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P21622

- ILVH_SALTY

UniProt

P21622 - ILVH_SALTY

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Protein

Acetolactate synthase isozyme 3 small subunit

Gene
ilvH, STM0117
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Enzyme regulationi

Sensitive to valine inhibition.

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. amino acid binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-115-MONOMER.
UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase isozyme 3 small subunit (EC:2.2.1.6)
Alternative name(s):
ALS-III
Acetohydroxy-acid synthase III small subunit
Short name:
AHAS-III
Gene namesi
Name:ilvH
Ordered Locus Names:STM0117
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Acetolactate synthase isozyme 3 small subunitPRO_0000151411Add
BLAST

Proteomic databases

PaxDbiP21622.
PRIDEiP21622.

Interactioni

Subunit structurei

Dimer of large and small chains.

Protein-protein interaction databases

STRINGi99287.STM0117.

Structurei

3D structure databases

ProteinModelPortaliP21622.
SMRiP21622. Positions 2-163.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7875ACTAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG0440.
HOGENOMiHOG000046747.
KOiK01653.
OMAiRGAKGWK.
OrthoDBiEOG6X3W8W.
PhylomeDBiP21622.

Family and domain databases

InterProiIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21622-1 [UniParc]FASTAAdd to Basket

« Hide

MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT    50
VGDEKVLEQI EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE 100
VKRNTEIFRG QIIDVTPTLY TVQLAGTSDK LDAFLASLRD VAKIVEVARS 150
GVVGLSRGDK IMR 163
Length:163
Mass (Da):18,063
Last modified:January 23, 2002 - v2
Checksum:i82066840D433D6B5
GO

Sequence cautioni

The sequence AAF65177.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 922IQ → ME in CAA39102. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55456 Genomic DNA. Translation: CAA39102.1.
AF117227 Genomic DNA. Translation: AAF65177.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL19081.1.
PIRiS15940.
RefSeqiNP_459122.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19081; AAL19081; STM0117.
GeneIDi1251635.
KEGGistm:STM0117.
PATRICi32378505. VBISalEnt20916_0122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55456 Genomic DNA. Translation: CAA39102.1 .
AF117227 Genomic DNA. Translation: AAF65177.1 . Different initiation.
AE006468 Genomic DNA. Translation: AAL19081.1 .
PIRi S15940.
RefSeqi NP_459122.1. NC_003197.1.

3D structure databases

ProteinModelPortali P21622.
SMRi P21622. Positions 2-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM0117.

Proteomic databases

PaxDbi P21622.
PRIDEi P21622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19081 ; AAL19081 ; STM0117 .
GeneIDi 1251635.
KEGGi stm:STM0117.
PATRICi 32378505. VBISalEnt20916_0122.

Phylogenomic databases

eggNOGi COG0440.
HOGENOMi HOG000046747.
KOi K01653.
OMAi RGAKGWK.
OrthoDBi EOG6X3W8W.
PhylomeDBi P21622.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .
BioCyci SENT99287:GCTI-115-MONOMER.

Family and domain databases

InterProi IPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF10369. ALS_ss_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2."
    Jahreis K., Postma P.W., Lengeler J.W.
    Mol. Gen. Genet. 226:332-336(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiILVH_SALTY
AccessioniPrimary (citable) accession number: P21622
Secondary accession number(s): Q9JP76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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