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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

COX10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.1 Publication

GO - Molecular functioni

  • protoheme IX farnesyltransferase activity Source: SGD

GO - Biological processi

  • heme a biosynthetic process Source: SGD
  • heme O biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-34067-MONOMER.
BRENDAi2.5.1.B36. 984.
ReactomeiR-SCE-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrial (EC:2.5.1.-)
Alternative name(s):
Heme O synthase
Gene namesi
Name:COX10
Ordered Locus Names:YPL172C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL172C.
SGDiS000006093. COX10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei141 – 16525HelicalSequence analysisAdd
BLAST
Transmembranei180 – 19819HelicalSequence analysisAdd
BLAST
Transmembranei221 – 23919HelicalSequence analysisAdd
BLAST
Transmembranei250 – 26819HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35619HelicalSequence analysisAdd
BLAST
Transmembranei369 – 38618HelicalSequence analysisAdd
BLAST
Transmembranei429 – 45325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 462432Protoheme IX farnesyltransferase, mitochondrialPRO_0000035925Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi36011. 163 interactions.
DIPiDIP-3982N.
MINTiMINT-494314.

Structurei

3D structure databases

ProteinModelPortaliP21592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008408.
HOGENOMiHOG000189335.
InParanoidiP21592.
KOiK02257.
OMAiNMGREPD.
OrthoDBiEOG092C3ETM.

Family and domain databases

CDDicd13957. PT_UbiA_Cox10. 1 hit.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF001773. COX10. 1 hit.
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH
60 70 80 90 100
GGKQQHINTA PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG
110 120 130 140 150
SEATTDASTQ LPFNVKLVDP MVRKSKRPSH AISEGLNMKT LKKKVIMPYL
160 170 180 190 200
QLTKPRLTIL VMLSAICSYA LSPYPASVNE LLCLTVGTTL CSGSANAINM
210 220 230 240 250
GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV SILYFGVNPT
260 270 280 290 300
VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH
310 320 330 340 350
PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL
360 370 380 390 400
RYSILMFPLC FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS
410 420 430 440 450
AKTLKDNVKF NKGLSVANIY ARKTFMASVL HLPAILILAI IHKKGRWDWI
460
YPGEAKRPQE RF
Length:462
Mass (Da):52,148
Last modified:May 1, 1991 - v1
Checksum:iA8535C6D1BE2674F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55566 Genomic DNA. Translation: AAA34509.1.
Z73528 Genomic DNA. Translation: CAA97879.1.
L29279 Genomic DNA. Translation: AAA64523.1.
BK006949 Genomic DNA. Translation: DAA11262.1.
PIRiA37812. COBY10.
RefSeqiNP_015153.1. NM_001183986.1.

Genome annotation databases

EnsemblFungiiYPL172C; YPL172C; YPL172C.
GeneIDi855931.
KEGGisce:YPL172C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55566 Genomic DNA. Translation: AAA34509.1.
Z73528 Genomic DNA. Translation: CAA97879.1.
L29279 Genomic DNA. Translation: AAA64523.1.
BK006949 Genomic DNA. Translation: DAA11262.1.
PIRiA37812. COBY10.
RefSeqiNP_015153.1. NM_001183986.1.

3D structure databases

ProteinModelPortaliP21592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36011. 163 interactions.
DIPiDIP-3982N.
MINTiMINT-494314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL172C; YPL172C; YPL172C.
GeneIDi855931.
KEGGisce:YPL172C.

Organism-specific databases

EuPathDBiFungiDB:YPL172C.
SGDiS000006093. COX10.

Phylogenomic databases

GeneTreeiENSGT00390000008408.
HOGENOMiHOG000189335.
InParanoidiP21592.
KOiK02257.
OMAiNMGREPD.
OrthoDBiEOG092C3ETM.

Enzyme and pathway databases

BioCyciYEAST:G3O-34067-MONOMER.
BRENDAi2.5.1.B36. 984.
ReactomeiR-SCE-189451. Heme biosynthesis.

Miscellaneous databases

PROiP21592.

Family and domain databases

CDDicd13957. PT_UbiA_Cox10. 1 hit.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF001773. COX10. 1 hit.
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX10_YEAST
AccessioniPrimary (citable) accession number: P21592
Secondary accession number(s): D6W3J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.