Reviewed, UniProtKB/Swiss-Prot P21577 (6PGD_SYNE7)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	Synpcc7942_0039

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090060
Experimental info
	Sequence conflict	154 – 159	6	EPIVRS → SRSVPT in AAA27330. Ref.1
	Sequence conflict	159	1	S → T in CAA41555. Ref.2
	Sequence conflict	407	1	A → R in CAA41555. Ref.2
	Sequence conflict	415 – 439	25	AAERG…YRRDR → RQNEEFRFRFQCFPGLLRQL PARS in CAA41555. Ref.2
	Sequence conflict	437 – 441	5	RDRLP → ASPA in AAA27330. Ref.1
	Sequence conflict	450 – 453	4	DYFG → TTC Ref.1
	Sequence conflict	458 – 465	8	ERTDRSGS → KAPIALL in AAA27330. Ref.1
	Sequence conflict	469 – 470	2	QW → M Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P21577-1 [UniParc]. Last modified April 18, 2006. Version 4. Checksum: 0C75D58209E124E7	FASTA	471	51,073
	10 20 30 40 50 60 MALQQFGLIG LAVMGENLAL NIERNGFSLT VYNRTAEKTE AFMADRAQGK NIVPAYSLED 70 80 90 100 110 120 FVASLERPRR ILVMVKAGGP VDAVVEQLKP LLDPGDLIID GGNSLFTDTE RRVKDLEALG 130 140 150 160 170 180 LGFMGMGVSG GEEGALNGPS LMPGGTQAAY EAVEPIVRSI AAQVDDGPCV TYIGPGGSGH 190 200 210 220 230 240 YVKMVHNGIE YGDMQLIAEA YDLLKSVAGL NASELHDVFA AWNKTPELDS FLIEITADIF 250 260 270 280 290 300 TKVDDLGTGQ PLVELILDAA GQKGTGRWTV ETALEIGVAI PTIIAAVNAR ILSSIKAERQ 310 320 330 340 350 360 AASEILSGPI TEPFSGDRQA FIDSVRDALY CSKICSYAQG MALLAKASQV YNYGLNLGEL 370 380 390 400 410 420 ARIWKGGCII RAGFLNKIKQ AYDADPTLAN LLLAPEFRQT ILDRQLAWRR VIAIAAERGI 430 440 450 460 470 PVPAFSASLD YFDSYRRDRL PQNLTQAQRD YFGAHTYERT DRSGSFHAQW F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase." Broedel S.E. Jr., Wolf R.E. Jr. J. Bacteriol. 172:4023-4031(1990) [PubMed: 2113917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBSTRATE-BINDING SITE.
[2]	"Amino acid sequence comparisons of 6-phosphogluconate dehydrogenase." Culler D.C., Krogmann D.W. Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M55002 Genomic DNA. Translation: AAA27330.1. X58719 Genomic DNA. Translation: CAA41555.1. CP000100 Genomic DNA. Translation: ABB56071.1.
PIR	S14628.
RefSeq	YP_399058.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Genome annotation databases
GeneID	3775852.
GenomeReviews	Gene locus Synpcc7942_0039 in contig CP000100_GR.
KEGG	syf:Synpcc7942_0039.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P21577.
Enzyme and pathway databases
BioCyc	SELO1140:SYNPCC7942_0039-MON.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_SYNE7

Accession

Primary (citable) accession number: P21577
Secondary accession number(s): Q31S98

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 63 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)