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P21594 (PYRF_HYPJE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:ura3
OrganismHypocrea jecorina (Trichoderma reesei)
Taxonomic identifier51453 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Orotidine 5'-phosphate decarboxylase
PRO_0000134688

Regions

Region64 – 663Substrate binding By similarity
Region99 – 10810Substrate binding By similarity

Sites

Active site1011Proton donor By similarity
Binding site421Substrate By similarity
Binding site3331Substrate By similarity
Binding site3521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P21594 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: C57FE146442983B9

FASTA38141,176
        10         20         30         40         50         60 
MAPHPTLKAT FAARSETATH PLTAYLFKLM DLKASNLCLS ADVPTARELL YLADKIGPSI 

        70         80         90        100        110        120 
VVLKTHYDMV SGWTSHPETG TGAQLASLAR KHGFLIFEDR KFGDIGHTVE LQYTGGSARI 

       130        140        150        160        170        180 
IDWAHIVNVN MVPGKASVAS LAQGAKRWLE RYPCEVKTSV TVGTPTMDSF DDDADSRDAE 

       190        200        210        220        230        240 
PAGAVNGMGS IGVLDKPIYS NRSGDGRKGS IVSITTVTQQ YESVSSPRLT KAIAEGDESL 

       250        260        270        280        290        300 
FPGIEEAPLS RGLLILAQMS SQGNFMNKEY TQASVEAARE HKDFVMGFIS QETLNTEPDD 

       310        320        330        340        350        360 
AFIHMTPGCQ LPPEDEDQQT NGSVGGDGQG QQYNTPHKLI GIAGSDIAIV GRGILKASDP 

       370        380 
VEEAERYRSA AWKAYTERLL R 

« Hide

References

[1]"Nucleotide sequences of the Trichoderma reesei ura3 (OMPdecase) and ura5 (OPRTase) genes."
Berges T., Perrot M., Barreau C.
Nucleic Acids Res. 18:7183-7183(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 26921 / CBS 392.92 / QM9414.
[2]"Isolation of uridine auxotrophs from Trichoderma reesei and efficient transformation with the cloned ura3 and ura5 genes."
Berges T., Barreau C.
Curr. Genet. 19:359-365(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 26921 / CBS 392.92 / QM9414.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55880 Genomic DNA. Translation: CAA39365.1.
PIRS14132.

3D structure databases

ProteinModelPortalP21594.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING51453.JGI74020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0284.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_HYPJE
AccessionPrimary (citable) accession number: P21594
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 16, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways