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P21577

- 6PGD_SYNE7

UniProt

P21577 - 6PGD_SYNE7

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 4 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031NADPBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Active sitei183 – 1831Proton acceptorBy similarity
    Active sitei190 – 1901Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei263 – 2631Substrate; via amide nitrogenBy similarity
    Binding sitei290 – 2901SubstrateBy similarity
    Binding sitei449 – 4491Substrate; shared with dimeric partnerBy similarity
    Binding sitei455 – 4551Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPBy similarity
    Nucleotide bindingi33 – 353NADPBy similarity
    Nucleotide bindingi75 – 773NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_0039-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:Synpcc7942_0039
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4714716-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090060Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_0039.

    Structurei

    3D structure databases

    ProteinModelPortaliP21577.
    SMRiP21577. Positions 1-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1313Substrate bindingBy similarity
    Regioni186 – 1872Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21577-1 [UniParc]FASTAAdd to Basket

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    MALQQFGLIG LAVMGENLAL NIERNGFSLT VYNRTAEKTE AFMADRAQGK    50
    NIVPAYSLED FVASLERPRR ILVMVKAGGP VDAVVEQLKP LLDPGDLIID 100
    GGNSLFTDTE RRVKDLEALG LGFMGMGVSG GEEGALNGPS LMPGGTQAAY 150
    EAVEPIVRSI AAQVDDGPCV TYIGPGGSGH YVKMVHNGIE YGDMQLIAEA 200
    YDLLKSVAGL NASELHDVFA AWNKTPELDS FLIEITADIF TKVDDLGTGQ 250
    PLVELILDAA GQKGTGRWTV ETALEIGVAI PTIIAAVNAR ILSSIKAERQ 300
    AASEILSGPI TEPFSGDRQA FIDSVRDALY CSKICSYAQG MALLAKASQV 350
    YNYGLNLGEL ARIWKGGCII RAGFLNKIKQ AYDADPTLAN LLLAPEFRQT 400
    ILDRQLAWRR VIAIAAERGI PVPAFSASLD YFDSYRRDRL PQNLTQAQRD 450
    YFGAHTYERT DRSGSFHAQW F 471
    Length:471
    Mass (Da):51,073
    Last modified:April 18, 2006 - v4
    Checksum:i0C75D58209E124E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1596EPIVRS → SRSVPT in AAA27330. (PubMed:2113917)Curated
    Sequence conflicti159 – 1591S → T in CAA41555. 1 PublicationCurated
    Sequence conflicti407 – 4071A → R in CAA41555. 1 PublicationCurated
    Sequence conflicti415 – 43925AAERG…YRRDR → RQNEEFRFRFQCFPGLLRQL PARS in CAA41555. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti437 – 4415RDRLP → ASPA in AAA27330. (PubMed:2113917)Curated
    Sequence conflicti450 – 4534DYFG → TTC in AAA27330. (PubMed:2113917)Curated
    Sequence conflicti458 – 4658ERTDRSGS → KAPIALL in AAA27330. (PubMed:2113917)Curated
    Sequence conflicti469 – 4702QW → M in AAA27330. (PubMed:2113917)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55002 Genomic DNA. Translation: AAA27330.1.
    X58719 Genomic DNA. Translation: CAA41555.1.
    CP000100 Genomic DNA. Translation: ABB56071.1.
    PIRiS14628.
    RefSeqiYP_399058.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB56071; ABB56071; Synpcc7942_0039.
    GeneIDi3775852.
    KEGGisyf:Synpcc7942_0039.
    PATRICi23785105. VBISynElo51371_0103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55002 Genomic DNA. Translation: AAA27330.1 .
    X58719 Genomic DNA. Translation: CAA41555.1 .
    CP000100 Genomic DNA. Translation: ABB56071.1 .
    PIRi S14628.
    RefSeqi YP_399058.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali P21577.
    SMRi P21577. Positions 1-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_0039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB56071 ; ABB56071 ; Synpcc7942_0039 .
    GeneIDi 3775852.
    KEGGi syf:Synpcc7942_0039.
    PATRICi 23785105. VBISynElo51371_0103.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SYNEL:SYNPCC7942_0039-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase."
      Broedel S.E. Jr., Wolf R.E. Jr.
      J. Bacteriol. 172:4023-4031(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBSTRATE-BINDING SITE.
    2. "Amino acid sequence comparisons of 6-phosphogluconate dehydrogenase."
      Culler D.C., Krogmann D.W.
      Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry namei6PGD_SYNE7
    AccessioniPrimary (citable) accession number: P21577
    Secondary accession number(s): Q31S98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 99 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3