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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

COX10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.1 Publication

GO - Molecular functioni

  • farnesyltranstransferase activity Source: GO_Central
  • protoheme IX farnesyltransferase activity Source: SGD

GO - Biological processi

  • cellular respiration Source: GO_Central
  • heme a biosynthetic process Source: SGD
  • heme O biosynthetic process Source: InterPro

Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-34067-MONOMER
BRENDAi2.5.1.B36 984
ReactomeiR-SCE-189451 Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrial (EC:2.5.1.-)
Alternative name(s):
Heme O synthase
Gene namesi
Name:COX10
Ordered Locus Names:YPL172C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL172C
SGDiS000006093 COX10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei141 – 165HelicalSequence analysisAdd BLAST25
Transmembranei180 – 198HelicalSequence analysisAdd BLAST19
Transmembranei221 – 239HelicalSequence analysisAdd BLAST19
Transmembranei250 – 268HelicalSequence analysisAdd BLAST19
Transmembranei338 – 356HelicalSequence analysisAdd BLAST19
Transmembranei369 – 386HelicalSequence analysisAdd BLAST18
Transmembranei429 – 453HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000003592531 – 462Protoheme IX farnesyltransferase, mitochondrialAdd BLAST432

Proteomic databases

PaxDbiP21592
PRIDEiP21592

Interactioni

Protein-protein interaction databases

BioGridi36011, 422 interactors
DIPiDIP-3982N
IntActiP21592, 1 interactor
STRINGi4932.YPL172C

Structurei

3D structure databases

ProteinModelPortaliP21592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008408
HOGENOMiHOG000189335
InParanoidiP21592
KOiK02257
OMAiVINTWVG
OrthoDBiEOG092C3ETM

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR016315 Protohaem_IX_farnesylTrfase_mt
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF001773 COX10, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH
60 70 80 90 100
GGKQQHINTA PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG
110 120 130 140 150
SEATTDASTQ LPFNVKLVDP MVRKSKRPSH AISEGLNMKT LKKKVIMPYL
160 170 180 190 200
QLTKPRLTIL VMLSAICSYA LSPYPASVNE LLCLTVGTTL CSGSANAINM
210 220 230 240 250
GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV SILYFGVNPT
260 270 280 290 300
VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH
310 320 330 340 350
PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL
360 370 380 390 400
RYSILMFPLC FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS
410 420 430 440 450
AKTLKDNVKF NKGLSVANIY ARKTFMASVL HLPAILILAI IHKKGRWDWI
460
YPGEAKRPQE RF
Length:462
Mass (Da):52,148
Last modified:May 1, 1991 - v1
Checksum:iA8535C6D1BE2674F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55566 Genomic DNA Translation: AAA34509.1
Z73528 Genomic DNA Translation: CAA97879.1
L29279 Genomic DNA Translation: AAA64523.1
BK006949 Genomic DNA Translation: DAA11262.1
PIRiA37812 COBY10
RefSeqiNP_015153.1, NM_001183986.1

Genome annotation databases

EnsemblFungiiYPL172C; YPL172C; YPL172C
GeneIDi855931
KEGGisce:YPL172C

Similar proteinsi

Entry informationi

Entry nameiCOX10_YEAST
AccessioniPrimary (citable) accession number: P21592
Secondary accession number(s): D6W3J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health