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P21589

- 5NTD_HUMAN

UniProt

P21589 - 5NTD_HUMAN

Protein

5'-nucleotidase

Gene

NT5E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.1 Publication

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

    Cofactori

    Zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361Zinc 1
    Metal bindingi38 – 381Zinc 1
    Metal bindingi85 – 851Zinc 1
    Metal bindingi85 – 851Zinc 2
    Metal bindingi117 – 1171Zinc 2
    Sitei118 – 1181Transition state stabilizer
    Sitei121 – 1211Transition state stabilizerCurated
    Metal bindingi220 – 2201Zinc 2
    Metal bindingi243 – 2431Zinc 2
    Binding sitei245 – 2451Substrate
    Binding sitei354 – 3541Substrate
    Binding sitei390 – 3901Substrate
    Binding sitei395 – 3951Substrate
    Binding sitei417 – 4171Substrate

    GO - Molecular functioni

    1. 5'-nucleotidase activity Source: Reactome
    2. metal ion binding Source: UniProtKB-KW
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. adenosine biosynthetic process Source: Ensembl
    2. AMP catabolic process Source: Ensembl
    3. dephosphorylation Source: GOC
    4. DNA metabolic process Source: ProtInc
    5. negative regulation of inflammatory response Source: Ensembl
    6. nucleobase-containing small molecule metabolic process Source: Reactome
    7. purine nucleobase metabolic process Source: Reactome
    8. purine nucleotide catabolic process Source: Reactome
    9. pyrimidine nucleobase metabolic process Source: Reactome
    10. pyrimidine nucleoside catabolic process Source: Reactome
    11. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:HS05981-MONOMER.
    RETL1328306-WGS:GSTH-3623-MONOMER.
    ReactomeiREACT_1023. Pyrimidine catabolism.
    REACT_2086. Purine catabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'-nucleotidase (EC:3.1.3.5)
    Short name:
    5'-NT
    Alternative name(s):
    Ecto-5'-nucleotidase
    CD_antigen: CD73
    Gene namesi
    Name:NT5E
    Synonyms:NT5, NTE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8021. NT5E.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cytoplasm Source: HPA
    3. extracellular vesicular exosome Source: UniProtKB
    4. membrane Source: ProtInc
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Calcification of joints and arteries (CALJA) [MIM:211800]: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti358 – 3581C → Y in CALJA. 1 Publication
    VAR_065185

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi211800. phenotype.
    Orphaneti289601. Hereditary arterial and articular multiple calcification syndrome.
    PharmGKBiPA31804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 5495235'-nucleotidase1 PublicationPRO_0000000015Add
    BLAST
    Propeptidei550 – 57425Removed in mature formPRO_0000000016Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 571 Publication
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)2 Publications
    Glycosylationi333 – 3331N-linked (GlcNAc...)2 Publications
    Disulfide bondi353 ↔ 3581 Publication
    Disulfide bondi365 ↔ 3871 Publication
    Glycosylationi403 – 4031N-linked (GlcNAc...)1 Publication
    Disulfide bondi476 ↔ 4791 Publication
    Lipidationi549 – 5491GPI-anchor amidated serine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiP21589.
    PaxDbiP21589.
    PRIDEiP21589.

    PTM databases

    PhosphoSiteiP21589.

    Expressioni

    Gene expression databases

    ArrayExpressiP21589.
    BgeeiP21589.
    CleanExiHS_NT5E.
    GenevestigatoriP21589.

    Organism-specific databases

    HPAiHPA017357.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi110962. 8 interactions.
    DIPiDIP-59992N.
    MINTiMINT-5002487.
    STRINGi9606.ENSP00000257770.

    Structurei

    Secondary structure

    1
    574
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 348
    Beta strandi48 – 503
    Helixi54 – 563
    Helixi61 – 7414
    Beta strandi76 – 827
    Beta strandi87 – 904
    Helixi91 – 966
    Helixi99 – 10810
    Beta strandi111 – 1144
    Helixi117 – 1204
    Helixi123 – 1286
    Turni129 – 1346
    Beta strandi142 – 1465
    Helixi150 – 1545
    Turni155 – 1573
    Beta strandi158 – 1669
    Beta strandi169 – 1779
    Helixi181 – 1844
    Beta strandi189 – 1935
    Helixi196 – 20914
    Beta strandi215 – 2217
    Helixi223 – 23210
    Beta strandi238 – 2403
    Beta strandi250 – 2523
    Beta strandi254 – 2563
    Beta strandi263 – 2686
    Beta strandi274 – 2785
    Beta strandi285 – 29410
    Beta strandi300 – 3056
    Helixi318 – 33518
    Beta strandi337 – 3448
    Helixi350 – 3534
    Helixi359 – 37113
    Helixi379 – 3813
    Beta strandi386 – 3905
    Helixi391 – 3933
    Turni401 – 4044
    Beta strandi405 – 4073
    Helixi408 – 4147
    Beta strandi420 – 4278
    Helixi428 – 43912
    Turni440 – 4434
    Beta strandi450 – 45910
    Beta strandi469 – 4757
    Beta strandi477 – 4815
    Beta strandi484 – 4863
    Beta strandi492 – 4987
    Helixi499 – 5024
    Helixi505 – 5073
    Helixi509 – 5146
    Beta strandi516 – 5238
    Helixi524 – 53512
    Beta strandi536 – 5383
    Beta strandi544 – 5485

