Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P21575

- DYN1_RAT

UniProt

P21575 - DYN1_RAT

Protein

Dynamin-1

Gene

Dnm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis By similarity.By similarity

    Catalytic activityi

    GTP + H2O = GDP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458GTPSequence Analysis
    Nucleotide bindingi136 – 1405GTPSequence Analysis
    Nucleotide bindingi205 – 2084GTPSequence Analysis

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. identical protein binding Source: RGD
    4. nitric-oxide synthase binding Source: RGD
    5. protein binding Source: UniProtKB
    6. protein complex binding Source: RGD
    7. protein C-terminus binding Source: RGD

    GO - Biological processi

    1. endosome organization Source: Ensembl
    2. receptor internalization Source: UniProtKB
    3. receptor-mediated endocytosis Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Motor protein

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.5.5. 5301.
    ReactomeiREACT_198830. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynamin-1 (EC:3.6.5.5)
    Alternative name(s):
    B-dynamin
    D100
    Dynamin, brain
    Gene namesi
    Name:Dnm1
    Synonyms:Dnm
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi71096. Dnm1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Microtubule-associated. Isoform-specific localization.

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. membrane coat Source: Ensembl
    3. microtubule Source: UniProtKB-KW
    4. plasma membrane Source: Reactome
    5. protein complex Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Dynamin-1PRO_0000206565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801PhosphotyrosineBy similarity
    Modified residuei125 – 1251Nitrated tyrosine; alternateBy similarity
    Modified residuei125 – 1251Phosphotyrosine; alternateBy similarity
    Modified residuei347 – 3471Phosphoserine2 Publications
    Modified residuei354 – 3541PhosphotyrosineBy similarity
    Modified residuei512 – 5121Phosphoserine2 Publications
    Modified residuei774 – 7741Phosphoserine2 Publications
    Modified residuei778 – 7781Phosphoserine2 Publications
    Modified residuei822 – 8221Phosphoserine2 Publications
    Modified residuei851 – 8511Phosphoserine2 Publications
    Modified residuei857 – 8571Phosphoserine2 Publications

    Post-translational modificationi

    Constitutively phosphorylated by CDK5 in nerve terminals and dephosphorylated by calcineurin when synaptic vesicle endocytosis (SVE) is stimulated by depolarization-dependent calcium influx.2 Publications

    Keywords - PTMi

    Nitration, Phosphoprotein

    Proteomic databases

    PaxDbiP21575.
    PRIDEiP21575.

    2D gel databases

    World-2DPAGE0004:P21575.

    PTM databases

    PhosphoSiteiP21575.

    Miscellaneous databases

    PMAP-CutDBP21575.

    Expressioni

    Tissue specificityi

    Brain-specific (peripheral sensory neurons).1 Publication

    Developmental stagei

    Expressed in neurons after maturation.

    Gene expression databases

    GenevestigatoriP21575.

    Interactioni

    Subunit structurei

    Interacts with CAV1 and SH3GLB1. Interacts with SNX9. Interacts with SNX33 (via SH3 domain) By similarity. Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 By similarity. Binds SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q5TCZ1-22EBI-80070,EBI-7014859From a different organism.
    AmphO088383EBI-80070,EBI-80080
    Bin1O088392EBI-80070,EBI-80095
    DNMBPQ6XZF73EBI-80070,EBI-2483419From a different organism.
    Grb2P629943EBI-80070,EBI-401775
    MYO1EQ129652EBI-80070,EBI-4279548From a different organism.
    Pacsin1Q9Z0W54EBI-80070,EBI-1550185
    Pik3r1Q637872EBI-80070,EBI-518443
    Sh3gl2O351796EBI-80070,EBI-1149197
    Sh3gl3O351802EBI-80070,EBI-1149266
    Wipf1Q6IN362EBI-80070,EBI-6986245

    Protein-protein interaction databases

    BioGridi250837. 20 interactions.
    DIPiDIP-30978N.
    IntActiP21575. 17 interactions.
    MINTiMINT-95899.
    STRINGi10116.ENSRNOP00000046016.

