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P21594

- PYRF_HYPJE

UniProt

P21594 - PYRF_HYPJE

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

ura3

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421SubstrateBy similarity
Active sitei101 – 1011Proton donorPROSITE-ProRule annotation
Binding sitei333 – 3331SubstrateBy similarity
Binding sitei352 – 3521SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:ura3
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Orotidine 5'-phosphate decarboxylasePRO_0000134688Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi51453.JGI74020.

Structurei

3D structure databases

ProteinModelPortaliP21594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 663Substrate bindingBy similarity
Regioni99 – 10810Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21594-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPHPTLKAT FAARSETATH PLTAYLFKLM DLKASNLCLS ADVPTARELL
60 70 80 90 100
YLADKIGPSI VVLKTHYDMV SGWTSHPETG TGAQLASLAR KHGFLIFEDR
110 120 130 140 150
KFGDIGHTVE LQYTGGSARI IDWAHIVNVN MVPGKASVAS LAQGAKRWLE
160 170 180 190 200
RYPCEVKTSV TVGTPTMDSF DDDADSRDAE PAGAVNGMGS IGVLDKPIYS
210 220 230 240 250
NRSGDGRKGS IVSITTVTQQ YESVSSPRLT KAIAEGDESL FPGIEEAPLS
260 270 280 290 300
RGLLILAQMS SQGNFMNKEY TQASVEAARE HKDFVMGFIS QETLNTEPDD
310 320 330 340 350
AFIHMTPGCQ LPPEDEDQQT NGSVGGDGQG QQYNTPHKLI GIAGSDIAIV
360 370 380
GRGILKASDP VEEAERYRSA AWKAYTERLL R
Length:381
Mass (Da):41,176
Last modified:May 1, 1991 - v1
Checksum:iC57FE146442983B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55880 Genomic DNA. Translation: CAA39365.1.
PIRiS14132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55880 Genomic DNA. Translation: CAA39365.1 .
PIRi S14132.

3D structure databases

ProteinModelPortali P21594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 51453.JGI74020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0284.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequences of the Trichoderma reesei ura3 (OMPdecase) and ura5 (OPRTase) genes."
    Berges T., Perrot M., Barreau C.
    Nucleic Acids Res. 18:7183-7183(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26921 / CBS 392.92 / QM9414.
  2. "Isolation of uridine auxotrophs from Trichoderma reesei and efficient transformation with the cloned ura3 and ura5 genes."
    Berges T., Barreau C.
    Curr. Genet. 19:359-365(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26921 / CBS 392.92 / QM9414.

Entry informationi

Entry nameiPYRF_HYPJE
AccessioniPrimary (citable) accession number: P21594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3