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P21577

- 6PGD_SYNE7

UniProt

P21577 - 6PGD_SYNE7

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, Synpcc7942_0039
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADP By similarity
Binding sitei103 – 1031Substrate By similarity
Active sitei183 – 1831Proton acceptor By similarity
Active sitei190 – 1901Proton donor By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei263 – 2631Substrate; via amide nitrogen By similarity
Binding sitei290 – 2901Substrate By similarity
Binding sitei449 – 4491Substrate; shared with dimeric partner By similarity
Binding sitei455 – 4551Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity
Nucleotide bindingi33 – 353NADP By similarity
Nucleotide bindingi75 – 773NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0039-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:Synpcc7942_0039
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4714716-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090060Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0039.

Structurei

3D structure databases

ProteinModelPortaliP21577.
SMRiP21577. Positions 1-471.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Substrate binding By similarity
Regioni186 – 1872Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21577-1 [UniParc]FASTAAdd to Basket

« Hide

MALQQFGLIG LAVMGENLAL NIERNGFSLT VYNRTAEKTE AFMADRAQGK    50
NIVPAYSLED FVASLERPRR ILVMVKAGGP VDAVVEQLKP LLDPGDLIID 100
GGNSLFTDTE RRVKDLEALG LGFMGMGVSG GEEGALNGPS LMPGGTQAAY 150
EAVEPIVRSI AAQVDDGPCV TYIGPGGSGH YVKMVHNGIE YGDMQLIAEA 200
YDLLKSVAGL NASELHDVFA AWNKTPELDS FLIEITADIF TKVDDLGTGQ 250
PLVELILDAA GQKGTGRWTV ETALEIGVAI PTIIAAVNAR ILSSIKAERQ 300
AASEILSGPI TEPFSGDRQA FIDSVRDALY CSKICSYAQG MALLAKASQV 350
YNYGLNLGEL ARIWKGGCII RAGFLNKIKQ AYDADPTLAN LLLAPEFRQT 400
ILDRQLAWRR VIAIAAERGI PVPAFSASLD YFDSYRRDRL PQNLTQAQRD 450
YFGAHTYERT DRSGSFHAQW F 471
Length:471
Mass (Da):51,073
Last modified:April 18, 2006 - v4
Checksum:i0C75D58209E124E7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1596EPIVRS → SRSVPT in AAA27330. 1 Publication
Sequence conflicti159 – 1591S → T in CAA41555. 1 Publication
Sequence conflicti407 – 4071A → R in CAA41555. 1 Publication
Sequence conflicti415 – 43925AAERG…YRRDR → RQNEEFRFRFQCFPGLLRQL PARS in CAA41555. 1 PublicationAdd
BLAST
Sequence conflicti437 – 4415RDRLP → ASPA in AAA27330. 1 Publication
Sequence conflicti450 – 4534DYFG → TTC in AAA27330. 1 Publication
Sequence conflicti458 – 4658ERTDRSGS → KAPIALL in AAA27330. 1 Publication
Sequence conflicti469 – 4702QW → M in AAA27330. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55002 Genomic DNA. Translation: AAA27330.1.
X58719 Genomic DNA. Translation: CAA41555.1.
CP000100 Genomic DNA. Translation: ABB56071.1.
PIRiS14628.
RefSeqiYP_399058.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56071; ABB56071; Synpcc7942_0039.
GeneIDi3775852.
KEGGisyf:Synpcc7942_0039.
PATRICi23785105. VBISynElo51371_0103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55002 Genomic DNA. Translation: AAA27330.1 .
X58719 Genomic DNA. Translation: CAA41555.1 .
CP000100 Genomic DNA. Translation: ABB56071.1 .
PIRi S14628.
RefSeqi YP_399058.1. NC_007604.1.

3D structure databases

ProteinModelPortali P21577.
SMRi P21577. Positions 1-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56071 ; ABB56071 ; Synpcc7942_0039 .
GeneIDi 3775852.
KEGGi syf:Synpcc7942_0039.
PATRICi 23785105. VBISynElo51371_0103.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci SYNEL:SYNPCC7942_0039-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase."
    Broedel S.E. Jr., Wolf R.E. Jr.
    J. Bacteriol. 172:4023-4031(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBSTRATE-BINDING SITE.
  2. "Amino acid sequence comparisons of 6-phosphogluconate dehydrogenase."
    Culler D.C., Krogmann D.W.
    Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry namei6PGD_SYNE7
AccessioniPrimary (citable) accession number: P21577
Secondary accession number(s): Q31S98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 98 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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