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P21622

- ILVH_SALTY

UniProt

P21622 - ILVH_SALTY

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Protein

Acetolactate synthase isozyme 3 small subunit

Gene

ilvH

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Enzyme regulationi

Sensitive to valine inhibition.

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. amino acid binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-115-MONOMER.
UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase isozyme 3 small subunit (EC:2.2.1.6)
Alternative name(s):
ALS-III
Acetohydroxy-acid synthase III small subunit
Short name:
AHAS-III
Gene namesi
Name:ilvH
Ordered Locus Names:STM0117
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Acetolactate synthase isozyme 3 small subunitPRO_0000151411Add
BLAST

Proteomic databases

PaxDbiP21622.
PRIDEiP21622.

Interactioni

Subunit structurei

Dimer of large and small chains.

Protein-protein interaction databases

STRINGi99287.STM0117.

Structurei

3D structure databases

ProteinModelPortaliP21622.
SMRiP21622. Positions 2-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7875ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0440.
HOGENOMiHOG000046747.
KOiK01653.
OMAiRGAKGWK.
OrthoDBiEOG6X3W8W.
PhylomeDBiP21622.

Family and domain databases

InterProiIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21622-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT
60 70 80 90 100
VGDEKVLEQI EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE
110 120 130 140 150
VKRNTEIFRG QIIDVTPTLY TVQLAGTSDK LDAFLASLRD VAKIVEVARS
160
GVVGLSRGDK IMR
Length:163
Mass (Da):18,063
Last modified:January 23, 2002 - v2
Checksum:i82066840D433D6B5
GO

Sequence cautioni

The sequence AAF65177.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 922IQ → ME in CAA39102. (PubMed:1851954)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55456 Genomic DNA. Translation: CAA39102.1.
AF117227 Genomic DNA. Translation: AAF65177.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL19081.1.
PIRiS15940.
RefSeqiNP_459122.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19081; AAL19081; STM0117.
GeneIDi1251635.
KEGGistm:STM0117.
PATRICi32378505. VBISalEnt20916_0122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55456 Genomic DNA. Translation: CAA39102.1 .
AF117227 Genomic DNA. Translation: AAF65177.1 . Different initiation.
AE006468 Genomic DNA. Translation: AAL19081.1 .
PIRi S15940.
RefSeqi NP_459122.1. NC_003197.1.

3D structure databases

ProteinModelPortali P21622.
SMRi P21622. Positions 2-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM0117.

Proteomic databases

PaxDbi P21622.
PRIDEi P21622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19081 ; AAL19081 ; STM0117 .
GeneIDi 1251635.
KEGGi stm:STM0117.
PATRICi 32378505. VBISalEnt20916_0122.

Phylogenomic databases

eggNOGi COG0440.
HOGENOMi HOG000046747.
KOi K01653.
OMAi RGAKGWK.
OrthoDBi EOG6X3W8W.
PhylomeDBi P21622.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .
BioCyci SENT99287:GCTI-115-MONOMER.

Family and domain databases

InterProi IPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF10369. ALS_ss_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2."
    Jahreis K., Postma P.W., Lengeler J.W.
    Mol. Gen. Genet. 226:332-336(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiILVH_SALTY
AccessioniPrimary (citable) accession number: P21622
Secondary accession number(s): Q9JP76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2002
Last modified: October 1, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3