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P21594

- PYRF_HYPJE

UniProt

P21594 - PYRF_HYPJE

Protein

Orotidine 5'-phosphate decarboxylase

Gene

ura3

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421SubstrateBy similarity
    Active sitei101 – 1011Proton donorPROSITE-ProRule annotation
    Binding sitei333 – 3331SubstrateBy similarity
    Binding sitei352 – 3521SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:ura3
    OrganismiHypocrea jecorina (Trichoderma reesei)
    Taxonomic identifieri51453 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Orotidine 5'-phosphate decarboxylasePRO_0000134688Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi51453.JGI74020.

    Structurei

    3D structure databases

    ProteinModelPortaliP21594.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 663Substrate bindingBy similarity
    Regioni99 – 10810Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21594-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPHPTLKAT FAARSETATH PLTAYLFKLM DLKASNLCLS ADVPTARELL    50
    YLADKIGPSI VVLKTHYDMV SGWTSHPETG TGAQLASLAR KHGFLIFEDR 100
    KFGDIGHTVE LQYTGGSARI IDWAHIVNVN MVPGKASVAS LAQGAKRWLE 150
    RYPCEVKTSV TVGTPTMDSF DDDADSRDAE PAGAVNGMGS IGVLDKPIYS 200
    NRSGDGRKGS IVSITTVTQQ YESVSSPRLT KAIAEGDESL FPGIEEAPLS 250
    RGLLILAQMS SQGNFMNKEY TQASVEAARE HKDFVMGFIS QETLNTEPDD 300
    AFIHMTPGCQ LPPEDEDQQT NGSVGGDGQG QQYNTPHKLI GIAGSDIAIV 350
    GRGILKASDP VEEAERYRSA AWKAYTERLL R 381
    Length:381
    Mass (Da):41,176
    Last modified:May 1, 1991 - v1
    Checksum:iC57FE146442983B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55880 Genomic DNA. Translation: CAA39365.1.
    PIRiS14132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55880 Genomic DNA. Translation: CAA39365.1 .
    PIRi S14132.

    3D structure databases

    ProteinModelPortali P21594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 51453.JGI74020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0284.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of the Trichoderma reesei ura3 (OMPdecase) and ura5 (OPRTase) genes."
      Berges T., Perrot M., Barreau C.
      Nucleic Acids Res. 18:7183-7183(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26921 / CBS 392.92 / QM9414.
    2. "Isolation of uridine auxotrophs from Trichoderma reesei and efficient transformation with the cloned ura3 and ura5 genes."
      Berges T., Barreau C.
      Curr. Genet. 19:359-365(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26921 / CBS 392.92 / QM9414.

    Entry informationi

    Entry nameiPYRF_HYPJE
    AccessioniPrimary (citable) accession number: P21594
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3