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Protein

Dynamin-1

Gene

Dnm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPSequence analysis8
Nucleotide bindingi136 – 140GTPSequence analysis5
Nucleotide bindingi205 – 208GTPSequence analysis4

GO - Molecular functioni

  • D2 dopamine receptor binding Source: RGD
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: RGD
  • microtubule binding Source: GO_Central
  • nitric-oxide synthase binding Source: RGD
  • poly(A) RNA binding Source: Ensembl
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • clathrin-dependent endocytosis Source: InterPro
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • endosome organization Source: Ensembl
  • G-protein coupled receptor internalization Source: RGD
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • positive regulation of synaptic vesicle recycling Source: RGD
  • protein tetramerization Source: Ensembl
  • receptor internalization Source: UniProtKB
  • receptor-mediated endocytosis Source: RGD
  • sensory perception of sound Source: Ensembl
  • synaptic transmission, GABAergic Source: Ensembl
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5. 5301.
ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-437239. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Alternative name(s):
B-dynamin
D100
Dynamin, brain
Gene namesi
Name:Dnm1
Synonyms:Dnm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi71096. Dnm1.

Subcellular locationi

Isoform 2 :
Isoform 6 :

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • Golgi apparatus Source: RGD
  • membrane coat Source: Ensembl
  • microtubule Source: UniProtKB-KW
  • mitochondrial membrane Source: GO_Central
  • myelin sheath Source: Ensembl
  • photoreceptor inner segment Source: Ensembl
  • plasma membrane Source: RGD
  • protein complex Source: RGD
  • synapse Source: RGD
  • synaptic vesicle Source: RGD
  • varicosity Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065651 – 864Dynamin-1Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphotyrosineBy similarity1
Modified residuei125Nitrated tyrosine; alternateBy similarity1
Modified residuei125Phosphotyrosine; alternateBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei347PhosphoserineCombined sources1 Publication1
Modified residuei354PhosphotyrosineBy similarity1
Modified residuei512Phosphoserine1 Publication1
Modified residuei774Phosphoserine1 Publication1
Modified residuei778Phosphoserine1 Publication1
Modified residuei796Omega-N-methylarginineBy similarity1
Modified residuei822Phosphoserine1 Publication1
Modified residuei851PhosphoserineCombined sources1 Publication1
Modified residuei857PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Constitutively phosphorylated by CDK5 in nerve terminals and dephosphorylated by calcineurin when synaptic vesicle endocytosis (SVE) is stimulated by depolarization-dependent calcium influx.2 Publications

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbiP21575.
PRIDEiP21575.

2D gel databases

World-2DPAGE0004:P21575.

PTM databases

iPTMnetiP21575.
PhosphoSitePlusiP21575.

Miscellaneous databases

PMAP-CutDBP21575.

Expressioni

Tissue specificityi

Brain-specific (peripheral sensory neurons).1 Publication

Developmental stagei

Expressed in neurons after maturation.

Gene expression databases

BgeeiENSRNOG00000033835.
ExpressionAtlasiP21575. baseline and differential.
GenevisibleiP21575. RN.

Interactioni

Subunit structurei

Interacts with CAV1 and SH3GLB1. Interacts with SNX9. Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5TCZ1-22EBI-80070,EBI-7014859From a different organism.
AmphO088383EBI-80070,EBI-80080
Bin1O088392EBI-80070,EBI-80095
DNMBPQ6XZF73EBI-80070,EBI-2483419From a different organism.
Grb2P629943EBI-80070,EBI-401775
MYO1EQ129652EBI-80070,EBI-4279548From a different organism.
Pacsin1Q9Z0W54EBI-80070,EBI-1550185
Pik3r1Q637872EBI-80070,EBI-518443
Sh3gl2O351796EBI-80070,EBI-1149197
Sh3gl3O351802EBI-80070,EBI-1149266
Wipf1Q6IN362EBI-80070,EBI-6986245

GO - Molecular functioni

  • D2 dopamine receptor binding Source: RGD
  • identical protein binding Source: RGD
  • microtubule binding Source: GO_Central
  • nitric-oxide synthase binding Source: RGD
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi250837. 22 interactors.
DIPiDIP-30978N.
IntActiP21575. 17 interactors.
MINTiMINT-95899.
STRINGi10116.ENSRNOP00000047444.

Chemistry databases

BindingDBiP21575.

Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi9 – 20Combined sources12
Turni22 – 24Combined sources3
Helixi27 – 29Combined sources3
Beta strandi33 – 39Combined sources7
Turni40 – 42Combined sources3
Helixi44 – 52Combined sources9
Beta strandi60 – 62Combined sources3
Beta strandi69 – 75Combined sources7
Beta strandi80 – 83Combined sources4
Turni85 – 88Combined sources4
Helixi94 – 108Combined sources15
Beta strandi120 – 126Combined sources7
Beta strandi131 – 136Combined sources6
Beta strandi146 – 148Combined sources3
Helixi152 – 164Combined sources13
Beta strandi169 – 179Combined sources11
Helixi181 – 183Combined sources3
Helixi185 – 193Combined sources9
Beta strandi198 – 205Combined sources8
Helixi207 – 209Combined sources3
Helixi217 – 220Combined sources4
Beta strandi231 – 233Combined sources3
Beta strandi240 – 247Combined sources8
Helixi248 – 261Combined sources14
Turni263 – 265Combined sources3
Helixi266 – 271Combined sources6
Helixi274 – 303Combined sources30
Beta strandi321 – 323Combined sources3
Helixi326 – 344Combined sources19
Helixi358 – 367Combined sources10
Helixi369 – 375Combined sources7
Helixi381 – 394Combined sources14
Helixi404 – 418Combined sources15
Helixi421 – 442Combined sources22
Helixi443 – 446Combined sources4
Helixi450 – 483Combined sources34
Beta strandi520 – 531Combined sources12
Beta strandi540 – 555Combined sources16
Beta strandi561 – 566Combined sources6
Beta strandi570 – 575Combined sources6
Beta strandi584 – 590Combined sources7
Beta strandi600 – 609Combined sources10
Helixi610 – 622Combined sources13
Helixi654 – 688Combined sources35
Helixi690 – 699Combined sources10
Helixi701 – 707Combined sources7
Turni711 – 715Combined sources5
Helixi719 – 742Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AKAX-ray1.90B6-304[»]
3ZVRX-ray3.10A1-752[»]
ProteinModelPortaliP21575.
SMRiP21575.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21575.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GAdd BLAST267
Domaini519 – 625PHPROSITE-ProRule annotationAdd BLAST107
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 851Pro-richAdd BLAST99

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
InParanoidiP21575.
KOiK01528.
OMAiNGDESAN.
PhylomeDBiP21575.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P21575-1) [UniParc]FASTAAdd to basket
Also known as: aa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
160 170 180 190 200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDLAFE ATVKKQVQKL KEPSIKCVDM VVSELTSTIR KCSEKLQQYP
460 470 480 490 500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
610 620 630 640 650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
760 770 780 790 800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
810 820 830 840 850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA
860
SPSRPESPRP PFDL
Length:864
Mass (Da):97,295
Last modified:June 10, 2008 - v2
Checksum:i02EC9B533CC2EC83
GO
Isoform 2 (identifier: P21575-2) [UniParc]FASTAAdd to basket
Also known as: ab

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Localized to numerous punctate spots of various sizes distributed along the plasma membrane and throughout the cytoplasm.
Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 3 (identifier: P21575-3) [UniParc]FASTAAdd to basket
Also known as: ac

The sequence of this isoform differs from the canonical sequence as follows:
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,376
Checksum:iA36766D15D5AC466
GO
Isoform 4 (identifier: P21575-4) [UniParc]FASTAAdd to basket
Also known as: ad

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

Show »
Length:856
Mass (Da):96,270
Checksum:i727CC965C3929D99
GO
Isoform 5 (identifier: P21575-5) [UniParc]FASTAAdd to basket
Also known as: ba

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 6 (identifier: P21575-6) [UniParc]FASTAAdd to basket
Also known as: bb

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Diffuse cytoplasmic distribution with some localization to the Golgi apparatus.
Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 7 (identifier: P21575-7) [UniParc]FASTAAdd to basket
Also known as: bc

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,505
Checksum:i686364B0BFE8865C
GO
Isoform 8 (identifier: P21575-8) [UniParc]FASTAAdd to basket
Also known as: bd

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

Show »
Length:856
Mass (Da):96,399
Checksum:i1A01F8B610A0EF9E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034033407 – 444LAFEA…RKCSE → MAFETIVKKQVKKIREPCLK CVDMVISELISTVRQCTK in isoform 5, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST38
Alternative sequenceiVSP_034034766 – 814QSVPA…GGAPP → AHVQPHAAAPSPRRAPSPAR VAGPCSWASACWIRPGGGSP RALQAGGFP in isoform 3 and isoform 7. CuratedAdd BLAST49
Alternative sequenceiVSP_034035815 – 864Missing in isoform 3 and isoform 7. CuratedAdd BLAST50
Alternative sequenceiVSP_034037845 – 864SRSGQ…PPFDL → RITISDP in isoform 2 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_034036845 – 864SRSGQ…PPFDL → SQPIGSGKSVPS in isoform 4 and isoform 8. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54531 mRNA. Translation: CAA38397.1.
CO398357 mRNA. No translation available.
CB583951 mRNA. No translation available.
CB708564 mRNA. No translation available.
PIRiS11508.
RefSeqiNP_542420.1. NM_080689.4. [P21575-2]
UniGeneiRn.10354.

Genome annotation databases

EnsembliENSRNOT00000047921; ENSRNOP00000041582; ENSRNOG00000033835. [P21575-1]
ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835. [P21575-2]
GeneIDi140694.
KEGGirno:140694.
UCSCiRGD:71096. rat. [P21575-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54531 mRNA. Translation: CAA38397.1.
CO398357 mRNA. No translation available.
CB583951 mRNA. No translation available.
CB708564 mRNA. No translation available.
PIRiS11508.
RefSeqiNP_542420.1. NM_080689.4. [P21575-2]
UniGeneiRn.10354.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AKAX-ray1.90B6-304[»]
3ZVRX-ray3.10A1-752[»]
ProteinModelPortaliP21575.
SMRiP21575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250837. 22 interactors.
DIPiDIP-30978N.
IntActiP21575. 17 interactors.
MINTiMINT-95899.
STRINGi10116.ENSRNOP00000047444.

Chemistry databases

BindingDBiP21575.
ChEMBLiCHEMBL1075191.

PTM databases

iPTMnetiP21575.
PhosphoSitePlusiP21575.

2D gel databases

World-2DPAGE0004:P21575.

Proteomic databases

PaxDbiP21575.
PRIDEiP21575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047921; ENSRNOP00000041582; ENSRNOG00000033835. [P21575-1]
ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835. [P21575-2]
GeneIDi140694.
KEGGirno:140694.
UCSCiRGD:71096. rat. [P21575-1]

Organism-specific databases

CTDi1759.
RGDi71096. Dnm1.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161069.
HOVERGENiHBG107833.
InParanoidiP21575.
KOiK01528.
OMAiNGDESAN.
PhylomeDBiP21575.

Enzyme and pathway databases

BRENDAi3.6.5.5. 5301.
ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-190873. Gap junction degradation.
R-RNO-196025. Formation of annular gap junctions.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-437239. Recycling pathway of L1.

Miscellaneous databases

EvolutionaryTraceiP21575.
PMAP-CutDBP21575.
PROiP21575.

Gene expression databases

BgeeiENSRNOG00000033835.
ExpressionAtlasiP21575. baseline and differential.
GenevisibleiP21575. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027741. DNM1.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF32. PTHR11566:SF32. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYN1_RAT
AccessioniPrimary (citable) accession number: P21575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Absence of tyrosine and threonine phosphorylation is demonstrated in PubMed:17376771. However, tyrosine and threonine phosphorylation may still occur in different experimental conditions.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.