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H1SX-ray2.20A/B27-549[»]
    4H1YX-ray1.58P27-549[»]
    4H2BX-ray1.70A27-549[»]
    4H2FX-ray1.85A27-549[»]
    4H2GX-ray1.55A27-549[»]
    4H2IX-ray2.00A27-549[»]
    ProteinModelPortaliP21589.
    SMRiP21589. Positions 27-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni500 – 5067Substrate binding

    Sequence similaritiesi

    Belongs to the 5'-nucleotidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0737.
    HOGENOMiHOG000247215.
    HOVERGENiHBG000026.
    InParanoidiP21589.
    KOiK01081.
    OMAiDKVQFPV.
    OrthoDBiEOG7TF78T.
    PhylomeDBiP21589.
    TreeFamiTF323589.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProiIPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PANTHERiPTHR11575. PTHR11575. 1 hit.
    PfamiPF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR01607. APYRASEFAMLY.
    SUPFAMiSSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P21589-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK    50
    CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE 100
    VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL 150
    ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL 200
    QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT 250
    GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV 300
    ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS 350
    QSCRFRECNM GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE 400
    RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL 450
    QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF 500
    LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST 550
    GSHCHGSFSL IFLSLWAVIF VLYQ 574
    Length:574
    Mass (Da):63,368
    Last modified:May 1, 1991 - v1
    Checksum:iA99AF170AB7EAECE
    GO
    Isoform 2 (identifier: P21589-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         404-453: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:524
    Mass (Da):57,949
    Checksum:i98A11D22CFC7C610
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti358 – 3581C → Y in CALJA. 1 Publication
    VAR_065185
    Natural varianti376 – 3761T → A.1 Publication
    Corresponds to variant rs2229523 [ dbSNP | Ensembl ].
    VAR_022091
    Natural varianti379 – 3791M → T.
    Corresponds to variant rs2229524 [ dbSNP | Ensembl ].
    VAR_048103

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei404 – 45350Missing in isoform 2. 1 PublicationVSP_043076Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55740 mRNA. Translation: CAA39271.1.
    AK075008 mRNA. Translation: BAG52050.1.
    AL135903, AL589666 Genomic DNA. Translation: CAH72337.1.
    AL589666, AL135903 Genomic DNA. Translation: CAI40168.1.
    U21730 Genomic DNA. Translation: AAA96950.1.
    AF069067 Genomic DNA. Translation: AAC98672.1.
    CCDSiCCDS5002.1. [P21589-1]
    CCDS56439.1. [P21589-2]
    PIRiS11032.
    RefSeqiNP_001191742.1. NM_001204813.1. [P21589-2]
    NP_002517.1. NM_002526.3. [P21589-1]
    UniGeneiHs.153952.

    Genome annotation databases

    EnsembliENST00000257770; ENSP00000257770; ENSG00000135318. [P21589-1]
    ENST00000369651; ENSP00000358665; ENSG00000135318. [P21589-2]
    GeneIDi4907.
    KEGGihsa:4907.
    UCSCiuc003pko.4. human. [P21589-1]
    uc010kbr.3. human. [P21589-2]

    Polymorphism databases

    DMDMi112825.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55740 mRNA. Translation: CAA39271.1 .
    AK075008 mRNA. Translation: BAG52050.1 .
    AL135903 , AL589666 Genomic DNA. Translation: CAH72337.1 .
    AL589666 , AL135903 Genomic DNA. Translation: CAI40168.1 .
    U21730 Genomic DNA. Translation: AAA96950.1 .
    AF069067 Genomic DNA. Translation: AAC98672.1 .
    CCDSi CCDS5002.1. [P21589-1 ]
    CCDS56439.1. [P21589-2 ]
    PIRi S11032.
    RefSeqi NP_001191742.1. NM_001204813.1. [P21589-2 ]
    NP_002517.1. NM_002526.3. [P21589-1 ]
    UniGenei Hs.153952.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H1S X-ray 2.20 A/B 27-549 [» ]
    4H1Y X-ray 1.58 P 27-549 [» ]
    4H2B X-ray 1.70 A 27-549 [» ]
    4H2F X-ray 1.85 A 27-549 [» ]
    4H2G X-ray 1.55 A 27-549 [» ]
    4H2I X-ray 2.00 A 27-549 [» ]
    ProteinModelPortali P21589.
    SMRi P21589. Positions 27-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110962. 8 interactions.
    DIPi DIP-59992N.
    MINTi MINT-5002487.
    STRINGi 9606.ENSP00000257770.

