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Protein

Angiogenin

Gene

Ang

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptorBy similarity1
Active sitei137Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Endonuclease, Hydrolase, Nuclease, Protein synthesis inhibitor
Biological processAngiogenesis, Differentiation, Stress response

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Angiogenin (EC:3.1.27.-)
Alternative name(s):
Angiogenin-1
Ribonuclease 5
Short name:
RNase 5
Gene namesi
Name:Ang
Synonyms:Ang1, Rnase5, Rnase5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88022 Ang

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003085725 – 145AngiogeninAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi50 ↔ 1041 Publication
Disulfide bondi63 ↔ 1151 Publication
Disulfide bondi81 ↔ 1301 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP21570
PeptideAtlasiP21570
PRIDEiP21570

PTM databases

PhosphoSitePlusiP21570

Expressioni

Gene expression databases

BgeeiENSMUSG00000072115
ExpressionAtlasiP21570 baseline and differential
GenevisibleiP21570 MM

Interactioni

Subunit structurei

Homodimer. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067434

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 37Combined sources9
Helixi47 – 56Combined sources10
Turni60 – 63Combined sources4
Beta strandi65 – 70Combined sources6
Helixi74 – 78Combined sources5
Helixi79 – 81Combined sources3
Turni82 – 84Combined sources3
Beta strandi85 – 88Combined sources4
Turni89 – 91Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi99 – 108Combined sources10
Beta strandi111 – 114Combined sources4
Beta strandi116 – 124Combined sources9
Beta strandi127 – 131Combined sources5
Beta strandi134 – 138Combined sources5
Helixi140 – 142Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BWKX-ray1.50A25-145[»]
2BWLX-ray1.62A25-145[»]
ProteinModelPortaliP21570
SMRiP21570
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21570

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 59Nucleolar localization signalBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3ET Eukaryota
ENOG410Y4FD LUCA
GeneTreeiENSGT00900000140967
HOGENOMiHOG000276883
HOVERGENiHBG008396
InParanoidiP21570
KOiK16631
OMAiRYKHFLT
OrthoDBiEOG091G0YDD
PhylomeDBiP21570
TreeFamiTF333393

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
PRINTSiPR00794 RIBONUCLEASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISPGPLFL IFVLGLVVIP PTLAQDDSRY TKFLTQHHDA KPKGRDDRYC
60 70 80 90 100
ERMMKRRSLT SPCKDVNTFI HGNKSNIKAI CGANGSPYRE NLRMSKSPFQ
110 120 130 140
VTTCKHTGGS PRPPCQYRAS AGFRHVVIAC ENGLPVHFDE SFFSL
Length:145
Mass (Da):16,228
Last modified:May 1, 1991 - v1
Checksum:i06944260BB764938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22516 Genomic DNA Translation: AAA91366.1
BC055355 mRNA Translation: AAH55355.1
CCDSiCCDS27034.1
PIRiA35932
RefSeqiNP_001155203.1, NM_001161731.2
NP_031473.1, NM_007447.3
UniGeneiMm.202665

Genome annotation databases

EnsembliENSMUST00000069011; ENSMUSP00000067434; ENSMUSG00000072115
ENSMUST00000171688; ENSMUSP00000132084; ENSMUSG00000072115
GeneIDi11727
KEGGimmu:11727
UCSCiuc007tml.2 mouse

Similar proteinsi

Entry informationi

Entry nameiANGI_MOUSE
AccessioniPrimary (citable) accession number: P21570
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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