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P21593 (PYRF_PHYB8) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismPhycomyces blakesleeanus (strain ATCC 8743b / FGSC 10004 / NBRC 33097 / NRRL 1555)
Taxonomic identifier763407 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesPhycomycetaceaePhycomyces

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Orotidine 5'-phosphate decarboxylase
PRO_0000134671

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2151Substrate By similarity
Binding site2341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P21593 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: CE5B132327F3FDDC

FASTA26729,899
        10         20         30         40         50         60 
MMLNTYKSYT ERAEQHPNAC ARSLFELMER KKTNLSVAVD VTTKKELLSI ADSVGPYVCV 

        70         80         90        100        110        120 
LKTHIDIVED FDKDLVAQLE ALAKKHDFLI FEDRKFADIG NTVKHQYEKG VYKIASWSHI 

       130        140        150        160        170        180 
TNAHTVPGEG IIKGLGEVGL PLGRGLLLLA EMSSKGALTK GSYTTESVEM ARRNKDFVFG 

       190        200        210        220        230        240 
FIAQHKMNEY PDEDFVVMTP GVGLDIKGDG LGQQYRTPHE VIVESGCDVI IVGRGIYGKP 

       250        260 
DEVEAQSKRY REAGWNAYLE RVRMHKA 

« Hide

References

[1]"Isolation and molecular analysis of the orotidine-5'-phosphate decarboxylase gene (pyrG) of Phycomyces blakesleeanus."
Diaz-Minguez J.M., Iturriaga E.A., Benito E.P., Corrochano L., Eslava A.P.
Mol. Gen. Genet. 224:269-278(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 8743b / FGSC 10004 / NBRC 33097 / NRRL 1555.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53601 Genomic DNA. Translation: CAA37670.1.
PIRDCUMOP. S13736.

3D structure databases

ProteinModelPortalP21593.
SMRP21593. Positions 8-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PHYB8
AccessionPrimary (citable) accession number: P21593
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 16, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways