P21569 (CYPH_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Cyclophilin
Cyclosporin A-binding protein
Rotamase

Gene names

Name:	CYP
Synonyms:	ROT1

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Cyclosporin
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Peptidyl-prolyl cis-trans isomerase		PRO_0000064146
Regions
	Domain	7 – 170	164	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	P21569 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 16863EB1AAA33C67	FASTA	172	18,349
	10 20 30 40 50 60 MANPRVFFDM TVGGAPAGRI VMELYANEVP KTAENFRALC TGEKGVGKSG KPLHYKGSTF 70 80 90 100 110 120 HRVIPEFMCQ GGDFTRGNGT GGESIYGEKF PDEKFVRKQP APGVLSMANA GPNTNGSQFF 130 140 150 160 170 ICTVATPWLD GKHVVFGQVV EGMDVVKAIE KVGTRNGSTS KVVKVADCGQ LS

References

[1]	"Structure and expression of cytosolic cyclophilin/peptidyl-prolyl cis-trans isomerase of higher plants and production of active tomato cyclophilin in Escherichia coli." Gasser C.S., Gunning D.A., Budelier K.A., Brown S.M. Proc. Natl. Acad. Sci. U.S.A. 87:9519-9523(1990) [PubMed: 1702215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence analysis of a cyclophilin gene from maize: developmental expression and regulation by salicylic acid." Marivet J., Frendo P., Burkard G. Mol. Gen. Genet. 247:222-228(1995) [PubMed: 7753032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55021 mRNA. Translation: AAA63403.1. X68678 Genomic DNA. Translation: CAA48638.1.
PIR	CSZM. C39252.
3D structure databases
ProteinModelPortal	P21569.
SMR	P21569. Positions 1-171.
ModBase	Search...
Proteomic databases
PRIDE	P21569.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P21569.
MaizeGDB	65166.
Phylogenomic databases
GeneTree	EPGT00070000028093.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PIRSF	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYPH_MAIZE

Accession

Primary (citable) accession number: P21569

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program