi104 – 1129
Helixi116 – 1194
Helixi120 – 1245
Helixi125 – 1284
Beta strandi132 – 1354
Helixi139 – 15012
Beta strandi157 – 1615
Beta strandi165 – 1684
Helixi169 – 17810
Beta strandi185 – 1884
Helixi195 – 20612

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F2VX-ray2.10A2-210[»]
1I1HX-ray2.60A2-210[»]
ProteinModelPortaliP21638.
SMRiP21638. Positions 2-210.

Miscellaneous databases

EvolutionaryTraceiP21638.

Family & Domainsi

Sequence similaritiesi

Belongs to the CobH family.

Family and domain databases

Gene3Di3.40.50.10230. 1 hit.
InterProiIPR003722. Cbl_synth_CobH/CbiC.
[Graphical view]
PfamiPF02570. CbiC. 1 hit.
[Graphical view]
SUPFAMiSSF63965. SSF63965. 1 hit.

Sequencei

Sequence statusi: Complete.

P21638-1 [UniParc]FASTAAdd to Basket

« Hide

MPEYDYIRDG NAIYERSFAI IRAEADLSRF SEEEADLAVR MVHACGSVEA    50
TRQFVFSPDF VSSARAALKA GAPILCDAEM VAHGVTRARL PAGNEVICTL 100
RDPRTPALAA EIGNTRSAAA LKLWSERLAG SVVAIGNAPT ALFFLLEMLR 150
DGAPKPAAIL GMPVGFVGAA ESKDALAENS YGVPFAIVRG RLGGSAMTAA 200
ALNSLARPGL 210
Length:210
Mass (Da):22,064
Last modified:May 1, 1991 - v1
Checksum:i506D1C4C5D972B3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59301 Genomic DNA. Translation: AAA25796.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59301 Genomic DNA. Translation: AAA25796.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1F2V X-ray 2.10 A 2-210 [» ]
1I1H X-ray 2.60 A 2-210 [» ]
ProteinModelPortali P21638.
SMRi P21638. Positions 2-210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00219 .
BioCyci MetaCyc:MONOMER-115.
RETL1328306-WGS:GSTH-6323-MONOMER.

Miscellaneous databases

EvolutionaryTracei P21638.

Family and domain databases

Gene3Di 3.40.50.10230. 1 hit.
InterProi IPR003722. Cbl_synth_CobH/CbiC.
[Graphical view ]
Pfami PF02570. CbiC. 1 hit.
[Graphical view ]
SUPFAMi SSF63965. SSF63965. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid."
    Crouzet J., Cameron B., Cauchois L., Rigault S., Rouyez M.-C., Blanche F., Thibaut D., Debussche L.
    J. Bacteriol. 172:5980-5990(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC510.
  2. "The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate."
    Thibaut D., Couder M., Famechon A., Debussche L., Cameron B., Crouzet J., Blanche F.
    J. Bacteriol. 174:1043-1049(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 6-210.

Entry informationi

Entry nameiCOBH_PSEDE
AccessioniPrimary (citable) accession number: P21638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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