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Protein

ATP synthase-coupling factor 6, mitochondrial

Gene

Atp5j

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.
R-RNO-8949613. Cristae formation.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase-coupling factor 6, mitochondrial
Short name:
ATPase subunit F6
Gene namesi
Name:Atp5j
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621376. Atp5j.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: RGD

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000000253133 – 108ATP synthase-coupling factor 6, mitochondrialAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-acetyllysineBy similarity1
Modified residuei46N6-acetyllysineBy similarity1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei84N6-acetyllysine; alternateBy similarity1
Modified residuei84N6-succinyllysine; alternateBy similarity1
Modified residuei99N6-acetyllysine; alternateBy similarity1
Modified residuei99N6-succinyllysine; alternateBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei108PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21571.
PRIDEiP21571.

2D gel databases

UCD-2DPAGEiP21571.

PTM databases

iPTMnetiP21571.
PhosphoSitePlusiP21571.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001551.
GenevisibleiP21571. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

BioGridi250190. 1 interactor.
STRINGi10116.ENSRNOP00000002116.

Structurei

3D structure databases

ProteinModelPortaliP21571.
SMRiP21571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4634. Eukaryota.
ENOG41122G1. LUCA.
GeneTreeiENSGT00390000008902.
HOGENOMiHOG000261672.
HOVERGENiHBG062261.
InParanoidiP21571.
KOiK02131.
OMAiYKQKSSG.
OrthoDBiEOG091G10KV.
PhylomeDBiP21571.
TreeFamiTF318998.

Family and domain databases

InterProiView protein in InterPro
IPR008387. ATP_synth_f6_mt.
PANTHERiPTHR12441. PTHR12441. 1 hit.
PfamiView protein in Pfam
PF05511. ATP-synt_F6. 1 hit.
PIRSFiPIRSF002455. ATP_synthase_coupling_factor_6. 1 hit.
SUPFAMiSSF111357. SSF111357. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVQRIFRLS SVLRSAVSVH LRRNIGVTAV AFNKELDPVQ KLFLDKIREY
60 70 80 90 100
KAKRLASGGP VDTGPEYQQE VDRELFKLKQ MYGKGEMDKF PTFNFEDPKF

EVLDKPQS
Length:108
Mass (Da):12,494
Last modified:May 1, 1991 - v1
Checksum:iFF1177C9681B5F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73030 mRNA. Translation: AAA40954.1.
X54510 mRNA. Translation: CAA38369.1.
BC059121 mRNA. Translation: AAH59121.1.
PIRiJC1167.
RefSeqiNP_446054.1. NM_053602.2.
XP_008766824.1. XM_008768602.2.
XP_008766825.1. XM_008768603.1.
XP_017453574.1. XM_017598085.1.
XP_017453575.1. XM_017598086.1.
UniGeneiRn.5790.

Genome annotation databases

EnsembliENSRNOT00000002116; ENSRNOP00000002116; ENSRNOG00000001551.
GeneIDi94271.
KEGGirno:94271.
UCSCiRGD:621376. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiATP5J_RAT
AccessioniPrimary (citable) accession number: P21571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 7, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families