    Chemistry

    ChEMBLi CHEMBL5957.
    DrugBanki DB00987. Cytarabine.
    DB00806. Pentoxifylline.
    GuidetoPHARMACOLOGYi 1232.

    PTM databases

    PhosphoSitei P21589.

    Polymorphism databases

    DMDMi 112825.

    Proteomic databases

    MaxQBi P21589.
    PaxDbi P21589.
    PRIDEi P21589.

    Protocols and materials databases

    DNASUi 4907.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257770 ; ENSP00000257770 ; ENSG00000135318 . [P21589-1 ]
    ENST00000369651 ; ENSP00000358665 ; ENSG00000135318 . [P21589-2 ]
    GeneIDi 4907.
    KEGGi hsa:4907.
    UCSCi uc003pko.4. human. [P21589-1 ]
    uc010kbr.3. human. [P21589-2 ]

    Organism-specific databases

    CTDi 4907.
    GeneCardsi GC06P086216.
    HGNCi HGNC:8021. NT5E.
    HPAi HPA017357.
    MIMi 129190. gene.
    211800. phenotype.
    neXtProti NX_P21589.
    Orphaneti 289601. Hereditary arterial and articular multiple calcification syndrome.
    PharmGKBi PA31804.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0737.
    HOGENOMi HOG000247215.
    HOVERGENi HBG000026.
    InParanoidi P21589.
    KOi K01081.
    OMAi DKVQFPV.
    OrthoDBi EOG7TF78T.
    PhylomeDBi P21589.
    TreeFami TF323589.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS05981-MONOMER.
    RETL1328306-WGS:GSTH-3623-MONOMER.
    Reactomei REACT_1023. Pyrimidine catabolism.
    REACT_2086. Purine catabolism.

    Miscellaneous databases

    ChiTaRSi NT5E. human.
    GeneWikii NT5E.
    GenomeRNAii 4907.
    NextBioi 18883.
    PROi P21589.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21589.
    Bgeei P21589.
    CleanExi HS_NT5E.
    Genevestigatori P21589.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProi IPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    PANTHERi PTHR11575. PTHR11575. 1 hit.
    Pfami PF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR01607. APYRASEFAMLY.
    SUPFAMi SSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form."
      Misumi Y., Ogata S., Ohkubo K., Hirose S., Ikehara Y.
      Eur. J. Biochem. 191:563-569(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, GPI-ANCHOR AT SER-549.
      Tissue: Placenta.
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene."
      Hansen K.R., Resta R., Webb C.F., Thompson L.F.
      Gene 167:307-312(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.
      Tissue: Placenta.
    5. Zanoni L., Rosi F., Pagani R., Marinello E.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 359-489, VARIANT ALA-376.
      Tissue: Leukocyte.
    6. "Characterization of soluble vs membrane-bound human placental 5'-nucleotidase."
      Klemens M.R., Sherman W.R., Holmberg N.J., Ruedi J.M., Low M.G., Thompson L.F.
      Biochem. Biophys. Res. Commun. 172:1371-1377(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-40.
      Tissue: Placenta.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-311; ASN-333 AND ASN-403.
      Tissue: Liver.
    8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333.
      Tissue: Leukemic T-cell.
    9. "The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism."
      Garavaglia S., Bruzzone S., Cassani C., Canella L., Allegrone G., Sturla L., Mannino E., Millo E., De Flora A., Rizzi M.
      Biochem. J. 441:131-141(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBSTRATE SPECIFICITY.
    10. "Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling."
      Knapp K., Zebisch M., Pippel J., El-Tayeb A., Muller C.E., Strater N.
      Structure 20:2161-2173(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 27-549 IN COMPLEXES WITH ATP ANALOG AND ZINC IONS, SUBUNIT, GLYCOSYLATION AT ASN-311, DISULFIDE BONDS.
    11. Cited for: VARIANT CALJA TYR-358.

    Entry informationi

    Entry namei5NTD_HUMAN
    AccessioniPrimary (citable) accession number: P21589
    Secondary accession number(s): B3KQI8, O75520, Q5W116
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 159 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3