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P21622 (ILVH_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetolactate synthase isozyme 3 small subunit

EC=2.2.1.6
Alternative name(s):
ALS-III
Acetohydroxy-acid synthase III small subunit
Short name=AHAS-III
Gene names
Name:ilvH
Ordered Locus Names:STM0117
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Enzyme regulation

Sensitive to valine inhibition.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Subunit structure

Dimer of large and small chains.

Miscellaneous

S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.

Sequence similarities

Belongs to the acetolactate synthase small subunit family.

Contains 1 ACT domain.

Sequence caution

The sequence AAF65177.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Acetolactate synthase isozyme 3 small subunit
PRO_0000151411

Regions

Domain4 – 7875ACT

Experimental info

Sequence conflict91 – 922IQ → ME in CAA39102. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21622 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 82066840D433D6B5

FASTA16318,063
        10         20         30         40         50         60 
MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT VGDEKVLEQI 

        70         80         90        100        110        120 
EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE VKRNTEIFRG QIIDVTPTLY 

       130        140        150        160 
TVQLAGTSDK LDAFLASLRD VAKIVEVARS GVVGLSRGDK IMR 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2."
Jahreis K., Postma P.W., Lengeler J.W.
Mol. Gen. Genet. 226:332-336(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[3]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55456 Genomic DNA. Translation: CAA39102.1.
AF117227 Genomic DNA. Translation: AAF65177.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL19081.1.
PIRS15940.
RefSeqNP_459122.1. NC_003197.1.

3D structure databases

ProteinModelPortalP21622.
SMRP21622. Positions 2-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM0117.

Proteomic databases

PaxDbP21622.
PRIDEP21622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL19081; AAL19081; STM0117.
GeneID1251635.
KEGGstm:STM0117.
PATRIC32378505. VBISalEnt20916_0122.

Phylogenomic databases

eggNOGCOG0440.
HOGENOMHOG000046747.
KOK01653.
OMARGAKGWK.
OrthoDBEOG6X3W8W.
PhylomeDBP21622.

Enzyme and pathway databases

BioCycSENT99287:GCTI-115-MONOMER.
UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00119. acolac_sm. 1 hit.
PROSITEPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVH_SALTY
AccessionPrimary (citable) accession number: P21622
Secondary accession number(s): Q9JP76
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways