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P21577 (6PGD_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating

EC=1.1.1.44
Gene names
Name:gnd
Ordered Locus Names:Synpcc7942_0039
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
   Biological processGluconate utilization
Pentose shunt
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-gluconate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4714716-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090060

Regions

Nucleotide binding10 – 156NADP By similarity
Nucleotide binding33 – 353NADP By similarity
Nucleotide binding75 – 773NADP By similarity
Region129 – 1313Substrate binding By similarity
Region186 – 1872Substrate binding By similarity

Sites

Active site1831Proton acceptor By similarity
Active site1901Proton donor By similarity
Binding site1031NADP By similarity
Binding site1031Substrate By similarity
Binding site1911Substrate By similarity
Binding site2631Substrate; via amide nitrogen By similarity
Binding site2901Substrate By similarity
Binding site4491Substrate; shared with dimeric partner By similarity
Binding site4551Substrate; shared with dimeric partner By similarity

Experimental info

Sequence conflict154 – 1596EPIVRS → SRSVPT in AAA27330. Ref.1
Sequence conflict1591S → T in CAA41555. Ref.2
Sequence conflict4071A → R in CAA41555. Ref.2
Sequence conflict415 – 43925AAERG…YRRDR → RQNEEFRFRFQCFPGLLRQL PARS in CAA41555. Ref.2
Sequence conflict437 – 4415RDRLP → ASPA in AAA27330. Ref.1
Sequence conflict450 – 4534DYFG → TTC in AAA27330. Ref.1
Sequence conflict458 – 4658ERTDRSGS → KAPIALL in AAA27330. Ref.1
Sequence conflict469 – 4702QW → M in AAA27330. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21577 [UniParc].

Last modified April 18, 2006. Version 4.
Checksum: 0C75D58209E124E7

FASTA47151,073
        10         20         30         40         50         60 
MALQQFGLIG LAVMGENLAL NIERNGFSLT VYNRTAEKTE AFMADRAQGK NIVPAYSLED 

        70         80         90        100        110        120 
FVASLERPRR ILVMVKAGGP VDAVVEQLKP LLDPGDLIID GGNSLFTDTE RRVKDLEALG 

       130        140        150        160        170        180 
LGFMGMGVSG GEEGALNGPS LMPGGTQAAY EAVEPIVRSI AAQVDDGPCV TYIGPGGSGH 

       190        200        210        220        230        240 
YVKMVHNGIE YGDMQLIAEA YDLLKSVAGL NASELHDVFA AWNKTPELDS FLIEITADIF 

       250        260        270        280        290        300 
TKVDDLGTGQ PLVELILDAA GQKGTGRWTV ETALEIGVAI PTIIAAVNAR ILSSIKAERQ 

       310        320        330        340        350        360 
AASEILSGPI TEPFSGDRQA FIDSVRDALY CSKICSYAQG MALLAKASQV YNYGLNLGEL 

       370        380        390        400        410        420 
ARIWKGGCII RAGFLNKIKQ AYDADPTLAN LLLAPEFRQT ILDRQLAWRR VIAIAAERGI 

       430        440        450        460        470 
PVPAFSASLD YFDSYRRDRL PQNLTQAQRD YFGAHTYERT DRSGSFHAQW F 

« Hide

References

« Hide 'large scale' references
[1]"Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase."
Broedel S.E. Jr., Wolf R.E. Jr.
J. Bacteriol. 172:4023-4031(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBSTRATE-BINDING SITE.
[2]"Amino acid sequence comparisons of 6-phosphogluconate dehydrogenase."
Culler D.C., Krogmann D.W.
Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55002 Genomic DNA. Translation: AAA27330.1.
X58719 Genomic DNA. Translation: CAA41555.1.
CP000100 Genomic DNA. Translation: ABB56071.1.
PIRS14628.
RefSeqYP_399058.1. NC_007604.1.

3D structure databases

ProteinModelPortalP21577.
SMRP21577. Positions 1-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_0039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB56071; ABB56071; Synpcc7942_0039.
GeneID3775852.
KEGGsyf:Synpcc7942_0039.
PATRIC23785105. VBISynElo51371_0103.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHOG000255147.
KOK00033.
OrthoDBEOG6MSS4W.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_0039-MONOMER.
UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_SYNE7
AccessionPrimary (citable) accession number: P21577
Secondary accession number(s): Q31S98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 18, 2006
Last modified: November 13, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways