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P21575

- DYN1_RAT

UniProt

P21575 - DYN1_RAT

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Protein

Dynamin-1

Gene
Dnm1, Dnm
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis By similarity.

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458GTP Reviewed prediction
Nucleotide bindingi136 – 1405GTP Reviewed prediction
Nucleotide bindingi205 – 2084GTP Reviewed prediction

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. identical protein binding Source: RGD
  4. nitric-oxide synthase binding Source: RGD
  5. protein binding Source: UniProtKB
  6. protein complex binding Source: RGD
  7. protein C-terminus binding Source: RGD

GO - Biological processi

  1. endosome organization Source: Ensembl
  2. receptor internalization Source: UniProtKB
  3. receptor-mediated endocytosis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5. 5301.
ReactomeiREACT_198830. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Alternative name(s):
B-dynamin
D100
Dynamin, brain
Gene namesi
Name:Dnm1
Synonyms:Dnm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi71096. Dnm1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton
Note: Microtubule-associated. Isoform-specific localization.1 Publication
Isoform 2 : Cytoplasm 1 Publication
Isoform 6 : Cytoplasm. Golgi apparatus 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. membrane coat Source: Ensembl
  3. microtubule Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
  5. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Dynamin-1PRO_0000206565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphotyrosine By similarity
Modified residuei125 – 1251Nitrated tyrosine; alternate By similarity
Modified residuei125 – 1251Phosphotyrosine; alternate By similarity
Modified residuei347 – 3471Phosphoserine1 Publication
Modified residuei354 – 3541Phosphotyrosine By similarity
Modified residuei512 – 5121Phosphoserine1 Publication
Modified residuei774 – 7741Phosphoserine1 Publication
Modified residuei778 – 7781Phosphoserine1 Publication
Modified residuei822 – 8221Phosphoserine1 Publication
Modified residuei851 – 8511Phosphoserine1 Publication
Modified residuei857 – 8571Phosphoserine1 Publication

Post-translational modificationi

Constitutively phosphorylated by CDK5 in nerve terminals and dephosphorylated by calcineurin when synaptic vesicle endocytosis (SVE) is stimulated by depolarization-dependent calcium influx.3 Publications

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiP21575.
PRIDEiP21575.

2D gel databases

World-2DPAGE0004:P21575.

PTM databases

PhosphoSiteiP21575.

Miscellaneous databases

PMAP-CutDBP21575.

Expressioni

Tissue specificityi

Brain-specific (peripheral sensory neurons).1 Publication

Developmental stagei

Expressed in neurons after maturation.

Gene expression databases

GenevestigatoriP21575.

Interactioni

Subunit structurei

Interacts with CAV1 and SH3GLB1. Interacts with SNX9. Interacts with SNX33 (via SH3 domain) By similarity. Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 By similarity. Binds SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5TCZ1-22EBI-80070,EBI-7014859From a different organism.
AmphO088383EBI-80070,EBI-80080
Bin1O088392EBI-80070,EBI-80095
DNMBPQ6XZF73EBI-80070,EBI-2483419From a different organism.
Grb2P629943EBI-80070,EBI-401775
MYO1EQ129652EBI-80070,EBI-4279548From a different organism.
Pacsin1Q9Z0W54EBI-80070,EBI-1550185
Pik3r1Q637872EBI-80070,EBI-518443
Sh3gl2O351796EBI-80070,EBI-1149197
Sh3gl3O351802EBI-80070,EBI-1149266
Wipf1Q6IN362EBI-80070,EBI-6986245

Protein-protein interaction databases

BioGridi250837. 20 interactions.
DIPiDIP-30978N.
IntActiP21575. 17 interactions.
MINTiMINT-95899.
STRINGi10116.ENSRNOP00000046016.

Structurei

Secondary structure

1
864
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Helixi9 – 2012
Turni22 – 243
Helixi27 – 293
Beta strandi33 – 397
Turni40 – 423
Helixi44 – 529
Beta strandi60 – 623
Beta strandi69 – 757
Beta strandi80 – 834
Turni85 – 884
Helixi94 – 10815
Beta strandi120 – 1267
Beta strandi131 – 1366
Beta strandi146 – 1483
Helixi152 – 16413
Beta strandi169 – 17911
Helixi181 – 1833
Helixi185 – 1939
Beta strandi198 – 2058
Helixi207 – 2093
Helixi217 – 2204
Beta strandi231 – 2333
Beta strandi240 – 2478
Helixi248 – 26114
Turni263 – 2653
Helixi266 – 2716
Helixi274 – 30330
Beta strandi321 – 3233
Helixi326 – 34419
Helixi358 – 36710
Helixi369 – 3757
Helixi381 – 39414
Helixi404 – 41815
Helixi421 – 44222
Helixi443 – 4464
Helixi450 – 48334
Beta strandi520 – 53112
Beta strandi540 – 55516
Beta strandi561 – 5666
Beta strandi570 – 5756
Beta strandi584 – 5907
Beta strandi600 – 60910
Helixi610 – 62213
Helixi654 – 68835
Helixi690 – 69910
Helixi701 – 7077
Turni711 – 7155
Helixi719 – 74224

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AKAX-ray1.90B6-304[»]
3ZVRX-ray3.10A1-752[»]
ProteinModelPortaliP21575.
SMRiP21575. Positions 6-304, 518-630.

Miscellaneous databases

EvolutionaryTraceiP21575.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 294267Dynamin-type GAdd
BLAST
Domaini519 – 625107PHAdd
BLAST
Domaini659 – 75092GEDAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi753 – 85199Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00740000115253.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
KOiK01528.
OMAiQYPHLRE.
OrthoDBiEOG76MK7N.
PhylomeDBiP21575.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21575-1) [UniParc]FASTAAdd to Basket

Also known as: aa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN    50
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE 100
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 150
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT 200
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 250
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 350
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 400
GLFTPDLAFE ATVKKQVQKL KEPSIKCVDM VVSELTSTIR KCSEKLQQYP 450
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 500
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 550
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 600
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 650
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 700
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 750
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 800
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA 850
SPSRPESPRP PFDL 864
Length:864
Mass (Da):97,295
Last modified:June 10, 2008 - v2
Checksum:i02EC9B533CC2EC83
GO
Isoform 2 (identifier: P21575-2) [UniParc]FASTAAdd to Basket

Also known as: ab

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Localized to numerous punctate spots of various sizes distributed along the plasma membrane and throughout the cytoplasm.

Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 3 (identifier: P21575-3) [UniParc]FASTAAdd to Basket

Also known as: ac

The sequence of this isoform differs from the canonical sequence as follows:
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,376
Checksum:iA36766D15D5AC466
GO
Isoform 4 (identifier: P21575-4) [UniParc]FASTAAdd to Basket

Also known as: ad

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

Show »
Length:856
Mass (Da):96,270
Checksum:i727CC965C3929D99
GO
Isoform 5 (identifier: P21575-5) [UniParc]FASTAAdd to Basket

Also known as: ba

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 6 (identifier: P21575-6) [UniParc]FASTAAdd to Basket

Also known as: bb

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Diffuse cytoplasmic distribution with some localization to the Golgi apparatus.

Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 7 (identifier: P21575-7) [UniParc]FASTAAdd to Basket

Also known as: bc

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,505
Checksum:i686364B0BFE8865C
GO
Isoform 8 (identifier: P21575-8) [UniParc]FASTAAdd to Basket

Also known as: bd

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

Show »
Length:856
Mass (Da):96,399
Checksum:i1A01F8B610A0EF9E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei407 – 44438LAFEA…RKCSE → MAFETIVKKQVKKIREPCLK CVDMVISELISTVRQCTK in isoform 5, isoform 6, isoform 7 and isoform 8. VSP_034033Add
BLAST
Alternative sequencei766 – 81449QSVPA…GGAPP → AHVQPHAAAPSPRRAPSPAR VAGPCSWASACWIRPGGGSP RALQAGGFP in isoform 3 and isoform 7. VSP_034034Add
BLAST
Alternative sequencei815 – 86450Missing in isoform 3 and isoform 7. VSP_034035Add
BLAST
Alternative sequencei845 – 86420SRSGQ…PPFDL → RITISDP in isoform 2 and isoform 6. VSP_034037Add
BLAST
Alternative sequencei845 – 86420SRSGQ…PPFDL → SQPIGSGKSVPS in isoform 4 and isoform 8. VSP_034036Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54531 mRNA. Translation: CAA38397.1.
CO398357 mRNA. No translation available.
CB583951 mRNA. No translation available.
CB708564 mRNA. No translation available.
PIRiS11508.
RefSeqiNP_542420.1. NM_080689.4. [P21575-2]
UniGeneiRn.10354.

