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Protein

Cytochrome P450-DIT2

Gene

DIT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29946-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450-DIT2 (EC:1.14.14.-)
Alternative name(s):
Cytochrome P450 56
Gene namesi
Name:DIT2
Synonyms:CYP56
Ordered Locus Names:YDR402C
ORF Names:D9509.20
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR402C.
SGDiS000002810. DIT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450-DIT2PRO_0000052042Add
BLAST

Expressioni

Developmental stagei

Sporulation.

Interactioni

Protein-protein interaction databases

BioGridi32462. 41 interactions.

Structurei

3D structure databases

ProteinModelPortaliP21595.
SMRiP21595. Positions 52-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000130641.
HOGENOMiHOG000160758.
InParanoidiP21595.
KOiK00493.
OMAiFNENIME.
OrthoDBiEOG092C1BL6.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKLLCLI LFLTLSYVAF AIIVPPLNFP KNIPTIPFYV VFLPVIFPID
60 70 80 90 100
QTELYDLYIR ESMEKYGAVK FFFGSRWNIL VSRSEYLAQI FKDEDTFAKS
110 120 130 140 150
GNQKKIPYSA LAAYTGDNVI SAYGAVWRNY RNAVTNGLQH FDDAPIFKNA
160 170 180 190 200
KILCTLIKNR LLEGQTSIPM GPLSQRMALD NISQVALGFD FGALTHEKNA
210 220 230 240 250
FHEHLIRIKK QIFHPFFLTF PFLDVLPIPS RKKAFKDVVS FRELLVKRVQ
260 270 280 290 300
DELVNNYKFE QTTFAASDLI RAHNNEIIDY KQLTDNIVII LVAGHENPQL
310 320 330 340 350
LFNSSLYLLA KYSNEWQEKL RKEVNGITDP KGLADLPLLN AFLFEVVRMY
360 370 380 390 400
PPLSTIINRC TTKTCKLGAE IVIPKGVYVG YNNFGTSHDP KTWGTTADDF
410 420 430 440 450
KPERWGSDIE TIRKNWRMAK NRCAVTGFHG GRRACLGEKL ALTEMRISLA
460 470 480
EMLKQFRWSL DPEWEEKLTP AGPLCPLNLK LKFNENIME
Length:489
Mass (Da):56,071
Last modified:October 1, 1996 - v2
Checksum:i9A301276DDBEB18F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451M → I in CAA39246 (PubMed:2249774).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55713 Genomic DNA. Translation: CAA39246.1.
U32274 Genomic DNA. Translation: AAB64842.1.
BK006938 Genomic DNA. Translation: DAA12244.1.
PIRiB36395.
RefSeqiNP_010690.1. NM_001180710.1.

Genome annotation databases

EnsemblFungiiYDR402C; YDR402C; YDR402C.
GeneIDi852011.
KEGGisce:YDR402C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55713 Genomic DNA. Translation: CAA39246.1.
U32274 Genomic DNA. Translation: AAB64842.1.
BK006938 Genomic DNA. Translation: DAA12244.1.
PIRiB36395.
RefSeqiNP_010690.1. NM_001180710.1.

3D structure databases

ProteinModelPortaliP21595.
SMRiP21595. Positions 52-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32462. 41 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR402C; YDR402C; YDR402C.
GeneIDi852011.
KEGGisce:YDR402C.

Organism-specific databases

EuPathDBiFungiDB:YDR402C.
SGDiS000002810. DIT2.

Phylogenomic databases

GeneTreeiENSGT00840000130641.
HOGENOMiHOG000160758.
InParanoidiP21595.
KOiK00493.
OMAiFNENIME.
OrthoDBiEOG092C1BL6.

Enzyme and pathway databases

BioCyciYEAST:G3O-29946-MONOMER.

Miscellaneous databases

PROiP21595.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP56_YEAST
AccessioniPrimary (citable) accession number: P21595
Secondary accession number(s): D6VT34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.