    Structurei

    Secondary structure

    1
    864
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Helixi9 – 2012
    Turni22 – 243
    Helixi27 – 293
    Beta strandi33 – 397
    Turni40 – 423
    Helixi44 – 529
    Beta strandi60 – 623
    Beta strandi69 – 757
    Beta strandi80 – 834
    Turni85 – 884
    Helixi94 – 10815
    Beta strandi120 – 1267
    Beta strandi131 – 1366
    Beta strandi146 – 1483
    Helixi152 – 16413
    Beta strandi169 – 17911
    Helixi181 – 1833
    Helixi185 – 1939
    Beta strandi198 – 2058
    Helixi207 – 2093
    Helixi217 – 2204
    Beta strandi231 – 2333
    Beta strandi240 – 2478
    Helixi248 – 26114
    Turni263 – 2653
    Helixi266 – 2716
    Helixi274 – 30330
    Beta strandi321 – 3233
    Helixi326 – 34419
    Helixi358 – 36710
    Helixi369 – 3757
    Helixi381 – 39414
    Helixi404 – 41815
    Helixi421 – 44222
    Helixi443 – 4464
    Helixi450 – 48334
    Beta strandi520 – 53112
    Beta strandi540 – 55516
    Beta strandi561 – 5666
    Beta strandi570 – 5756
    Beta strandi584 – 5907
    Beta strandi600 – 60910
    Helixi610 – 62213
    Helixi654 – 68835
    Helixi690 – 69910
    Helixi701 – 7077
    Turni711 – 7155
    Helixi719 – 74224

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AKAX-ray1.90B6-304[»]
    3ZVRX-ray3.10A1-752[»]
    ProteinModelPortaliP21575.
    SMRiP21575. Positions 6-304, 518-630.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP21575.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 294267Dynamin-type GAdd
    BLAST
    Domaini519 – 625107PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 75092GEDPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi753 – 85199Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GED domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0699.
    GeneTreeiENSGT00740000115253.
    HOGENOMiHOG000161069.
    HOVERGENiHBG107833.
    KOiK01528.
    OMAiQYPHLRE.
    OrthoDBiEOG76MK7N.
    PhylomeDBiP21575.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    PfamiPF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00195. DYNAMIN.
    SMARTiSM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P21575-1) [UniParc]FASTAAdd to Basket

    Also known as: aa

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN    50
    FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE 100
    IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 150
    DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT 200
    IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 250
    ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
    QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 350
    IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 400
    GLFTPDLAFE ATVKKQVQKL KEPSIKCVDM VVSELTSTIR KCSEKLQQYP 450
    RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 500
    QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 550
    SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 600
    RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 650
    MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 700
    LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 750
    STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 800
    GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA 850
    SPSRPESPRP PFDL 864
    Length:864
    Mass (Da):97,295
    Last modified:June 10, 2008 - v2
    Checksum:i02EC9B533CC2EC83
    GO
    Isoform 2 (identifier: P21575-2) [UniParc]FASTAAdd to Basket

    Also known as: ab

    The sequence of this isoform differs from the canonical sequence as follows:
         845-864: SRSGQASPSRPESPRPPFDL → RITISDP

    Note: Localized to numerous punctate spots of various sizes distributed along the plasma membrane and throughout the cytoplasm.

    Show »
    Length:851
    Mass (Da):95,927
    Checksum:i5D9294C5D1015A88
    GO
    Isoform 3 (identifier: P21575-3) [UniParc]FASTAAdd to Basket

    Also known as: ac

    The sequence of this isoform differs from the canonical sequence as follows:
         766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
         815-864: Missing.

    Show »
    Length:814
    Mass (Da):92,376
    Checksum:iA36766D15D5AC466
    GO
    Isoform 4 (identifier: P21575-4) [UniParc]FASTAAdd to Basket

    Also known as: ad

    The sequence of this isoform differs from the canonical sequence as follows:
         845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

    Show »
    Length:856
    Mass (Da):96,270
    Checksum:i727CC965C3929D99
    GO
    Isoform 5 (identifier: P21575-5) [UniParc]FASTAAdd to Basket

    Also known as: ba

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK

    Show »
    Length:864
    Mass (Da):97,424
    Checksum:i4E27474E413CCEE7
    GO
    Isoform 6 (identifier: P21575-6) [UniParc]FASTAAdd to Basket

    Also known as: bb

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
         845-864: SRSGQASPSRPESPRPPFDL → RITISDP

    Note: Diffuse cytoplasmic distribution with some localization to the Golgi apparatus.

    Show »
    Length:851
    Mass (Da):96,057
    Checksum:i5FE0938290E39F51
    GO
    Isoform 7 (identifier: P21575-7) [UniParc]FASTAAdd to Basket

    Also known as: bc

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
         766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
         815-864: Missing.

    Show »
    Length:814
    Mass (Da):92,505
    Checksum:i686364B0BFE8865C
    GO
    Isoform 8 (identifier: P21575-8) [UniParc]FASTAAdd to Basket

    Also known as: bd

    The sequence of this isoform differs from the canonical sequence as follows:
         407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
         845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

    Show »
    Length:856
    Mass (Da):96,399
    Checksum:i1A01F8B610A0EF9E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 44438LAFEA…RKCSE → MAFETIVKKQVKKIREPCLK CVDMVISELISTVRQCTK in isoform 5, isoform 6, isoform 7 and isoform 8. CuratedVSP_034033Add
    BLAST
    Alternative sequencei766 – 81449QSVPA…GGAPP → AHVQPHAAAPSPRRAPSPAR VAGPCSWASACWIRPGGGSP RALQAGGFP in isoform 3 and isoform 7. CuratedVSP_034034Add
    BLAST
    Alternative sequencei815 – 86450Missing in isoform 3 and isoform 7. CuratedVSP_034035Add
    BLAST
    Alternative sequencei845 – 86420SRSGQ…PPFDL → RITISDP in isoform 2 and isoform 6. 1 PublicationVSP_034037Add
    BLAST
    Alternative sequencei845 – 86420SRSGQ…PPFDL → SQPIGSGKSVPS in isoform 4 and isoform 8. CuratedVSP_034036Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54531 mRNA. Translation: CAA38397.1.
    CO398357 mRNA. No translation available.
    CB583951 mRNA. No translation available.
    CB708564 mRNA. No translation available.
    PIRiS11508.
    RefSeqiNP_542420.1. NM_080689.4. [P21575-2]
    UniGeneiRn.10354.

    Genome annotation databases

    EnsembliENSRNOT00000042762; ENSRNOP00000047444; ENSRNOG00000033835. [P21575-5]
    ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835. [P21575-3]
    GeneIDi140694.
    KEGGirno:140694.
    UCSCiRGD:71096. rat. [P21575-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54531 mRNA. Translation: CAA38397.1 .
    CO398357 mRNA. No translation available.
    CB583951 mRNA. No translation available.
    CB708564 mRNA. No translation available.
    PIRi S11508.
    RefSeqi NP_542420.1. NM_080689.4. [P21575-2 ]
    UniGenei Rn.10354.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AKA X-ray 1.90 B 6-304 [» ]
    3ZVR X-ray 3.10 A 1-752 [» ]
    ProteinModelPortali P21575.
    SMRi P21575. Positions 6-304, 518-630.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250837. 20 interactions.
    DIPi DIP-30978N.
    IntActi P21575. 17 interactions.
    MINTi MINT-95899.
    STRINGi 10116.ENSRNOP00000046016.

    Chemistry

    BindingDBi P21575.
    ChEMBLi CHEMBL1075191.

    PTM databases

    PhosphoSitei P21575.

    2D gel databases

    World-2DPAGE 0004:P21575.

    Proteomic databases

    PaxDbi P21575.
    PRIDEi P21575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000042762 ; ENSRNOP00000047444 ; ENSRNOG00000033835 . [P21575-5 ]
    ENSRNOT00000064039 ; ENSRNOP00000060845 ; ENSRNOG00000033835 . [P21575-3 ]
    GeneIDi 140694.
    KEGGi rno:140694.
    UCSCi RGD:71096. rat. [P21575-1 ]

    Organism-specific databases

    CTDi 1759.
    RGDi 71096. Dnm1.

    Phylogenomic databases

    eggNOGi COG0699.
    GeneTreei ENSGT00740000115253.
    HOGENOMi HOG000161069.
    HOVERGENi HBG107833.
    KOi K01528.
    OMAi QYPHLRE.
    OrthoDBi EOG76MK7N.
    PhylomeDBi P21575.

    Enzyme and pathway databases

    BRENDAi 3.6.5.5. 5301.
    Reactomei REACT_198830. MHC class II antigen presentation.

    Miscellaneous databases

    EvolutionaryTracei P21575.
    NextBioi 620679.
    PMAP-CutDB P21575.

    Gene expression databases

    Genevestigatori P21575.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR027741. DNM1.
    IPR000375. Dynamin_central.
    IPR001401. Dynamin_GTPase.
    IPR019762. Dynamin_GTPase_CS.
    IPR022812. Dynamin_SF.
    IPR003130. GED.
    IPR020850. GTPase_effector_domain_GED.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR11566. PTHR11566. 1 hit.
    PTHR11566:SF32. PTHR11566:SF32. 1 hit.
    Pfami PF01031. Dynamin_M. 1 hit.
    PF00350. Dynamin_N. 1 hit.
    PF02212. GED. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00195. DYNAMIN.
    SMARTi SM00053. DYNc. 1 hit.
    SM00302. GED. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
    PS51718. G_DYNAMIN_2. 1 hit.
    PS51388. GED. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins."
      Obar R.A., Collins C.A., Hammarback J.A., Shpetner H.S., Vallee R.B.
      Nature 347:256-261(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Lubec G., Afjehi-Sadat L., Diao W.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 5-15; 45-54; 67-87; 91-107; 116-157; 167-188; 257-266; 300-315; 328-342; 400-415; 511-522 AND 584-594 (ISOFORM 1/2/3/4), IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus and Spinal cord.
    3. Cited for: PROTEIN SEQUENCE OF 343-364; 511-522 AND 797-838 (ISOFORM 1/2/4/5/6/8), PROTEIN SEQUENCE OF 847-864 (ISOFORM 1/5), PHOSPHORYLATION AT SER-347; SER-512; SER-774; SER-778; SER-822; SER-851 AND SER-857, IDENTIFICATION BY MASS SPECTROMETRY.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-581 (ISOFORM 5/6/7/8).
      Tissue: Brain.
    5. "Amgen rat EST program."
      Amgen EST program
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 668-864 (ISOFORM 1/5).
      Tissue: Brain and Hypothalamus.
    6. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."
      Krendel M., Osterweil E.K., Mooseker M.S.
      FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYO1E.
    7. "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain."
      Ringstad N., Nemoto Y., De Camilli P.
      Proc. Natl. Acad. Sci. U.S.A. 94:8569-8574(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SH3GL1; SH3GL2 AND SH3GL3.
      Tissue: Brain.
    8. "Differential distribution of dynamin isoforms in mammalian cells."
      Cao H., Garcia F., McNiven M.A.
      Mol. Biol. Cell 9:2595-2609(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis."
      Cousin M.A., Robinson P.J.
      Trends Neurosci. 24:659-665(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE OF PHOSPHORYLATION.
    10. "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
      Baillat G., Gaillard S., Castets F., Monneron A.
      J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PHOCN.
    11. Cited for: PHOSPHORYLATION BY CDK5.
    12. "Dynamin I phosphorylation and the control of synaptic vesicle endocytosis."
      Smillie K.J., Cousin M.A.
      Biochem. Soc. Symp. 72:87-97(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 6-304.

    Entry informationi

    Entry nameiDYN1_RAT
    AccessioniPrimary (citable) accession number: P21575
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3