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P21622

- ILVH_SALTY

UniProt

P21622 - ILVH_SALTY

Protein

Acetolactate synthase isozyme 3 small subunit

Gene

ilvH

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 pyruvate = 2-acetolactate + CO2.

    Enzyme regulationi

    Sensitive to valine inhibition.

    Pathwayi

    GO - Molecular functioni

    1. acetolactate synthase activity Source: UniProtKB-EC
    2. amino acid binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-115-MONOMER.
    UniPathwayiUPA00047; UER00055.
    UPA00049; UER00059.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetolactate synthase isozyme 3 small subunit (EC:2.2.1.6)
    Alternative name(s):
    ALS-III
    Acetohydroxy-acid synthase III small subunit
    Short name:
    AHAS-III
    Gene namesi
    Name:ilvH
    Ordered Locus Names:STM0117
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Acetolactate synthase isozyme 3 small subunitPRO_0000151411Add
    BLAST

    Proteomic databases

    PaxDbiP21622.
    PRIDEiP21622.

    Interactioni

    Subunit structurei

    Dimer of large and small chains.

    Protein-protein interaction databases

    STRINGi99287.STM0117.

    Structurei

    3D structure databases

    ProteinModelPortaliP21622.
    SMRiP21622. Positions 2-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7875ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0440.
    HOGENOMiHOG000046747.
    KOiK01653.
    OMAiRGAKGWK.
    OrthoDBiEOG6X3W8W.
    PhylomeDBiP21622.

    Family and domain databases

    InterProiIPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF10369. ALS_ss_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21622-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT    50
    VGDEKVLEQI EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE 100
    VKRNTEIFRG QIIDVTPTLY TVQLAGTSDK LDAFLASLRD VAKIVEVARS 150
    GVVGLSRGDK IMR 163
    Length:163
    Mass (Da):18,063
    Last modified:January 23, 2002 - v2
    Checksum:i82066840D433D6B5
    GO

    Sequence cautioni

    The sequence AAF65177.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 922IQ → ME in CAA39102. (PubMed:1851954)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55456 Genomic DNA. Translation: CAA39102.1.
    AF117227 Genomic DNA. Translation: AAF65177.1. Different initiation.
    AE006468 Genomic DNA. Translation: AAL19081.1.
    PIRiS15940.
    RefSeqiNP_459122.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL19081; AAL19081; STM0117.
    GeneIDi1251635.
    KEGGistm:STM0117.
    PATRICi32378505. VBISalEnt20916_0122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55456 Genomic DNA. Translation: CAA39102.1 .
    AF117227 Genomic DNA. Translation: AAF65177.1 . Different initiation.
    AE006468 Genomic DNA. Translation: AAL19081.1 .
    PIRi S15940.
    RefSeqi NP_459122.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P21622.
    SMRi P21622. Positions 2-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM0117.

    Proteomic databases

    PaxDbi P21622.
    PRIDEi P21622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL19081 ; AAL19081 ; STM0117 .
    GeneIDi 1251635.
    KEGGi stm:STM0117.
    PATRICi 32378505. VBISalEnt20916_0122.

    Phylogenomic databases

    eggNOGi COG0440.
    HOGENOMi HOG000046747.
    KOi K01653.
    OMAi RGAKGWK.
    OrthoDBi EOG6X3W8W.
    PhylomeDBi P21622.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00055 .
    UPA00049 ; UER00059 .
    BioCyci SENT99287:GCTI-115-MONOMER.

    Family and domain databases

    InterProi IPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF10369. ALS_ss_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2."
      Jahreis K., Postma P.W., Lengeler J.W.
      Mol. Gen. Genet. 226:332-336(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiILVH_SALTY
    AccessioniPrimary (citable) accession number: P21622
    Secondary accession number(s): Q9JP76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3