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P21579

- SYT1_HUMAN

UniProt

P21579 - SYT1_HUMAN

Protein

Synaptotagmin-1

Gene

SYT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi172 – 1721Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi173 – 1731Calcium 1By similarity
    Metal bindingi173 – 1731Calcium 2By similarity
    Metal bindingi179 – 1791Calcium 1By similarity
    Metal bindingi231 – 2311Calcium 1By similarity
    Metal bindingi231 – 2311Calcium 2By similarity
    Metal bindingi232 – 2321Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi233 – 2331Calcium 1By similarity
    Metal bindingi233 – 2331Calcium 2By similarity
    Metal bindingi233 – 2331Calcium 3By similarity
    Metal bindingi236 – 2361Calcium 3By similarity
    Metal bindingi237 – 2371Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi239 – 2391Calcium 2By similarity
    Metal bindingi239 – 2391Calcium 3By similarity

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. calcium-dependent phospholipid binding Source: Ensembl
    3. calcium ion binding Source: Ensembl
    4. low-density lipoprotein particle receptor binding Source: MGI
    5. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    6. phosphatidylserine binding Source: Ensembl
    7. phospholipid binding Source: ProtInc
    8. protein binding Source: UniProtKB
    9. syntaxin-1 binding Source: UniProtKB
    10. transporter activity Source: InterPro

    GO - Biological processi

    1. detection of calcium ion Source: UniProtKB
    2. glutamate secretion Source: Reactome
    3. neurotransmitter secretion Source: UniProtKB
    4. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
    5. positive regulation of vesicle fusion Source: Ensembl
    6. protein homooligomerization Source: UniProtKB
    7. regulation of exocytosis Source: UniProtKB
    8. synaptic transmission Source: Reactome
    9. synaptic vesicle exocytosis Source: Ensembl
    10. vesicle docking Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.
    REACT_200743. Toxicity of botulinum toxin type G (BoNT/G).
    REACT_200782. Toxicity of botulinum toxin type B (BoNT/B).
    REACT_23947. GABA synthesis, release, reuptake and degradation.

    Protein family/group databases

    TCDBi1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-1
    Alternative name(s):
    Synaptotagmin I
    Short name:
    SytI
    p65
    Gene namesi
    Name:SYT1
    Synonyms:SVP65, SYT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11509. SYT1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chromaffin granule membrane Source: UniProtKB-SubCell
    3. clathrin-sculpted acetylcholine transport vesicle membrane Source: Reactome
    4. clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Source: Reactome
    5. clathrin-sculpted glutamate transport vesicle membrane Source: Reactome
    6. clathrin-sculpted monoamine transport vesicle membrane Source: Reactome
    7. dense core granule Source: Ensembl
    8. endocytic vesicle membrane Source: Reactome
    9. excitatory synapse Source: Ensembl
    10. integral component of membrane Source: UniProtKB-KW
    11. neuron projection Source: ParkinsonsUK-UCL
    12. plasma membrane Source: Reactome
    13. presynaptic membrane Source: Ensembl
    14. synaptic vesicle Source: UniProtKB
    15. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36290.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Synaptotagmin-1PRO_0000183936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Lipidationi75 – 751S-palmitoyl cysteineBy similarity
    Lipidationi76 – 761S-palmitoyl cysteineBy similarity
    Lipidationi78 – 781S-palmitoyl cysteineBy similarity
    Lipidationi80 – 801S-palmitoyl cysteineBy similarity
    Lipidationi83 – 831S-palmitoyl cysteineBy similarity
    Modified residuei129 – 1291Phosphothreonine1 Publication
    Modified residuei230 – 2301PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP21579.
    PRIDEiP21579.

    PTM databases

    PhosphoSiteiP21579.

    Miscellaneous databases

    PMAP-CutDBP21579.

    Expressioni

    Gene expression databases

    ArrayExpressiP21579.
    BgeeiP21579.
    CleanExiHS_SYT1.
    GenevestigatoriP21579.

    Organism-specific databases

    HPAiHPA008394.
    HPA064788.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 By similarity.By similarityCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CACNB4O00305-22EBI-524909,EBI-714855
    IKBKGQ9Y6K93EBI-524909,EBI-81279

    Protein-protein interaction databases

    BioGridi112723. 23 interactions.
    DIPiDIP-34042N.
    IntActiP21579. 16 interactions.
    MINTiMINT-1400342.
    STRINGi9606.ENSP00000261205.

    Structurei

    Secondary structure

    1
    422
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi37 – 4711
    Beta strandi145 – 1539
    Turni154 – 1574
    Beta strandi158 – 16710
    Helixi173 – 1753
    Beta strandi180 – 1889
    Beta strandi206 – 2138
    Helixi217 – 2204
    Beta strandi224 – 2318
    Beta strandi234 – 2363
    Beta strandi239 – 2479
    Helixi248 – 2503
    Beta strandi257 – 2626
    Beta strandi276 – 2849
    Turni285 – 2884
    Beta strandi289 – 29911
    Beta strandi311 – 3199
    Beta strandi322 – 3287
    Beta strandi333 – 3375
    Beta strandi339 – 3479
    Turni350 – 3523
    Helixi353 – 3553
    Beta strandi356 – 3649
    Beta strandi367 – 3693
    Beta strandi373 – 3808
    Helixi385 – 39612
    Beta strandi402 – 4076
    Helixi411 – 4188

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K45NMR-A141-268[»]
    2K4ANMR-A141-268[»]
    2K8MNMR-A/D141-268[»]
    2KI6NMR-A/F141-268[»]
    2LHANMR-A272-422[»]
    2R83X-ray2.70A/B141-422[»]
    3F00X-ray1.36A141-266[»]
    3F01X-ray1.70A141-266[»]
    3F04X-ray1.35A141-266[»]
    3F05X-ray1.40A141-266[»]
    4ISQX-ray2.65D/E/F33-53[»]
    ProteinModelPortaliP21579.
    SMRiP21579. Positions 141-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP21579.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757VesicularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 422342CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 8023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini157 – 24589C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini287 – 37892C2 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni136 – 382247Phospholipid bindingCuratedAdd
    BLAST

    Domaini

    The first C2 domain mediates Ca2+-dependent phospholipid binding.
    The second C2 domain mediates interaction with SV2A and STN2.By similarity

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292488.
    HOGENOMiHOG000232127.
    HOVERGENiHBG005010.
    InParanoidiP21579.
    KOiK15290.
    OMAiHDIIGEY.
    PhylomeDBiP21579.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015428. Synaptotagmin1.
    [Graphical view]
    PANTHERiPTHR10024:SF183. PTHR10024:SF183. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE    50
    LHKIPLPPWA LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN 100
    AINMKDVKDL GKTMKDQALK DDDAETGLTD GEEKEEPKEE EKLGKLQYSL 150
    DYDFQNNQLL VGIIQAAELP ALDMGGTSDP YVKVFLLPDK KKKFETKVHR 200
    KTLNPVFNEQ FTFKVPYSEL GGKTLVMAVY DFDRFSKHDI IGEFKVPMNT 250
    VDFGHVTEEW RDLQSAEKEE QEKLGDICFS LRYVPTAGKL TVVILEAKNL 300
    KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT IKKNTLNPYY NESFSFEVPF 350
    EQIQKVQVVV TVLDYDKIGK NDAIGKVFVG YNSTGAELRH WSDMLANPRR 400
    PIAQWHTLQV EEEVDAMLAV KK 422
    Length:422
    Mass (Da):47,573
    Last modified:May 1, 1991 - v1
    Checksum:i467F7C58E411AFA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55047 mRNA. Translation: AAA60609.1.
    AK094616 mRNA. Translation: BAG52897.1.
    AK126908 mRNA. Translation: BAG54392.1.
    CR627387 mRNA. Translation: CAH10483.1.
    CH471054 Genomic DNA. Translation: EAW97343.1.
    BC058917 mRNA. Translation: AAH58917.1.
    CCDSiCCDS9017.1.
    PIRiA39052. BMHU1Y.
    RefSeqiNP_001129277.1. NM_001135805.1.
    NP_001129278.1. NM_001135806.1.
    NP_005630.1. NM_005639.2.
    UniGeneiHs.310545.

    Genome annotation databases

    EnsembliENST00000261205; ENSP00000261205; ENSG00000067715.
    ENST00000393240; ENSP00000376932; ENSG00000067715.
    ENST00000552744; ENSP00000447575; ENSG00000067715.
    GeneIDi6857.
    KEGGihsa:6857.
    UCSCiuc001sys.3. human.

    Polymorphism databases

    DMDMi135086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55047 mRNA. Translation: AAA60609.1 .
    AK094616 mRNA. Translation: BAG52897.1 .
    AK126908 mRNA. Translation: BAG54392.1 .
    CR627387 mRNA. Translation: CAH10483.1 .
    CH471054 Genomic DNA. Translation: EAW97343.1 .
    BC058917 mRNA. Translation: AAH58917.1 .
    CCDSi CCDS9017.1.
    PIRi A39052. BMHU1Y.
    RefSeqi NP_001129277.1. NM_001135805.1.
    NP_001129278.1. NM_001135806.1.
    NP_005630.1. NM_005639.2.
    UniGenei Hs.310545.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K45 NMR - A 141-268 [» ]
    2K4A NMR - A 141-268 [» ]
    2K8M NMR - A/D 141-268 [» ]
    2KI6 NMR - A/F 141-268 [» ]
    2LHA NMR - A 272-422 [» ]
    2R83 X-ray 2.70 A/B 141-422 [» ]
    3F00 X-ray 1.36 A 141-266 [» ]
    3F01 X-ray 1.70 A 141-266 [» ]
    3F04 X-ray 1.35 A 141-266 [» ]
    3F05 X-ray 1.40 A 141-266 [» ]
    4ISQ X-ray 2.65 D/E/F 33-53 [» ]
    ProteinModelPortali P21579.
    SMRi P21579. Positions 141-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112723. 23 interactions.
    DIPi DIP-34042N.
    IntActi P21579. 16 interactions.
    MINTi MINT-1400342.
    STRINGi 9606.ENSP00000261205.

    Protein family/group databases

    TCDBi 1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    PTM databases

    PhosphoSitei P21579.

    Polymorphism databases

    DMDMi 135086.

    Proteomic databases

    PaxDbi P21579.
    PRIDEi P21579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261205 ; ENSP00000261205 ; ENSG00000067715 .
    ENST00000393240 ; ENSP00000376932 ; ENSG00000067715 .
    ENST00000552744 ; ENSP00000447575 ; ENSG00000067715 .
    GeneIDi 6857.
    KEGGi hsa:6857.
    UCSCi uc001sys.3. human.

    Organism-specific databases

    CTDi 6857.
    GeneCardsi GC12P079232.
    HGNCi HGNC:11509. SYT1.
    HPAi HPA008394.
    HPA064788.
    MIMi 185605. gene.
    neXtProti NX_P21579.
    PharmGKBi PA36290.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292488.
    HOGENOMi HOG000232127.
    HOVERGENi HBG005010.
    InParanoidi P21579.
    KOi K15290.
    OMAi HDIIGEY.
    PhylomeDBi P21579.
    TreeFami TF315600.

    Enzyme and pathway databases

    Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.
    REACT_200743. Toxicity of botulinum toxin type G (BoNT/G).
    REACT_200782. Toxicity of botulinum toxin type B (BoNT/B).
    REACT_23947. GABA synthesis, release, reuptake and degradation.

    Miscellaneous databases

    ChiTaRSi SYT1. human.
    EvolutionaryTracei P21579.
    GeneWikii SYT1.
    GenomeRNAii 6857.
    NextBioi 26767.
    PMAP-CutDB P21579.
    PROi P21579.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21579.
    Bgeei P21579.
    CleanExi HS_SYT1.
    Genevestigatori P21579.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015428. Synaptotagmin1.
    [Graphical view ]
    PANTHERi PTHR10024:SF183. PTHR10024:SF183. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans."
      Perin M.S., Johnston P.A., Oezcelik T., Jahn R., Francke U., Suedhof T.C.
      J. Biol. Chem. 266:615-622(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala and Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    6. "Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery."
      Han C., Chen T., Yang M., Li N., Liu H., Cao X.
      J. Immunol. 182:2986-2996(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCAMP5.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYT1_HUMAN
    AccessioniPrimary (citable) accession number: P21579
    Secondary accession number(s): Q6AI31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 157 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3