Genome annotation databases

EnsembliENSRNOT00000042762; ENSRNOP00000047444; ENSRNOG00000033835. [P21575-5]
ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835. [P21575-3]
GeneIDi140694.
KEGGirno:140694.
UCSCiRGD:71096. rat. [P21575-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54531 mRNA. Translation: CAA38397.1 .
CO398357 mRNA. No translation available.
CB583951 mRNA. No translation available.
CB708564 mRNA. No translation available.
PIRi S11508.
RefSeqi NP_542420.1. NM_080689.4. [P21575-2 ]
UniGenei Rn.10354.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AKA X-ray 1.90 B 6-304 [» ]
3ZVR X-ray 3.10 A 1-752 [» ]
ProteinModelPortali P21575.
SMRi P21575. Positions 6-304, 518-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250837. 20 interactions.
DIPi DIP-30978N.
IntActi P21575. 17 interactions.
MINTi MINT-95899.
STRINGi 10116.ENSRNOP00000046016.

Chemistry

BindingDBi P21575.
ChEMBLi CHEMBL1075191.

PTM databases

PhosphoSitei P21575.

2D gel databases

World-2DPAGE 0004:P21575.

Proteomic databases

PaxDbi P21575.
PRIDEi P21575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000042762 ; ENSRNOP00000047444 ; ENSRNOG00000033835 . [P21575-5 ]
ENSRNOT00000064039 ; ENSRNOP00000060845 ; ENSRNOG00000033835 . [P21575-3 ]
GeneIDi 140694.
KEGGi rno:140694.
UCSCi RGD:71096. rat. [P21575-1 ]

Organism-specific databases

CTDi 1759.
RGDi 71096. Dnm1.

Phylogenomic databases

eggNOGi COG0699.
GeneTreei ENSGT00740000115253.
HOGENOMi HOG000161069.
HOVERGENi HBG107833.
KOi K01528.
OMAi QYPHLRE.
OrthoDBi EOG76MK7N.
PhylomeDBi P21575.

Enzyme and pathway databases

BRENDAi 3.6.5.5. 5301.
Reactomei REACT_198830. MHC class II antigen presentation.

Miscellaneous databases

EvolutionaryTracei P21575.
NextBioi 620679.
PMAP-CutDB P21575.

Gene expression databases

Genevestigatori P21575.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins."
    Obar R.A., Collins C.A., Hammarback J.A., Shpetner H.S., Vallee R.B.
    Nature 347:256-261(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Lubec G., Afjehi-Sadat L., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 5-15; 45-54; 67-87; 91-107; 116-157; 167-188; 257-266; 300-315; 328-342; 400-415; 511-522 AND 584-594 (ISOFORM 1/2/3/4), IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  3. Cited for: PROTEIN SEQUENCE OF 343-364; 511-522 AND 797-838 (ISOFORM 1/2/4/5/6/8), PROTEIN SEQUENCE OF 847-864 (ISOFORM 1/5), PHOSPHORYLATION AT SER-347; SER-512; SER-774; SER-778; SER-822; SER-851 AND SER-857, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-581 (ISOFORM 5/6/7/8).
    Tissue: Brain.
  5. "Amgen rat EST program."
    Amgen EST program
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 668-864 (ISOFORM 1/5).
    Tissue: Brain and Hypothalamus.
  6. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."
    Krendel M., Osterweil E.K., Mooseker M.S.
    FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYO1E.
  7. "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain."
    Ringstad N., Nemoto Y., De Camilli P.
    Proc. Natl. Acad. Sci. U.S.A. 94:8569-8574(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3GL1; SH3GL2 AND SH3GL3.
    Tissue: Brain.
  8. "Differential distribution of dynamin isoforms in mammalian cells."
    Cao H., Garcia F., McNiven M.A.
    Mol. Biol. Cell 9:2595-2609(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis."
    Cousin M.A., Robinson P.J.
    Trends Neurosci. 24:659-665(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE OF PHOSPHORYLATION.
  10. "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
    Baillat G., Gaillard S., Castets F., Monneron A.
    J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PHOCN.
  11. Cited for: PHOSPHORYLATION BY CDK5.
  12. "Dynamin I phosphorylation and the control of synaptic vesicle endocytosis."
    Smillie K.J., Cousin M.A.
    Biochem. Soc. Symp. 72:87-97(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 6-304.

Entry informationi

Entry nameiDYN1_RAT
AccessioniPrimary (citable) accession number: P21575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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