Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21583

- SCF_HUMAN

UniProt

P21583 - SCF_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kit ligand

Gene

KITLG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei97 – 971Not glycosylated

GO - Molecular functioni

  1. stem cell factor receptor binding Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell proliferation Source: ProtInc
  3. ectopic germ cell programmed cell death Source: Ensembl
  4. embryonic hemopoiesis Source: DFLAT
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. Fc-epsilon receptor signaling pathway Source: Reactome
  8. fibroblast growth factor receptor signaling pathway Source: Reactome
  9. innate immune response Source: Reactome
  10. male gonad development Source: UniProtKB
  11. negative regulation of mast cell apoptotic process Source: Ensembl
  12. neural crest cell migration Source: Ensembl
  13. neurotrophin TRK receptor signaling pathway Source: Reactome
  14. phosphatidylinositol-mediated signaling Source: Reactome
  15. positive regulation of DNA replication Source: BHF-UCL
  16. positive regulation of MAP kinase activity Source: Ensembl
  17. positive regulation of mast cell proliferation Source: Ensembl
  18. positive regulation of melanocyte differentiation Source: Ensembl
  19. positive regulation of myeloid leukocyte differentiation Source: Ensembl
  20. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  21. positive regulation of Ras protein signal transduction Source: Ensembl
  22. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_111225. Regulation of KIT signaling.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_75829. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Kit ligand
Alternative name(s):
Mast cell growth factor
Short name:
MGF
Stem cell factor
Short name:
SCF
c-Kit ligand
Cleaved into the following chain:
Soluble KIT ligand
Short name:
sKITLG
Gene namesi
Name:KITLG
Synonyms:MGF, SCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6343. KITLG.

Subcellular locationi

Isoform 2 : Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. extracellular region Source: Reactome
  4. extracellular space Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Familial progressive hyperpigmentation (FPH) [MIM:145250]: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361N → S in FPH; gain-of-function mutation; sKITLG reveales that the mutant Ser-36 sKITLG increases the content of the melanin by 109% compared with the wild-type sKITLG; tyrosinase activity is significantly increased by the mutant sKITLG compared to wild-type control. 1 Publication
VAR_063237

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi145250. phenotype.
611664. phenotype.
Orphaneti280628. Familial progressive hyper- and hypopigmentation.
79146. Familial progressive hyperpigmentation.
363494. Testicular non seminomatous germ cell tumor.
PharmGKBiPA30129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 273248Kit ligandPRO_0000031913Add
BLAST
Chaini26 – 190165Soluble KIT ligandPRO_0000403391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 114
Disulfide bondi68 ↔ 163
Glycosylationi90 – 901N-linked (GlcNAc...); partial1 Publication
Glycosylationi118 – 1181N-linked (GlcNAc...); partial1 Publication
Glycosylationi145 – 1451N-linked (GlcNAc...)1 Publication
Glycosylationi167 – 1671O-linked (GalNAc...)1 Publication
Glycosylationi168 – 1681O-linked (GalNAc...)1 Publication
Glycosylationi180 – 1801O-linked (GalNAc...)1 Publication
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.1 Publication
Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.1 Publication
A soluble form exists as a cleavage product of the extracellular domain.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP21583.
PaxDbiP21583.
PRIDEiP21583.

PTM databases

PhosphoSiteiP21583.

Miscellaneous databases

PMAP-CutDBP21583.

Expressioni

Developmental stagei

Acts in the early stages of hematopoiesis.

Gene expression databases

BgeeiP21583.
CleanExiHS_KITLG.
ExpressionAtlasiP21583. baseline and differential.
GenevestigatoriP21583.

Organism-specific databases

HPAiCAB004569.

Interactioni

Subunit structurei

Homodimer, non-covalently linked Probable. Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.1 PublicationCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
KITP107212EBI-1379527,EBI-1379503

Protein-protein interaction databases

BioGridi110410. 7 interactions.
IntActiP21583. 2 interactions.
STRINGi9606.ENSP00000228280.

Structurei

Secondary structure

1
273
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323
Helixi37 – 4610
Beta strandi53 – 564
Turni59 – 635
Helixi66 – 683
Helixi70 – 8516
Beta strandi92 – 943
Helixi97 – 11418
Beta strandi120 – 1223
Beta strandi132 – 1354
Helixi137 – 14913
Turni150 – 1523
Beta strandi157 – 1604

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EXZX-ray2.30A/B/C/D26-166[»]
1SCFX-ray2.20A/B/C/D1-273[»]
2E9WX-ray3.50C/D26-166[»]
ProteinModelPortaliP21583.
SMRiP21583. Positions 36-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21583.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 214189ExtracellularSequence AnalysisAdd
BLAST
Topological domaini238 – 27336CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei215 – 23723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SCF family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39386.
GeneTreeiENSGT00390000018272.
HOVERGENiHBG036146.
InParanoidiP21583.
KOiK05461.
OMAiVKTKGIC.
OrthoDBiEOG70ZZP2.
PhylomeDBiP21583.
TreeFamiTF330811.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003452. SCF.
[Graphical view]
PANTHERiPTHR11574. PTHR11574. 1 hit.
PfamiPF02404. SCF. 1 hit.
[Graphical view]
PIRSFiPIRSF015599. SCF. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21583-1) [UniParc]FASTAAdd to Basket

Also known as: SCF248

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD
60 70 80 90 100
YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI
110 120 130 140 150
IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA
160 170 180 190 200
FKDFVVASET SDCVVSSTLS PEKDSRVSVT KPFMLPPVAA SSLRNDSSSS
210 220 230 240 250
NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR QPSLTRAVEN
260 270
IQINEEDNEI SMLQEKEREF QEV
Length:273
Mass (Da):30,899
Last modified:May 1, 1991 - v1
Checksum:i19FD362CB59C6607
GO
Isoform 2 (identifier: P21583-2) [UniParc]FASTAAdd to Basket

Also known as: SCF220

The sequence of this isoform differs from the canonical sequence as follows:
     174-202: DSRVSVTKPFMLPPVAASSLRNDSSSSNR → G

Show »
Length:245
Mass (Da):27,867
Checksum:i937AEA64456DF4FA
GO
Isoform 3 (identifier: P21583-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-43: NVKDVTKL → MPSCLAAQ

Note: No experimental confirmation available.

Show »
Length:238
Mass (Da):26,667
Checksum:i7D6B1E487BE3709B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551L → S in AAD22048. (PubMed:10049787)Curated
Sequence conflicti55 – 551L → S in AAK92486. 1 PublicationCurated
Sequence conflicti128 – 1281K → R in AAD22048. (PubMed:10049787)Curated
Sequence conflicti128 – 1281K → R in AAK92486. 1 PublicationCurated
Sequence conflicti134 – 1341L → F in AAD22048. (PubMed:10049787)Curated
Sequence conflicti134 – 1341L → F in AAK92486. 1 PublicationCurated

Polymorphismi

Genetic variants in KITLG define the skin/hair/eye pigmentation variation locus 7 (SHEP7) [MIMi:611664]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.
A non-coding SNP (dbSNP:rs12821256) has been shown to be associated with classic blond hair color in Europeans. This SNP is located 350 kb upstream from KITLG, in an enhancer specifically active in the hair follicle environment. It alters a LEF1 binding site, reducing LEF1 responsiveness in cultured keratinocytes. This SNP is not associated with eye pigmentation. It is most prevalent in Northern Europe (PubMed:24880339).1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361N → S in FPH; gain-of-function mutation; sKITLG reveales that the mutant Ser-36 sKITLG increases the content of the melanin by 109% compared with the wild-type sKITLG; tyrosinase activity is significantly increased by the mutant sKITLG compared to wild-type control. 1 Publication
VAR_063237
Natural varianti54 – 541T → A.
Corresponds to variant rs3741457 [ dbSNP | Ensembl ].
VAR_042652
Natural varianti210 – 2101D → Y.
Corresponds to variant rs41283112 [ dbSNP | Ensembl ].
VAR_063238
Natural varianti232 – 2321F → Y.
Corresponds to variant rs12721563 [ dbSNP | Ensembl ].
VAR_042653

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535Missing in isoform 3. 1 PublicationVSP_032762Add
BLAST
Alternative sequencei36 – 438NVKDVTKL → MPSCLAAQ in isoform 3. 1 PublicationVSP_032763
Alternative sequencei174 – 20229DSRVS…SSSNR → G in isoform 2. 6 PublicationsVSP_006022Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59964 mRNA. Translation: AAA85450.1.
AF119835 mRNA. Translation: AAD22048.1.
AF400436 mRNA. Translation: AAK92485.1.
AF400437 mRNA. Translation: AAK92486.1.
AK290319 mRNA. Translation: BAF83008.1.
AK293002 mRNA. Translation: BAF85691.1.
CR749222 mRNA. Translation: CAH18078.1.
CH471054 Genomic DNA. Translation: EAW97417.1.
BC069733 mRNA. Translation: AAH69733.1.
BC069783 mRNA. Translation: AAH69783.1.
BC069797 mRNA. Translation: AAH69797.1.
BC074725 mRNA. Translation: AAH74725.1.
BC126166 mRNA. Translation: AAI26167.1.
BC143899 mRNA. Translation: AAI43900.1.
S42571 mRNA. Translation: AAB22846.2.
CCDSiCCDS31867.1. [P21583-2]
CCDS31868.1. [P21583-1]
PIRiA35974.
B61190.
S29052.
RefSeqiNP_000890.1. NM_000899.4. [P21583-1]
NP_003985.2. NM_003994.5. [P21583-2]
UniGeneiHs.1048.

Genome annotation databases

EnsembliENST00000228280; ENSP00000228280; ENSG00000049130. [P21583-1]
ENST00000347404; ENSP00000054216; ENSG00000049130. [P21583-2]
GeneIDi4254.
KEGGihsa:4254.
UCSCiuc001tav.3. human. [P21583-1]
uc001taw.3. human. [P21583-2]

Polymorphism databases

DMDMi134289.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight

two's company - Issue 163 of August 2014

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59964 mRNA. Translation: AAA85450.1 .
AF119835 mRNA. Translation: AAD22048.1 .
AF400436 mRNA. Translation: AAK92485.1 .
AF400437 mRNA. Translation: AAK92486.1 .
AK290319 mRNA. Translation: BAF83008.1 .
AK293002 mRNA. Translation: BAF85691.1 .
CR749222 mRNA. Translation: CAH18078.1 .
CH471054 Genomic DNA. Translation: EAW97417.1 .
BC069733 mRNA. Translation: AAH69733.1 .
BC069783 mRNA. Translation: AAH69783.1 .
BC069797 mRNA. Translation: AAH69797.1 .
BC074725 mRNA. Translation: AAH74725.1 .
BC126166 mRNA. Translation: AAI26167.1 .
BC143899 mRNA. Translation: AAI43900.1 .
S42571 mRNA. Translation: AAB22846.2 .
CCDSi CCDS31867.1. [P21583-2 ]
CCDS31868.1. [P21583-1 ]
PIRi A35974.
B61190.
S29052.
RefSeqi NP_000890.1. NM_000899.4. [P21583-1 ]
NP_003985.2. NM_003994.5. [P21583-2 ]
UniGenei Hs.1048.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EXZ X-ray 2.30 A/B/C/D 26-166 [» ]
1SCF X-ray 2.20 A/B/C/D 1-273 [» ]
2E9W X-ray 3.50 C/D 26-166 [» ]
ProteinModelPortali P21583.
SMRi P21583. Positions 36-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110410. 7 interactions.
IntActi P21583. 2 interactions.
STRINGi 9606.ENSP00000228280.

Chemistry

BindingDBi P21583.
ChEMBLi CHEMBL2346489.

PTM databases

PhosphoSitei P21583.

Polymorphism databases

DMDMi 134289.

Proteomic databases

MaxQBi P21583.
PaxDbi P21583.
PRIDEi P21583.

Protocols and materials databases

DNASUi 4254.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228280 ; ENSP00000228280 ; ENSG00000049130 . [P21583-1 ]
ENST00000347404 ; ENSP00000054216 ; ENSG00000049130 . [P21583-2 ]
GeneIDi 4254.
KEGGi hsa:4254.
UCSCi uc001tav.3. human. [P21583-1 ]
uc001taw.3. human. [P21583-2 ]

Organism-specific databases

CTDi 4254.
GeneCardsi GC12M088823.
HGNCi HGNC:6343. KITLG.
HPAi CAB004569.
MIMi 145250. phenotype.
184745. gene.
611664. phenotype.
neXtProti NX_P21583.
Orphaneti 280628. Familial progressive hyper- and hypopigmentation.
79146. Familial progressive hyperpigmentation.
363494. Testicular non seminomatous germ cell tumor.
PharmGKBi PA30129.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39386.
GeneTreei ENSGT00390000018272.
HOVERGENi HBG036146.
InParanoidi P21583.
KOi K05461.
OMAi VKTKGIC.
OrthoDBi EOG70ZZP2.
PhylomeDBi P21583.
TreeFami TF330811.

Enzyme and pathway databases

Reactomei REACT_111040. Signaling by SCF-KIT.
REACT_111225. Regulation of KIT signaling.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_75829. PIP3 activates AKT signaling.

Miscellaneous databases

ChiTaRSi KITLG. human.
EvolutionaryTracei P21583.
GeneWikii Stem_cell_factor.
GenomeRNAii 4254.
NextBioi 16773.
PMAP-CutDB P21583.
PROi P21583.
SOURCEi Search...

Gene expression databases

Bgeei P21583.
CleanExi HS_KITLG.
ExpressionAtlasi P21583. baseline and differential.
Genevestigatori P21583.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003452. SCF.
[Graphical view ]
PANTHERi PTHR11574. PTHR11574. 1 hit.
Pfami PF02404. SCF. 1 hit.
[Graphical view ]
PIRSFi PIRSF015599. SCF. 1 hit.
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24."
    Anderson D.M., Williams D.E., Tushinski R., Gimpel S., Eisenman J., Cannizzaro L.A., Aronson M., Croce C.M., Huebner K., Cosman D.
    Cell Growth Differ. 2:373-378(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells."
    Blair H.C., Julian B.A., Cao X., Jordan S.E., Dong S.S.
    Biochem. Biophys. Res. Commun. 255:778-784(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. Han C., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Tongue and Trachea.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Amygdala.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Colon.
  9. "Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells."
    Lu H.S., Clogston C.L., Wypych J., Parker V.P., Lee T.D., Swiderek K., Baltera R.F. Jr., Patel A.C., Chang D.C., Brankow D.W., Liu X.-D., Ogden S.G., Karkare S.B., Hu S.S., Zsebo K.M., Langley K.E.
    Arch. Biochem. Biophys. 298:150-158(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40; 64-79; 87-102; 110-149 AND 154-190 (ISOFORM 1), DISULFIDE BONDS, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING, GLYCOSYLATION AT ASN-90; ASN-118; ASN-145; SER-167; THR-168 AND THR-180.
  10. "Expression of two types of kit ligand mRNAs in human tumor cells."
    Toyota M., Hinoda Y., Itoh F., Tsujisaki M., Imai K., Yachi A.
    Int. J. Hematol. 55:301-304(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-248 (ISOFORM 2).
  11. "Stem cell factor/c-kit system in spermatogenesis."
    Mauduit C., Hamamah S., Benahmed M.
    Hum. Reprod. Update 5:535-545(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Signal transduction via the stem cell factor receptor/c-Kit."
    Ronnstrand L.
    Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. "Normal and oncogenic forms of the receptor tyrosine kinase kit."
    Lennartsson J., Jelacic T., Linnekin D., Shivakrupa R.
    Stem Cells 23:16-43(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. Cited for: INVOLVEMENT IN SHEP7.
  15. "A molecular basis for classic blond hair color in Europeans."
    Guenther C.A., Tasic B., Luo L., Bedell M.A., Kingsley D.M.
    Nat. Genet. 46:748-752(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM LINKED TO BLOND HAIR COLOR.
  16. "Structure of the active core of human stem cell factor and analysis of binding to its receptor kit."
    Jiang X., Gurel O., Mendiaz E.A., Stearns G.W., Clogston C.L., Lu H.S., Osslund T.D., Syed R.S., Langley K.E., Hendrickson W.A.
    EMBO J. 19:3192-3203(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), DISULFIDE BONDS.
  17. "Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation."
    Zhang Z., Zhang R., Joachimiak A., Schlessinger J., Kong X.P.
    Proc. Natl. Acad. Sci. U.S.A. 97:7732-7737(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-166, DISULFIDE BONDS.
  18. "Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."
    Yuzawa S., Opatowsky Y., Zhang Z., Mandiyan V., Lax I., Schlessinger J.
    Cell 130:323-334(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 26-166 IN COMPLEX WITH KIT, DISULFIDE BONDS.
  19. "Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."
    Wang Z.-Q., Si L., Tang Q., Lin D., Fu Z., Zhang J., Cui B., Zhu Y., Kong X., Deng M., Xia Y., Xu H., Le W., Hu L., Kong X.
    Am. J. Hum. Genet. 84:672-677(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT FPH SER-36, CHARACTERIZATION OF VARIANT FPH SER-36.

Entry informationi

Entry nameiSCF_HUMAN
AccessioniPrimary (citable) accession number: P21583
Secondary accession number(s): A0AV09
, A8K2Q4, B7ZLM4, Q16487, Q68DZ2, Q7M4N8, Q9UQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3