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P21614

- VTDB_MOUSE

UniProt

P21614 - VTDB_MOUSE

Protein

Vitamin D-binding protein

Gene

Gc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. calcidiol binding Source: Ensembl
    3. vitamin transporter activity Source: InterPro

    GO - Biological processi

    1. vitamin D metabolic process Source: MGI

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Actin-binding, Vitamin D

    Enzyme and pathway databases

    ReactomeiREACT_218811. Vitamin D (calciferol) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin D-binding protein
    Short name:
    DBP
    Short name:
    VDB
    Alternative name(s):
    Gc-globulin
    Group-specific component
    Gene namesi
    Name:Gc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95669. Gc.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 16161 PublicationAdd
    BLAST
    Chaini17 – 476460Vitamin D-binding proteinPRO_0000001103Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 75PROSITE-ProRule annotation
    Disulfide bondi74 ↔ 83PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 112PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 122PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 190PROSITE-ProRule annotation
    Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi220 ↔ 266PROSITE-ProRule annotation
    Disulfide bondi265 ↔ 273PROSITE-ProRule annotation
    Disulfide bondi286 ↔ 300PROSITE-ProRule annotation
    Glycosylationi288 – 2881N-linked (GlcNAc...)1 Publication
    Disulfide bondi299 ↔ 311PROSITE-ProRule annotation
    Disulfide bondi335 ↔ 376PROSITE-ProRule annotation
    Disulfide bondi375 ↔ 384PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 453PROSITE-ProRule annotation
    Disulfide bondi452 ↔ 462PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP21614.
    PaxDbiP21614.
    PRIDEiP21614.

    2D gel databases

    REPRODUCTION-2DPAGEP21614.

    PTM databases

    PhosphoSiteiP21614.

    Expressioni

    Gene expression databases

    BgeeiP21614.
    CleanExiMM_GC.
    GenevestigatoriP21614.

    Interactioni

    Protein-protein interaction databases

    IntActiP21614. 5 interactions.
    MINTiMINT-1857787.

    Structurei

    3D structure databases

    ProteinModelPortaliP21614.
    SMRiP21614. Positions 20-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 208192Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini209 – 394186Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini395 – 47682Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG40465.
    GeneTreeiENSGT00390000000113.
    HOGENOMiHOG000140946.
    HOVERGENiHBG009729.
    InParanoidiP21614.
    KOiK12258.
    OMAiRKLCMAA.
    OrthoDBiEOG7B05CR.
    PhylomeDBiP21614.
    TreeFamiTF335561.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    IPR000213. VitD-bd.
    IPR015247. VitD-bind_III.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 2 hits.
    PF09164. VitD-bind_III. 1 hit.
    [Graphical view]
    PRINTSiPR00802. SERUMALBUMIN.
    PR00804. VITAMNDBNDNG.
    SMARTiSM00103. ALBUMIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 1 hit.
    PS51438. ALBUMIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21614-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRVLVLLLA LAFGHALERG RDYEKDKVCN ELAMLGKEDF RSLSLILYSR    50
    KFSSSTFEQV NQLVKEVVSL TEECCAEGAD PTCYDTRTSE LSVKSCESDA 100
    PFPVHPGTPE CCTKEGLERK LCMAALSHQP QEFPTYVEPT NDEICEAFRR 150
    DPKGFADQFL YEYSSNYGQA PLPLLVAYTK NYLSMVGSCC TSANPTVCFV 200
    KERLQMKHLS LLTTMSNRVC SQYAAYGKEK SRLSHLIKLA QKVPTANLEN 250
    VLPLAEDFTE ILSRCCESTS EDCMASELPE HTIKICQNLS KKNSKFEECC 300
    QENTPMNIFM CTYFMPAAEP LQLPAIKLPT GKDLCGQSTT QAMDQYTFEL 350
    SRRTQVPEVF LSKVLEPTLK TLRECCDTQD SVACFSTQSP LLKRQLTSFI 400
    EKGQEMCADY SENTFTEYKK KLAERLRTKT PNTSPAELKD MVEKHSDFAS 450
    KCCSINSPPL YCSSQIDAEM IDTLQS 476
    Length:476
    Mass (Da):53,600
    Last modified:October 10, 2003 - v2
    Checksum:i633B0CE183CD43FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471N → K in BAB27297. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010965 mRNA. Translation: BAB27297.1.
    BC010762 mRNA. Translation: AAH10762.1.
    BC051395 mRNA. Translation: AAH51395.2.
    M55413 mRNA. Translation: AAA37669.1.
    CCDSiCCDS19407.1.
    PIRiA35327.
    RefSeqiNP_032122.1. NM_008096.2.
    UniGeneiMm.196595.

