P21622 (ILVH_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetolactate synthase isozyme 3 small subunit
EC=2.2.1.6

Alternative name(s):
ALS-III
Acetohydroxy-acid synthase III small subunit
Short name=AHAS-III

Gene names

Name:	ilvH
Ordered Locus Names:	STM0117

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2.
Enzyme regulation	Sensitive to valine inhibition.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
Subunit structure	Dimer of large and small chains.
Miscellaneous	S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.
Sequence similarities	Belongs to the acetolactate synthase small subunit family. Contains 1 ACT domain.
Sequence caution	The sequence AAF65177.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway valine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	acetolactate synthase activity Inferred from electronic annotation. Source: EC amino acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Acetolactate synthase isozyme 3 small subunit		PRO_0000151411
Regions
	Domain	3 – 76	74	ACT
Experimental info
	Sequence conflict	91 – 92	2	IQ → ME in CAA39102. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P21622 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 82066840D433D6B5	FASTA	163	18,063
	10 20 30 40 50 60 MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT VGDEKVLEQI 70 80 90 100 110 120 EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE VKRNTEIFRG QIIDVTPTLY 130 140 150 160 TVQLAGTSDK LDAFLASLRD VAKIVEVARS GVVGLSRGDK IMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2." Jahreis K., Postma P.W., Lengeler J.W. Mol. Gen. Genet. 226:332-336(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55456 Genomic DNA. Translation: CAA39102.1. AF117227 Genomic DNA. Translation: AAF65177.1. Different initiation. AE006468 Genomic DNA. Translation: AAL19081.1.
PIR	S15940.
RefSeq	NP_459122.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P21622.
SMR	P21622. Positions 2-163.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM0117.
Proteomic databases
PaxDb	P21622.
PRIDE	P21622.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL19081; AAL19081; STM0117.
GeneID	1251635.
KEGG	stm:STM0117.
PATRIC	32378505. VBISalEnt20916_0122.
Phylogenomic databases
eggNOG	COG0440.
HOGENOM	HOG000046747.
KO	K01653.
OMA	RMTIVVN.
ProtClustDB	PRK11895.
Enzyme and pathway databases
UniPathway	UPA00047; UER00055. UPA00049; UER00059.
Family and domain databases
InterPro	IPR004789. Acetalactate_synth_ssu. IPR019455. Acetolactate_synth_ssu_C. IPR002912. ACT_dom. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF10369. ALS_ss_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00119. acolac_sm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVH_SALTY

Accession

Primary (citable) accession number: P21622
Secondary accession number(s): Q9JP76

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program