Reviewed, UniProtKB/Swiss-Prot P21557 (GYRA_HALSQ)

Names and origin

Protein names

Recommended name:
    DNA gyrase subunit A
    EC=5.99.1.3

Gene names

Name:

gyrA

Organism

Haloferax sp. (strain Aa 2.2)

Taxonomic identifier

2254 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloferax

Protein attributes

Sequence length	82 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis.
Miscellaneous	Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria.
Sequence similarities	Belongs to the topoisomerase gyrA/parC subunit family.

Ontologies

Keywords
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Isomerase Topoisomerase
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›82	›82	DNA gyrase subunit A		PRO_0000145273
Experimental info
	Non-terminal residue	82	1

Sequences

	Sequence		Length	Mass (Da)
	P21557-1 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 8DD3543CF5111286	FASTA	82	8,847
	10 20 30 40 50 60 MSSDAPDSFE PGAGIAAEVK NARIEDEMEQ SYIDYAMSVI AGRALPDVRD GLKPVHRRIL 70 80 YAMHQAGVTS NSSHRKSSSI VG

References

[1]	"Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria." Holmes M.L., Dyall-Smith M.L. J. Bacteriol. 173:642-648(1991) [PubMed: 1846146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M38373 Genomic DNA. Translation: AAB09606.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ModBase	Search...
Family and domain databases
InterPro	IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
Pfam	PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
ProDom	PD000742. DNA_topoisoIV. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

GYRA_HALSQ

Accession

Primary (citable) accession number: P21557

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)