    Genome annotation databases

    EnsembliENSMUST00000049209; ENSMUSP00000046636; ENSMUSG00000035540.
    GeneIDi14473.
    KEGGimmu:14473.
    UCSCiuc008yam.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010965 mRNA. Translation: BAB27297.1 .
    BC010762 mRNA. Translation: AAH10762.1 .
    BC051395 mRNA. Translation: AAH51395.2 .
    M55413 mRNA. Translation: AAA37669.1 .
    CCDSi CCDS19407.1.
    PIRi A35327.
    RefSeqi NP_032122.1. NM_008096.2.
    UniGenei Mm.196595.

    3D structure databases

    ProteinModelPortali P21614.
    SMRi P21614. Positions 20-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21614. 5 interactions.
    MINTi MINT-1857787.

    PTM databases

    PhosphoSitei P21614.

    2D gel databases

    REPRODUCTION-2DPAGE P21614.

    Proteomic databases

    MaxQBi P21614.
    PaxDbi P21614.
    PRIDEi P21614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049209 ; ENSMUSP00000046636 ; ENSMUSG00000035540 .
    GeneIDi 14473.
    KEGGi mmu:14473.
    UCSCi uc008yam.2. mouse.

    Organism-specific databases

    CTDi 2638.
    MGIi MGI:95669. Gc.

    Phylogenomic databases

    eggNOGi NOG40465.
    GeneTreei ENSGT00390000000113.
    HOGENOMi HOG000140946.
    HOVERGENi HBG009729.
    InParanoidi P21614.
    KOi K12258.
    OMAi RKLCMAA.
    OrthoDBi EOG7B05CR.
    PhylomeDBi P21614.
    TreeFami TF335561.

    Enzyme and pathway databases

    Reactomei REACT_218811. Vitamin D (calciferol) metabolism.

    Miscellaneous databases

    ChiTaRSi GC. mouse.
    NextBioi 286142.
    PROi P21614.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21614.
    CleanExi MM_GC.
    Genevestigatori P21614.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    IPR000213. VitD-bd.
    IPR015247. VitD-bind_III.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 2 hits.
    PF09164. VitD-bind_III. 1 hit.
    [Graphical view ]
    PRINTSi PR00802. SERUMALBUMIN.
    PR00804. VITAMNDBNDNG.
    SMARTi SM00103. ALBUMIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 1 hit.
    PS51438. ALBUMIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Liver.
    3. "Mapping and conservation of the group-specific component gene in mouse."
      Yang F., Bergeron J.M., Linehan L.A., Lalley P.A., Sakaguchi A.Y., Bowman B.H.
      Genomics 7:509-516(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-476.
    4. "The isolation, characterization and amino terminal sequence of the vitamin D-binding protein (group specific component) from mouse plasma."
      Borke J.L., Litwiller R.D., Bell M.P., Fass D.N., McKean D.J., Kumar R.
      Int. J. Biochem. 20:1343-1349(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-38.
    5. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-288.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiVTDB_MOUSE
    AccessioniPrimary (citable) accession number: P21614
    Secondary accession number(s): Q7TS97, Q91XG1, Q9CY31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3